CN102038761B - Medicament for treating rheumatoid diseases - Google Patents

Abstract

The invention relates to a medicament for treating rheumatoid diseases, and belongs to the technical field of traditional Chinese medicines. The medicament mainly solves the problems that the conventional antiphlogistic and analgesic medicaments, glucocorticoids and immunosuppressive agents, which are the only medicines taken by patients with rheumatoid diseases, only can relieve pain temporarily but cannot radically cure patients with rheumatoid diseases, and have large side effect. The medicament is mainly characterized by being prepared from the following raw materials in part by weight: 5 to 15 parts of pubescent angelica root, 5 to 15 parts of cassia bark, 5 to 15 parts of prepared common monkshood mother root, 10 to 25 parts of earthworm, 10 to 25 parts of safflower, 5 to 15 parts of menispermaceae, 10 to 25 parts of Chinese angelica, 10 to 25 parts of large gentian root, 10 to 25 parts of eucommia bark and 10 to 25 parts of twotooth achyranthes root. The medicament has the characteristics of unique formula and obvious treatment effect, is mainly used for treating the patients with mild and moderate rheumatoid diseases, and can relieve or eliminate pain diseases quickly to restore joint function.

Description

The medicine of treatment rheumatoid disease

Technical field

The invention belongs to technical field of Chinese medicines, being specifically related to a kind of is Chinese patent medicine feedstock production, that be used to treat rheumatoid disease with the Chinese herbal medicine.

Background technology

Rheumatoid disease be a kind of chronic repeatedly the outbreak change into main painful diseases with panarthritis disease, RA write a Chinese character in simplified form in English, is a kind of commonly encountered diseases; Frequently-occurring disease, patient is very painful during morbidity, limitation of activity; Life is rough for weight person to take care of oneself, and is the high disease of a kind of disability rate.

The domestic and international at present treatment to primary disease runs into following thorny problem:

1, only take anti-inflammation analgesic and glucocorticoid, immunosuppressant, be temporary transient pain relieving with regard to thinking that problem has solved, can not fundamentally cure.

2, blindly take the Chinese patent medicine that contains a large amount of hormones, osteoporosis occurs, complication and toxic and side effects such as hypertension, disease are uncontrollable at all, cause the state of an illness more and more serious.

3, the operative treatment scope extensively has a big risk, and often can't effect a radical cure.

Though also have some analgesic such as aspirin sheet, the ibuprofen capsule etc. can alleviating pain, its side effect be big, can produce dependency, more can't reach the radical cure purpose.

Summary of the invention

The object of the invention is exactly to above-mentioned weak point and a kind of inflammation of controlling joint and other tissue is provided, and relief of symptoms keeps function of joint and prevents deformity, repairs the medicine of impaired joint to ease the pain with the treatment rheumatoid disease of restore funcitons.

Solution of the present invention based on motherland's traditional medicine to atrophic diseases and pathogenetic understanding of complication and Therapeutic Principle, with reference to modern pharmacological research achievement, a kind of pure Chinese medicinal preparation of researching and developing through clinical practice for many years; Ability wind-damp dispelling stopping numbness pain, liver and kidney tonifying fill blood, and the rheumatoid disease what is called is controlled wind and invigorated blood circulation earlier, and the blood sector-style is from going out; Not only focus on expelling wind and dampness, and tonification healthy energy is removed the waist gonalgia, extremity joint stuffiness; The whole body rheumatism of loosing, Shu Li joint and blood stasis dispelling.

Medicine of the present invention is the preparation of being processed by following component (in weight portion):

Radix Angelicae Pubescentis 5-15; Cortex Cinnamomi 5-15; Radix Aconiti Preparata 5-15; Pheretima 10-25;

Flos Carthami 10-25; Radix Stephaniae Tetrandrae 5-15; Radix Angelicae Sinensis 10-25; Radix Gentianae Macrophyllae 10-25;

Cortex Eucommiae 10-25; Radix Achyranthis Bidentatae 10-25.

Preparing pharmaceutical formulation preferred weight part ratio range of the present invention is:

Radix Angelicae Pubescentis 6-15; Cortex Cinnamomi 8-10; Radix Aconiti Preparata 6-10; Pheretima 12-20;

Flos Carthami 15-20; Radix Stephaniae Tetrandrae 6-10; Radix Angelicae Sinensis 15-20; Radix Gentianae Macrophyllae 15-20;

Cortex Eucommiae 18-20; Radix Achyranthis Bidentatae 10-20

Medicine optimum weight of the present invention (part) proportioning is:

Radix Angelicae Pubescentis 15; Cortex Cinnamomi 8; Radix Aconiti Preparata 8; Pheretima 12;

Flos Carthami 12; Radix Stephaniae Tetrandrae 10; Radix Angelicae Sinensis 15; Radix Gentianae Macrophyllae 15;

The Cortex Eucommiae 18; Radix Achyranthis Bidentatae 15.

The said preparation of medicine of the present invention is powder or pill.

Above-mentioned each component is processed production of medicine method of the present invention is:

1. get Radix Aconiti Preparata earlier and be dried and crushed into 120 order fine powders separately;

2. get Cortex Cinnamomi, Pheretima is dried and crushed into 120 order fine powders;

3. get Radix Angelicae Pubescentis, Flos Carthami, Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, the Cortex Eucommiae, Radix Achyranthis Bidentatae and be ground into 120 order fine powder powder after air-dry;

4. above-mentioned whole powder components were carried out the ripening sterilization treatment 15-30 minute, the powder medicine of the rheumatoid disease that can obtain medical treatment after by said mixed under 100 ℃-110 ℃.

Here the ripening disinfecting action is to adopt segmentation ladder cooling ripening sterilization, is raised to 110 ℃ to temperature rapidly, and the ripening sterilization time is 15-30 minute.

Powder after the ripening sterilization also can be reprocessed into pill, in the molding of negative pressure pressed.Dry and with the vacuum mode packing, promptly acquire bulk ball shape preparation.

The contained composition of each raw material components of the present invention, pharmacology, meridian distribution of property and flavor and effect are following.

1, Radix Angelicae Pubescentis

Meridian distribution of property and flavor: acrid in the mouth, hardship, slightly warm in nature, return liver, urinary bladder channel.

Effect: wind-damp dispelling, dispersing wind and cold, pain relieving.

Composition and pharmacology: these article contain volatile oil, have wherein detected thymol, tens of kinds of compositions such as sylvestrene; Contained Coumarins has Columbianetin (+)-Columbianetin., isoimperatorin, bergapten, xanthotoxin; Angelols etc., and to contain with the oleanolic acid be the compositions such as multiple Saponin of glycoside unit form and platelet aggregation has inhibitory action experimental thrombosis; And analgesia, calmness, antiinflammatory, spasmolytic, antibiotic are arranged, and protect experimental gastric ulcer to form, reduce anesthetized dog and cat blood pressure.

Use and note: Sheng person is unsuitable in these article property of medicine warm-dryness syndrome, deficiency of YIN anemia and excess-heat.

2, Cortex Cinnamomi

Meridian distribution of property and flavor: hot, sweet, hot, return spleen, kidney, the heart, Liver Channel.

Effect: it is supporing yang to mend fire, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.

Composition and pharmacology: these article contain volatile oil, are called Oleum Cinnamomi or Oleum Cinnamomi, and main component is a cinnamic aldehyde in the oil; Acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, acetic acid propyl benzene ester etc. still contain phlegmatic temperament, tannin in addition, and these article have blood vessel dilating; Blood circulation promoting; Increase arteria coronaria and cerebral blood flow, make degradation effect under the vascular resistance, Fortificar has effects such as analgesia, calmness, analgesic, convulsion.

Use is noted: these article are hot, the cloudy moving blood of consumption, the hope hyperactivity of fire caused by deficiency of YIN, and heat in blood bleeder avoids usefulness, and the careful usefulness of anemia of pregnant woman should not be used together with Halloysitum Rubrum.

3, Radix Aconiti Preparata

Meridian distribution of property and flavor: hot, bitter, heat, very toxic (give birth to), return the liver,kidney,spleen warp.

Effect: wind-damp dispelling, dispersing cold for relieving pain.

Composition and pharmacology: these article contain multiple alkaloid, like aconitine, hypaconitine, mesaconitine; Higenamine, ester aconitine, ester hypaconitine; The ester mesaconitine, 3-deoxyaconitine, karacoline, Xin Wuning alkali; And aconitane A, B, C, D etc., tangible antiinflammatory, analgesic activity are arranged.But dosage strengthens and then causes arrhythmia.Cause heart eventually and suppress, aconitine has tangible local anesthesia effect.

Use and note: these article should not be used together with the Rhizoma Pinelliae, Fructus Trichosanthis, Bulbus Fritillariae Uninbracteatae, Radix Ampelopsis, Pseudobulbus Bletillae (Rhizoma Bletillae).Contraindication in pregnancy.

4, Pheretima

Meridian distribution of property and flavor: salty, tremble with fear, return liver, lung, urinary bladder channel.

Effect: clearing away heat and relieving the wind syndrome, collateral dredging, relieving asthma, diuresis.

Composition and pharmacology: these article mainly contain several amino acids, neutral fat, complexation fat and dehydrogenation isozyme, esterification isozyme etc., and contain lumbrifebrine, lumbricin, terrestro-lumbrolysin, still close the purine class; Choline and nitrogen substance etc.; Pheretima water logging agent and Lumbricus alkali have good refrigeration function, its hot dipping liquid, and alcohol extract has calmness, anticonvulsant action; And ability blood pressure lowering arrhythmia; Antithrombotic, anticoagulation and fibrinolysis, Pheretima extract can participate in regulating body's immunity, the nutritious and beautification function of its contained multiple free amino acid.

5, Flos Carthami

Meridian distribution of property and flavor: suffering, tepor, GUIXIN, Liver Channel.

Effect: blood circulation promoting and blood stasis dispelling, the Yu lumps in the chest and abdomen of Yonging, cards such as trusted subordinate's stasis of blood pain, traumatic injury and the swollen skin infection of pain.

Composition and pharmacology: these article contain Flos Carthami quinone glycoside, and glycoside such as neocarthamin and Flos Carthami glycoside contain Carthamus yellow again; Its water decoction has remarkable excitation to the uterus of laboratory animal; Low dose can make the uterus that rhythm and pace of moving things contraction takes place, and heavy dose can make the uterus shrink reinforcement automatically, even reaches the degree of spasm; The Flos Carthami water extract has slight excited heart, increases the effect of coronary flow, and the dog acute myocardial ischemia is had the effect of alleviating; And make decreased heart rate; The amplitude that electrocardiogram S-T section is raised significantly descends, and safflower yellow has certain antagonism to aconitine institute proarrhythmia, and anesthetized animal is had hypotensive effect in various degree; Anticoagulant is arranged and increase the fibrinolytic effect, safflower oil also has the effect of blood fat reducing in addition.

Use and note: be not taken by pregnant women, have bleeding tendency person to use more.

6, Radix Stephaniae Tetrandrae

Meridian distribution of property and flavor: bitter, hot, tremble with fear, return liver, kidney, urinary bladder channel.

Effect: wind-damp dispelling, pain relieving, diuretic, detumescence.

Composition and pharmacology: these article Radix stephaniae tetrandrae contains alkaloids composition such as Tetrandrine, second element, third element, fourth element and tetrandrine, fangchinoline, Cyclanoline and flavonoid glycosides, phenols, organic acid etc., and effects such as antiinflammatory, analgesia, calmness, antibiotic, antiallergic, lax striped muscle, coronary artery dilator, arrhythmia, blood pressure lowering are arranged.

Use and note: these article bitter cold is prone to injure one's stomach, the careful usefulness of Deficiency and coldness of spleen and stomach person.

7, Radix Gentianae Macrophyllae

Meridian distribution of property and flavor: bitter, hot, be slightly cold, return liver, kidney, stomach gallbladder meridian.

Effect is used: wind-damp dispelling, the meridian dredging, pain relieving, clearing away damp-heat, reducing the asthenic fever, be used for rheumatic arthralgia and apoplectic dyscinesia, be called " patient with susceptibility to wind pathogen demulcen " by forefathers.

The composition pharmacology: these article contain gentiopicrin, saccharide and volatilization wet goods chemical analysis, and in leaching process, gentiopicrin and ammonium hydroxide reaction generate gentianin, second, third gradegrade C alkaloid.Gentianin has antiinflammatory action; Its effect of formaldehyde property " arthritis " that can alleviate rat is suitable with sodium salicylate 20mg/kg; Gentianin also has calmness, eases pain, brings high blood pressure down; Alleviate asthma and tic that Cavia porcellus causes because of histamine, reduce capillary permeability, effects such as antianaphylaxis shock.

Use to note: these article have the property of bitter cold, the taste careful usefulness of person of trembling with fear.

8, Radix Angelicae Sinensis

Meridian distribution of property and flavor: sweet, hot, warm, return liver, the heart, large intestine channel.

Effect: enrich blood, invigorate blood circulation, pain relieving, regulating menstruation, loosening bowel to relieve constipation.

Composition and pharmacology: these article contain volatile ingredient; Other compositions such as organic acid, saccharide, vitamin, aminoacid, inorganic elements, alkaline components and stigmasterol, sitosterol; Radix Angelicae Sinensis water logging fluid power significantly promotes hemoglobin and erythrocytic generation, and Radix Angelicae Sinensis polysaccharide can make laboratory animal leukocyte and reticulocyte increase; Eumenol is the coronary artery dilator coronary blood flow increasing significantly, reduces myocardial oxygen consumption, and resisting myocardial ischemia, antiarrhythmic effect are arranged; Effect for reducing blood fat is arranged, and its volatile oil can cause increased blood pressure, and water-soluble substances then can cause blood pressure drops; Antioxidation, the effect of inhibition free radical are to a certain degree arranged, can alleviate cerebral anoxia, can expand peripheral blood vessel; Alleviate the peripheral blood vessel smooth muscle spasm, increase middle blood flow, improve peripheral circulation; Analgesia, antiinflammatory action are arranged, with specific immune function potentiation is arranged all non-specific.

9, the Cortex Eucommiae

Meridian distribution of property and flavor: sweet, warm, return kidney, Liver Channel.

Effect: kidney-replenishing, bone and muscle strengthening, pain relieving, antiabortive.

Composition and pharmacology: these article contain gutta-percha, eucommito, eucommoil, phenols, organic acid, fat, flavonoid, aldose, tannin etc., still contain multiple free amino acid in addition, various trace elements; Trace alkaloid and a certain amount of vitamin C etc.; Cortex Eucommiae ability enhancing body's immunological function, the pair cell immunity shows the two-phase Accommodation, and antiinflammatory action is arranged; Strengthening the animal adrenal gland cortex hormone function is one of its antiinflammatory mechanism, and calmness and analgesic activity are arranged.

10, Radix Achyranthis Bidentatae

Meridian distribution of property and flavor: hot, bitter, sweet, put down, return liver, kidney, urinary bladder channel.

Effect: blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards, inducing diuresis for treating stranguria syndrome.

Composition and pharmacology: these article contain ecdysterone, inokosterone, rubrosterone and Saponin composition, and other contains peptide polysaccharide ABAB and various trace elements, and the total Saponin of Radix Achyranthis Bidentatae has the effect of obvious excited uterine smooth muscle; Radix Achyranthis Bidentatae has the rat of reduction WBV, packed cell volume, the effect of erythrocyte aggregation index; And ability prolong rats prothrombin time and blood plasma recalcification time, Radix Achyranthis Bidentatae has anti-inflammatory and antalgic detumescence effect, ability human body immunity improving function; The activating macrophage system is to the phagocytosis of antibacterial; Blood vessel dilating improves circulation, promotes inflammatory pain to become and absorbs.

An important feature of the present invention is to contain abundant nutrition in the medicament, wherein contains a large amount of aminoacid and trace element, has not only replenished the nutrition of needed by human, improves body constitution, and powerful resistant effect is arranged.

Another important feature of the present invention is that medicine cooperatively interacts, and wind-damp dispelling, stopping numbness pain, liver and kidney tonifying, the effect that fills blood are not only arranged, and in the side Radix Aconiti Preparata, Pheretima, Flos Carthami to help expel wind to dredge collateral, promoting blood circulation and stopping pain; Cortex Cinnamomi, Radix Stephaniae Tetrandrae focus on dispels cold-evil's damp, and Radix Angelicae Pubescentis is got its reason volt wind, the kind wind-cold damp pathogen between the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and muscles and bones of dispelling for monarch; Radix Gentianae Macrophyllae removes rheumatism and Shujin, the invigorating the liver and kidney of holding concurrently of the Cortex Eucommiae, Radix Achyranthis Bidentatae wind-damp dispelling, and Chinese Angelica blood replonishing is double again invigorates blood circulation; All medicines share eliminating pathogenic factor for supporting vital QI, giving consideration to both the incidental and fundamental, can make the vim and vigour foot and rheumatism is removed, and the strong and arthralgia pain of Liver and kidney more; Effectively the treatment patient is stiff morning, eliminates arthralgia.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, to select the pure natural plant medicine for use be raw material in the present invention, and each component meets the drug control law regulation, and the comprehensive function treatment rheumatoid disease of the Chinese medicine of respectively distinguishing the flavor of of utilization is to human non-toxic, harmless, safe and reliable.

2, the present invention need not to decoct, no bitterness sense, and nutritious, wind-expelling pain-stopping is remarkable, and taking convenience meets state food law of medicine management law regulation.

3, the patient of all genus rheumatoid disease takes this medicine and can alleviate rapidly and eliminate pain, recovers the effect that function of joint reaches treatment.

It is unique that the present invention has prescription, the therapeutic effect outstanding feature.The present invention is mainly used in the light middle disease person of treatment, can alleviate rapidly or eliminate pain disease recovery function of joint.

The specific embodiment

Embodiment

Take by weighing raw material (kilogram) by following proportioning:

Radix Angelicae Pubescentis 8.5; Cortex Cinnamomi 4.5; Radix Aconiti Preparata 5; Pheretima 9;

Flos Carthami 9; Radix Stephaniae Tetrandrae 6; Radix Angelicae Sinensis 9; Radix Gentianae Macrophyllae 9;

The Cortex Eucommiae 9; Radix Achyranthis Bidentatae 9.

Production method is following:

With independent drying and crushing to 120 order of Radix Aconiti Preparata, again Cortex Cinnamomi, Pheretima are dried and crushed into 120 order fine powders, earlier at last Radix Angelicae Pubescentis, Flos Carthami Radix Stephaniae Tetrandrae, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, the Cortex Eucommiae, the air-dry 120 order fine powders that are crushed to of Radix Achyranthis Bidentatae; Mixing according to the above ratio; Process bulk powder, be incubated 10 minutes down, cool to 105 ℃ of insulations 5 minutes then at 110 ℃; Cool to 100 ℃ of insulations 15 minutes again, carry out the ripening sterilization treatment and make finished product powder.

For the therapeutic effect of checking medicine of the present invention,, and select medical history, the state of an illness, age, sex and suitable this disease patient 102 examples of former Therapeutic Method through the clinical observation of 102 routine systems to rheumatoid disease.

A, male 21 examples wherein, women 81 examples, man: women 1:3.8; In age 34-69 year, wherein 50-59 year age bracket accounts for 60.8%, occupation: workman's 65 examples, peasant's 23 examples, cadre's 7 examples, teacher's 2 examples, other 5 examples; The course of disease 3.5 months-27 years, average 5.5 years, having in various degree, trauma history person accounted for 39%.

B, symptom and sign 1. sharp ache joint motion are obviously limited because of pain; Patient refuses the doctor and does the tenderness inspection, and joint height swelling also exceeds near bone protuberance; The stiff time in morning was greater than 2 hours (86 example); 2. also pain during inertia, pain increases the weight of when movable, not only tells pain during compressing, and the expression of fear or this joint of withdrawing are still arranged, and swelling is obviously equal with the bone protuberance, and soft tissue depression disappears, the deadlock time (76 example) within 1-2 hour in morning; 3. do not have pain during inertia, when movable mild pain is arranged, patient has told pain during compressing, arthroncus, but surpass juxtra-articular bone protuberance as yet, the stiff time in morning is within an hour (64 example); 4. do not have pain, do not have tenderness, abandon swelling, no morning deadlock person's 26 examples, body is looked into: function of joint is complete, general activity unimpaired person 52 examples have joint discomfort or obstacle, but still can accomplish general activity 28 examples; Joint motion is obviously limited, 30 examples but the life of big portion can be taken care of oneself, 20 examples of can't take care of oneself or lie in bed.

C, imaging data: the erosion of skeleton and cartilage is the characteristics of rheumatoid arthritis; The joint is corroded and can be occurred very early, and progress is the fastest in early days, and the 147 routine courses of disease have been carried out following up a case by regular visits to of 2-3 less than the patient with rheumatoid arthritis in 1 year; With hands with the foot X-ray film as monitoring index; The 1st year skeletal injury progress that discovery is followed up a case by regular visits to is the fastest, and observation of another early stage RA patients (course of disease was less than 1 year) of group 128 examples shows, the progress of disease damaged condition in joint when going to a doctor first is proportionate on the iconography; The person makes fast progress promptly the bone erosion to occur in early days; MRI has been used to evaluation of prognosis, and observed result shows that the synovial membrane volume in a certain joint that MRI measures is directly proportional with the destructive progress degree of this joint skeleton.

D, treatment and result: this group case is almost recovered after the Drug therapy through invention, wherein has 72 examples to obtain and follows up a case by regular visits to, and follows up a case by regular visits to 8 months time-5 year, and average 2.6 years, criterion of therapeutical effect: excellent: uncomfortable disease complete obiteration, recover operate as normal; Very: uncomfortable disease disappears basically, can recover operate as normal; Can: symptom and sign makes moderate progress, and being engaged in physical work has certain difficulty; Difference: do not have obviously and improve, or, need long-term rest person with sequela.Excellent 43 examples, good 26 examples can 2 examples, differ from 11 examples, acceptance rate 95.7%.

Claims (3)

1. a powder or pill of treating rheumatoid disease is characterized in that it is made up of following weight parts proportion raw material medicine:

Radix Angelicae Pubescentis 5-15; Cortex Cinnamomi 5-15; Radix Aconiti Preparata 5-15; Pheretima 10-25;

Flos Carthami 10-25; Radix Stephaniae Tetrandrae 5-15; Radix Angelicae Sinensis 10-25; Radix Gentianae Macrophyllae 10-25;

Cortex Eucommiae 10-25; Radix Achyranthis Bidentatae 10-25.

2. the powder of treatment rheumatoid disease according to claim 1 or pill is characterized in that wherein the weight portion proportioning of each raw material is:

Radix Angelicae Pubescentis 6-15; Cortex Cinnamomi 8-10; Radix Aconiti Preparata 6-10; Pheretima 12-20;

Flos Carthami 12-20; Radix Stephaniae Tetrandrae 6-10; Radix Angelicae Sinensis 15-20; Radix Gentianae Macrophyllae 15-20;

Cortex Eucommiae 15-20; Radix Achyranthis Bidentatae 15-20.

3. the powder of treatment rheumatoid disease according to claim 1 or pill is characterized in that wherein the weight portion proportioning of each raw material is:

Radix Angelicae Pubescentis 15; Cortex Cinnamomi 8; Radix Aconiti Preparata 8; Pheretima 12;

Flos Carthami 12; Radix Stephaniae Tetrandrae 10; Radix Angelicae Sinensis 15; Radix Gentianae Macrophyllae 15;

The Cortex Eucommiae 18; Radix Achyranthis Bidentatae 15.