CN102068675A - Traditional Chinese medicine composition for treatment of chronic diarrhoea and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treatment of chronic diarrhoea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for the treatment of chronic diarrhoea and a preparation method thereof, belonging to the modernization field of traditional Chinese medicine. The active ingredients of the traditional Chinese medicine composition for the treatment of chronic diarrhoea are the following raw materials in parts by weight: 500 parts of halloysitum rubrum (forged), 250 parts of coptis root, 250 parts of phellodendron bark, 250 parts of myrobalan fruit (kernel removed), 250 parts of mace (stewed), 250 parts of magnolia bark (stir-baked), 250 parts of massa medicata fermentata, 200 parts of evodia rutaecarpa (prepared), 200 parts of cinnamon, 250 parts of rhizoma zingiberis, 200 parts of pericarpium zanthoxyli, 200 parts of chuanxiong rhizome, 200 parts of oyster (forged), 250 parts of gallnut and 250 parts of dark plum (kernel removed). By analyzing the prescription on the basis of the theory of traditional Chinese medicine, the preparation method of the traditional Chinese medicine composition containing reasonable and stable active ingredients is provided according to the research conclusion related to physicochemical properties and pharmacological actions of medicinal ingredients. The pharmaceutical preparation prepared according to the technical proposal has the advantages of stable and controllable quality, prominently enhanced therapeutic effect compared with current commercially-available dosage forms, lowered dosage for patients, improved bioavailability and remarkable economic and social benefits.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method for the treatment of chronic diarrhea, belong to modern Chinese traditional medicine field.
Background technology
Chronic diarrhea claims chronic diarrhea again, is clinical common disease.In the most taste of this patient gas plain empty, feel seasonal pathogen again, the outbreak repeatedly that causes having loose bowels of the depression of eating and drinking without temperance, or irritability in addition, asthenia of both the spleen and kidney with the passing of time, the state of an illness is more delayed.The clinical witness of primary disease, for seeing, what have has also held damp and hot witness under the arm more with deficiency-cold syndrome.This class is had loose bowels that general morbidity is anxious, the course of disease is short, is treated than being easier to.Chronic diarrhea is the person that has loose bowels, practises claiming chronic diarrhea.Chronic diarrhea is long with the course of disease, difficult recovery from illness, and easily recurrence is characteristics, its etiology and pathogenesis is complicated.
Guchang capsule is the Chinese medicine of at present commercially available a kind of effective treatment chronic diarrhea, and it adopts Halloysitum Rubrum, Rhizoma Coptidis, Cortex Phellodendri, Fructus Chebulae, Semen Myristicae, Cortex Magnoliae Officinalis, Fructus Evodiae, Massa Medicata Fermentata, Cortex Cinnamomi, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Rhizoma Chuanxiong, Concha Ostreae, Galla Chinensis and Fructus Mume to pulverize and makes.Fructus Mume is sour and astringent in the side, and relieving diarrhea with astringents is used for the chronic diarrhea chronic dysentery.The Rhizoma Coptidis bitter cold, heat clearing and damp drying, Galla Chinensis relieving diarrhea with astringents, a heat clearing away one antidiarrheal, giving consideration to both the incidental and fundamental.The hot warming spleen and stomach for dispelling cold of Rhizoma Zingiberis is used for the middle-jiao yang, function of the spleen and stomach deficiency and coldness that the chronic diarrhea chronic dysentery produces, but Rhizoma Coptidis (processed) is cold in addition, the Cortex Cinnamomi promoting the circulation of QI to relieve pain, and strengthening the spleen to promote digestion, the pain relieving of Rhizoma Chuanxiong blood-activating and qi-promoting, the stomachache that can alleviate stagnation of QI-blood is coerced, and is adjuvant drug altogether.Full side's compatibility is received regulating the liver and spleen altogether, the merit of astringing intestine to stop diarrhea pain relieving.
This medicine has the function of relieving diarrhea with astringents, dissipating cold, clearing heat, QI and blood regulating, and clinical treatment chronic diarrhea, coldheat complex, deficient and excessive syndromes appearing together disease are effective, and it is clear rare or accompany a little sticking in vain freezing to be used for stool, or aqueous-grainy diarrhea, very then slippage be can't help, the stomachache borborygmus, aversion to cold and cold limbs, soreness of the waist and knees.Curative effect of medication is not subjected to the influence of age, the course of disease, the state of an illness, effective and safe.
The method for making of Guchang capsule is: ten five tastes crude drugs are pressed the recipe quantity compatibility, select the roguing thing, after silt was removed in washing, oven dry was ground into fine powder, and mixing adds suitable quantity of water, the system granule, and drying, granulate divides the capsule of packing into, every dress 0.375g.Drug oral, one time 4,3 times on the one.
This medicine method for making is simple, evident in efficacy, but patient's dose is relatively large, and bioavailability has much room for improvement.
Summary of the invention
First technical problem that the present invention will solve provides a kind of Chinese medicine composition for the treatment of chronic diarrhea.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine composition for the treatment of chronic diarrhea, its active component is made by the raw material of following parts by weight: 500 parts of Halloysitum Rubrums (forging), 250 parts of Rhizoma Coptidis, 250 parts of Cortex Phellodendris, 250 parts of Fructus Chebulae'ss (enucleation), 250 parts of Semen Myristicaes (stewing), 250 parts of Cortex Magnoliae Officinalis (processing), 250 parts of Massa Medicata Fermentata, 200 parts of Fructus Evodiaes (system), 200 parts of Cortex Cinnamomis, 250 parts of Rhizoma Zingiberiss, 200 parts in Pericarpium Zanthoxyli, 200 parts of Rhizoma Chuanxiongs, 200 parts of Concha Ostreaes (forging), 250 parts of Galla Chinensiss, 250 parts of Fructus Mumes (enucleation).
Described active component adopts following method to prepare: all raw material is carried 2-3 time with 8-14 times of water gaging, each 2-6 hour, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.03～1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
Described whole raw material is carried 2-3 time with 10-12 times of water gaging, each 3-5 hour, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.05～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
Described whole raw material is carried 3 times with 10 times of water gagings, each 4 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.06～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
Described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, xylitol, aspartame, citric acid, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation method for the treatment of the Chinese medicine composition of chronic diarrhea takes by weighing 500 parts of Halloysitum Rubrums (forging), 250 parts of Rhizoma Coptidis, 250 parts of Cortex Phellodendris, 250 parts of Fructus Chebulae'ss (enucleation), 250 parts of Semen Myristicaes (stewing), 250 parts of Cortex Magnoliae Officinalis (processing), 250 parts of Massa Medicata Fermentata, 200 parts of Fructus Evodiaes (system), 200 parts of Cortex Cinnamomis, 250 parts of Rhizoma Zingiberiss, 200 parts in Pericarpium Zanthoxyli, 200 parts of Rhizoma Chuanxiongs, 200 parts of Concha Ostreaes (forging), 250 parts of Galla Chinensiss, 250 parts of Fructus Mumes (enucleation); All raw material is carried 2-3 time with 8-14 times of water gaging, each 2-6 hour, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.03～1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.This preparation technology's paste-forming rate is 25-30%.
Described whole raw material is carried 2-3 time with 10-12 times of water gaging, each 3-5 hour, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.05～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
Described whole raw material is carried 3 times with 10 times of water gagings, each 4 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.06～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
Chinese medicine composition that technical solution of the present invention is related and preparation thereof all have the effect of good relieving diarrhea with astringents, dissipating cold, clearing heat, QI and blood regulating, take safety.By zoopery, we unexpectedly find, the pharmaceutical composition of prepared of the present invention compared with prior art, can significant prolongation diarrhoea incubation period, reduce the accumulative total number of times of suffering from diarrhoea.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All raw materials are carried 2 times with 12 times of amounts, 10 times of water gagings, the first time 6h, the second time, 2h collected volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, drying under reduced pressure; Spray into volatile oil, get extract powder 10g5g.
Embodiment 2: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All raw material is carried 2 times with 14 times of amounts, 12 times of water gagings, 6 hours for the first time, 4 hours for the second time, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder 960g.
Embodiment 3: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All raw material is carried 2 times with 10 times of water gagings, each 4 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder 1100g.
Embodiment 4: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All raw material is carried 3 times with 8 times of water gagings, each 6 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder 1108g.
Embodiment 5: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All raw material is carried 3 times with 12 times of water gagings, each 3 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder 940g.
Embodiment 6: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All the raw material water is carried 3 times, for the first time with 14 times of water gagings, extracts 6 hours, for the second time with 12 times of water gagings, extracts 4 hours, uses 10 times of water gagings for the third time, extracts 2 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.07 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder 1098g.
Embodiment 7: the preparation Chinese medicine extract
One. prescription:
Halloysitum Rubrum (forging) 500g, Rhizoma Coptidis 250g, Cortex Phellodendri 250g, Fructus Chebulae's (enucleation) 250g, Semen Myristicae (stewing) 250g, Cortex Magnoliae Officinalis (processing) 250g, Massa Medicata Fermentata 250g, Fructus Evodiae (system) 200g, Cortex Cinnamomi 200g, Rhizoma Zingiberis 250g, Pericarpium Zanthoxyli 200g, Rhizoma Chuanxiong 200g, Concha Ostreae (forging) 200g, Galla Chinensis 250g, Fructus Mume (enucleation) 250g.
Two. method for making:
All raw material is carried 3 times with 10 times of water gagings, each 4 hours, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder 1120g.
Embodiment 8: the preparation tablet
The extract powder 500g that embodiment 1 obtains adds microcrystalline Cellulose 100g, lactose 100g, and cross-linked pvp 50g, magnesium stearate 5g, tabletting gets tablet, and every is 0.35g.
Embodiment 9: the preparation granule
The extract powder 100g that embodiment 2 obtains adds xylitol 60g, dextrin 40g, and aspartame 0.2g, citric acid 0.5g, the system granule gets granule, and every bag is 5g.
Embodiment 10: zoopery one: to the influence of small intestine movement of mice propulsion functions
One. material and method
Animal: the ICR mice, 18-22g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-0003.
Guchang capsule (lot number 090122) reaches core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin and produces.
Furazolidone (lot number 091125), Jintaiyang Pharmaceutical Co., Ltd., Ningxia
Get 50 of healthy ICR mices, body weight 18～22g, be divided into 5 groups at random, every group 10, be respectively blank group, furazolidone positive controls (100mg/kg), Gu intestinal extract (extract powder that embodiment 1 prepares) is low, high dose group (3.0,6.0g crude drug/kg), Guchang capsule group (3.0g crude drug/kg).Except that the blank group gave isopyknic pure water, all by the continuous gastric infusion of above-mentioned dosage 3 days, the administration volume was 20ml/kg to other administration groups.Fasting 12h before the last administration, 1h after the administration, every mice is all irritated the 10% charcoal end suspension (Arabic gelatin preparation) that stomach gives 0.4ml, taking off cervical vertebra behind the 20min puts to death, measure the advance distance of every Mus small intestinal length and charcoal end front end to pylorus, calculate the propelling rate (distance/small intestinal total length of charcoal end propelling rate %=charcoal end forward position and pylorus) of charcoal end at small intestinal, experimental data is added up with variance analysis.
Two. result: see Table.
Table one: Gu the intestinal extract is to the influence of small intestine movement of mice propulsion functions
With the blank group than * P＜0.05 * * P＜0.01
The result shows: extract of the present invention is 3.0, under 6.0g crude drug/kg dosage, with the blank group relatively, significant difference (P＜0.05, P＜0.01) is all arranged, prompting the present invention can obviously suppress the small intestine movement of mice propulsion functions, and have must dose-effect relationship.Under Isodose, the present invention and commercially available Guchang capsule be there was no significant difference relatively, and it is suitable with the former dosage form effect of Guchang capsule that prompting the present invention suppresses the effect of intestinal propulsion function aspects.
Embodiment 11: zoopery two: to the influence of diarrhea mice due to the Folium Sennae
One. material and method:
Material is with embodiment 1.
Get 50 of healthy ICR mices, body weight 18～22g, be divided into 5 groups at random, every group 10, be respectively blank group, furazolidone positive controls (100mg/kg), Gu intestinal extract (extract powder that embodiment 2 prepares) is low, high dose group (3.0,6.0g crude drug/kg), Guchang capsule group (3.0g crude drug/kg).Except that the blank group gave isopyknic pure water, all by the continuous gastric infusion of above-mentioned dosage 3 days, the administration volume was 20ml/kg to other administration groups.Fasting 12h before the last administration, 30min after the last administration, every mouse stomach gives 20% Folium Sennae decoct 0.3ml/10g body weight, and every is placed in the mouse cage that is lined with filter paper, changes packing paper every 1h, observes diarrhoea stand number in diarrhea of mouse incubation period and the 6h.Experimental data is added up with variance analysis.
Two. result: see Table two.
Table two: Gu the intestinal extract is to the influence of diarrhea mice due to the Folium Sennae
With the blank group than * P＜0.05 * * P＜0.01 and Guchang capsule group than #P＜0.05
The result shows: extract of the present invention is 3.0, under 6.0g crude drug/kg dosage, its diarrhoea incubation period and the number of times of totally suffering from diarrhoea, compare with the blank group, significant difference (P＜0.05 is all arranged, P＜0.01), prompting the present invention can prolong Folium Sennae induced mice diarrheal incubation period, and the accumulation diarrhoea number of times of different time is reduced, and certain dose relationship is arranged, show that the present invention has certain antagonism to the diarrhea of mouse due to the Folium Sennae.Under Isodose, extract of the present invention and Guchang capsule relatively, both suffer from diarrhoea effect incubation period quite, but extract of the present invention can reduce in the 6h accumulative total number of times (P＜0.05) of suffering from diarrhoea, effect is better than former dosage form in this respect.
Claims (10)
1. Chinese medicine composition for the treatment of chronic diarrhea, it is characterized in that: its active component is made by the raw material of following parts by weight: 500 parts of Halloysitum Rubrums (forging), 250 parts of Rhizoma Coptidis, 250 parts of Cortex Phellodendris, 250 parts of Fructus Chebulae'ss (enucleation), 250 parts of Semen Myristicaes (stewing), 250 parts of Cortex Magnoliae Officinalis (processing), 250 parts of Massa Medicata Fermentata, 200 parts of Fructus Evodiaes (system), 200 parts of Cortex Cinnamomis, 250 parts of Rhizoma Zingiberiss, 200 parts in Pericarpium Zanthoxyli, 200 parts of Rhizoma Chuanxiongs, 200 parts of Concha Ostreaes (forging), 250 parts of Galla Chinensiss, 250 parts of Fructus Mumes (enucleation).
2. a kind of Chinese medicine composition for the treatment of chronic diarrhea according to claim 1 is characterized in that described active component adopts following method to prepare: all raw material is carried 2-3 time with 8-14 times of water gaging, each 2-6 hour, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.03～1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
3. a kind of Chinese medicine composition for the treatment of chronic diarrhea according to claim 2 is characterized in that: described whole raw materials are carried 2-3 time with 10-12 times of water gaging, each 3-5 hour, collect volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.05～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
4. a kind of Chinese medicine composition for the treatment of chronic diarrhea according to claim 3 is characterized in that: described whole raw materials are carried 3 times with 10 times of water gagings, each 4 hours, collect volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.06～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
5. according to any one described a kind of Chinese medicine composition for the treatment of chronic diarrhea in the claim 1 to 4, it is characterized in that: described pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. a kind of Chinese medicine composition for the treatment of chronic diarrhea according to claim 5 is characterized in that: described pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, xylitol, aspartame, citric acid, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
7. a kind of Chinese medicine composition for the treatment of chronic diarrhea according to claim 5 is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule or oral liquid.
8. the described a kind of preparation method for the treatment of the Chinese medicine composition of chronic diarrhea of claim 1 is characterized in that: take by weighing 500 parts of Halloysitum Rubrums (forging), 250 parts of Rhizoma Coptidis, 250 parts of Cortex Phellodendris, 250 parts of Fructus Chebulae'ss (enucleation), 250 parts of Semen Myristicaes (stewing), 250 parts of Cortex Magnoliae Officinalis (processing), 250 parts of Massa Medicata Fermentata, 200 parts of Fructus Evodiaes (system), 200 parts of Cortex Cinnamomis, 250 parts of Rhizoma Zingiberiss, 200 parts in Pericarpium Zanthoxyli, 200 parts of Rhizoma Chuanxiongs, 200 parts of Concha Ostreaes (forging), 250 parts of Galla Chinensiss, 250 parts of Fructus Mumes (enucleation); All raw material is carried 2-3 time with 8-14 times of water gaging, each 2-6 hour, collects volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.03～1.10 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
9. a kind of preparation method for the treatment of the Chinese medicine composition of chronic diarrhea according to claim 8 is characterized in that: described whole raw materials are carried 2-3 time with 10-12 times of water gaging, each 3-5 hour, collect volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.05～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
10. a kind of preparation method for the treatment of the Chinese medicine composition of chronic diarrhea according to claim 8 is characterized in that: described whole raw materials are carried 3 times with 10 times of water gagings, each 4 hours, collect volatile oil simultaneously; Merge extractive liquid, is concentrated into that relative density is 1.06～1.08 under the 50-60 ℃ of condition, drying under reduced pressure or spray drying; Spray into volatile oil, get extract powder.
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Application publication date: 20110525 |