CN208892542U - Optical coherence tomography and the confocal synchronous imaging system of spot scan - Google Patents

Optical coherence tomography and the confocal synchronous imaging system of spot scan Download PDF

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Publication number
CN208892542U
CN208892542U CN201820539003.6U CN201820539003U CN208892542U CN 208892542 U CN208892542 U CN 208892542U CN 201820539003 U CN201820539003 U CN 201820539003U CN 208892542 U CN208892542 U CN 208892542U
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module
scan
scan module
confocal
coherence tomography
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CN201820539003.6U
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史国华
金幸杰
高峰
王丽荣
邢利娜
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Abstract

The utility model relates to imagers, a kind of optical coherence tomography and the confocal synchronous imaging system of spot scan be provided, including optical coherence tomography module, fast axle scan module, slow axis scan module, spectroscope, point confocal imaging module, the confocal lighting module of point, dichroscope, shares scan module and connects mesh object lens.In the utility model, by the way that spot scan confocal imaging technology and Optical Coherence Tomography Imaging Technology are combined, system hardware is effectively reduced using total optical path resonant mirror synchronous scanning imaging method, the effective use for realizing optical coherence tomography and spot scan confocal imaging scanning speed achievees the purpose that the imaging of quick face and the tomographic imaging of eye ground.

Description

Optical coherence tomography and the confocal synchronous imaging system of spot scan
Technical field
The utility model relates to imager more particularly to a kind of optical coherence tomographies and the confocal synchronous imaging system of spot scan System.
Background technique
Clinically there is various fundus retina image-forming technology, including fundus camera at present, optical coherence tomography is total Burnt scanning technique etc. all plays an important role to biological study and medical diagnosis on disease.
Laser cofocus scanning ophthalmoscope filters out the high-resolution imaging mode of veiling glare by numerous studies by being conjugated aperture, And it is successfully applied to biological study and medical diagnosis, including on ophthalmology is imaged, and laser rays cofocus scanning technology is total in laser Conjugation aperture is changed to conjugation slit on the basis of coke scanning, substantially increases image taking speed, may be implemented real to eyeground high speed When be imaged.In addition to this, gold standard of the optical coherence tomography as ophthalmology funduscopy can be realized high-resolution disconnected Layer scanning and three-dimensional reconstruction, the confocal fundus imaging technology of line and Optical Coherence Tomography Imaging Technology are combined, can be mentioned simultaneously For the multi-faceted information in eyeground.
Patent (a kind of fundus camera of combination OCT system, CN104224109A) is mentioned fundus camera and optical coherence Chromatographic technique combines, but since fundus camera is using flash exposure, strong light generates very big stimulation to eyes, cannot Lasting imaging;There is article (" Noise analysis of a combined optical coherence tomography And a confocal scanning ophthalmoscope [J], Applied Optics, 1999) and patent (uses OCT The two-dimentional confocal imaging of light source and scanning optical device, CN104684457A) it mentions the sample of optical coherence tomography Light takes imaging of the part as confocal imaging, but laser cofocus scanning imaging is transversal scanning, and optical coherence tomography is vertical It is very slow in transverse direction speed to tomoscan, the speed of confocal imaging will be largely effected on;Article (Real-time eye Motion correction in phase-resolved OCT angiography with tracking SLO [J], BOE, 2013) be optical path by laser confocal scanning system and optical coherence tomography system and scanning independently of each other to eyeground into Row fast imaging, so two systems scanning does not synchronize, only system is superimposed, and does not reduce the complexity of system;In addition exist It is disclosed in patent (confocal spot scan and optical coherent chromatographic imaging instrument based on adaptive optical technique, CN101869466) Optical coherence tomography is combined with confocal scanning technique, but using Wavefront sensor, can be returned to from human eye The optical signal that the Huis comes carries out Wavefront detecting, and restores the aberration information of human eye out, and carries out multiple reflections and vibration mirror scanning, knot Structure is complicated.
Utility model content
The utility model is regarding to the issue above and insufficient, propose a kind of optical coherence tomography and spot scan it is confocal it is synchronous at As system, it can synchronize and realize optical coherence tomography and laser cofocus scanning.
The utility model is realized in this way:
The utility model embodiment provides a kind of optical coherence tomography and the confocal synchronous imaging system of spot scan, including optics Coherent tomographic module, fast axle scan module, slow axis scan module, spectroscope, point confocal imaging module, the confocal lighting module of point, Dichroscope shares scan module and connects mesh object lens;
The sample light issued in optical coherence tomography module is by slow axis scan module and transmits dichroscope, and altogether with point The light that burnt lighting module issues is combined by the reflected light that fast axle scan module reaches dichroscope, jointly successively by sharing Scan module and connect mesh object lens illumination imaging carried out to eyeground, in conjunction with imaging reflected by sample and successively process connects mesh object lens And shared scan module, the chromatography light beam of scan module is shared after the transmission of dichroscope and slow axis scan module, It is after the reflection of dichroscope and fast to share the confocal imaging light beam of scan module for interference imaging in optical coherence tomography module Axis scan module is imaged in confocal imaging module.
Preferably, the optical coherence tomography module includes spectral domain optical coherent tomographic system or swept-source optical coherence Tomographic system.
Preferably, the scan axis of scanning galvanometer and scanning galvanometer in the slow axis scan module in the fast axle scan module Scan axis it is parallel and vertical with the scan axis of scanning galvanometer in the shared scan module.
Preferably, the condenser lens of the condenser lens of the slow axis scan module and the shared scan module constitutes 4f system System, scanning galvanometer is located at the lens focus of 4f system in scanning galvanometer and the shared scan module in the slow axis scan module Position;
The condenser lens of the condenser lens of the fast axle scan module and the shared scan module constitutes 4f system, described The scanning galvanometer of the scanning galvanometer of fast axle scan module and the shared scan module is located at the lens focus position of 4f system.
Preferably, the scan axis of the scanning galvanometer light with the confocal lighting module of point respectively in the fast axle scan module The optical axis of condenser lens is vertical in axis and the fast axle scan module;
The scan axis of the scanning galvanometer of the slow axis scan module issues light with the optical coherence tomography module respectively The optical axis of the condenser lens of optical axis direction and the slow axis scan module is vertical;
The scan axis of the scanning galvanometer of the shared scan module respectively with the condenser lens of the shared scan module The optical axis of the scanning lens of optical axis and the shared scan module is vertical.
Preferably, the fast axle scan module includes MEMS galvanometer, resonant galvanometer or multiple surface rotating mirror.
Preferably, the optical coherence tomography module includes optical coherence tomography light source, interferometer, reference arm and detection Optical path, the light that the optical coherence tomography light source issues enter the road the reference arm Nei Qiebeiyuan through the interferometer, a part The interferometer is reflexed to, another part enters the slow axis scan module, and the light beam after being reflected by sample reenters interference The beam interference reflected in instrument with reference arm, interfering beam are detected in detection optical path.
The utility model has the following beneficial effects:
In the system of the utility model, by the way that spot scan confocal imaging technology is mutually tied with Optical Coherence Tomography Imaging Technology It closes, system hardware is effectively reduced using total optical path resonant mirror synchronous scanning imaging method, realizes optical coherence tomography and point The effective use of scanning confocal image scanning speed achievees the purpose that the imaging of quick face and the tomographic imaging of eye ground.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor Under, it can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is the light channel structure figure of Tthe utility model system;
Fig. 2 is in the utility model specific embodiment using spectral domain optical coherent tomographic and the confocal synchronous scanning of spot scan Structure chart;
Fig. 3 is the scanning light of optical coherence tomography scanning and point cofocus scanning in the utility model specific embodiment Spot track schematic diagram.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work All other embodiment obtained, fall within the protection scope of the utility model.
Referring to figures 1-3, the utility model embodiment provides a kind of optical coherence tomography and the confocal synchronous imaging of spot scan System, including optical coherence tomography module 8, fast axle scan module 3, slow axis scan module 7, spectroscope 2, point confocal imaging module 9, confocal lighting module 1, dichroscope 4 are put, scan module 5 is shared and connects mesh object lens 6, in which:
Optical coherence tomography module 8, including optical coherence tomography light source 811, interferometer 812, reference arm and detection optical path, For carrying out Depth Imaging to sample, wherein sample can be eye ground 10, and certain optical coherence tomography module can also adopt With other structure type, such as unicoupler structure or double coupler structures or circulator structure etc., form is relatively more Sample;
Fast axle scan module 3, including scanning galvanometer 31 and condenser lens 32, for point confocal scanning imaging system, deflection Point cofocus scanning light beam is realized and is scanned to the row of sample;Fast axle scan module 3 includes MEMS galvanometer, resonant galvanometer or more Face galvanometer, the scanning speed that scanning galvanometer 31 is set as 16KHz, mirror surface size be 3mm x 4mm, model EOPC SC-30, Scanning axis direction is mutually perpendicular to 51 scanning direction of scanning galvanometer in scan module 5 together, and is scanned in fast axle scan module 3 The scan axis of galvanometer 31 respectively with put confocal lighting module 1 optical axis and fast axle scan module 3 in condenser lens 32 optical axis Vertically;
Slow axis scan module 7, including scanning galvanometer 71 and condenser lens 72 are used for Optical coherence tomography, deflect light Coherent tomographic light beam is learned, realizes the field scan to sample, the scanning speed that scanning galvanometer 71 is set is scanned as 0.1Hz with fast axle 31 scanning direction of scanning galvanometer in module 3 is parallel to each other, the scan axis of the scanning galvanometer 71 for axis scan module 7 of waiting a moment respectively with Optical coherence tomography module 8 issues the optical axis direction of light and the optical axis of the condenser lens 72 of slow axis scan module 7 is vertical;
Scan module 5, including scanning galvanometer 51 and condenser lens 52 are shared, is used for optical coherence tomography module 8 and point The illumination light of confocal lighting module 1 deflects simultaneously, realizes that optical coherence tomography scans the row of sample, point cofocus scanning imaging system The field scan united to sample, scanning galvanometer 51 set scanning speed as 40Hz, and mirror surface size 10mm x 5mm scans mould with fast axle The scanning direction of the scanning galvanometer 31 of block 3 is mutually perpendicular to, and the scan axis difference of the scanning galvanometer 51 of shared scan module 5 is together Optical axis with the scanning lens of the optical axis and shared scan module 5 of the condenser lens 52 of scan module 5 is vertical;
Spectroscope 2 is used to reflect spot scan confocal imaging light beam for light splitting plain film or Amici prism or pellicle The detector of inlet point confocal imaging module 9, while the illuminating bundle that confocal lighting module 1 is emitted will be put be transmitted into fast axle and sweeping Retouch the propagation of module 3;
Dichroscope 4, the sample beam of the optical coherence tomography module 8 for slow axis scan module 7 to be emitted transmit into Enter shared scan module 5, while the sample beam for the optical coherence tomography module 8 that shared scan module 5 is emitted being transmitted into Slow axis scan module 7 is propagated, and is also used to for the point confocal imaging light beam that shared scan module 5 is emitted being reflected into fast axle scanning mould Block 3, while the illuminating bundle that fast axle scan module 3 is emitted is reflected into shared scan module 5 and is propagated.
The sample light issued in optical coherence tomography module 8 is by slow axis scan module 7 and transmits dichroscope 4, and with The light that the confocal lighting module 1 of point issues is combined by the reflected light that fast axle scan module 3 reaches dichroscope 4, jointly successively Illumination imaging is carried out to eyeground by sharing scan module 5 and connecing mesh object lens 6, in conjunction with imaging reflected by eye ground 10 And the chromatography light beam of scan module 5 successively is shared by the saturating of dichroscope 4 by connecing mesh object lens 6 and shared scan module 5 It penetrates with after slow axis scan module 7, the interference imaging in optical coherence tomography module 8 shares the confocal imaging light beam of scan module 5 It is imaged in confocal imaging module 9 after the reflection of dichroscope 4 with fast axle scan module 3.Specifically, dichroscope 4 Can be with the sending light of transmission optics coherent tomographic module 8 and received reflected light, and the sending of the confocal lighting module 1 of reflection point Light and the reception light for putting confocal imaging module 9 can be realized optical coherence tomography module 8 and issues light and put confocal lighting module 1 issues the separation of light, and dichroscope 4 is 805nm by wavelength, and long wave is logical, and shortwave is anti-;And spectroscope 2, for putting confocal illumination The sending light transmission of module 1, and the light beam reflected by the scanning galvanometer of fast axle scan module 3 31 reflexes to a little altogether through spectroscope 2 Burnt image-forming module 9, to achieve the purpose that a confocal imaging, the optical axis near spectroscope 2 is provided with extinction module 11, can inhale Receive optical axis near by reflected light.To in system disclosed in this utility model embodiment, by by spot scan confocal imaging skill Art and Optical Coherence Tomography Imaging Technology combine, and it is hard to effectively reduce system using total optical path resonant mirror synchronous scanning imaging method Part realizes the effective use of optical coherence tomography and spot scan confocal imaging scanning speed, reaches eye ground 10 The purpose of quick face imaging and tomographic imaging.It is illustrated in figure 3 the trajectory diagram of the vibration mirror scanning of shared scan module 5: Fig. 3 (left side) For a cofocus scanning track, complete single pass time 1/30 (Hz)=33.3 (ms);Fig. 3 (in) it is that optical coherence tomography scans Trajectory diagram;Each scan line both corresponds to the entire image scanning of a cofocus scanning, as shown in Fig. 3 (right side), optics phase in figure Dried layer analyses complete sweep time as 1/0.1 (Hz)=10s.
Referring to fig. 2, it is preferable that in optical coherence tomography module 8, reference light and transmitting are realized at interferometer 812 extremely The separation of light beam at eye ground 10, and interference is formed at interferometer 812, specifically optical coherence tomography light source 811 exists It is separated at interferometer 812, wherein interferometer 812 is coupler, and the light beam allocation proportion of coupler is 20:80, wherein 80% Light beam enters in reference arm, and reflexes in interferometer 812 on the road reference arm Nei Beiyuan, and other 20% light beam is as sample Light enters in slow axis scan module 7 by a collimating mirror 813, is specifically first incident upon the scanning galvanometer 71 of slow axis scan module 7, scans Galvanometer 71 is reflexed to the condenser lens 72 of slow axis scan module 7, and is transmitted dichroscope 4 after focusing and entered shared scanning In module 5, successively by sharing the scanning galvanometer 52 and condenser lens 51 of scan module 5, and penetrated under the action of connecing mesh object lens 6 To eye ground 10, eye ground 10 reflexes on its former road at interferometer 812, and the reference light with reference arm internal reflection Interference is generated, interfering beam enters in detection optical path.Optical coherence tomography module 8 include spectral domain optical coherent tomographic system or Swept-source optical coherence tomographic system, when using spectral domain optical coherent tomographic system, optical coherence tomography light source 811 is broadband Light source, such as semiconductor laser, the central wavelength of semiconductor laser is 830nm, bandwidth 80nm, and uses swept-source optical When tomographic system, optical coherence tomography light source 811 uses Sweep Source.
It specifically, mainly include grating 819 and detector 821, when relevant using spectral domain optical for detecting optical path When tomographic system, which is spectrometer, and when using swept-source optical tomographic system, detector 821 is linear array phase Machine, interfering beam pass through two collimating mirrors 817 (818) successively to form collimated light beam, when collimated light beam passes through grating 819, incite somebody to action The light beam of each frequency spectrum separates, and by being received after 820 focussing force of condenser lens by detector 821.For reference arm, master It to include collimating mirror 814, compensating glass 815 and reflecting mirror 816, three is located in same optical axis, and separated along interferometer 812 With reference to light direction, collimating mirror 814, compensating glass 815 and reflecting mirror 816 are set gradually, i.e., reference light successively passes through collimating mirror 814, compensating glass 815 and reflecting mirror 816, and after being reflected by reflecting mirror 816, reference light successively pass through compensating glass 815 and quasi- Straight mirror 814 enters in interferometer 812 and the sample interference of light.
Referring to Fig. 1, it is preferable that point confocal imaging module 9 includes condenser lens 93, light-transmitting plate 92 and detector 91, thoroughly It is provided with loophole on tabula rasa 92, shares point confocal imaging light beam successively line focus lens 93 and the loophole of scan module 5 It is imaged in into detector 9-1.Specifically, it puts the illuminating bundle that confocal lighting module 1 issues and becomes parallel by collimating mirror 12 Light and transmission spectroscope 2 enter fast axle scan module 3 by spectroscope 2, specifically successively pass through the scanning of fast axle scan module 3 Galvanometer 31 and condenser lens 32, and be incident upon after the focusing of condenser lens 32 at dichroscope 4 reflection and with optical coherence tomography mould The sample beam of block 8 is combined into shared scan module 5, successively by sharing the condenser lens 52 of scan module 5 and sweeping Retouch galvanometer 51, and after connecing mesh object lens 6 to eyeground synchronize illumination imaging, imaging by eye ground 10 reflect and according to Secondary process connects mesh object lens 6 and shared scan module 5, and the confocal light beam in midpoint is swept after the reflection of dichroscope 4 through fast axle It retouches module 3 and reflexes to a confocal imaging module 9 at spectroscope 2.In above process, putting confocal lighting module 1 includes half Conductor laser 11 issues the point light source of 650nm, and becoming size after collimating mirror 12 is the parallel hot spot that diameter is 2mm.
Referring to fig. 2 and Fig. 3, it is preferable that the focusing of the condenser lens 72 and shared scan module 5 of slow axis scan module 7 Lens 52 constitute 4f system, and scanning galvanometer 51 is located at 4f system in scanning galvanometer 71 and shared scan module 5 in slow axis scan module 7 The lens focus position of system;The condenser lens 72 of fast axle scan module 3 and the condenser lens 52 of shared scan module 5 constitute 4f system System, the scanning galvanometer 31 of fast axle scan module 3 and the scanning galvanometer 51 of shared scan module 5 are located at the lens focus position of 4f system It sets.Wherein, the f=40mm of the condenser lens 72 of slow axis scan module 7 shares the f=of the condenser lens 52 of scan module 5 60mm, the f=20mm of the condenser lens 32 of fast axle scan module 3.For connecing mesh object lens 6 comprising two condenser lenses 61 (62), that is, the light beam that scan module 5 issues is shared to need successively to enter eye ground 10 by two condenser lenses 61 (62), The light beam that eye ground 10 reflects also successively passes through two condenser lenses 61 (62), the f=of the two condenser lenses 61 (62) 30mm。
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model Protection scope within.

Claims (7)

1. a kind of optical coherence tomography and the confocal synchronous imaging system of spot scan, it is characterised in that: including optical coherence tomography mould Block, slow axis scan module, spectroscope, point confocal imaging module, the confocal lighting module of point, dichroscope, is total to fast axle scan module With scan module and connect mesh object lens;
The sample light issued in optical coherence tomography module by slow axis scan module and transmission dichroscope, and with put confocal photograph The light that bright module issues is combined by the reflected light that fast axle scan module reaches dichroscope, jointly successively by sharing scanning Module and connect mesh object lens illumination imaging carried out to eyeground, in conjunction with imaging reflected by sample and successively through connecing mesh object lens and Scan module is shared, the chromatography light beam of scan module is shared after the transmission of dichroscope and slow axis scan module, in optics Interference imaging in coherent tomographic module shares the confocal imaging light beam of scan module and sweeps after the reflection of dichroscope with fast axle Module is retouched to be imaged in confocal imaging module.
2. optical coherence tomography as described in claim 1 and the confocal synchronous imaging system of spot scan, it is characterised in that: the light Learning coherent tomographic module includes spectral domain optical coherent tomographic system or swept-source optical coherence tomographic system.
3. optical coherence tomography as described in claim 1 and the confocal synchronous imaging system of spot scan, it is characterised in that: described fast The scan axis of scanning galvanometer is parallel with the scan axis of scanning galvanometer in the slow axis scan module in axis scan module, and and institute The scan axis for stating scanning galvanometer in shared scan module is vertical.
4. optical coherence tomography as described in claim 1 and the confocal synchronous imaging system of spot scan, it is characterised in that: described slow The condenser lens of the condenser lens of axis scan module and the shared scan module constitutes 4f system, in the slow axis scan module Scanning galvanometer is located at the lens focus position of 4f system in scanning galvanometer and the shared scan module;
The condenser lens of the condenser lens of the fast axle scan module and the shared scan module constitutes 4f system, the fast axle The scanning galvanometer of the scanning galvanometer of scan module and the shared scan module is located at the lens focus position of 4f system.
5. optical coherence tomography as described in claim 1 and the confocal synchronous imaging system of spot scan, it is characterised in that: described fast The scan axis of scanning galvanometer scans mould with the optical axis of the confocal lighting module of point and the fast axle respectively in axis scan module The optical axis of condenser lens is vertical in block;
The scan axis of the scanning galvanometer of the slow axis scan module issues the optical axis of light with the optical coherence tomography module respectively The optical axis of the condenser lens of direction and the slow axis scan module is vertical;
The scan axis of the scanning galvanometer of the shared scan module optical axis with the condenser lens of the shared scan module respectively And the optical axis of the scanning lens of the shared scan module is vertical.
6. optical coherence tomography as described in claim 1 and the confocal synchronous imaging system of spot scan, it is characterised in that: described fast Axis scan module includes MEMS galvanometer, resonant galvanometer or multiple surface rotating mirror.
7. optical coherence tomography as described in claim 1 and the confocal synchronous imaging system of spot scan, it is characterised in that: the light Learning coherent tomographic module includes optical coherence tomography light source, interferometer, reference arm and detection optical path, the optical coherence tomography For the light that light source issues through the interferometer, a part reflexes to the interferometer into the road the reference arm Nei Qiebeiyuan, another Part enters the slow axis scan module, and the light beam after being reflected by sample reenters the light beam in interferometer with reference arm reflection Interference, interfering beam are detected in detection optical path.
CN201820539003.6U 2018-04-16 2018-04-16 Optical coherence tomography and the confocal synchronous imaging system of spot scan Withdrawn - After Issue CN208892542U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108567410A (en) * 2018-04-16 2018-09-25 中国科学院苏州生物医学工程技术研究所 Optical coherence tomography and the confocal synchronous imaging system of spot scan
CN110448267A (en) * 2019-09-06 2019-11-15 重庆贝奥新视野医疗设备有限公司 A kind of multimode eyeground dynamic imaging analysis system and its method

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108567410A (en) * 2018-04-16 2018-09-25 中国科学院苏州生物医学工程技术研究所 Optical coherence tomography and the confocal synchronous imaging system of spot scan
CN108567410B (en) * 2018-04-16 2024-05-17 中国科学院苏州生物医学工程技术研究所 Confocal synchronous imaging system for optical coherence tomography and point scanning
CN110448267A (en) * 2019-09-06 2019-11-15 重庆贝奥新视野医疗设备有限公司 A kind of multimode eyeground dynamic imaging analysis system and its method
CN110448267B (en) * 2019-09-06 2021-05-25 重庆贝奥新视野医疗设备有限公司 Multimode fundus dynamic imaging analysis system and method

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