CN102057053A - 用于促红细胞生成素发酵生产的方法 - Google Patents

用于促红细胞生成素发酵生产的方法 Download PDF

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Publication number
CN102057053A
CN102057053A CN2009801207656A CN200980120765A CN102057053A CN 102057053 A CN102057053 A CN 102057053A CN 2009801207656 A CN2009801207656 A CN 2009801207656A CN 200980120765 A CN200980120765 A CN 200980120765A CN 102057053 A CN102057053 A CN 102057053A
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China
Prior art keywords
cell
erythropoietin
described method
cells
reactor
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Pending
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CN2009801207656A
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English (en)
Chinese (zh)
Inventor
W·维南德
F-R·孔茨
D·赖歇特
W·奥伊尔
R·汉科
C·比尔
M·辛霍费尔-沃夫拉
D·朔波尔-柯尼希
L·法贝尔
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Evonik Operations GmbH
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Evonik Degussa GmbH
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Publication of CN102057053A publication Critical patent/CN102057053A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2009801207656A 2008-06-04 2009-06-03 用于促红细胞生成素发酵生产的方法 Pending CN102057053A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008002210.1 2008-06-04
DE102008002210A DE102008002210A1 (de) 2008-06-04 2008-06-04 Verfahren zur fermentativen Herstellung von Erythropoietin
PCT/EP2009/056820 WO2009147175A1 (de) 2008-06-04 2009-06-03 Verfahren zur fermentativen herstellung von erythropoietin

Publications (1)

Publication Number Publication Date
CN102057053A true CN102057053A (zh) 2011-05-11

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ID=41090241

Family Applications (1)

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CN2009801207656A Pending CN102057053A (zh) 2008-06-04 2009-06-03 用于促红细胞生成素发酵生产的方法

Country Status (9)

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US (1) US20110189732A1 (https=)
EP (1) EP2283147A1 (https=)
JP (1) JP2011521660A (https=)
CN (1) CN102057053A (https=)
BR (1) BRPI0913622A2 (https=)
CA (1) CA2727045A1 (https=)
DE (1) DE102008002210A1 (https=)
IL (1) IL209655A0 (https=)
WO (1) WO2009147175A1 (https=)

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CN103820514A (zh) * 2014-03-10 2014-05-28 深圳赛保尔生物药业有限公司 一种高效生产促红细胞生成素的方法

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US10370635B2 (en) 2012-03-15 2019-08-06 Flodesign Sonics, Inc. Acoustic separation of T cells
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
WO2015006730A1 (en) * 2013-07-12 2015-01-15 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
EP3209402B1 (en) 2014-10-24 2019-11-20 Life Technologies Corporation Acoustically settled liquid-liquid sample purification system
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
WO2016176663A1 (en) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Acoustophoretic device for angled wave particle deflection
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
CA2986238A1 (en) 2015-05-20 2016-11-24 Bart Lipkens Acoustic manipulation of particles in standing wave fields
US10161926B2 (en) 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
EP3319739B1 (en) 2015-07-09 2021-03-31 Flodesign Sonics Inc. Non-planar and non-symmetrical piezolectric crystals and reflectors
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US10710006B2 (en) 2016-04-25 2020-07-14 Flodesign Sonics, Inc. Piezoelectric transducer for generation of an acoustic standing wave
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
WO2017192760A1 (en) 2016-05-03 2017-11-09 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
CA3041517A1 (en) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
WO2019118921A1 (en) 2017-12-14 2019-06-20 Flodesign Sonics, Inc. Acoustic transducer drive and controller

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103820514A (zh) * 2014-03-10 2014-05-28 深圳赛保尔生物药业有限公司 一种高效生产促红细胞生成素的方法
CN103820514B (zh) * 2014-03-10 2017-10-31 深圳赛保尔生物药业有限公司 一种高效生产促红细胞生成素的方法

Also Published As

Publication number Publication date
US20110189732A1 (en) 2011-08-04
IL209655A0 (en) 2011-02-28
CA2727045A1 (en) 2009-12-10
BRPI0913622A2 (pt) 2015-08-25
EP2283147A1 (de) 2011-02-16
JP2011521660A (ja) 2011-07-28
DE102008002210A1 (de) 2009-12-10
WO2009147175A1 (de) 2009-12-10

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Application publication date: 20110511