CN102079979A - Composition of squalene and beta-carotene and application thereof in cigarettes - Google Patents
Composition of squalene and beta-carotene and application thereof in cigarettes Download PDFInfo
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Abstract
The invention provides a composition of squalene and beta-carotene and application thereof in cigarettes. The composition comprises the following components in weight percentage: 0.05%-70% of squalene, 0.05%-70% of beta-carotene and the balance of solvents. By utilizing the synergic function of the squalene and the beta-carotene, the composition achieves the purpose of simultaneously and effectively removing solid-phase radicals in cigarette tar and gas-phase radicals in smoke and can obviously reduce the consumption of antioxidants, thereby providing a powerful technical support for solving the problems of smoking and health.
Description
Technical field
The invention belongs to technical field of chemistry, relate to a kind of natural antioxidants composition, be specifically related to the synergistic composition of squalene and two kinds of natural antioxidantss of β-Hu Luobusu, and the application aspect the gaseous phase free radical in solid phase free radical and the cigarette smoke in reducing coke tar in cigarette of described composition.
Background technology
The World tobacco industry be with the contradiction struggle of antismoke tide in grow up gradually, the 1950's, medical circles such as English, U.S. at first connect diseases such as smoking and lung cancer, further cause people's generally attention.No smoking with administration means has been impracticable, conduct vigorous propaganda dissuasion smoking and also do not reach the ideal effect, best mode is that the sanitary condition of improvement cigarette and the cigarette of seeking the low evil of safety relax smoking and healthy contradiction at present, smoker's needs both can have been satisfied, can reduce and even eliminate the influence of smoking again, just can accomplish really the human consumer to be responsible for health of people.
But the burning of cigarette is except that producing thousands of kinds of compounds, also produce the free radical of high density, comprise the solid phase free radical that the life-span is relatively long, the active oxygen radical such as the superoxide anion (O of quinones and semiquinone class, polycyclic aromatic hydrocarbons free radical and they and oxygen reaction generation
2 -), hydrogen peroxide (H
2O
2), hydroxy radical qiao (OH), singlet oxygen (
1O
2) relative with lifetime short gaseous phase free radical with lipid peroxidation free radical (ROO) etc., alkoxy free group (RO), alkyl diradical (R), oxynitride free radical etc.And to the health effect the strongest the most deleterious be the gaseous phase free radical of cigarette, it can cause tuberculosis, heart trouble and cancer.The crowd of these radical pairs smoker and passive suction " second-hand " cigarette can produce serious injury.
At present in to flue gas aspect the free radical scavenging research and few, mainly reduce the injury to human body of free radical the flue gas from adding natural antioxidants, VITAMIN, amino acid, protein etc. and biological enzyme free-radical scavengers and trace element, natural mineral matter.But these free-radical scavengerss all are one or more simple mixed additive generally, the ability of antioxidant for clearing free radical has certain selectivity, generally is difficult to the relative short gaseous phase free radical with lifetime of long-life solid phase free radical is played scavenging(action) simultaneously.
Squalene is a kind of lipid unsaponifiables, being a kind of many unsaturated olefins (squalene), is to find from the liver oil of shark at first, is named as Squalene in 1914, its chemical name is 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa carbon six alkene belong to the open chain triterpene, claim the Oils,glyceridic,cod-liver terpene again, participate in body's cholesterol and synthesize also and can enhance metabolism, have superoxide dismutase enhancement (SOD) activity, the enhancing body immunological competence, anti-ageing, antifatigue, different physiological roles such as antitumor is a kind of avirulent marine bioactivity material with the effect of preventing and curing diseases.Squalene distributes very wide in plant, but content is not high, is lower than 5% of unsaponifiables in the vegetables oil more, and only minority content is more, contains squalene 150～700mg/100g as sweet oil, and its content is 332mg/100g in the Rice pollard oil.
β-Hu Luobusu is a kind of green and yellow vegetable of extensively being present in, and the natural antioxidants in the fruit has good anti-chromosome aberration, protective effect on cancer risk and stronger physiologically active.And β-Hu Luobusu still is an important potential aroma component in the tobacco, and the height of its content has very big influence to cigarette quality.Contain 18 kinds of carotenoid in the tobacco, carotenoid is the precursor of fragrance matter important in the tobacco, can be biodegradable into more than 80 kind of aroma component through enzyme effect or atmospheric oxidation effect in the alcoholization process, and they have very big influence to perfume (or spice), the flavor of cigarette.Wherein β-Hu Luobusu is a main component wherein.Also Just because of this, the variation of the content of β-Hu Luobusu produces bigger influence to perfume (or spice), the flavor of cigarette.How to determine the suitable content of β-Hu Luobusu in the tobacco and seek suitable synergistic complex scheme, reach the effective simultaneously removing free radical of the quality of improving tobacco and require further study with the security that improves cigarette.
At present relevant squalene and β-Hu Luobusu be mixed synergy research also seldom, any technology report is not seen in the research that especially is applied to the production of cigarettes aspect as yet.
Summary of the invention
The objective of the invention is to overcome the deficiency of free radical scavenging technology in the existing cigarette product, a kind of squalene and the β-Hu Luobusu antioxidant synergistic composition that is mixed is provided.By squalene and β-Hu Luobusu reasonably are mixed, reach synergistic function between the two, realize the purpose of mutual supplement with each other's advantages, the natural free-radical scavengers composition of gaseous phase free radical in solid phase free radical in the coke tar in cigarette and the flue gas can be efficiently removed simultaneously in acquisition, meanwhile, guarantee the fragrance and the quality such as jealous of cigarette.
Purpose of the present invention is achieved by the following technical programs:
A kind of squalene and β-Hu Luobusu composition are provided, by weight, comprise 0.05～70% squalene, 0.05～70% β-Hu Luobusu and the solvent of surplus.
Preferably, described squalene and β-Hu Luobusu composition by weight, comprise 0.5～50% squalene, 1～50% β-Hu Luobusu and the solvent of surplus.
Preferably, the part by weight that described squalene and β-Hu Luobusu are mixed is 1: 12～12: 1, and more preferably the part by weight that is mixed of squalene and β-Hu Luobusu is 1: 6～6: 1.
It is 60%～90% aqueous ethanolic solution that described solvent can be selected volume by volume concentration for use, preferred 70%.
Described squalene can be the extract that from plant, animal or microorganism, extracts or purified after pure product, can adopt commercial bulk drug product.
Described β-Hu Luobusu can be that the β-Hu Luobusu extract that extracts from plant also can be the pure product after purified, can adopt commercial product, for example commercially available β-Hu Luobusu powder.
The present invention provides the application of described squalene and β-Hu Luobusu composition simultaneously, is applied to production of cigarettes.
Main application is that described composition is directly added in the cigarette shreds, the solid phase free radical of the tar that produces when being used for reducing cigarette burning and the gaseous phase free radical in the cigarette smoke.
Preferably, the ratio of interpolation is the described composition of 0.3～3g/100g pipe tobacco.
The invention has the beneficial effects as follows:
1, the ability of the removing free radical of the present invention's composition of selecting squalene and β-Hu Luobusu rationally to be mixed to obtain improves greatly, obtains obvious synergistic effect, can obviously reduce usage quantity.
2, the present invention adopts the suitable scheme that is mixed, after squalene and β-Hu Luobusu rationally be mixed, make squalene and β-Hu Luobusu bring into play synergistic function preferably, reach the simultaneously efficient usage quantity of removing in the coke tar in cigarette purpose of gaseous phase free radical in the solid phase free radical and flue gas and can obviously reducing antioxidant, provide strong technical support with healthy problem for solving smoking.
3, after the present invention reasonably is mixed by squalene and β-Hu Luobusu, add in the cigarette shreds, can increase the fragrance of cigarette and jealous, have tobacco product and have general adaptability by burning.
Embodiment
Further describe the present invention below in conjunction with specific embodiment.Employed test method is ordinary method if no special instructions among the following embodiment; Employed material, reagent etc. if no special instructions, are the reagent and the material that can obtain from commercial channels.
Embodiment 1 squalene and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, that is:
The solvent of 0.05% squalene+1% β-Hu Luobusu+surplus.
The product that the present embodiment squalene adopts the true Bioisystech Co., Ltd in Shanghai to produce, squalene content be greater than 96.0%, perhaps other producers like product of producing; β-Hu Luobusu adopts the β-Hu Luobusu powder, and by Zhengzhou litchi promise bio tech ltd, content beta-carotene is greater than 96.0%, perhaps other producers like product of producing; Following example together.
Embodiment 2 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 0.05% squalene+0.6% β-Hu Luobusu+surplus.
Embodiment 3 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 0.1% squalene+0.6% β-Hu Luobusu+surplus.
Embodiment 4 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+1% β-Hu Luobusu+surplus.
Embodiment 5 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+0.05% β-Hu Luobusu+surplus.
Embodiment 6 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1.2% squalene+0.1% β-Hu Luobusu+surplus.
Embodiment 7 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 0.6% squalene+0.1% β-Hu Luobusu+surplus.
Embodiment 8 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, promptly.
The solvent of 5% squalene+60% β-Hu Luobusu+surplus.
Embodiment 9 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, promptly.
The solvent of 5% squalene+30% β-Hu Luobusu+surplus.
Embodiment 10 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, promptly.
The solvent of 5% squalene+5% β-Hu Luobusu+surplus.
Embodiment 11 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 30% squalene+5% β-Hu Luobusu+surplus.
Embodiment 12 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 60% squalene+5% β-Hu Luobusu+surplus.
Embodiment 13 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 35% squalene+70% β-Hu Luobusu+surplus.
Embodiment 14 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 30% squalene+45% β-Hu Luobusu+surplus.
Embodiment 15 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 30% squalene+30% β-Hu Luobusu+surplus.
Embodiment 16 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, promptly.
The solvent of 45% squalene+30% β-Hu Luobusu+surplus.
Embodiment 17 squalenes and β-Hu Luobusu preparation of compositions
According to the following weight ratio a certain amount of squalene and β-Hu Luobusu being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, promptly.
The solvent of 70% squalene+35% β-Hu Luobusu+surplus.
The preparation of embodiment 18 squalene solution
According to the following weight ratio a certain amount of squalene being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+surplus.
The preparation of embodiment 19 squalene solution
According to the following weight ratio a certain amount of squalene being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, promptly.
The solvent of 70% squalene+surplus.
The preparation of embodiment 20 β-Hu Luobusu solution
According to the following weight ratio a certain amount of β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% β-Hu Luobusu+surplus.
The preparation of embodiment 21 β-Hu Luobusu solution
According to the following weight ratio a certain amount of β-Hu Luobusu being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 70% β-Hu Luobusu+surplus.
Embodiment 22 application experiments
In the production of cigarettes technology for making tobacco threds, program according to flavoring and casing, be mixed composition and squalene or β-Hu Luobusu solution in the foregoing description 1～21 are sprayed onto on the pipe tobacco continuously equably, the pipe tobacco that is sprayed with composition, squalene or β-Hu Luobusu solution are dried in the pipe tobacco water content after between 11%～13%, make cigarette with this area ordinary method again in 10 ℃ cold wind.Being sprayed with composition on per 100 gram pipe tobaccos and being respectively 0.3,1 and 3 grams, is contrast with 70% aqueous ethanolic solution that does not contain squalene or β-Hu Luobusu.
Free radical scavenging effect detection in the cigarette smoke: free radical adopts spectrum (ESR) technology to detect in the coke tar in cigarette, smoke gaseous phase free radical adopts spin catching agent PBN(2-benzene tert-butylnitrone) capture the back detection, tar solid phase free radical adopts cambridge filter to capture the back and detects.
Adopt conventional gaseous phase free radical detection method: adopt glassware to collect the flue gas free radical.The carbon tetrachloride solution that adds certain density free radical scavenger PBN is linked collector on the smoking machine in collector, is 35.0mL with the suction capacity, and suction time is 2s, and suction is spaced apart the standard suction speed smoking cigarette of 60s.Constant volume is collected the flue gas free-atom aqueous solution after the smoking, and it is freezing then to put into liquid nitrogen.Detection volume is 200 μ L.
Solid phase free radical detection method: after the smoking cambridge filter is taken off, cut out down 1/10th filter disc and pack into and carry out ESR in the 3mm diameter silica tube and detect.
By detecting the content that the natural antioxidants synergistic composition cigarette that adds different content and different proportionings produces free radical, compared with the control, calculation composition is to the removing effect of solid phase free radical and gaseous phase free radical in the cigarette smoke.Experimental result is as follows:
Add 0.3 gram composition to solid phase free radical in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 1
Add 1 gram composition to solid phase free radical in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 2
Add 3 gram compositions to solid phase free radical in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 3
Experiment conclusion: to cigarette gaseous phase free radical and solid phase free radical scavenging effect as can be seen from the foregoing description, when the addition of composition during at 0.3 gram/100 gram pipe tobaccos, it has certain removing effect simultaneously to solid phase free radical and gas phase freedom, particularly work as the proportioning of squalene and β-Hu Luobusu between 1: 12～12: 1, especially in the time of between 1: 6～6: 1, composition has obvious synergistic effect to solid phase and gas phase free radical scavenging effect.When the addition of composition during at 1 gram/100 gram pipe tobaccos, it has tangible removing effect simultaneously to cigarette solid phase and gaseous phase free radical, and the weight proportion of working as squalene and β-Hu Luobusu is between 1: 12～12: 1, especially in the time of between 1: 6～6: 1, composition has obvious synergistic effect to solid phase and gas phase free radical scavenging effect, for single agent, remove effect and improved 8～11 times.When the addition of composition during at 3 grams/100 gram pipe tobaccos, for single agent, composition also has obvious synergistic effect to the removing ability of cigarette solid phase and gaseous phase free radical, but for addition was 1 gram/100 gram pipe tobaccos, otherness was not remarkable between the two.Actual according to producing, the present invention is used for the natural antioxidants composition of cigarette, its the removing ability synergism to solid phase and gaseous phase free radical between 1: 12～12: 1 of the proportioning of squalene and β-Hu Luobusu is obvious, and per 100 gram pipe tobaccos interpolation amount of composition are suitable between 0.3～3 gram.
The method of smokeing panel test: the cigarette that the tobacco leaf group is rolled into same specification is propped up with the CMB120 cigarette machine.With CIJECTOR essence injector the natural antioxidants composition is propped up by adding the rolled cigarette of 1 gram composition injection in per 100 gram pipe tobaccos, be placed in the climatic chamber (22 ± 1 ℃ of temperature, humidity 60 ± 2%) behind the balance 48h, smoke panel test the expert from quality and quantity, the pleasant impression of fragrance and have or not assorted gas and cigarette perfume (or spice) whether to coordinate, whether have aspect such as excitement to smoke panel test, estimate by tobacco.Propping up with the cigarette of injecting same amount 70% aqueous ethanolic solution respectively is contrast, and table 4 provides the smoke panel test experimental result of part embodiment to the cigarette of interpolation composition:
Add 1 gram composition smoking result in the per 100 gram pipe tobaccos of table 4
The present invention creatively analyzes summary as can be known through long-term a large amount of experiment and to smoking result, it is comparatively preferred between 1: 12～12: 1 to add in the cigarette proportioning of composition squalene and β-Hu Luobusu to, and per 100 gram pipe tobaccos to add amount of composition be comparatively suitable between 0.5～3 gram.
Claims (9)
1. the composition of squalene and β-Hu Luobusu is characterized in that by weight, comprises 0.05～70% squalene, 0.05～70% β-Hu Luobusu and the solvent of surplus.
2. according to the composition of described squalene of claim 1 and β-Hu Luobusu, it is characterized in that comprising by weight 0.5～50% squalene, 1～50% β-Hu Luobusu and the solvent of surplus.
3. according to the composition of claim 1 or 2 described squalenes and β-Hu Luobusu, it is characterized in that the part by weight that described squalene and β-Hu Luobusu are mixed is 1: 12～12: 1.
4. according to the composition of described squalene of claim 3 and β-Hu Luobusu, it is characterized in that the part by weight that described squalene and β-Hu Luobusu are mixed is 1: 6～6: 1.
5. according to the composition of claim 1 or 2 described squalenes and β-Hu Luobusu, it is characterized in that described squalene for the extract that from plant, animal or microorganism, extracts or purified after pure product.
6. according to the composition of claim 1 or 2 described squalenes and β-Hu Luobusu, it is characterized in that described β-Hu Luobusu for the β-Hu Luobusu extract that from plant, extracts or purified after pure product.
7. according to the composition of claim 1 or 2 described squalenes and β-Hu Luobusu, it is characterized in that described solvent is that volume by volume concentration is 60～90% aqueous ethanolic solutions.
8. the application of the composition of a claim 1 or 2 described squalenes and β-Hu Luobusu, it is characterized in that it being that described squalene and β-Hu Luobusu composition are added in the cigarette shreds, the solid phase free radical of the tar that produces when being used for reducing cigarette burning and the gaseous phase free radical in the cigarette smoke.
9. application according to claim 7 is characterized in that it being that described squalene and β-Hu Luobusu composition are added in the cigarette shreds according to the ratio of 0.3～3g composition/100g pipe tobacco.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102161611A (en) * | 2011-03-11 | 2011-08-24 | 中国烟草总公司广东省公司 | Method for preparing squalene based on tobacco as raw material |
| CN102805425A (en) * | 2012-08-30 | 2012-12-05 | 江苏中烟工业有限责任公司 | Application of beta-carotene/beta-cyclodextrin inclusion compounds to release quantity reduction of phenolic compounds in cigarette smoke gas |
| CN102813279A (en) * | 2012-08-30 | 2012-12-12 | 江苏中烟工业有限责任公司 | Method for efficiently reducing specific nitrosamines in cigarette smoke |
| CN103750562A (en) * | 2014-01-15 | 2014-04-30 | 中国烟草总公司广东省公司 | Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm |
| CN103767070A (en) * | 2014-01-15 | 2014-05-07 | 中国烟草总公司广东省公司 | Preparation method of squalene and astaxanthin composition liquid precursor lipidosome and radical reducing and harm reduction application of squalene and astaxanthin composition liquid precursor lipidosome |
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| CN109717505A (en) * | 2019-02-22 | 2019-05-07 | 广东省金叶科技开发有限公司 | A kind of cigarette additive and its application |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1782052A (en) * | 2004-09-01 | 2006-06-07 | 马来西亚棕油局 | Specialty palm oil products and other specialty vegetable oil products |
| CN101795697A (en) * | 2007-06-23 | 2010-08-04 | 法摩康国际股份有限公司 | Gastropod biological fluid, preparation and process for purification and purposes |
-
2010
- 2010-12-08 CN CN 201010578167 patent/CN102079979B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1782052A (en) * | 2004-09-01 | 2006-06-07 | 马来西亚棕油局 | Specialty palm oil products and other specialty vegetable oil products |
| CN101795697A (en) * | 2007-06-23 | 2010-08-04 | 法摩康国际股份有限公司 | Gastropod biological fluid, preparation and process for purification and purposes |
Cited By (14)
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|---|---|---|---|---|
| CN102161611B (en) * | 2011-03-11 | 2013-08-07 | 中国烟草总公司广东省公司 | Method for preparing squalene based on tobacco as raw material |
| CN102161611A (en) * | 2011-03-11 | 2011-08-24 | 中国烟草总公司广东省公司 | Method for preparing squalene based on tobacco as raw material |
| CN102813279B (en) * | 2012-08-30 | 2014-05-28 | 江苏中烟工业有限责任公司 | Method for efficiently reducing specific nitrosamines in cigarette smoke |
| CN102813279A (en) * | 2012-08-30 | 2012-12-12 | 江苏中烟工业有限责任公司 | Method for efficiently reducing specific nitrosamines in cigarette smoke |
| CN102805425A (en) * | 2012-08-30 | 2012-12-05 | 江苏中烟工业有限责任公司 | Application of beta-carotene/beta-cyclodextrin inclusion compounds to release quantity reduction of phenolic compounds in cigarette smoke gas |
| CN103750562A (en) * | 2014-01-15 | 2014-04-30 | 中国烟草总公司广东省公司 | Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm |
| CN103767070A (en) * | 2014-01-15 | 2014-05-07 | 中国烟草总公司广东省公司 | Preparation method of squalene and astaxanthin composition liquid precursor lipidosome and radical reducing and harm reduction application of squalene and astaxanthin composition liquid precursor lipidosome |
| CN103859589A (en) * | 2014-03-20 | 2014-06-18 | 广西中烟工业有限责任公司 | Preparation method of squalene and beta-carotene composition liquid proliposomes and method for reducing free radical and harm by adopting proliposomes |
| CN103859588A (en) * | 2014-03-20 | 2014-06-18 | 广西中烟工业有限责任公司 | Preparation method of squalene and astaxanthin composite multivesicular liposome and radical lowering and harm reducing method thereof |
| CN103859589B (en) * | 2014-03-20 | 2016-04-13 | 广西中烟工业有限责任公司 | The preparation of a kind of squalene and beta carotene composition liquid precursor liposome and fall base harm reduction |
| CN103859588B (en) * | 2014-03-20 | 2016-04-13 | 广西中烟工业有限责任公司 | The preparation of squalene and astaxanthin composition multivesicular liposome and fall base harm reduction |
| CN109717505A (en) * | 2019-02-22 | 2019-05-07 | 广东省金叶科技开发有限公司 | A kind of cigarette additive and its application |
| CN112678833A (en) * | 2020-11-17 | 2021-04-20 | 广西中烟工业有限责任公司 | Nano-silica modified squalene organic silicon particles and preparation and use methods thereof |
| CN112678833B (en) * | 2020-11-17 | 2023-08-04 | 广西中烟工业有限责任公司 | Nano silicon dioxide modified squalene organic silicon particles and preparation and use methods thereof |
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