CN113195486A - 类酰胺类衍生物的杂质及用途 - Google Patents

类酰胺类衍生物的杂质及用途 Download PDF

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Publication number
CN113195486A
CN113195486A CN201980083058.8A CN201980083058A CN113195486A CN 113195486 A CN113195486 A CN 113195486A CN 201980083058 A CN201980083058 A CN 201980083058A CN 113195486 A CN113195486 A CN 113195486A
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formula
impurity
compound
compound shown
prepare
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CN201980083058.8A
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English (en)
Inventor
窦飞
靖鹏
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Nhwa Pharmaceutical Corp
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Nhwa Pharmaceutical Corp
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Publication of CN113195486A publication Critical patent/CN113195486A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

杂质A、杂质B和杂质G，及其制备方法以及作为式Ⅵ所示化合物质量控制的参照标准品的应用。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201980083058.8A 2018-12-17 2019-12-16 类酰胺类衍生物的杂质及用途 Pending CN113195486A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018115458453 2018-12-17
CN201811545845.3A CN111320619A (zh) 2018-12-17 2018-12-17 一种类酰胺类衍生物的杂质及用途
PCT/CN2019/125643 WO2020125580A1 (zh) 2018-12-17 2019-12-16 类酰胺类衍生物的杂质及用途

Publications (1)

Publication Number Publication Date
CN113195486A true CN113195486A (zh) 2021-07-30

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CN201811545845.3A Pending CN111320619A (zh) 2018-12-17 2018-12-17 一种类酰胺类衍生物的杂质及用途
CN201980083058.8A Pending CN113195486A (zh) 2018-12-17 2019-12-16 类酰胺类衍生物的杂质及用途

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US (1) US20220048887A1 (zh)
EP (1) EP3901149A4 (zh)
JP (1) JP2022515070A (zh)
CN (2) CN111320619A (zh)
WO (1) WO2020125580A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111285862A (zh) * 2018-12-07 2020-06-16 江苏恩华药业股份有限公司 一种丙酰胺类衍生物的结晶形式及其制备方法
CN112480102B (zh) * 2020-12-02 2022-04-22 江苏恩华药业股份有限公司 一种丙酰胺衍生物及其用于精神分裂症的用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155804A (zh) * 2005-04-14 2008-04-02 大塚制药株式会社 用于治疗精神疾病的哌嗪取代的苯并噻吩
CN101506171A (zh) * 2006-06-19 2009-08-12 阿斯利康(瑞典)有限公司 作为细胞因子介导的疾病的抑制剂的异喹啉衍生物及其用途
CN106749219A (zh) * 2015-11-20 2017-05-31 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
CN106995410A (zh) * 2016-01-26 2017-08-01 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
WO2018118734A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
WO2008092292A1 (en) * 2007-01-17 2008-08-07 The Hong Kong University Of Science And Technology Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101155804A (zh) * 2005-04-14 2008-04-02 大塚制药株式会社 用于治疗精神疾病的哌嗪取代的苯并噻吩
CN101506171A (zh) * 2006-06-19 2009-08-12 阿斯利康(瑞典)有限公司 作为细胞因子介导的疾病的抑制剂的异喹啉衍生物及其用途
CN106749219A (zh) * 2015-11-20 2017-05-31 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
CN106995410A (zh) * 2016-01-26 2017-08-01 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
WO2018118734A1 (en) * 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARRY M. TROST等: "Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3-sp2 and sp2-sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds", 《CHEM.EUR.J.》 *
RAVI JANGIR等: "Facile Synthesis of the Isoquinoline Alkaloids Doryanine and Oxyhydrastinine", 《SYNTHESIS》 *
易封萍等: "《合成香料工艺学》", 31 May 2016 *

Also Published As

Publication number Publication date
EP3901149A1 (en) 2021-10-27
JP2022515070A (ja) 2022-02-17
WO2020125580A1 (zh) 2020-06-25
EP3901149A4 (en) 2022-09-07
CN111320619A (zh) 2020-06-23
US20220048887A1 (en) 2022-02-17

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