CN102860815B - Line scanning confocal imaging image guidance-based self-adaption confocal scanning retina imaging method and device - Google Patents
Line scanning confocal imaging image guidance-based self-adaption confocal scanning retina imaging method and device Download PDFInfo
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Abstract
The invention relates to a line scanning confocal imaging image guidance-based self-adaption confocal scanning retina imaging method and device. By adopting the method, on the basis that one-dimensional scanning is performed on fundus retinae by a line scanning confocal imaging unit to obtain large-visual field imaging of the retinae, local small region positions of the retinae can be randomly selected and are marked from large-visual field imaged images, and a self-adaption confocal scanning retina imaging unit can be used for realizing accurate positioning on the small regions of the retinae and performing high-resolution imaging on the small regions. According to the line scanning confocal imaging image guidance-based self-adaption confocal scanning retina imaging method and device, the large-visual field imaging of the line scanning confocal fundus retinae and the accurate high-resolution imaging of the small region positions of the self-adaption confocal scanning fundus retinae can be obtained at the same time. Under the image guidance of the fundus retinae large-visual field imaging acquired by the line scanning confocal imaging unit, the accurate positioning can be realized on the local small regions by the self-adaption confocal scanning retinae imaging unit, and meanwhile, the high-resolution imaging is realized on the small region positions.
Description
Technical field
The present invention relates to biological ophthalmology imaging field, particularly a kind of self adaptation confocal scanning retina formation method and device based on the guiding of line sweep confocal imaging image.
Background technology
At present, the technology for living human eye retina image-forming mainly contains three kinds: fundus camera, optical coherent chromatographic imaging and laser cofocus scanning ophthalmoscope, they have all obtained good successful Application at present.In order to guarantee the brightness of illumination, fundus camera adopts traditional thermal light source as the illuminating device of system, therefore its resolution is lower, conventionally in tens micron levels, cannot effectively observe the fine structure of retina micron level, in particular, fundus camera longitudinal resolution is lower, cannot observe retina interior laminate layer tissue.Optical Coherence Tomography Imaging Technology is in fact a low coherence interferometer, application heterodyne detection technology, realize the tomography of Liao Dui biological tissue, it has successfully realized the imaging to retina interior laminate layer structure, reached the imaging resolution of tens microns, but due to the Physical Mechanism of its tomography, this technology cannot provide the dynamic high-resolution imaging of retinal plane.Development along with laser scanner technique, high-speed data acquisition and computer technology, laser cofocus scanning ophthalmoscope is by introducing confocal pinhole, can stop from the light outside uninterested layer of retina, significantly improved signal to noise ratio and the picture contrast of imaging, and the optical chromatography ability that provides fundus camera not possess.At present, laser cofocus scanning ophthalmoscope has been realized commercialization widely, has also become the most convenient and common retina image-forming equipment.
Although laser cofocus scanning ophthalmoscope has been obtained a feather in one's cap in ophthalmology image field, but its resolution aspect is still not enough to some extent, particularly due to the impact of human eye aberration, the Oph optical resolution of commercial lasers cofocus scanning is about ten microns, cannot be to the imaging of micron-sized retina optic cell.The people such as the Zhang Yudong of Photoelectric Technology Inst., Chinese Academy of Sciences have successfully developed a kind of reflection-type confocal scanning retina imaging system (license number: ZL201010197028.0) based on adaptive optics, this system is successfully applied to confocal imaging field by adaptive optical technique, adaptive optics energy real-time detection human eye aberration also passes through wave-front corrector real time correction aberration, eliminate the picture element disperse that human eye aberration causes, obtained the high-resolution imaging result up to 2 μ m.This self adaptation cofocus scanning imaging technique, imaging effect is good, but still there is defect in himself: owing to adopting the mode of spot scan, imaging viewing field is little, only has 1-3 degree, correspond to retinal plane and be about 290-870 micron, although can observe near other retinal area central visual axis region by the guiding of another eye sighting target system, but because having limited areas imaging, sighting target dot matrix layout areas is about 8 degree, for retinopathy rationality observe conventionally need to approximately 30 degree imaging viewing field scopes, correspond to retinal plane and be about 9.5mm, this system cannot realize this function.In addition,, because the guiding of another eye sighting target system belongs to the tropism guiding without reference, for the concrete regional area of retinal plane, adopt and be difficult in this way be easy to realize accurate positioning and imaging.
As shown in Figure 2-5, the people such as Shi Guohua of Photoelectric Technology Inst., Chinese Academy of Sciences have proposed confocal system and the method (license number: ZL201010595574.X and ZL201010595587.7) based on line sweep.This line sweep confocal system adopts one dimension line sweep to optical fundus retina image-forming, compare and the confocal laser ophthalmoscope that adopts spot scan, imaging viewing field is large, be convenient to retina to observe on a large scale, but because the resolution of large view field imaging is poor, need to could observe retina fine structure in conjunction with high-resolution small field of view imaging.
Summary of the invention
The technical problem to be solved in the present invention is: overcome above-mentioned the deficiencies in the prior art part, the patent of invention of having applied in conjunction with self, a kind of self adaptation confocal scanning retina formation method and device based on the guiding of line sweep confocal imaging image is provided, can obtain the amphiblestroid small field of view high-resolution imaging of the amphiblestroid large view field imaging in the confocal optical fundus of line and self adaptation cofocus scanning optical fundus simultaneously, the present invention is by observing the large view field imaging result of the confocal retina obtaining of line, directly by large view field imaging image is chosen to position, local zonule, datatron is transferred to the local zonule position coordinates of choosing the another eye sighting target system of retina image-forming unit, self adaptation cofocus scanning optical fundus in real time, can realize the accurate high-resolution imaging for the position, local zonule of choosing.
The technical scheme that the present invention solves above-mentioned technical problem employing is: a kind of self adaptation confocal scanning retina formation method based on the guiding of line sweep confocal imaging image, is characterized in that performing step is as follows:
Step 1, start, starting device;
Step 2, demarcates visual field, demarcates the imaging viewing field of self adaptation confocal scanning retina image-generating unit according to the imaging viewing field center of line sweep confocal imaging unit;
Step 3, line sweep confocal imaging unit carries out imaging to retina, obtains amphiblestroid large view field imaging image;
Step 4, the large view field imaging image of retina that the line sweep confocal imaging unit of exporting by observation display obtains, chooses and the local zonule of the interested retina of labelling position coordinates;
Step 5, the another eye sighting target system of self adaptation confocal scanning retina image-generating unit exported to the good local zonule of the interested retina position coordinates of labelling by datatron; The deflection of the another eye sighting target system guiding eyes optical axis, the ZhaoMing Center of the position, the local zonule of retina that labelling is crossed in self adaptation confocal scanning retina image-generating unit, thus realize its high-resolution imaging;
Step 6, guiding finishes, imaging results output display.
Line sweep confocal imaging unit described in described step 3 carries out imaging to retina and specifically comprises:
Step 31, line sweep confocal imaging unit emergent ray light beam arrives human eye retina through spectrophotometric unit deflecting reflection;
Step 32, the imaging line light beam reflecting from human eye retina is through spectrophotometric unit deflecting reflection loop line scanning confocal image-generating unit;
Step 33, line sweep confocal imaging unit is surveyed imaging line light beam, surveys after the treated machine processing of the signal obtaining, and is converted into image and exports to display demonstration.
The also local zonule of the interested retina of the labelling position coordinates of choosing described in described step 4 specifically comprises:
Step 41, chooses interested to be seen zonule position the large view field imaging image of retina obtaining from line sweep confocal imaging unit;
Step 42, datatron to large view field imaging image, and shows interested zonule to be seen position coordinates labelling on display.
Described step 5 is specially:
Step 51, the another eye sighting target system of self adaptation confocal scanning retina image-generating unit exported to the good retina zonule positional information of labelling by datatron;
Step 52, the outgoing beam of self adaptation confocal scanning retina image-generating unit is directly transmitted to through spectrophotometric unit the position, zonule that on intelligent's eyes retina, labelling is good under the guiding of another eye sighting target system;
Step 53, the imaging beam reflecting from human eye retina, after the direct transmission of spectrophotometric unit, transmits back self adaptation confocal scanning retina image-generating unit;
Step 54, self adaptation confocal scanning retina image-generating unit is surveyed imaging beam, and the treated machine of its detectable signal is processed by display output, obtains the high-resolution imaging image of the position, zonule that this retina labelling crosses.
The present invention also provides a kind of self adaptation confocal scanning retina imaging device based on the guiding of line sweep confocal imaging image, comprising: line sweep confocal imaging unit, self adaptation confocal scanning retina image-generating unit, spectrophotometric unit, datatron and display;
Line sweep confocal imaging unit is connected with spectrophotometric unit, datatron, line sweep confocal imaging unit is the confocal ophthalmoscope system of a kind of line sweep or a kind of confocal ophthalmoscope system of line sweep based on laser diffraction, for human eye retina is carried out to large view field imaging, line sweep confocal imaging unit comprises Line beam generation module, spectral module, scan module, image-forming module and output module.The emergent ray light beam of line sweep confocal imaging unit arrives human eye optical fundus through spectrophotometric unit deflecting reflection, and the imaging line light beam going out from fundus reflex is surveyed through spectrophotometric unit deflecting reflection loop line scanning confocal image-generating unit, and result of detection is exported to datatron and processed;
Self adaptation confocal scanning retina image-generating unit and spectrophotometric unit, datatron is connected, self adaptation confocal scanning retina image-generating unit is a kind of reflection-type confocal scanning retina imaging system based on adaptive optics, for human eye retina being carried out to the high-resolution imaging of position, zonule, comprise light source, reflective contracting bundle beam-expanding system, two-dimensional scan galvanometer, Hartmann sensor, distorting lens, Photodetection system, data acquisition and processing (DAP) system and another eye sighting target system, the outgoing beam of self adaptation confocal scanning retina image-generating unit arrives human eye optical fundus after spectrophotometric unit transmission, the imaging beam going out from fundus reflex returns self adaptation confocal scanning retina image-generating unit through spectrophotometric unit transmission and surveys, result of detection is exported to datatron and is processed,
Spectrophotometric unit is connected with line sweep confocal imaging unit, self adaptation confocal scanning retina image-generating unit and human eye, spectrophotometric unit is dichroic light splitting plain film or dichroic Amici prism, for the imaging beam of self adaptation confocal scanning retina image-generating unit output is directly transmitted to intelligent's eye, from the direct transmission of self adaptation cofocus scanning imaging beam of human eye retina's outgoing, arrive self adaptation confocal scanning retina image-generating unit; With Line beam deflecting reflection from the unit outgoing of line sweep confocal imaging is arrived to human eye, from the Line beam deflecting reflection of human eye retina's outgoing, arrive line sweep confocal imaging unit;
Datatron is connected with line sweep confocal imaging unit, self adaptation confocal scanning retina image-generating unit and display, the treated machine of imaging signal that line sweep confocal imaging unit detects is processed, obtain the large view field imaging image of retina, datatron is exported to display by large view field imaging image and is shown; Side by side, the imaging signal that processor pair self adaptation confocal scanning retina image-generating unit detects is reconstructed, and obtains the high-resolution imaging image of position, retina zonule, and exports to display demonstration;
Display is connected with datatron, for the large view field imaging image of retina of display processor output and the high-resolution imaging image of position, zonule, and the zone position information of guiding imaging.
Described datatron is analog control circuit or digital computer.
The present invention compares with existing living human eye retina image-forming technology, has following advantage:
(1), self adaptation confocal scanning retina imaging system and the method based on line sweep confocal imaging image guiding of the present invention, line sweep confocal imaging unit can access the amphiblestroid large view field imaging in optical fundus.
(2), the present invention is based on self adaptation confocal scanning retina imaging system and the method for the guiding of line sweep confocal imaging image, can be intuitively from the large view field imaging image of the confocal retina obtaining of line, directly labelling is carried out in position, the interested zonule of retina, accurate positioning is reliable, and convenient.
(3), the present invention is based on self adaptation confocal scanning retina imaging system and the method for the guiding of line sweep confocal imaging image, the another eye sighting target system of self adaptation confocal scanning retina image-generating unit exported to the good retina interested zonule position coordinates of labelling by datatron, be the imaging beam of bootable self adaptation confocal scanning retina image-generating unit this region of throwing light on, thereby realize, high-resolution imaging realized in the exact position of regional area interested.
Accompanying drawing explanation
Fig. 1 is a kind of reflection-type confocal scanning retina imaging system structural representation based on adaptive optics of prior art;
Fig. 2 is the confocal Oph system and method structure chart of a kind of line sweep of prior art;
Fig. 3 is the confocal Oph system and method light path schematic diagram of a kind of line sweep of prior art;
Fig. 4 is the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction of prior art structure chart;
Fig. 5 is the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction of prior art light path schematic diagram;
Fig. 6 is the self adaptation confocal scanning retina imaging system structure chart that the present invention is based on the guiding of line sweep confocal imaging image;
Fig. 7 is the self adaptation confocal scanning retina formation method flow chart that the present invention is based on the guiding of line sweep confocal imaging image;
In Fig. 1, 1. semiconductor laser light resource, 2. spectroscope, 3. spectroscope, 4. pin hole, 5. photomultiplier tube, 6. data collecting system, 7. wave front processor, 8. tested, 9. Hartmann wave front sensor, 10. see sighting target eye, 11 ~ 18. spherical reflectors, 19. plane mirrors, 20. cylindrical mirrors, 21. collimating mirrors, 22. distorting lenss, 23.X scanning direction galvanometer, 24.Y scanning direction galvanometer, 25. test lenses, conjugate planes before 26. Hartmanns, 27. collecting lenses, 30. another sighting target systems, 30-1. lens, 30-2. plane mirror, 30-3.LED array.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, further illustrate the present invention.
As shown in Figure 6, for the present invention is based on the self adaptation confocal scanning retina imaging system structure chart of line sweep confocal imaging image guiding, self adaptation confocal scanning retina imaging system and method based on the guiding of line sweep confocal imaging image of the present invention, comprises line sweep confocal imaging unit 101, spectrophotometric unit 102, self adaptation confocal scanning retina image-generating unit 103, datatron 104 and display 105.
Line sweep confocal imaging unit 101 is connected with spectrophotometric unit 102, datatron 104, and line sweep confocal imaging unit 101 comprises Line beam generation module, spectral module, scan module, image-forming module and output module.Line sweep confocal imaging unit 101 is Chinese invention patent " the confocal Oph system and method for a kind of line sweep, grant number: ZL201010595574.X " or Chinese invention patent " the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction, grant number: ZL201010595587.7 ", when line sweep confocal imaging unit 101 is the confocal Oph system and method for a kind of line sweep, the confocal Oph system and method for a kind of line sweep comprises Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6, as shown in Figures 2 and 3.Line beam generation module 1 is connected with spectral module 2, Line beam generation module 1 consists of point source 100, collimator and extender device 110 and Line beam capture device 120, the divergent beams that point source 100 sends are by the rear output of collimator and extender device 110 collimation collimated light beam, and Line beam capture device 120 is sent into spectral module 2 by the collimated light beam intercepting of collimator and extender device 110 outputs for one dimension linear light bunch, spectral module 2 is light splitting plain film or Amici prism, and spectral module 2 arrives scanning element 3 for the direct transmission of an one dimension Line beam part that Line beam generation module 1 is produced, scan module 3 consists of scanning galvanometer 300 and illumination objective lens group 310, the Line beam of spectral module 2 direct outgoing passes through scanning galvanometer 300 and illumination objective lens group 310 successively, then from 101 outgoing of line sweep confocal imaging unit, after spectrophotometric unit 102 deflecting reflections, enter human eye 106 optical fundus, the imaging line light beam going out from fundus reflex is in spectrophotometric unit 102 deflecting reflection loop line scanning confocal image-generating units 101, pass through successively illumination objective lens group 310 and scanning galvanometer 300 synchronous reflections to spectral module 2, spectral module 2 reflexes to image-forming module 5 by imaging line beam deflection, image-forming module 5 is by image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530 form, the imaging line light beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500 successively, cylindrical lens 510 and confocal slit 520, arrive line detector 530 and convert the signal of telecommunication to by light intensity signal, and be transferred to output module 6, confocal slit 520 and optical fundus retina 4 planar conjugates, the veiling glare that confocal slit 520 can be got rid of non-optical fundus retina 4 planes enters line detector 530, thereby realize the high-resolution of confocal imaging principle, output module 6 consists of image pick-up card 600 and outut device 610, and image pick-up card 600 converts the signal of telecommunication of image-forming module 5 outputs to picture signal, and exports by outut device 610, outut device 610 is connected with datatron 104, and the retina image-forming result that outut device 610 is obtained is exported to datatron 104, and datatron 104 is reconstructed into image by imaging results and exports to display 105 and shows.
When line sweep confocal imaging unit 101 is the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction, the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction comprises Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6, as shown in Figure 4 and Figure 5.Line beam generation module 1 is connected with spectral module 2, Line beam generation module 1 consists of point source 100, collimator apparatus 110 and Line beam converting means 120, the divergent beams of point source 100 are transformed to collimated light beam through collimator apparatus 110, and this collimated light beam is transformed to one dimension Line beam through Line beam converting means 120 and is transmitted to spectral module 2; Spectral module 2 is light splitting plain film or Amici prism, for the direct transmission of an one dimension Line beam part that Line beam generation module 1 is produced, arrives scan module 3; Scan module 3 consists of scanning galvanometer 300 and illumination objective lens 310, the Line beam of spectral module 2 direct outgoing passes through scanning galvanometer 300 and illumination objective lens 310 successively, then from 101 outgoing of line sweep confocal imaging unit, after spectrophotometric unit 102 deflecting reflections, enter human eye 106 optical fundus, the imaging line light beam going out from fundus reflex is in spectrophotometric unit 102 deflecting reflection loop line scanning confocal image-generating units 101, pass through successively illumination objective lens group 310 and scanning galvanometer 300 synchronous reflections to spectral module 2, spectral module 2 reflexes to image-forming module 5 by imaging line beam deflection; Image-forming module 5 consists of image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530, the imaging line light beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500, cylindrical lens 510 and confocal slit 520 successively, arrive line detector 530 and convert the signal of telecommunication to by light intensity signal, and be transferred to output module 6, confocal slit 520 and optical fundus retina 4 planar conjugates, the veiling glare that confocal slit 520 can be got rid of non-optical fundus retina 4 planes enters line detector 530, thereby realizes the high-resolution of confocal imaging principle; Output module 6 consists of image pick-up card 600 and outut device 610, and image pick-up card 600 converts the signal of telecommunication of image-forming module 5 outputs to picture signal, and exports by outut device 610; Outut device 610 is connected with datatron 104, and the retina image-forming result that outut device 610 is obtained is exported to datatron 106, and datatron 104 is reconstructed into image by imaging results and exports to display 105 and shows.
Self adaptation confocal scanning retina image-generating unit 103 and spectrophotometric unit 102, datatron 104 is connected, for Chinese invention patent " a kind of reflection-type confocal scanning retina imaging system based on adaptive optics, grant number: ZL201010197028.0 ", as shown in Figure 1, comprise semiconductor laser light resource 1, a plurality of reflective contracting bundle beam-expanding system 11-18, the two-dimensional scan galvanometer being formed by directions X scanning galvanometer 23 and Y-direction scanning galvanometer 24, Hartmann wave front sensor 9, distorting lens 22, by collecting lens 27, pin hole 4 and photomultiplier tube 5 Photodetection systems, data acquisition and processing (DAP) system 6, wave front processor 7 and another eye sighting target system 30.The light sending with the semiconductor laser light resource 1 of tail optical fiber can be similar to regards point source as, through collimating mirror 21, be collimated to 6mm, and by spectroscope 2 light splitting, the beam-expanding system that the part process spherical reflector 11 of reflection and spherical reflector 12 form expands with distorting lens 22 and mates, and reflected by distorting lens 22, next the contracting beam system contracting Shu Zhiyu directions X scanning galvanometer 23 through spherical reflector 13 and spherical reflector 14 compositions mates, and arrive directions X scanning galvanometer 23, 23 pairs of incident beams of directions X scanning galvanometer carry out transversal scanning, and by by spherical reflector and 15 and the beam-expanding system that forms of spherical reflector 16 expand with Y-direction scanning galvanometer 24 and mate, and arrive Y-direction scanning galvanometer 24, 24 pairs of incident beams of Y-direction scanning galvanometer carry out longitudinal scanning, and reflex to the beam-expanding system that spherical reflector 17 and spherical reflector 18 forms, wherein for fear of light beam, block, between spherical reflector 17 and 18, inserted plane mirror 19, now beam size mates with human eye entrance pupil, and be reflected to cylindrical mirror 20, cylindrical mirror 20 will be proofreaied and correct because spherical reflector off-axis is used the astigmatism producing above together, beam reflection is gone out to self adaptation confocal scanning retina image-generating unit 103 and arrive spectrophotometric unit 102, the direct transmitted light beam of spectrophotometric unit 102 is to human eye 106, and focus of the light beam into a bit by the optical system of human eye, there is scattering process on human eye 106 optical fundus to incident illumination, scattered light is carrying the aberration information of human eye and the intensity signal of this point of optical fundus, from human eye 106 outgoing, by the direct transmission of spectrophotometric unit 102, return self adaptation confocal scanning retina image-generating unit 103, scattered beam turns back to spectroscope 2 on the inner Yan Yuan road of continuing of self adaptation confocal scanning retina image-generating unit 103, and arriving spectroscope 3, spectroscope 3 is to the light splitting again of this part scattered light: a part enters Hartmann wave front sensor 9, another part arrives photomultiplier tube 5 by collecting lens 27 and pin hole 4.The dot matrix that contains human eye aberration information that Hartmann wave front sensor 9 receives, and dot array data is passed to wave front processor 7, wave front processor 7 is by the slope in every sub-aperture before the calculations of offset efferent echo of dot matrix barycenter, by direct Slope Method, calculate control voltage again, and will pass to distorting lens 22, thereby realize the real-time detection of human eye aberration and correction.Scattered light after real time correction arrives photomultiplier tube 5 through pin hole 4 after collecting lens 27 focuses on, 5 pairs of light intensity of photomultiplier tube are carried out continuous probe, side by side, the driving synchronizing voltage of directions X scanning galvanometer 23 and Y-direction scanning galvanometer, and the continuous light intensity signal that photomultiplier tube 5 obtains is exported to data acquisition and processing (DAP) system 6, determine that the light intensity signal in a certain moment is corresponding to retinal illumination light spot position, with the image-forming information of a certain scanning area of this reconstruct place retina.On the other hand, reflection-type confocal scanning retina imaging system based on adaptive optics also comprises another eye sighting target system 3, another eye sighting target system 3 is by imaging len 30-1, plane mirror 30-2 and LED array 30-3 form, a lamp in point range LED array 30-3, the light that it sends is after plane mirror 30-2 reflection, through imaging len, being collimated into collimated light beam enters and sees that sighting target human eye 10 is focused into the luminous point in retinal plane, in lighting LED array 30-3 during the lamp of diverse location, the optical axis of seeing sighting target human eye 10 can rotate thereupon, because people's eyes have servo-actuated property, the optical axis of imaging human eye 8 also can rotate thereupon, just can realize thus the illumination imaging to imaging human eye 8 zones of different positions, at this, imaging human eye 8 is same eyes with human eye 106.
Datatron 104 is connected with line sweep confocal imaging unit 101, self adaptation confocal scanning retina image-generating unit 103 and display 105, the imaging results of line sweep confocal imaging unit 101 is exported to datatron 104,104 pairs of imaging results of datatron are reconstructed and obtain the large view field imaging image of retina and export to display 105 showing, by the large view field imaging image of direct observation retina, can carry out labelling by position, the local zonule of interested retina in 104 pairs of images of datatron, and be presented on display 105.The local zonule of the retina position coordinates that on the large view field imaging image of retina that line sweep confocal imaging unit 101 obtains, labelling is good is exported to the another eye sighting target system in self adaptation confocal scanning retina image-generating unit 103 by datatron 104, under its guiding, self adaptation confocal scanning retina image-generating unit 103 is realized this retinal area is thrown light on and surveyed, result of detection is exported to datatron 104 and is reconstructed the high-resolution imaging image that obtains the interested local zonule of retina, and exports to display 105 demonstrations.
As shown in Figure 7, the self adaptation confocal scanning retina formation method based on the guiding of line sweep confocal imaging image of the present invention, comprises the following steps:
Step s1, start, starting device;
Step s2, demarcates visual field, demarcates the imaging viewing field of self adaptation confocal scanning retina image-generating unit according to the imaging viewing field center of line sweep confocal imaging unit;
Step s3, line sweep confocal imaging unit carries out imaging to retina, obtains amphiblestroid large view field imaging image;
Step s4, the large view field imaging image of retina that the line sweep confocal imaging unit of exporting by observation display obtains, chooses and the local zonule of the interested retina of labelling position coordinates;
Step s5, the another eye sighting target system of self adaptation confocal scanning retina image-generating unit exported to the good local zonule of the interested retina position coordinates of labelling by datatron;
Step s6, the deflection of the another eye sighting target system guiding eyes optical axis, the ZhaoMing Center of the position, the local zonule of retina that labelling is crossed in self adaptation confocal scanning retina image-generating unit, thus realize its high-resolution imaging;
Step s7, guiding finishes, imaging results output display.
The present invention does not limit to and above-mentioned example, and persons skilled in the art can adopt numerous embodiments to realize the present invention according to content disclosed by the invention.Non-elaborated part of the present invention belongs to techniques well known.
Claims (1)
1. the self adaptation confocal scanning retina formation method guiding based on line sweep confocal imaging image, is characterized in that performing step is as follows:
Step 1, start, starting device;
Step 2, demarcates visual field, demarcates the imaging viewing field of self adaptation confocal scanning retina image-generating unit according to the imaging viewing field center of line sweep confocal imaging unit;
Step 3, line sweep confocal imaging unit carries out imaging to retina, obtains amphiblestroid large view field imaging image;
Line sweep confocal imaging unit described in described step 3 carries out imaging to retina and specifically comprises:
Step 31, line sweep confocal imaging unit emergent ray light beam arrives human eye retina through spectrophotometric unit deflecting reflection;
Step 32, the imaging line light beam reflecting from human eye retina is through spectrophotometric unit deflecting reflection loop line scanning confocal image-generating unit;
Step 33, line sweep confocal imaging unit is surveyed imaging line light beam, surveys after the treated machine processing of the signal obtaining, and is converted into image and exports to display demonstration;
Step 4, the large view field imaging image of retina that the line sweep confocal imaging unit of exporting by observation display obtains, chooses and the local zonule of the interested retina of labelling position coordinates;
The also local zonule of the interested retina of the labelling position coordinates of choosing described in described step 4 specifically comprises:
Step 41, chooses interested to be seen zonule position the large view field imaging image of retina obtaining from line sweep confocal imaging unit;
Step 42, datatron to large view field imaging image, and shows interested zonule to be seen position coordinates labelling on display;
Step 5, the another eye sighting target system of self adaptation confocal scanning retina image-generating unit exported to the good local zonule of the interested retina position coordinates of labelling by datatron; The deflection of the another eye sighting target system guiding eyes optical axis, the ZhaoMing Center of the position, the local zonule of retina that labelling is crossed in self adaptation confocal scanning retina image-generating unit, thus realize its high-resolution imaging;
Described step 5 is specially:
Step 51, the another eye sighting target system of self adaptation confocal scanning retina image-generating unit exported to the good retina zonule positional information of labelling by datatron;
Step 52, the outgoing beam of self adaptation confocal scanning retina image-generating unit is directly transmitted to through spectrophotometric unit the position, zonule that on intelligent's eyes retina, labelling is good under the guiding of another eye sighting target system;
Step 53, the imaging beam reflecting from human eye retina, after the direct transmission of spectrophotometric unit, transmits back self adaptation confocal scanning retina image-generating unit;
Step 54, self adaptation confocal scanning retina image-generating unit is surveyed imaging beam, and the treated machine of its detectable signal is processed by display output, obtains the high-resolution imaging image of the position, zonule that this retina labelling crosses
Step 6, guiding finishes, imaging results output display.
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| CN110584592B (en) * | 2019-09-09 | 2021-06-18 | 中国科学院苏州生物医学工程技术研究所 | Large-field-of-view adaptive optical retina imaging system and method for common-path beam scanning |
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| CN101862178B (en) * | 2010-06-02 | 2012-07-11 | 中国科学院光电技术研究所 | Reflection-type confocal scanning retina imaging system based on adaptive optics |
| CN102008288B (en) * | 2010-12-17 | 2012-02-01 | 中国科学院光电技术研究所 | System and method for line scan confocal ophthalmoscope |
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