CN102070516A - 一种制备氨氯地平的方法 - Google Patents

一种制备氨氯地平的方法 Download PDF

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Publication number
CN102070516A
CN102070516A CN201110042786XA CN201110042786A CN102070516A CN 102070516 A CN102070516 A CN 102070516A CN 201110042786X A CN201110042786X A CN 201110042786XA CN 201110042786 A CN201110042786 A CN 201110042786A CN 102070516 A CN102070516 A CN 102070516A
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CN
China
Prior art keywords
amlodipine
equivalent
sodium
combination
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201110042786XA
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English (en)
Chinese (zh)
Inventor
西格弗里德.高曼
郭兴州
周东生
官京鹏
吴加梁
江丽娇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yichang Changjiang Pharmaceutical Co Ltd
Guangdong HEC Pharmaceutical
Original Assignee
Yichang Changjiang Pharmaceutical Co Ltd
Guangdong HEC Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yichang Changjiang Pharmaceutical Co Ltd, Guangdong HEC Pharmaceutical filed Critical Yichang Changjiang Pharmaceutical Co Ltd
Priority to CN201110042786XA priority Critical patent/CN102070516A/zh
Publication of CN102070516A publication Critical patent/CN102070516A/zh
Priority to PCT/CN2012/071413 priority patent/WO2012113325A1/fr
Priority to CN201280003318.4A priority patent/CN103168030B/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201110042786XA 2011-02-22 2011-02-22 一种制备氨氯地平的方法 Pending CN102070516A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201110042786XA CN102070516A (zh) 2011-02-22 2011-02-22 一种制备氨氯地平的方法
PCT/CN2012/071413 WO2012113325A1 (fr) 2011-02-22 2012-02-21 Procédé de préparation d'amlodipine
CN201280003318.4A CN103168030B (zh) 2011-02-22 2012-02-21 一种制备氨氯地平的方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201110042786XA CN102070516A (zh) 2011-02-22 2011-02-22 一种制备氨氯地平的方法

Publications (1)

Publication Number Publication Date
CN102070516A true CN102070516A (zh) 2011-05-25

Family

ID=44029297

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201110042786XA Pending CN102070516A (zh) 2011-02-22 2011-02-22 一种制备氨氯地平的方法
CN201280003318.4A Active CN103168030B (zh) 2011-02-22 2012-02-21 一种制备氨氯地平的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280003318.4A Active CN103168030B (zh) 2011-02-22 2012-02-21 一种制备氨氯地平的方法

Country Status (2)

Country Link
CN (2) CN102070516A (fr)
WO (1) WO2012113325A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012113325A1 (fr) * 2011-02-22 2012-08-30 广东东阳光药业有限公司 Procédé de préparation d'amlodipine
CN103922996A (zh) * 2013-01-11 2014-07-16 广东东阳光药业有限公司 一种药物新型中间体及其制备方法
CN107573279A (zh) * 2017-09-01 2018-01-12 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸氨氯地平降解杂质的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572909A (en) * 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
US6046337A (en) * 1997-08-12 2000-04-04 Egis Gyogyszergyar Rt. Process for the preparation of a dihydropyridine derivative
US6492523B2 (en) * 2001-03-13 2002-12-10 Hanmi Pharm. Co., Ltd. Method for preparing amlodipine
CN1927837A (zh) * 2006-09-27 2007-03-14 上海应用技术学院 氨氯地平苯磺酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6784297B2 (en) * 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
AU2002368531A1 (en) * 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572909A (en) * 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
US6046337A (en) * 1997-08-12 2000-04-04 Egis Gyogyszergyar Rt. Process for the preparation of a dihydropyridine derivative
US6492523B2 (en) * 2001-03-13 2002-12-10 Hanmi Pharm. Co., Ltd. Method for preparing amlodipine
CN1927837A (zh) * 2006-09-27 2007-03-14 上海应用技术学院 氨氯地平苯磺酸盐的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
《化学工业与工程》 20060131 刘鹤超,冯亚青 新一代心血管药物氨氯地平的合成 88-92 1-10 第23卷, 第1期 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012113325A1 (fr) * 2011-02-22 2012-08-30 广东东阳光药业有限公司 Procédé de préparation d'amlodipine
CN103922996A (zh) * 2013-01-11 2014-07-16 广东东阳光药业有限公司 一种药物新型中间体及其制备方法
CN103922996B (zh) * 2013-01-11 2019-01-04 广东东阳光药业有限公司 一种药物新型中间体及其制备方法
CN107573279A (zh) * 2017-09-01 2018-01-12 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸氨氯地平降解杂质的合成方法
CN107573279B (zh) * 2017-09-01 2020-06-09 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸氨氯地平降解杂质的合成方法

Also Published As

Publication number Publication date
WO2012113325A1 (fr) 2012-08-30
CN103168030B (zh) 2014-10-08
CN103168030A (zh) 2013-06-19

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Application publication date: 20110525