WO2023193480A1

WO2023193480A1 - Retinal imaging apparatus and imaging method thereof

Info

Publication number: WO2023193480A1
Application number: PCT/CN2022/141647
Authority: WO
Inventors: 任骥; 王鑫; 张�杰
Original assignee: 南京博视医疗科技有限公司
Priority date: 2022-04-08
Filing date: 2022-12-23
Publication date: 2023-10-12

Abstract

Disclosed are a retinal imaging apparatus and an imaging method thereof. The imaging apparatus comprises a light source detection module, a light beam modulation module, and an acquisition control module. The light source detection module generates an imaging light beam incident on the light beam modulation module. The light beam modulation module modulates an incident angle of the light beam. The modulated light beam is incident on an eyeball. A feedback light beam reflected by the retina passes through the light beam modulation module and is incident on the light source detection module. The light source detection module generates a detection signal. The acquisition control module, on the basis of the detection signal, controls an optical path state of the light beam modulation module. By means of the combination of line-scanning confocal microscopic imaging and optical coherence tomography and the combination of point-scanning confocal microscopy and optical coherence tomography, the apparatus can achieve real-time eyeball movement tracking, eliminate the influence of eyeball movement, and improve the acquisition success rate of three-dimensional imaging. By means of a line scanning mode, the number of optical elements can be reduced, the compactness and cost-efficiency of the apparatus are improved, and the scanning speed is increased.

Description

Retinal imaging device and imaging method thereof

This application is required to be submitted to the China Patent Office on April 8, 2022, with the application number 202210365051.9, and the invention title is "A retinal imaging device and its imaging method" and to be submitted to the China Patent Office on April 8, 2022, with the application number 202210366690.7 , the priority of a Chinese patent application titled "A line-scanning retinal imaging device and its imaging method", the entire content of which is incorporated into this application by reference.

Technical field

The present application relates to the field of optical design technology, and in particular to a retinal imaging device and an imaging method thereof.

Background technique

The retina is an important part of the human eye. Currently, more than one billion people in the world suffer from retina-related diseases. In order to achieve more effective treatment of retina-related diseases, the optimization of its treatment devices is inevitable. That is to say, the retina High-resolution imaging devices are of great significance for the diagnosis and therapeutic evaluation of retina-related diseases.

Early retinal imaging devices were mainly based on slit lamps or fundus cameras, but these technical methods were affected by the aberrations of the imperfect human eye, resulting in low imaging resolution and the inability to observe the microscopic cell-level structure of the retina.

Researchers LiangJunzhong et al. (Liang et al. "Supernormal vision and high-resolution retinalimaging through adaptive optics", J.Opt.Soc.Am.A/Vol.14, No.11/Nov.1997) proposed a method based on common vision The focused adaptive optical retinal imaging device can dynamically detect in real time, compensate for human eye aberrations, and improve the lateral resolution by an order of magnitude; however, the longitudinal resolution of this retinal imaging device is low and cannot distinguish the multi-layered structure of the retina.

Researchers Donald.Miller et al. (Yan Zhang, JungtaeRha, Ravi S.Jonnal, and Donald T.Miller "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina", Optics Express, Vol.13, No.12/Jun .2005) proposed an imaging device that combines optical coherence tomography (OCT) and adaptive optics, which can further improve the longitudinal resolution while maintaining high lateral resolution; however, this imaging device It is a single-channel floodlight that cannot track eye movement, and image collection will be affected by human eye movement. Common eye twitching can cause image tearing and blurring, resulting in low image availability; then the imaging device is in order to obtain usable images. , it will need to be collected repeatedly, which will also cause problems such as long collection time and low clinical efficiency.

Therefore, how to provide a high-performance retinal imaging device is an urgent technical problem to be solved by those skilled in the art. In addition, retinal imaging equipment using line scanning has also attracted the attention of researchers because line scanning technology has a higher scanning speed than point scanning technology, a simple system structure, and low cost.

Contents of the invention

In view of this, in order to solve the above problems, this application provides a retinal imaging device and its imaging method. The technical solution is as follows:

A retinal imaging device, which includes: a light source detection module, a beam modulation module and a collection control module;

Wherein, the light source detection module is used to generate reflected light or dual-channel illumination light including reflected light and OCT light. The reflected light or the dual-channel illuminating light is combined to form a scanning beam and is incident on the beam modulation module;

The beam modulation module is used to modulate the incident angle of the scanning beam. The modulated scanning beam enters the eyeball, and the feedback beam reflected by the retina is incident on the light source detection module through the beam modulation module;

The light source detection module is also used to generate a detection signal based on the feedback beam;

The collection control module is used to collect the detection signal, and control the optical path state of the beam modulation module based on the detection signal to achieve eye movement tracking.

Preferably, the light source detection module includes: a light source and a light detector, the light source is used to generate reflected light or dual-channel illumination light, and the light detector is used to generate a reflected light detection signal based on the reflected light in the feedback beam;

When the light source generates dual-channel illumination light, the light source detection module further includes an OCT detector, and the OCT detector is used to generate an OCT light detection signal based on the OCT light in the feedback beam.

Preferably, the light source detection module includes a light source and a line array camera, and the light source is used to generate reflected light or dual-channel illumination light, wherein the reflected light is linear reflected light, and the reflection in the dual-channel illumination light The light and OCT light are linear reflected light and linear OCT light respectively; the line array camera is used to generate a reflected light detection signal based on the linear reflected light in the feedback beam;

When the light source generates the above-mentioned dual-channel illumination light, the light source detection module further includes: a linear array OCT detector. The linear array OCT detector is used to generate an OCT light detection signal based on the linear OCT light in the feedback beam. .

Preferably, (1) when the light source detection module generates reflected light, the beam modulation module includes: three eye pupil conjugate surfaces to form three images of the human eye pupil; the beam modulation module also includes an oscillator. Mirror unit, the galvanometer unit includes: a first galvanometer, a second galvanometer and a third galvanometer, the first to third galvanometers are respectively located on the conjugate surfaces of the three eyeball pupils;

The first galvanometer is used for lateral scanning of the reflected light;

The second galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light;

The third galvanometer is used for lateral tracking of the reflected light;

(2) When the light source detection module generates dual-channel illumination light, the beam modulation module includes: three eye pupil conjugate surfaces to form three images of the human eye pupil. The beam modulation module also includes: a third A galvanometer, a second galvanometer and a third galvanometer, the first to third galvanometers are respectively located on the conjugate surfaces of the three eyeball pupils;

The first galvanometer is used for lateral scanning of the reflected light and the OCT light;

The second galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light and the OCT light;

The third galvanometer is used for lateral tracking of the reflected light and the OCT light;

Alternatively, the beam modulation module includes: four eye pupil conjugate surfaces to form four images of the human eye pupil, the beam modulation module further includes a galvanometer unit, the galvanometer unit includes: a first galvanometer, A second galvanometer, a third galvanometer and a fourth galvanometer, the first to fourth galvanometers are respectively located on the conjugate surfaces of the four eyeball pupils;

The first galvanometer is used for lateral scanning of the reflected light;

The second galvanometer is used for lateral scanning of the OCT light;

The third galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light and the OCT light;

The fourth galvanometer is used for lateral tracking of the reflected light and the OCT light.

Preferably, the beam modulation module includes: two conjugate surfaces of eyeball pupils to form two images of human eye pupils. The beam modulation module also includes a galvanometer unit, and the galvanometer unit includes: a first galvanometer. and a second galvanometer, the first galvanometer and the second galvanometer are respectively located on the conjugate surfaces of the pupils of the two eyeballs;

The first galvanometer is used for longitudinal scanning and longitudinal tracking of the scanning beam;

The second galvanometer is used for lateral tracking of the scanning beam.

Preferably, the beam modulation module is further equipped with an eyeball pupil conjugate surface, and the beam modulation module further includes a compensation mirror, the compensation mirror is located on the eyeball pupil conjugate surface for real-time aberration compensation.

Preferably, the acquisition control module includes: a data acquisition unit, a galvanometer control unit and a calculation unit;

Wherein, the data collection unit is used to collect the reflected light detection signal, or collect the OCT light detection signal simultaneously;

The calculation unit is used to generate a two-dimensional reflection image based on the reflected light detection signal, or simultaneously generate a three-dimensional retinal image based on the OCT light detection signal. The calculation unit is also used to generate a first first image based on the two-dimensional reflection image. control signal;

The galvanometer control unit is used to control the deflection state of the galvanometer in the beam modulation module according to the first control signal to achieve eye movement tracking.

Preferably, the reflected light includes light of multiple different wavelengths, and the computing unit is further configured to generate a colored two-dimensional reflection image based on the reflected light detection signal.

Preferably, the light source detection module further includes: a wavefront detector, the wavefront detector is used to generate a wavefront detection signal based on a part of the reflected light in the feedback beam;

When the reflected light and the dual-channel illumination light generated by the light source detection module are linear beams, the light source detection module further includes: a wavefront detection light source, and the wavefront detection light source is used to output wavefront detection The light is combined with the scanning beam and then enters the beam modulation module. The wavefront detector is used to generate a wavefront detection signal based on the wavefront detection light in the feedback beam.

Preferably, the acquisition control module includes: a data acquisition unit, a galvanometer control unit, a compensation mirror control unit and a calculation unit;

Wherein, the data acquisition unit is used to collect the reflected light control signal and the wavefront detection signal, or also collect the OCT light detection signal at the same time;

The computing unit is configured to generate a two-dimensional reflection image based on the reflected light detection signal, and generate a wavefront image based on the wavefront detection signal, or simultaneously generate the three-dimensional retinal image based on the OCT light detection signal; The computing unit is further configured to generate a first control signal based on the two-dimensional reflection image, and generate a second control signal based on the wavefront image;

The galvanometer control unit is used to control the deflection state of the galvanometer in the beam modulation module according to the first control signal to achieve eye movement tracking;

The compensation mirror control unit is used to control the compensation value of the compensation mirror in the beam modulation module according to the second control signal to achieve real-time aberration compensation.

A retinal imaging method, based on the retinal imaging device described in any of the above embodiments, the retinal imaging method includes:

The light source detection module generates reflected light or dual-channel illumination light including reflected light and OCT light, and forms a scanning beam that is incident on the beam modulation module; the beam modulation module modulates the incident angle of the scanning beam, and The modulated scanning beam enters the eyeball, and the feedback beam reflected by the retina passes through the beam modulation module and is incident on the light source detection module; the light source detection module generates a detection signal based on the feedback beam; the acquisition control module collects The detection signal is used to control the optical path state of the beam modulation module based on the detection signal to achieve eye movement tracking.

Preferably, the light source detection module also generates a wavefront detection signal based on a part of the reflected light in the feedback beam, the collection control module collects the wavefront detection signal, and controls the scanning beam based on the wavefront detection signal. Light wavefront phase to achieve real-time aberration compensation.

Preferably, the reflected light is linear reflected light, and the reflected light and OCT light in the dual-channel illumination light are linear reflected light and linear OCT light respectively;

The light source detection module also generates wavefront detection light, which is combined with the scanning beam and then is incident on the beam modulation module; the light source detection module is based on the wavefront detection light in the feedback beam. A wavefront detection signal is generated, and the acquisition control module collects the wavefront detection signal and controls the optical wavefront phase of the scanning beam based on the wavefront detection signal to achieve real-time aberration compensation.

Compared with the existing technology, the above technical solution has the following advantages:

The retinal imaging device combines confocal imaging scanning and optical coherence tomography, including confocal imaging point scanning and optical coherence tomography, and confocal imaging line scanning and optical coherence tomography, to achieve real-time eyeballing. Motion tracking eliminates the influence of eye movements and improves the collection efficiency of 3D imaging. At the same time, using adaptive optics technology and adding compensating mirrors and wavefront detectors, real-time aberration compensation can be achieved and the quality of retinal imaging can be significantly improved to obtain cell-level high-resolution images. Moreover, the retinal imaging device utilizes the conjugate surface of the eyeball pupil and has the advantage of simple optical path. In addition, the confocal imaging line scan mode in this application can reduce the number of optical components, reduce the size and cost of the device, and increase the scanning speed.

Description of the drawings

In order to explain the embodiments of the present application or the technical solutions in the prior art more clearly, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are only These are some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without exerting creative efforts.

Figure 1 is a schematic diagram of the principle structure of a retinal imaging device provided by an embodiment of the present application;

Figure 2 is a schematic diagram of the principle structure of another retinal imaging device provided by an embodiment of the present application;

Figure 3 is a schematic structural diagram of another retinal imaging device provided by an embodiment of the present application;

Figure 4 is a schematic structural diagram of a collection control module provided by an embodiment of the present application;

Figure 5 is a schematic diagram of dual-channel scanning control logic of a retinal imaging device provided by an embodiment of the present application;

Figure 6 is a schematic structural diagram of another collection control module provided by an embodiment of the present application;

Figure 7 is a schematic diagram of dual-channel scanning control logic of another retinal imaging device provided by an embodiment of the present application;

Figure 8 is a schematic structural diagram of another collection control module provided by an embodiment of the present application;

Figure 9 is a schematic diagram of dual-channel scanning control logic of yet another retinal imaging device provided by an embodiment of the present application.

Detailed ways

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of this application.

Many specific details are set forth in the following description to fully understand the present application. However, the present application can also be implemented in other ways different from those described here. Those skilled in the art can do so without violating the connotation of the present application. Similar generalizations are made, and therefore the present application is not limited to the specific embodiments disclosed below.

Secondly, the present application will be described in detail in conjunction with schematic diagrams. When describing the embodiments of the present application in detail, for the convenience of explanation, the cross-sectional diagram showing the device structure will not be partially enlarged according to the general scale, and the schematic diagrams are only examples and should not be limited here. The scope of protection of this application. In addition, the three-dimensional dimensions of length, width and depth should be included in actual production.

In order to make the above objects, features and advantages of the present application more obvious and understandable, the present application will be described in further detail below in conjunction with the accompanying drawings and specific implementation modes.

Referring to Figure 1, a retinal imaging device according to an embodiment of the present application includes: a light source detection module, a beam control module and a collection control module;

The beam modulation module is used to modulate the incident angle of the scanning beam. The modulated scanning beam enters the eyeball and is reflected by the retina to form a feedback beam. The feedback beam after being reflected by the retina is incident on the beam through the beam modulation module. Light source detection module;

The light source modulation module is also used to generate a detection signal based on the feedback beam;

Specifically, the light source detection module generates reflected light (used to illuminate the retina and generate a reflected signal) or dual-channel illumination light, in which one of the dual-channel illuminating light is reflected light (used to illuminate the retina and generate a reflected signal), and the other is OCT light (used to illuminate the retina and generate interference signals) is combined inside or outside the beam detection module to form a scanning beam and enters the beam modulation module.

The beam modulation module at least modulates the incident angle of the scanning beam, and causes the modulated scanning beam to enter the eyeball.

The feedback beam reflected by the retina returns to the light source detection module along its original path, that is, the feedback beam reflected by the retina passes through the beam modulation module and is incident on the light source detection module.

The light source detection module processes the feedback beam to generate a corresponding detection signal, which is processed by the acquisition control module.

The collection control module collects the detection signal and controls the optical path state of the beam modulation module based on the detection signal to at least achieve eye movement tracking.

Based on the above embodiments, in one embodiment of the present application, as shown in Figure 1, the light source detection module includes: a light source and a light detector, the light source is used to output reflected light or dual-channel illumination light, The light detector is used to generate a reflected light detection signal based on the reflected light in the feedback beam; when the light source generates dual-channel illumination light, the light source detection module also includes an OCT detector, and the OCT detector is used to generate a reflected light detection signal based on the reflected light in the feedback beam. The OCT light in the feedback beam generates an OCT light detection signal. Correspondingly, the collection control module collects the OCT detection signal and generates a three-dimensional retinal image based on the detection signal.

Furthermore, the beam modulation module can also be provided with a compensation mirror, and at the same time, a wavefront detector is provided in the light source detection module. The wavefront detector is used to generate a wavefront detection signal based on a part of the reflected light in the feedback beam. Correspondingly, the collection control module collects the wavefront detection signal and controls the compensation value of the compensation mirror according to the detection signal to achieve real-time aberration compensation.

It should be noted that the reflected light source and the OCT light source can be two independent light source devices as shown in Figure 1, which output reflected light and OCT light respectively; they can also be shown in Figure 2, which is provided in this embodiment. Another structural schematic diagram of a retinal imaging device. An OCT light source outputs a beam of light, both as reflected light and OCT light. This beam of light is reflected by the eyeball and split into two beams by the optical device in the light source detection module. The beam of light is received by the light detector and the OCT detector respectively.

In another embodiment of the present application, as shown in Figure 3, the light source detection module includes a light source and a line array camera. The light source is used to generate reflected light or dual-channel illumination light. In this embodiment, when When the light source generates reflected light, the reflected light is linear reflected light, and the line array camera is used to generate a reflected light detection signal based on the linear reflected light in the feedback beam.

When the light source generates dual-channel illumination light including reflected light and OCT light, the reflected light and OCT light in the dual-channel illumination light are linear reflected light and linear OCT light respectively, that is, the optical channel illuminating light It is a linear beam, and the linear reflected light and the linear OCT light beam are combined to form a scanning beam. When the light source generates dual-channel illumination light, the light source module further includes a linear array OCT detector, and the linear array OCT detector is used to generate an OCT light detection signal based on the linear OCT light in the feedback beam.

That is to say, the light source detection module generates linear reflected light (used to illuminate the retina and generate a reflected signal) or linear dual-channel illuminating light, wherein one of the dual-channel illuminating light is linear reflected light (used to illuminate the retina and generate a reflected signal). Illuminating the retina to produce a reflected signal), the other is OCT light (used to illuminate the retina to produce an interference signal), linear reflected light or linear dual-channel illumination light enters the beam modulation module as a scanning beam.

Moreover, in this embodiment, when the light source generates the linear dual-channel illumination light, the light source detection module further includes: a linear array OCT detector, the linear array OCT detector is used to detect light based on the feedback beam The linear OCT light generates an OCT detection signal. Correspondingly, the acquisition control module collects the OCT detection signal and generates a three-dimensional retinal image based on the detection signal.

It should be noted that in this embodiment, when the light source outputs linear dual-channel illumination light, as shown in Figure 3, a beam of light output by one light source can be used as both imaging light and OCT light, or it can be Two independent light source devices output imaging light and OCT light respectively, and the two beams of light are combined and then incident on the light source detection module.

Based on any of the above embodiments, in one embodiment of the present application, the light source in the light source detection module can emit light of one wavelength, can also emit light of multiple different wavelengths, or can be provided with light of different wavelengths. Multiple light sources, such as the light source using three lasers of red light, green light and blue light, can be received by three light detectors to obtain a colorful two-dimensional reflection image, thereby obtaining richer retinal information.

Further, the beam modulation module can also be provided with a compensation mirror, and at the same time, a wavefront detector and a wavefront detection light source are provided in the light source detection module. The wavefront detection light source is used to generate wavefront detection light. The front detection light is combined with the scanning beam and then is incident on the beam modulation module. The wavefront detector is used to generate a wavefront detection signal based on the wavefront detection light in the feedback beam. Correspondingly, the acquisition control module collects the wavefront detection signal and controls the compensation value of the compensation mirror based on the detection signal to achieve real-time aberration compensation.

The retinal imaging device provided by this application will be introduced in detail below.

As shown in Figure 1, Figure 1 is a schematic structural diagram of a retinal imaging device provided by the present application. When the light source outputs dual-channel illumination light, the light source detection module of the retinal imaging device includes: a reflected light source, an OCT light source, and an optical fiber. Coupler, beam splitter C1, beam splitter C2, beam splitter C3, lens, aperture, light detector, OCT detector and wavefront detector.

Specifically, when the retinal device is working, the reflected light source and the OCT light source are first turned on. The OCT light output by the OCT light source passes through the fiber coupler and is collimated and incident on the beam splitter C1; the reflected light output by the reflected light source passes through the beam splitter. C2 is combined with the OCT light at the beam splitter C1. The combined scanning light enters the beam modulation module through the reflector SM1. The reflector SM1 can be set in the beam modulation module.

Further, the feedback light reflected by the retina returns to the light source detection module via the original path, that is, the feedback light beam reflected by the retina is incident on the light source detection module through the beam modulation module, and the OCT light in the feedback light beam is returned to the fiber coupler by the spectroscope C1. , and then reaches the OCT detector, which generates an OCT light detection signal CJ3 based on the OCT light in the feedback beam; after the reflected light in the feedback beam transmits the beam splitter C1 and the beam splitter C2, part of the reflected light is reflected by the beam splitter C3 Reaching the wavefront detector, another part of the reflected light is focused by the lens C3 through the transmission beam splitter, and reaches the photodetector through the small hole; wherein the photodetector generates a wavefront detection signal CJ2 based on another part of the reflected light in the feedback beam, and the wave The front detector generates a wavefront detection signal CJ1 based on another part of the reflected light in the feedback beam.

The beam modulation module of the retinal imaging device includes: reflector SM2, beam splitter C4, reflector SM3, reflector SM4, reflector SM5, reflector SM6, reflector SM7, reflector SM8, reflector SM9, reflector SM10 and Reflector P1. That is to say, there are five conjugate surfaces of the eyeball pupil in the beam modulation module, which form optical conjugation with the eyeball pupil through the nine mirrors SM2-SM10 and the beam splitter C4. In this embodiment, the beam modulation module further includes a galvanometer unit and a compensation mirror. The galvanometer unit includes a first galvanometer, a second galvanometer, a third galvanometer and a fourth galvanometer. Among the five galvanometers, Four galvanometers (i.e., the first to fourth galvanometers) and a compensation mirror are respectively placed on the optical conjugate surface. The first galvanometer G1 is used to realize lateral scanning of reflected light; the second galvanometer G2 is used to realize lateral scanning of OCT light; the third galvanometer G3 is used to realize longitudinal scanning and longitudinal tracking of reflected light and OCT light; the fourth galvanometer The galvanometer G4 is used to achieve lateral tracking of reflected light and OCT light; the compensation mirror is used for real-time aberration compensation.

Specifically, the scanning beam output by the light source detection module enters the beam modulation module through the reflector SM1, is reflected by the reflector SM2, and then enters the beam splitter C4. The reflected light transmits the beam splitter C4 and is reflected by the first galvanometer G1. After the secondary transmission beam splitter C4, it reaches the reflection mirror SM3.

The OCT light is reflected for the first time at the beam splitter C4, is reflected by the second galvanometer G2, and is reflected again by the beam splitter C4 for a second time, and then reaches the reflector SM3.

After the reflected light and OCT light reach the reflector SM3, they pass through the reflector SM4, the third galvanometer G3, the reflector SM5, the reflector SM6, the compensation mirror, the reflector SM7, the reflector SM8, the fourth galvanometer G4, and the reflector in sequence. SM9, reflector SM10 and reflector P1 reach the eyeball, that is, they reach the retina of the eyeball.

The feedback beam reflected by the retina returns to the light source detection module along its original path, that is, the feedback beam reflected by the retina returns to the light source detection module through the beam modulation module.

Based on the above embodiments, in one embodiment of the present application, refer to Figure 4, which is a schematic structural diagram of the acquisition module in the retinal imaging device provided by the embodiment of the present application. The acquisition control module includes: data acquisition Unit, galvanometer control unit, compensation mirror control unit and calculation unit;

Wherein, the data acquisition unit is used to collect the reflected light detection signal and the wavefront detection signal, and also collect the OCT light detection signal at the same time;

The computing unit is configured to generate a two-dimensional reflection image based on the reflected light detection signal, generate a wavefront image based on the wavefront detection signal, and simultaneously generate the three-dimensional retinal image based on the OCT light detection signal; The computing unit is also configured to generate a first control signal based on the two-dimensional reflection image, and generate a second control signal based on the wavefront image;

The galvanometer control unit is used to control the deflection state of the galvanometer in the beam modulation module according to the first control signal to achieve eye movement tracking. The first control signal includes: a first galvanometer control signal K1, used to control the deflection state of the first galvanometer G1; a second galvanometer control signal K2, used to control the deflection of the second galvanometer G2 state; the third galvanometer control signal K3 is used to control the deflection state of the third galvanometer G3; the fourth galvanometer control signal K4 is used to control the deflection state of the fourth galvanometer G4. Among them, since the deflection angle of the galvanometer is proportional to the spot position on the retina and has a linear relationship, the scanning and tracking functions of the eyeball can be realized by controlling the deflection angle of the galvanometer;

Specifically, in this embodiment, the acquisition control module has three input signals and five output signals. Among them, the three input signals are the OCT light detection signal CJ3, the reflected light detection signal CJ2 and the wavefront detection signal collected by the data acquisition unit. CJ1; the five output signals are the first galvanometer control signal K1, the second galvanometer control signal K2, the third galvanometer control signal K3, the fourth galvanometer control signal K4 and the second control signal that controls the compensation value of the compensation mirror. K5. The control logic of the device will be described in detail below in this embodiment. Refer to FIG. 5 , which is a schematic diagram of a dual-channel scanning control logic of a retinal imaging device provided in this embodiment.

Specifically, the solid line in Figure 5 is reflected light, and the dotted line is OCT light.

The transverse scanning signal of the reflected light is superimposed on the first galvanometer control signal K1 to drive the first galvanometer G1.

The longitudinal scanning signal of the reflected light is superimposed on the third galvanometer control signal K3 to drive the third galvanometer G3.

The lateral tracking signal of the reflected light is superimposed on the fourth galvanometer control signal K4 to drive the fourth galvanometer G4.

The longitudinal tracking signal of the reflected light is superimposed on the third galvanometer control signal K3 to drive the third galvanometer G3.

The transverse scanning signal of the OCT light is superimposed on the second galvanometer control signal K2 to drive the second galvanometer G2.

The longitudinal scanning signal of the OCT light is superimposed on the third galvanometer control signal K3 to drive the third galvanometer G3.

The lateral tracking signal of the OCT light is superimposed on the fourth galvanometer control signal K4 to drive the fourth galvanometer G4.

The longitudinal tracking signal of the OCT light is superimposed on the third galvanometer control signal K3 to drive the third galvanometer G3.

During the working process of the retinal imaging device, the principle of real-time compensation of wavefront aberration is as follows:

After the data acquisition unit in the acquisition control module collects the wavefront detection signal, the calculation unit solves the human eye aberration and obtains the second control signal. The compensation mirror control unit drives the compensation mirror to modulate the wavefront to the human eye through the second control signal K5. The opposite value of eye aberration offsets the human eye aberration, realizing the function of human eye wavefront aberration compensation.

It should be noted that during the working process of the retinal imaging device, due to the inconsistent collection frequencies of the light detector and the OCT detector, the speed of the OCT detector is generally slower than the speed of the reflected light detector. Therefore, the scanning method used in this embodiment is as follows :

Reflected light scanning: The galvanometer control unit controls the vibration amplitude and frequency of the deflection angle of the first galvanometer G1 through the first galvanometer control signal K1 to control the size and frequency of the lateral scanning field of view of the reflected light; it controls the size and frequency of the lateral scanning field of view through the third galvanometer control signal K3. Control the vibration amplitude and frequency of the deflection angle of the third galvanometer G3 to control the size and frequency of the longitudinal scanning field of view of the reflected light.

OCT light scanning: The galvanometer control unit controls the vibration amplitude and frequency of the deflection angle of the second galvanometer G2 through the second galvanometer control signal K2 to control the size and frequency of the lateral scanning field of view of the OCT light; it controls the size and frequency of the lateral scanning field of view through the third galvanometer control signal K3. Control the vibration amplitude and frequency of the deflection angle of the third galvanometer G3 to control the size and frequency of the longitudinal scanning field of view of the OCT light.

The lateral scanning of reflected light and OCT light is realized through different galvanometers (i.e., the first galvanometer G1 and the second galvanometer G2), which can work at different lateral frequencies. Usually, the lateral frequency of reflected light is higher than that of OCT light. Frequency scheme.

The longitudinal scanning of reflected light and OCT light is realized through the same galvanometer (i.e., the third galvanometer G3), and the longitudinal field of view size and frequency of the two channels remain consistent.

This embodiment uses a combination of the first galvanometer G1 and the second galvanometer G2 to ensure that the photodetector and the OCT detector scan the same area at different speeds and share most of the components, making the retinal imaging device smaller in size. This saves device costs.

Specifically, during the working process of the retinal imaging device, the real-time eye movement tracking principle is as follows:

The data acquisition unit of the acquisition control module performs multi-level amplification of the reflected light signal. After analog-to-digital conversion, the computing unit generates a real-time two-dimensional retinal reflection image. The computing unit calculates the horizontal and vertical directions of the current frame of the two-dimensional reflection image relative to the previous frame. After the relative displacement value, a lateral and longitudinal deflection value equal to the above relative displacement value is superimposed on the fourth galvanometer control signal K4 and the third galvanometer control signal K3 of the galvanometer control unit, so that the reflected light and OCT light The position of the scanning field of view relative to the retina remains unchanged, thereby achieving real-time eye movement tracking.

As can be seen from the above description, this embodiment provides a retinal imaging device as shown in Figure 1. On the premise of maintaining the high lateral resolution of adaptive optical confocal point scanning, adding an OCT light source improves the axial resolution by approximately One order of magnitude, three-dimensional micron-level resolution is achieved, and three-dimensional cell-level imaging of the multi-layered structure of the retina can be obtained.

Moreover, in this embodiment, the pupil conjugate surface four-galvanometer scanning structure and the compensation mirror of the beam modulation module simultaneously realize the three major functions of three-dimensional imaging, real-time eye movement tracking and human eye wavefront aberration compensation, solving the problem of human eye movement. It eliminates problems such as image tearing and blurring, improves single image quality and image acquisition success rate, thereby increasing the acquisition rate in clinical environments.

As shown in Figure 2, this embodiment provides another imaging device when the light source outputs dual-channel illumination light. The beam modulation module includes four eye pupil conjugate surfaces to form four images of the human eye pupil; The first to third galvanometers and a compensating mirror are placed on the conjugate surfaces of the four eyeball pupils.

In this embodiment, as shown in Figure 2, the light source detection module includes: OCT light source, optical fiber coupler, beam splitter C1, beam splitter C2, lens, small hole, OCT detector, light detector and wavefront detector.

The beam modulation module includes: reflector SM2, first galvanometer M1, reflector SM3, reflector SM4, second galvanometer M2, reflector SM5, reflector SM6, reflector SM7, reflector SM8, third vibrator. Mirror M3, mirror SM9 and mirror SM10, so that there are four conjugate surfaces of the eyeball pupil in the beam modulation module, which form optical conjugation with the eyeball pupil through nine reflectors SM2-SM10. The beam modulation module also includes a galvanometer unit and a compensation mirror. The galvanometer unit includes a first galvanometer, a second galvanometer and a third galvanometer. Three galvanometers are placed on the above-mentioned four optical conjugate surfaces ( That is, the first to third galvanometers) and a compensation mirror simultaneously realize the three major functions of three-dimensional imaging, eye movement tracking and real-time aberration compensation. Among them, the first galvanometer M1 is used to achieve lateral scanning of reflected light and transverse scanning of OCT light; the second galvanometer M2 is used to achieve longitudinal scanning and longitudinal tracking of reflected light and OCT light; and the third galvanometer M3 is used to achieve Lateral tracking of reflected light and OCT light; compensation mirror is used for real-time aberration compensation. The reflector P1 is set outside the beam modulation module.

Further, with reference to Figure 6, Figure 6 is a schematic structural diagram of an acquisition control module provided in this embodiment. The acquisition control module includes: a data acquisition unit, a galvanometer control unit, a compensation mirror control unit and a calculation unit;

Wherein, the data acquisition unit is used to collect the reflected light detection signal and the wavefront detection signal, and also collect the OCT light detection signal at the same time.

Specifically, in this embodiment, the acquisition control module has three input signals and four output signals, wherein the three input signals are the OCT light detection signal CJ3, the reflected light detection signal CJ2 and the wavefront collected by the data acquisition unit. Detection signal CJ1; the four output signals are the first galvanometer control signal Q1, the second galvanometer control signal Q2, the third galvanometer control signal Q3, and the second control signal Q4 that controls the compensation value of the compensation mirror.

It should be noted that during the operation of the retinal imaging device, the photodetector and the OCT detector of this embodiment have the same collection frequency, so the same frequency scanning method is used. The control logic of the device is explained in detail below. Refer to FIG. 7 , which is a schematic diagram of a dual-channel scanning control logic of a retinal imaging device provided in this embodiment. Specifically, the lateral scanning signal of the reflected light and the lateral scanning signal of the OCT light are superimposed on the first galvanometer control signal Q1 to drive the first galvanometer M1.

The longitudinal scanning signal of the reflected light, the longitudinal tracking signal of the reflected light, the longitudinal scanning signal of the OCT light, and the longitudinal tracking signal of the OCT light are superimposed on the second galvanometer control signal Q2 to drive the second galvanometer M2.

The lateral tracking signal of the reflected light and the lateral tracking signal of the OCT light are superimposed on the third galvanometer control signal Q3 to drive the third galvanometer M3.

It should also be noted that other principles of the retinal imaging device shown in FIG. 2 are the same as those of the retinal imaging device shown in FIG. 1 , and will not be described again here.

Optionally, based on the retinal imaging device shown in Figures 1 and 2, when the light source is reflected light, the beam modulation module includes: three eye pupil conjugate surfaces to form three images of the human eye pupil. ; The first to third galvanometers are placed on the conjugate surfaces of the three eyeball pupils.

The first galvanometer is used for lateral scanning of the reflected light.

The second galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light.

The third galvanometer is used for lateral tracking of the reflected light.

In other words, this solution is a retinal imaging device without an OCT detection solution. Its working principle is the same as that of the reflected light part in Figures 1 and 2. In this device, a conjugate surface of the eyeball pupil can also be added to place the compensating mirror to realize the function of aberration compensation, which will not be described again here.

As shown in Figure 3, Figure 3 is another retinal imaging device provided by the present application. The light source of the retinal imaging device outputs a linear beam. Referring to Figure 3, the light source detection module includes: a first cylindrical lens 11, a second Cylindrical lens 12, beam splitter C1, beam splitter C2, beam splitter C3, beam splitter C4, reflection mirror P1, lens 13 and slit 14.

It should be noted that when the imaging light source only outputs imaging light, the reflector P1 and the second cylindrical lens 12 can be omitted.

Specifically, when the retinal imaging device is working, the imaging light source is first turned on. The collimated light emitted by the imaging light source is refracted into a linear beam through the first cylindrical lens 11 and then enters the beam splitter C1. Part of the light is reflected and reaches the beam splitter. C3 enters the beam modulation module, and this part of the light constitutes the imaging light; when the light beam includes OCT light, the other part of the light transmits the beam splitter C1 and is refracted by the second cylindrical lens 12. After restoring collimation, it reaches the reflecting mirror P1 and is reflected by the reflecting mirror P1. After reflection, it passes through the reflection of the dichroic mirror C1 and the reflection of the dichroic mirror C4, and enters the linear array OCT detector. This part of the light constitutes the OCT reference light and is defined as the OCT reference light.

Further, the feedback beam reflected by the retina returns to the light source detection module along its original path, that is, the feedback beam reflected by the retina is incident on the light source detection module through the beam modulation module, and the imaging light in the feedback beam is transmitted through the spectroscope C4 , after focusing processing by the lens 13, it reaches the line array camera through the slit 14 to generate the imaging light detection signal CJ2. The OCT light in the feedback beam transmits the beam splitter C3 and the beam splitter C1, and is partially reflected by the beam splitter C4 and enters the line array OCT detection. The interference between the detector and the OCT reference light forms the OCT light detection signal CJ3.

Further, the beam modulation module can also be provided with a compensation mirror, and at the same time, a wavefront detection light source and a wavefront detector are provided in the light source detection module. The wavefront detection light source is used to output the wavefront detection light and is used with the scanning beam. After combining, the beams are incident on the beam modulation module; the wavefront detector is used to generate a wavefront detection signal based on the wavefront detection light in the feedback beam. Correspondingly, the collection control module collects the wavefront detection signal and controls the compensation value of the compensation mirror according to the detection signal to achieve real-time aberration compensation.

After the collimated wavefront detection light emitted by the wavefront detection light source is reflected by the spectroscope C2, it is combined with the linear imaging light or the linear imaging light and the linear OCT light at the spectroscope C3. The combined scanning beam enters the beam modulation module through the reflector SM1.

After the wavefront detection light in the feedback beam is reflected by the beam splitter C3, it is transmitted by the transmission beam splitter C2 and reaches the wavefront detector to generate the wavefront detection signal CJ1.

The beam modulation module in this embodiment includes: reflector SM2, reflector SM3, reflector SM4, reflector SM5, reflector SM6, reflector SM7, reflector SM8, reflector P2, first galvanometer G1, second galvanometer Mirror G2 and compensation mirror.

That is to say, there are three eyeball through-hole conjugate surfaces in the beam modulation module, which form optical conjugate with the eyeball pupil through seven mirrors SM2-SM8. The first oscillator is placed on these three optical conjugate surfaces. Mirror G1, second galvanometer G2 and compensation mirror. The first galvanometer G1 is used for longitudinal scanning and longitudinal tracking of the imaging light and the OCT light; the second galvanometer G2 is used for transverse tracking of the imaging light and the OCT light; the compensation The mirror is used for real-time aberration compensation; in this way, synchronous line scanning of imaging light and OCT light is realized at the same time, and the three major functions of scanning imaging, eye movement tracking and human eye wavefront aberration compensation are realized.

Specifically, the light beam output by the light source detection module enters the beam modulation module through the reflector SM1, and is reflected by the reflector SM2 before being incident on the first galvanometer G1. The first galvanometer G1 can be controlled to point at any longitudinal angle; After being reflected by the first galvanometer G1, it continues to be reflected by the mirrors SM3 and SM4, and reaches the second galvanometer G2. The second galvanometer G2 can be controlled to point to any angle in the lateral direction; it is reflected by the second galvanometer G2 After reflection, it continues to be reflected by mirror SM5 and mirror SM6, and reaches the compensation mirror, which can modulate the light wavefront phase; after being reflected by the compensation mirror, it continues to be reflected by mirror SM7, mirror SM8 and mirror P2. Processed, it enters the pupil of the human eye, that is, reaches the retina of the eyeball.

Based on this, refer to FIG. 8 , which is a schematic structural diagram of a collection control module provided in this embodiment.

The acquisition control module includes: a data acquisition unit, a galvanometer control unit, a compensation mirror control unit and a calculation unit.

The data acquisition unit is used to collect the imaging light detection signal, the OCT light detection signal and the wavefront detection signal.

The computing unit is configured to generate a two-dimensional reflection image based on the imaging light detection signal, generate the retinal three-dimensional image based on the OCT light detection signal, and generate a wavefront image based on the wavefront detection signal; the computing unit It is also used to generate a first control signal based on the two-dimensional reflection image, and generate a second control signal based on the wavefront image.

The galvanometer control unit is used to control the deflection state of the galvanometer in the beam modulation module according to the first control signal to achieve eye movement tracking; the first control signal includes: a first galvanometer control signal K1, with The second galvanometer control signal K2 is used to control the deflection state of the second galvanometer G2. Among them, since the deflection angle of the galvanometer is proportional to the spot position on the retina and has a linear relationship, the scanning and tracking functions of the eyeball can be realized by controlling the deflection angle of the galvanometer.

Specifically, in this embodiment, the acquisition control module has three input signals and three output signals, wherein the three input signals are the OCT light detection signal CJ3, the imaging light detection signal CJ2 and the wavefront collected by the data acquisition unit. Detection signal CJ1; the three output signals are the first galvanometer control signal K1 that controls the deflection state of the first galvanometer G1, the second galvanometer control signal K2 that controls the deflection state of the second galvanometer G2, and the control The second control signal K3 of the compensation value of the compensation mirror.

Referring to FIG. 9 , FIG. 9 is a schematic diagram of a linear scanning mode of a retinal imaging device according to an embodiment of the present invention.

Specifically, the linear beam in Figure 9 is the linear area produced by the light source illuminating the retina.

The longitudinal scanning signal of the scanning beam is superimposed on the first galvanometer control signal K1 to drive the first galvanometer G1.

The longitudinal tracking signal of the scanning beam is superimposed on the first galvanometer control signal K1 to drive the first galvanometer G1.

The transverse tracking signal of the scanning beam is superimposed on the second galvanometer control signal K2 to drive the second galvanometer G2.

It should be noted that in this embodiment, the principle of real-time compensation of wavefront aberration and the principle of real-time eye movement tracking are the same as those of the previous embodiments, and therefore will not be described again.

As can be seen from the above description, the line scanning retinal imaging device provided by this application, while maintaining the high lateral resolution of adaptive optical confocal line scanning, improves the axial resolution by about an order of magnitude after outputting OCT light, achieving three-dimensional Micron-level resolution to obtain three-dimensional cell-level imaging of the multi-layered structure of the retina.

The two-dimensional imaging of traditional point-scanning adaptive optical confocal ophthalmoscopes relies on two galvanometers for progressive scanning, which requires high scanning speed of the galvanometers, slow imaging frame rate, and cannot achieve the tracking function in the fast scanning direction; and In this application, the pupil conjugate surface two-galvanometer line scanning structure uses two low-speed galvanometers to simultaneously achieve dual-channel synchronous scanning imaging and real-time eye movement tracking, solving problems such as image tearing and blurring caused by human eye movement. , improve the quality of single images and the success rate of image acquisition, thereby increasing the acquisition rate in clinical environments.

It should be noted that in the aforementioned embodiments, the beam splitter includes but is not limited to a dichroic mirror, a flat beam splitter, a thin film beam splitter, a cubic beam splitter, etc.; the compensating mirror serves as a wavefront aberration compensation device for the human eye. , including but not limited to deformable mirrors, spatial light modulators, etc.; each galvanometer in the galvanometer unit serves as a reflector that can change the angle, including but not limited to resonant mirrors, scanning galvanometers, acousto-optic modulators, MEMS Galvanometers, etc.; light sources include but are not limited to superluminescent diodes, vertical cavity surface emitting lasers, gem lasers, etc.; linear array OCT detectors include but are not limited to spectrometers, balanced detectors, etc.; wavefront detectors include but are not limited to Limited to microlens wavefront sensors, interference wavefront sensors, etc.; the line array cameras include but are not limited to CCD line array cameras, CMOS line array cameras, etc.; the light detectors include but are not limited to photomultiplier tubes, avalanche photodiodes wait.

Moreover, the optical path topology of the light source detection module is only an optimal optical path structure, which has the advantages of simple optical path structure and superior performance. In other embodiments, it can also be other forms of optical path topology. For dual-channel The illumination light only needs to meet the core functions of incident dual-channel light beam combining and outgoing dual-channel light beam splitting.

It should also be noted that the placement order of the galvanometer mirrors and the compensation mirrors in the retinal imaging devices described in the above embodiments is not limited, and they can be adjusted and exchanged at will according to the situation in the optical path. If you need to reduce the number of conjugate surfaces of the eyeball pupil, you can correspondingly reduce the number of reflectors and galvanometers/compensating mirrors on the optical path. The conjugate surface of the eyeball pupil can also be realized using a lens-type structure. The conjugate surface of the eyeball pupil can also be realized using a lens-type structure.

Based on the aforementioned retinal imaging device, this application also provides a retinal imaging method, which includes:

Based on the above embodiments, in one embodiment of the present application, the light source detection module also generates a wavefront detection signal based on a part of the reflected light in the feedback beam, and the acquisition control module collects the wavefront detection signal. signal, and controls the optical wavefront phase of the scanning beam based on the wavefront detection signal to achieve real-time aberration compensation.

In another embodiment of the present application, when the light source detection module generates reflected light, the reflected light is linear reflected light; when the light source detection module generates a dual-channel illumination beam, the reflected light in the dual-channel illumination light The light and OCT light are linear reflected light and linear OCT light respectively, and the light source detection module also generates wavefront detection light. The wavefront detection light is combined with the scanning beam and then is incident on the beam modulation module. ; The light source detection module generates a wavefront detection signal based on the wavefront detection light in the feedback beam, and the collection control module collects the wavefront detection signal and controls the optical wavefront phase of the scanning beam based on the wavefront detection signal. , to achieve real-time aberration compensation.

It should be noted that the principles of the retinal imaging method provided by the embodiments of the present application are the same as the principles of the retinal imaging device provided by the above-mentioned embodiments of the present application, and will not be described again here.

The above describes a retinal imaging device and its imaging method provided by the present application in detail. Specific examples are used in this article to illustrate the principles and implementations of the present application. The description of the above embodiments is only used to help understand the present application. The method and its core idea; at the same time, for those of ordinary skill in the field, there will be changes in the specific implementation and application scope based on the ideas of this application. In summary, the contents of this specification should not be understood as Limitations on this Application.

Claims

A retinal imaging device, characterized in that the retinal imaging device includes: a light source detection module, a beam modulation module and a collection control module;

Wherein, the light source detection module is used to generate reflected light or dual-channel illumination light including reflected light and OCT light. The reflected light or the dual-channel illuminating light is combined to form a scanning beam and is incident on the beam modulation module;

The beam modulation module is used to modulate the incident angle of the scanning beam. The modulated scanning beam enters the eyeball, and the feedback beam reflected by the retina is incident on the light source detection module through the beam modulation module;

The light source detection module is also used to generate a detection signal based on the feedback beam;

The collection control module is used to collect the detection signal, and control the optical path state of the beam modulation module based on the detection signal to achieve eye movement tracking.
A retinal imaging device according to claim 1, characterized in that the light source detection module includes: a light source and a light detector, the light source is used to generate reflected light or dual-channel illumination light, and the light detector is used to generate light based on The reflected light in the feedback beam generates a reflected light detection signal;

When the light source generates dual-channel illumination light, the light source detection module further includes an OCT detector, and the OCT detector is used to generate an OCT light detection signal based on the OCT light in the feedback beam.
A retinal imaging device according to claim 1, characterized in that the light source detection module includes a light source and a line array camera, and the light source is used to generate reflected light or dual-channel illumination light; wherein the reflected light is Linear reflected light, the reflected light and OCT light in the dual-channel illumination light are linear reflected light and linear OCT light respectively; the line array camera is used to generate reflections based on the linear reflected light in the feedback beam light detection signal;

When the light source generates the above-mentioned dual-channel illumination light, the light source detection module further includes: a linear array OCT detector. The linear array OCT detector is used to generate an OCT light detection signal based on the linear OCT light in the feedback beam. .
A retinal imaging device according to claim 1, characterized in that:

(1) When the light source detection module generates reflected light, the beam modulation module includes: three eye pupil conjugate surfaces to form three images of the human eye pupil; the beam modulation module also includes a galvanometer unit, The galvanometer unit includes: a first galvanometer, a second galvanometer and a third galvanometer, the first to third galvanometers are respectively located on the conjugate surfaces of the three eyeball pupils;

The first galvanometer is used for lateral scanning of the reflected light;

The second galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light;

The third galvanometer is used for lateral tracking of the reflected light;

(2) When the light source detection module generates dual-channel illumination light, the beam modulation module includes: three eye pupil conjugate surfaces to form three images of the human eye pupil. The beam modulation module also includes: a third A galvanometer, a second galvanometer and a third galvanometer, the first to third galvanometers are respectively located on the conjugate surfaces of the three eyeball pupils;

The first galvanometer is used for lateral scanning of the reflected light and the OCT light;

The second galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light and the OCT light;

The third galvanometer is used for lateral tracking of the reflected light and the OCT light;

Alternatively, the beam modulation module includes: four eye pupil conjugate surfaces to form four images of the human eye pupil, the beam modulation module further includes a galvanometer unit, the galvanometer unit includes: a first galvanometer, A second galvanometer, a third galvanometer and a fourth galvanometer, the first to fourth galvanometers are respectively located on the conjugate surfaces of the four eyeball pupils;

The first galvanometer is used for lateral scanning of the reflected light;

The second galvanometer is used for lateral scanning of the OCT light;

The third galvanometer is used for longitudinal scanning and longitudinal tracking of the reflected light and the OCT light;

The fourth galvanometer is used for lateral tracking of the reflected light and the OCT light.
A retinal imaging device according to claim 3, characterized in that the beam modulation module includes: two eye pupil conjugate surfaces to form two images of human eye pupils, and the beam modulation module further includes an oscillator. Mirror unit, the galvanometer unit includes: a first galvanometer and a second galvanometer, the first galvanometer and the second galvanometer are respectively located on the conjugate surfaces of the two eyeball pupils;

The first galvanometer is used for longitudinal scanning and longitudinal tracking of the scanning beam;

The second galvanometer is used for lateral tracking of the scanning beam.
A retinal imaging device according to claim 4 or 5, characterized in that the beam modulation module is further provided with an eyeball pupil conjugate surface, the beam modulation module further includes a compensation mirror, the compensation mirror is located The pupil conjugate surface of the eyeball is used for real-time aberration compensation.
A retinal imaging device according to any one of claims 1 to 5, characterized in that the acquisition control module includes: a data acquisition unit, a galvanometer control unit and a calculation unit;

Wherein, the data collection unit is used to collect the reflected light detection signal, or collect the OCT light detection signal simultaneously;

The calculation unit is used to generate a two-dimensional reflection image based on the reflected light detection signal, or simultaneously generate a three-dimensional retinal image based on the OCT light detection signal. The calculation unit is also used to generate a first first image based on the two-dimensional reflection image. control signal;

The galvanometer control unit is used to control the deflection state of the galvanometer in the beam modulation module according to the first control signal to achieve eye movement tracking.
The retinal imaging device according to claim 7, wherein the reflected light includes a plurality of lights of different wavelengths, and the computing unit generates a colored two-dimensional reflection image based on the reflected light detection signal.
A retinal imaging device according to any one of claims 1 to 5, characterized in that the light source detection module further includes: a wavefront detector, the wavefront detector is used to detect a part of the feedback beam according to The reflected light generates a wavefront detection signal;

When the reflected light and the dual-channel illumination light generated by the light source detection module are linear beams, the light source detection module further includes: a wavefront detection light source, and the wavefront detection light source is used to output wavefront detection The light is combined with the scanning beam and then enters the beam modulation module. The wavefront detector is used to generate a wavefront detection signal based on the wavefront detection light in the feedback beam.
A retinal imaging device according to claim 9, characterized in that the acquisition control module includes: a data acquisition unit, a galvanometer control unit, a compensation mirror control unit and a calculation unit;

Wherein, the data acquisition unit is used to collect the reflected light control signal and the wavefront detection signal, or also collect the OCT light detection signal at the same time;

The computing unit is configured to generate a two-dimensional reflection image based on the reflected light detection signal, and generate a wavefront image based on the wavefront detection signal, or simultaneously generate the three-dimensional retinal image based on the OCT light detection signal; The computing unit is further configured to generate a first control signal based on the two-dimensional reflection image, and generate a second control signal based on the wavefront image;

The galvanometer control unit is used to control the deflection state of the galvanometer in the beam modulation module according to the first control signal to achieve eye movement tracking;

The compensation mirror control unit is used to control the compensation value of the compensation mirror in the beam modulation module according to the second control signal to achieve real-time aberration compensation.
A retinal imaging method, characterized in that, based on the retinal imaging device according to any one of claims 1 or 3, the retinal imaging method includes:

The light source detection module generates reflected light or dual-channel illumination light including reflected light and OCT light, and forms a scanning beam that is incident on the beam modulation module; the beam modulation module modulates the incident angle of the scanning beam, and The modulated scanning beam enters the eyeball, and the feedback beam reflected by the retina passes through the beam modulation module and is incident on the light source detection module; the light source detection module generates a detection signal based on the feedback beam; the acquisition control module collects The detection signal is used to control the optical path state of the beam modulation module based on the detection signal to achieve eye movement tracking.
A retinal imaging method according to claim 11, characterized in that the light source detection module also generates a wavefront detection signal based on a part of the reflected light in the feedback beam, and the acquisition control module collects the wavefront detection signal. signal, and controls the optical wavefront phase of the scanning beam based on the wavefront detection signal to achieve real-time aberration compensation.
A retinal imaging method according to claim 11, characterized in that the reflected light is linear reflected light, and the reflected light and OCT light in the dual-channel illumination light are linear reflected light and linear OCT respectively. Light;

The light source detection module also generates wavefront detection light, which is combined with the scanning beam and then is incident on the beam modulation module; the light source detection module is based on the wavefront detection light in the feedback beam. A wavefront detection signal is generated, and the acquisition control module collects the wavefront detection signal and controls the optical wavefront phase of the scanning beam based on the wavefront detection signal to achieve real-time aberration compensation.