CN102068236B - Line scanning confocal ophthalmoscope system and method based on laser diffraction - Google Patents

Line scanning confocal ophthalmoscope system and method based on laser diffraction Download PDF

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CN102068236B
CN102068236B CN2010105955877A CN201010595587A CN102068236B CN 102068236 B CN102068236 B CN 102068236B CN 2010105955877 A CN2010105955877 A CN 2010105955877A CN 201010595587 A CN201010595587 A CN 201010595587A CN 102068236 B CN102068236 B CN 102068236B
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line
confocal
imaging
line beam
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CN102068236A (en
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史国华
何益
张雨东
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Institute of Optics and Electronics of CAS
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Institute of Optics and Electronics of CAS
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Abstract

A line scanning confocal ophthalmoscope system and method based on laser diffraction comprises a line beam generation module, a light splitting module, a scanning module, an imaging module and an output module. The method is characterized in that: the line beam light intensity generated by the line scanning confocal ophthalmoscope based on laser diffraction is uniformly distributed in a non-Gaussian shape, a scanning galvanometer is adopted to perform one-dimensional space scanning on the line beam to illuminate the fundus retina, meanwhile, a line detector is used for imaging the non-scanning line beam reflected from the fundus retina, the system only uses one scanning galvanometer and one line detector, and the number of movable parts is small; meanwhile, the confocal slit is conjugated with the fundus retina plane, so that the influence of non-retina plane stray light on imaging quality is eliminated, and the high resolution of the confocal imaging principle is realized. The invention has the advantages of good line beam quality, simple system structure, simple and convenient manufacture, short light path, proper adjustment, small size, applicability, good stability and high imaging frame frequency.

Description

The confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction
Technical field
The present invention relates to confocal imaging system and method in a kind of optical imaging field, the confocal ophthalmoscope system and method for particularly a kind of line sweep based on laser diffraction can be widely used in biomedical ophthalmologic examination.
Background technology
The successful Application of cofocus scanning technology aspect imaging broken through the bottleneck that traditional optical forms images, and can obtain high-resolution imaging, promoted the development of optical imagery detection technique.Scholars have carried out big quantity research to this technology in recent years, have realized multiple cofocus scanning imaging device.
The optical principle of cofocus scanning technology is as shown in Figure 1; Scanned samples is in the focal plane position of illumination objective lens; Guarantee that simultaneously detector is in the focal plane position of image-forming objective lens, promptly be in the conjugate position that objective lens corresponds to each other, whole view field imaging is realized through scanning; Can not get into detector image-forming for the veiling glare on the non-focal plane of scanned samples (shown in the dotted line light beam), thereby obtain the high-resolution imaging of scanned samples.
At present, in the product that adopts the cofocus scanning principle, be example with the laser cofocus scanning ophthalmoscope, this system adopts LASER Light Source LD illumination, and laser beam forms point source through illumination pin hole FO, and the every bit on the eye retina is scanned.Illuminated point on the retina; Form images at detecting pinhole CP place; Illumination pin hole FO and detecting pinhole CP are conjugated with respect to the focal plane of object lens CL, and the point outside the retina focal plane can not form images at the detecting pinhole place, and the confocal images that obtains like this is amphiblestroid optics transverse section; Realized high flat resolution, its concrete structure is as shown in Figure 2.This spot scan confocal imaging technology, imaging effect is good, but himself has a lot of defectives: (1) optical path component is many, and light path is complicated, and system structure is big, uses inconvenience, should not be widely used; (2) need two galvanometers of horizontal sweep HS and vertical scanning VS simultaneously, movable part is many, and is wayward; (3) the luminous point energy of spot scan is small, need to use photomultiplier tube PMT or other weak spot detector, and the picture contrast that obtains is low, and frame frequency speed little (<30fps), thereby cause the retina shake image of I picture to eliminate; (4) adopt spot scan to the optical fundus retina image-forming, need mydriasis to observe usually, and require to be had the good ability of looking of consolidating by the observer, these are all very difficult for ophthalmic diseases patient, old man and child.These defectives have all limited its application, have particularly hindered it and directly have been used for the inspection of ophthalmic diseases.
Be directed to the many disadvantages of spot scan mode, R.Daniel Ferguson etc. has proposed a kind of method of line sweep laser ophthalmoscope, sees patent " Line-scan laser ophthalmoscope " R.Daniel Ferguson; PatentNo:US 7,284,859B2; Oct.23,2007.The device sketch map that this patent is announced is as shown in Figure 3, and this device adopts 202 illuminations of laser spots light source, and the outgoing divergent beams of point source are through behind the cylindrical lens 204 and 206; Form the Line beam of certain width and length, pass through rotary prism 208 then with its deflection outgoing, this Line beam is by scanning galvanometer 210 deflection scannings; Focus on optical fundus retina 222 through objective lens 212,214 and 216; By the imaging beam of retina 222 reflection from the pupil outgoing, after objective lens 212,214 and 216 transmissions, by scanning galvanometer 210 synchronous reflections to rotary prism 208; Rotary prism 208 turn 90 degrees imaging beam with the outgoing of incident beam vertical separation partially and arrives diaphragm 224; Diaphragm 224 and human eye pupil position conjugation can be eliminated the influence of non-conjugated veiling glare of pupil, are then focused on line array CCD by image-forming objective lens 226 from the imaging beam of diaphragm 224 outgoing and form images; Line array CCD and optical fundus retina position conjugate have been realized the high-resolution imaging of " standard " confocal principle.Whole system is seen shown in Figure 3, and dotted line is depicted as incident beam, and solid line is depicted as the imaging beam of retinal reflex.
This device adopts the one dimension line sweep to the optical fundus retina image-forming, compares and adopt the confocal laser ophthalmoscope of spot scan to have many advantages: Line beam illumination optical fundus is adopted in (1), only uses a scanning galvanometer, and the movable part number is few, and system structure is little; (2) imaging beam still is a wire, adopts the line array CCD imaging, and the imaging beam energy is big, and the picture contrast that obtains is high, and frame frequency is big, and shake significantly reduces in the retina frame; (3) adopt Line beam illumination optical fundus, the ability of looking is not admittedly had strict demand.This device has been realized the high-resolution purpose of " standard " confocal imaging, but still there are a lot of defectives in self: the laser spots light illumination is adopted in (1), and light source is regulated complicated, and the beam energy skewness, is Gauss distribution; (2) for the divergent beams of point source, the Line beam generating apparatus is made up of two cylindrical lenses, and Line beam generating apparatus complex structure is regulated difficulty, and the ray beam quality that generates is bad; (3) Line beam is generated by cylindrical lens, and its Energy distribution is inhomogeneous, is Gauss distribution, and Line beam repeatedly focuses on and disperses in propagate arriving the process on optical fundus, and ray beam quality is poor; (4) scanning light beam that arrives human eye is just being given the incident beam that arrives scanning galvanometer, and incident beam is turn 90 degrees laggard line scanning partially by galvanometer, and scan mode is complicated, is not easy control, and precision is low etc.
Summary of the invention
Technology of the present invention is dealt with problems: the weak point that overcomes above-mentioned prior art; Provide a kind of line sweep based on laser diffraction confocal ophthalmoscope system and method, it is even to have the Line beam Energy distribution, and optical path component is few; System structure is little; The one-dimensional scanning mode is simple, and advantage such as control accuracy is high and speed is fast, and imaging frame frequency is big.
Technical solution of the present invention: the confocal ophthalmoscope of a kind of line sweep based on laser diffraction system comprises: Line beam generation module, spectral module, scan module;
The Line beam generation module links to each other with spectral module, is used for the divergent beams of point source are generated the one dimension Line beam, is made up of point source, collimator apparatus and Line beam converting means; The divergent beams that point source sends are exported collimated light beam after through collimator and extender device collimation, and the Line beam converting means is transformed to one dimension linear light bunch with this collimated light beam and sends into spectral module; Said Line beam converting means is made up of the grating and first cylindrical lens; The axle of the grating diffration direction and first cylindrical lens is vertical each other; The position of the grating and first cylindrical lens can exchange, and effect is the same, and grating is diffracted into the diffraction spot that certain spatial dimension direction distributes with the collimated light beam of point source outgoing; Cylindrical lens suitably stretches said diffraction spot on this direction, overlaps to form Line beam; Said collimator apparatus is formed or is made up of optical fiber collimator by standard 4f lens combination, filtering pin hole and collimating lens, and the divergent beams of point source are transformed to collimated light beam through described standard 4f lens combination, filtering pin hole and collimating lens successively;
Spectral module is beam split plain film or Amici prism, and an one dimension Line beam part that is used for the Line beam generation module is produced directly transmission arrives scan module and will carry out deflection from the imaging beam of scan module reflected back and shines and reach the picture module;
Scan module, the Line beam that is used to utilize the direct outgoing of spectral module human eye optical fundus retina is scanned illumination and to the imaging beam synchronous reflection of retinal reflex from the optical fundus to spectral module; Constitute by scanning galvanometer and illumination objective lens; The one dimension Line beam of the direct outgoing of spectral module scans illumination optical fundus retina through said scanning galvanometer and illumination objective lens group by scanning galvanometer successively, and the imaging beam that retinal reflex returns from the optical fundus arrives spectral module through illumination objective lens group and scanning galvanometer synchronous reflection successively;
Image-forming module is made up of image-forming objective lens, second cylindrical lens, confocal slit and line detector, is used for converting the imaging beam light intensity signal of spectral module deflection outgoing to the signal of telecommunication, and is transferred to output module; The imaging beam of spectral module deflection outgoing passes through image-forming objective lens, second cylindrical lens and confocal slit, receiving track detector successively; Said confocal slit and optical fundus retinal plane conjugation;
Output module is made up of image pick-up card and outut device, and image pick-up card becomes picture signal with the electrical signal conversion of image-forming module output, and through outut device output.
The confocal ophthalmoscope method of a kind of line sweep based on laser diffraction, performing step is following:
Step 1, the divergent beams of point source generate the one dimension Line beam through the Line beam generation module;
Step 2, said one dimension Line beam arrives scan module through the direct transmission of a spectral module part;
Step 3, scan module scans illumination through scanning galvanometer and illumination objective lens to human eye optical fundus retina with the Line beam of the direct outgoing of spectral module, and will be from the optical fundus imaging beam synchronous reflection of retinal reflex to spectral module;
Step 4, spectral module will carry out from the imaging beam of scan module reflected back deflection shine reach the picture module;
Step 5, image-forming module converts the imaging beam light intensity signal of spectral module deflection outgoing to the signal of telecommunication, and is transferred to output module;
Step 6, the image pick-up card in the output module becomes picture signal with the electrical signal conversion of image-forming module output, and through outut device output;
Said step 1 comprises:
Step 91, collimator apparatus is a collimated light beam with the divergent beams collimation that point source produces; Said collimator apparatus is formed or is made up of optical fiber collimator by standard 4f lens combination, filtering pin hole and collimating lens, and the divergent beams collimation that is used for point source is a collimated light beam;
Step 92, the Line beam converting means is transformed to the one dimension Line beam with said collimated light beam.
Said step 92 comprises:
Step 101, grating forms the diffraction spot that certain spatial dimension direction distributes with incident collimated light beam diffraction;
Step 102, cylindrical lens is made said diffraction spot suitably to stretch on this direction, overlap to form Line beam.
Said step 5 comprises:
Step 111, image-forming objective lens and cylindrical lens are focused into wire with the imaging beam of spectral module deflection outgoing, then the receiving track detector;
Step 112, the imaging beam light intensity signal after line detector will focus on converts the signal of telecommunication to.
Said step 6 comprises:
Step 121, image pick-up card becomes picture signal with the electrical signal conversion of line detector output;
Step 122, outut device receive said picture signal, show, handle, and storage is also printed.
Said point source is LASER Light Source or light emitting diode or super-radiance light emitting diode.
Said scanning galvanometer is the reflective scanning mode galvanometer;
Said grating is diffraction grating or holographic grating;
Said line detector is linear charge-coupled array or linear array complementary metal oxide semiconductors (CMOS) array or linear array photodiode array;
Said outut device is a computer.
The present invention compares with the line sweep laser ophthalmoscope of prior art, and following advantage is arranged:
(1) the confocal ophthalmoscope of the line sweep based on laser diffraction of the present invention, the Line beam converting means is made up of grating and cylindrical lens, and the Line beam Energy distribution of formation is even, and ray beam quality is good.
(2) the present invention is based on the confocal Oph system and method for line sweep of laser diffraction, confocal slit and optical fundus retina conjugation have been got rid of the influence of non-retina conjugate planes veiling glare to image quality, have realized the high-resolution of confocal imaging principle.
(3) the present invention is based on the confocal Oph system and method for line sweep of laser diffraction; Scanning light beam and imaging beam are equidirectional wire, and Line beam distributes along same axle all the time, and propagates along primary optical axis all the time; Scanning galvanometer and line detector clock are easy synchronously; Image configuration speed is fast, and picture frame frequency is high, and real-time performance is good.
(4) the present invention is based on the confocal Oph system and method for line sweep of laser diffraction, illumination objective lens is a two gummed achromat, and scanning light beam is accurately focused on the optical fundus retinal plane, and scanning light beam is translation vertically, illuminates whole retinal surface imaging.
(5) the present invention is based on the confocal Oph system and method for line sweep of laser diffraction; Only use a scanning galvanometer and a line detector; The movable part number is few; Have simple in structure, make that easy, light path is shortly suitablely regulated, small and exquisitely is suitable for, the advantage of good stability and high imaging frame frequency, be suitable for making and extensively promoting the use of in a large number.
Description of drawings
Fig. 1 is the optical schematic diagram of cofocus scanning;
Fig. 2 adopts the confocal laser ophthalmoscope light path sketch map of spot scan for prior art;
Fig. 3 is a prior art line sweep laser ophthalmoscope light path sketch map;
Fig. 4 is the confocal ophthalmoscope system construction drawing of a kind of line sweep based on laser diffraction of the present invention;
Fig. 5 is Line beam generation module sketch map among the present invention;
The Line beam surface of intensity distribution that Fig. 6 adopts cylindrical lens to generate for prior art;
The diffraction spot surface of intensity distribution that Fig. 7 generates for grating among the present invention;
Fig. 8 is the center line light beam surface of intensity distribution of the present invention;
Fig. 9 is the confocal ophthalmoscope light path of a kind of line sweep based on laser diffraction of a present invention sketch map.
The specific embodiment
As shown in Figure 4; Be the confocal ophthalmoscope system construction drawing of a kind of line sweep of the present invention based on laser diffraction; The confocal ophthalmoscope of a kind of line sweep based on laser diffraction of the present invention system comprises Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6.
Line beam generation module 1 links to each other with spectral module 2; Constitute by point source 100, collimator apparatus 110 and Line beam converting means 120; Be used for the divergent beams of point source 100 are generated the one dimension Line beam; The divergent beams of point source 100 are transformed to collimated light beam through collimator apparatus 110, and this collimated light beam is transformed to the one dimension Line beam through Line beam converting means 120 and is transmitted to spectral module 2.
Spectral module 2 is beam split plain film or Amici prism, and an one dimension Line beam part that is used for Line beam generation module 1 is produced directly transmission arrives scan module 3 and will carry out deflection from the imaging beam of scan module 3 reflected backs and shines and reach picture module 5.
Scan module 3 is made up of scanning galvanometer 300 and illumination objective lens 310; The Line beam of spectral module 2 direct outgoing successively through scanning galvanometer 300 and illumination objective lens 310 by scanning galvanometer 300 scanning illumination optical fundus retinas 4, the imaging beam of optical fundus retina 4 reflections passes through illumination objective lens 310 and scanning galvanometer 300 synchronous reflections successively to spectral module 2.
Image-forming module 5; Constitute by image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530; The imaging beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500, cylindrical lens 510 and confocal slit 520 successively; Receiving track detector 530, line 530 converts the imaging beam light intensity signal to the signal of telecommunication, and is transferred to output module 6.Confocal slit 520 and optical fundus retina 4 planar conjugates, confocal slit 520 can be got rid of non-optical fundus retina 4 planar veiling glares and get into line detector 530, thereby realize the high-resolution of confocal imaging principle.
Output module 6 is made up of image pick-up card 600 and outut device 610, and image pick-up card 600 becomes picture signal with the electrical signal conversion of image-forming module 5 outputs, and through outut device 610 outputs.
Line beam generation module 1 is made up of point source 100, collimator apparatus 110 and Line beam converting means 120.Collimator apparatus 110 is made up of standard 4f lens combination, filtering pin hole and collimating lens, or is made up of optical fiber collimator.In specific embodiment of the present invention, collimator apparatus 110 is made up of standard 4f lens combination 111, filtering pin hole 112 and collimating lens 113, and is as shown in Figure 5.
The divergent beams of point source 100 outgoing are focused into new point source again through standard 4f lens combination 111, through first energy level distribution of the new point source of filtering pin hole 112 conversion, are the collimated light beam outgoing of certain radius then through collimating lens 113 collimations.Line beam converting means 120 is transformed to the one dimension Line beam with the outgoing collimated light beam of collimator apparatus 110; Form by grating 121 and cylindrical lens 122; The axle of the diffraction direction of grating 121 and cylindrical lens 122 is vertical each other; The position of grating 121 and cylindrical lens 122 can exchange, and effect is the same.Grating 121 is diffracted into the diffraction spot that certain spatial dimension direction distributes with the collimated light beam of 110 outgoing, and cylindrical lens 122 suitably stretches said diffraction spot on this direction, overlaps to form Line beam.
Line beam in the prior art line sweep laser ophthalmoscope is collimated light beam and generates through cylindrical lens, because the light distribution in the laser beam cross section is uneven, the functional relationship of light intensity I and beam cross section radius r is:
I = I 0 * exp { - ( r 2 w 2 ) } - - - ( 1 )
In the formula, I 0Be the amplitude at beam cross section center, w is a parameter relevant with the beam cross section radius, and r is the beam cross section radius, and formula (1) can be known thus, and laser beam sake light intensity is the Gaussian function and distributes.Laser beam is through after the cylindrical lens conversion, reflect along the axial pencil of cylindrical lens, vertically and the axial pencil of cylindrical lens do not reflect; Thereby form Line beam vertically, the light distribution in this Line beam cross section still is uneven, is and sees shown in Figure 6 suc as formula the gaussian shaped profile of (1); The online central area of this Line beam is brighter; Deepening rapidly on the edge of, beam quality is poor, causes image quality also poor.
The confocal ophthalmoscope of a kind of line sweep of the present invention based on laser diffraction; Its Line beam converting means 120 is made up of grating 121 and cylindrical lens 122; Collimated light beam is diffracted into the diffraction spot that certain spatial dimension direction distributes through grating 120 earlier; According to the light-dividing principle of grating, the light intensity of any point is on the spectrum face that diffraction spot is done:
I = I 0 * sin 2 u u 2 * sin 2 NV sin 2 V - - - ( 2 )
In the formula, I 0Zero order spectrum light intensity for single slit diffraction; N is a grating cutting sum;
Figure BSA00000391098600063
Be the wave surface at the wave surface at cutting edge and the cutting center phase contrast at diffraction direction θ, a is the width of single cutting;
Figure BSA00000391098600071
Be half the at the phase contrast of diffraction direction θ of the wave surface at adjacent two cutting centers, d is the distance (grating constant) between two cuttings.Can be known that by formula (2) for single wavelength collimated light beam, behind grating beam splitting, the light distribution that on the diffraction spectra face, can observe diffraction spot is as shown in Figure 7, the arrangement for the primary maximum and the secondary minimum of a series of light intensity has many times very big between the primary maximum.
The diffraction spot that is obtained by grating stretches in the direction via cylindrical lens again, and the primary maximum and the secondary maximum of diffraction spot overlap each other, after proximate mean effort again and again; Light distribution becomes evenly, and diffraction spot also overlaps into wire and becomes Line beam, and the Line beam light distribution that the present invention generates is as shown in Figure 8; Be the uniform distribution in the certain limit, but not gaussian shaped profile, Line beam brightness is even; Quality is good, thereby has guaranteed image quality.
As shown in Figure 4, the confocal ophthalmoscope method of a kind of line sweep based on laser diffraction according to the invention may further comprise the steps:
Step 1, the divergent beams of point source 100 are collimated light beam through collimator apparatus 110 collimations;
Step 2, Line beam converting means 120 is transformed to the one dimension Line beam with collimated light beam;
Step 3, the one dimension Line beam arrives scan module 3 through the direct transmission of spectral module 2 a part of luminous energy;
Step 4, the Line beam of spectral module 2 direct outgoing scans illumination through the scanning galvanometer in the scan module 3 310 and 320 pairs of optical fundus retinas 4 of illumination objective lens;
Step 5, the imaging beam of optical fundus retina 4 reflection through scan module 3 synchronous reflections to spectral module 2;
Step 6, spectral module 2 will carry out the deflection outgoing from the imaging beam of scan module 3 reflected backs;
Step 7, the imaging beam of spectral module 2 deflection outgoing is focused into wire through image-forming objective lens 500 and cylindrical lens 510, and the receiving track detector 530 then;
Step 8, the imaging beam light intensity signal after line detector 530 will focus on converts the signal of telecommunication to;
Step 9, image pick-up card 600 become picture signal with electrical signal conversion;
Step 10, outut device 610 receives institute's picture signal, shows, handles, and storage is also printed.
As shown in Figure 9; Be the confocal ophthalmoscope light path of the line sweep based on the laser diffraction sketch map based on laser diffraction of the present invention, dotted line is depicted as system's primary optical axis, and all elements are all arranged along primary optical axis; Clear apertures etc. are with one heart high; Light beam is all propagated along system's primary optical axis, is illustrative nature among the figure, does not represent real optical design parameter.
Point source is LASER Light Source or light emitting diode or super-radiance light emitting diode, and what adopt in the present embodiment is single wavelength laser light source, and wavelength is 635nm.
Collimator apparatus is made up of standard 4f lens combination, filtering pin hole and collimating lens, or is made up of optical fiber collimator, and it is that standard 4f lens combination, 80nm filtering pin hole and the focal length that 50mm forms is the collimating lens of 20mm that present embodiment adopts two focal lengths.
The Line beam converting means is made up of grating and cylindrical lens, and the optical grating diffraction wavelength that adopts in the present embodiment is 600nm, and the groove number is 300 every millimeter; Cylindrical lens adopts the flat convex cylindrical lenses of plain edition, and its focal length is 100mm.
Spectroscope is beam split plain film or Amici prism, adopts Amici prism in the present embodiment.
Scanning galvanometer is the reflective scanning mode galvanometer, adopts the model 6210H type product of CT company in the present embodiment, and effectively face width is 10mm.
Illumination objective lens adopts two gummed achromats, and its focal length is 50mm.
Image-forming objective lens adopts lens, and its focal length is 200mm.
Cylindrical lens adopts the flat convex cylindrical lenses of plain edition, and its focal length is 100mm.
Confocal slit is an adjustable slit, adopts the stand upright APAS80-1A of Chinese light of Beijing in the present embodiment, its position and optical fundus retinal plane conjugation.
Line detector is linear charge-coupled array or linear array complementary metal oxide semiconductors (CMOS) array or linear array photodiode array, adopts the line array CCD of e2v company in the present embodiment, and the line pixel is 1024, and pixel dimension is 14 μ m * 14 μ m.
The present invention does not limit to and above-mentioned instance, and persons skilled in the art can adopt numerous embodiments to realize the present invention according to content disclosed by the invention.
The present invention does not set forth part in detail and belongs to techniques well known.

Claims (10)

1. the confocal ophthalmoscope of the line sweep based on a laser diffraction system is characterized in that: comprise Line beam generation module, spectral module, scan module, image-forming module and output module;
The Line beam generation module links to each other with spectral module, is used for the divergent beams of point source are generated the one dimension Line beam, is made up of point source, collimator apparatus and Line beam converting means; The divergent beams that point source sends are exported collimated light beam after through the collimator apparatus collimation, and the Line beam converting means is transformed to one dimension linear light bunch with this collimated light beam and sends into spectral module; Said Line beam converting means is made up of the grating and first cylindrical lens; The axle of the grating diffration direction and first cylindrical lens is vertical each other; The position of the grating and first cylindrical lens can exchange, and effect is the same, and grating is diffracted into the diffraction spot that certain spatial dimension direction distributes with the collimated light beam of point source outgoing; Cylindrical lens suitably stretches said diffraction spot on this direction, overlaps to form Line beam; Said collimator apparatus is made up of standard 4f lens combination, filtering pin hole and collimating lens, and the divergent beams of point source are transformed to collimated light beam through described standard 4f lens combination, filtering pin hole and collimating lens successively;
Spectral module is beam split plain film or Amici prism, and an one dimension Line beam part that is used for the Line beam generation module is produced directly transmission arrives scan module and will carry out deflection from the imaging beam of scan module reflected back and shines and reach the picture module;
Scan module, the Line beam that is used to utilize the direct outgoing of spectral module human eye optical fundus retina is scanned illumination and to the imaging beam synchronous reflection of retinal reflex from the optical fundus to spectral module; Constitute by scanning galvanometer and illumination objective lens; The one dimension Line beam of the direct outgoing of spectral module scans illumination optical fundus retina through said scanning galvanometer and illumination objective lens by scanning galvanometer successively, and the imaging beam that retinal reflex returns from the optical fundus arrives spectral module through illumination objective lens and scanning galvanometer synchronous reflection successively;
Image-forming module is made up of image-forming objective lens, second cylindrical lens, confocal slit and line detector, is used for converting the imaging beam light intensity signal of spectral module deflection outgoing to the signal of telecommunication, and is transferred to output module; The imaging beam of spectral module deflection outgoing passes through image-forming objective lens, second cylindrical lens and confocal slit, receiving track detector successively; Said confocal slit and optical fundus retinal plane conjugation;
Output module is made up of image pick-up card and outut device, and image pick-up card becomes picture signal with the electrical signal conversion of image-forming module output, and through outut device output.
2. the confocal ophthalmoscope of a kind of line sweep based on laser diffraction according to claim 1 system, it is characterized in that: said point source is LASER Light Source or light emitting diode.
3. the confocal ophthalmoscope of a kind of line sweep based on laser diffraction according to claim 1 system, it is characterized in that: said scanning galvanometer is the reflective scanning mode galvanometer.
4. the confocal ophthalmoscope of a kind of line sweep based on laser diffraction according to claim 1 system is characterized in that: the grating in the said Line beam converting means is diffraction grating or holographic grating.
5. the confocal ophthalmoscope of a kind of line sweep based on laser diffraction according to claim 1 system is characterized in that: said line detector is linear charge-coupled array or linear array complementary metal oxide semiconductors (CMOS) array or linear array photodiode array.
6. the confocal ophthalmoscope of a kind of line sweep based on laser diffraction according to claim 1 system, it is characterized in that: said outut device is a computer.
7. confocal ophthalmoscope method of the line sweep based on laser diffraction is characterized in that performing step is following:
Step 1, the divergent beams of point source generate the one dimension Line beam through the Line beam generation module;
Step 2, said one dimension Line beam arrives scan module through the direct transmission of a spectral module part;
Step 3, scan module scans illumination through scanning galvanometer and illumination objective lens to human eye optical fundus retina with the Line beam of the direct outgoing of spectral module, and will be from the optical fundus imaging beam synchronous reflection of retinal reflex to spectral module;
Step 4, spectral module will carry out from the imaging beam of scan module reflected back deflection shine reach the picture module;
Step 5, image-forming module converts the imaging beam light intensity signal of spectral module deflection outgoing to the signal of telecommunication, and is transferred to output module;
Step 6, the image pick-up card in the output module becomes picture signal with the electrical signal conversion of image-forming module output, and through outut device output;
Said step 1 comprises:
Step 91, collimator apparatus is a collimated light beam with the divergent beams collimation that point source produces; Said collimator apparatus is formed or is made up of optical fiber collimator by standard 4f lens combination, filtering pin hole and collimating lens, and the divergent beams collimation that is used for point source is a collimated light beam;
Step 92, the Line beam converting means is transformed to the one dimension Line beam with said collimated light beam;
Said step 92 comprises:
Step 101, grating forms the diffraction spot that certain spatial dimension direction distributes with incident collimated light beam diffraction;
Step 102, cylindrical lens is made said diffraction spot suitably to stretch on this direction, overlap to form Line beam;
Said step 5 comprises:
Step 111, image-forming objective lens and cylindrical lens are focused into wire with the imaging beam of spectral module deflection outgoing, then the receiving track detector;
Step 112, the imaging beam light intensity signal after line detector will focus on converts the signal of telecommunication to.
8. the confocal ophthalmoscope method of a kind of line sweep based on laser diffraction according to claim 7 is characterized in that said step 6 comprises:
Step 121, image pick-up card becomes picture signal with the electrical signal conversion of line detector output;
Step 122, outut device receive said picture signal, show, handle, and storage is also printed.
9. the confocal ophthalmoscope method of a kind of line sweep based on laser diffraction according to claim 7, it is characterized in that: said point source is LASER Light Source or light emitting diode.
10. the confocal ophthalmoscope method of a kind of line sweep according to claim 7 based on laser diffraction, it is characterized in that: said scanning galvanometer is the reflective scanning mode galvanometer; Said grating is diffraction grating or holographic grating; Said line detector is linear charge-coupled array or linear array complementary metal oxide semiconductors (CMOS) array or linear array photodiode array; Said outut device is a computer.
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