CN102027005A - 通过固相合成制备的肽的纯化 - Google Patents

通过固相合成制备的肽的纯化 Download PDF

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Publication number
CN102027005A
CN102027005A CN2009801169438A CN200980116943A CN102027005A CN 102027005 A CN102027005 A CN 102027005A CN 2009801169438 A CN2009801169438 A CN 2009801169438A CN 200980116943 A CN200980116943 A CN 200980116943A CN 102027005 A CN102027005 A CN 102027005A
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CN
China
Prior art keywords
glp
peptide
propionyl
butyryl
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN2009801169438A
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English (en)
Chinese (zh)
Inventor
C·科恩贝克
T·B·汉森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
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Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN102027005A publication Critical patent/CN102027005A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
CN2009801169438A 2008-05-15 2009-05-15 通过固相合成制备的肽的纯化 Withdrawn CN102027005A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08156221.7 2008-05-15
EP08156221 2008-05-15
PCT/EP2009/055908 WO2009138488A1 (en) 2008-05-15 2009-05-15 Purification of peptides prepared by solid phase synthesis

Publications (1)

Publication Number Publication Date
CN102027005A true CN102027005A (zh) 2011-04-20

Family

ID=40843333

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801169438A Withdrawn CN102027005A (zh) 2008-05-15 2009-05-15 通过固相合成制备的肽的纯化

Country Status (5)

Country Link
US (1) US20120149868A1 (https=)
EP (1) EP2280993A1 (https=)
JP (1) JP2011520844A (https=)
CN (1) CN102027005A (https=)
WO (1) WO2009138488A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
WO2017136690A1 (en) * 2016-02-04 2017-08-10 University Of Washington Solid supports for use in solid-phase peptide synthesis, kits, and related methods
CN116390723B (zh) 2020-09-09 2024-12-31 社会利益网络公司 用于将生物素递送至线粒体的方法和组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69220888T2 (de) * 1991-11-05 1998-01-29 Perkin Elmer Corp Vorrichtung und Verfahren zur Herstellung von Biopolymeren
US6703362B1 (en) * 1997-05-15 2004-03-09 Cytogen Corporation Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
EP1060192A2 (en) 1998-02-27 2000-12-20 Novo Nordisk A/S Glp-2 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates
JP2003522099A (ja) 1998-02-27 2003-07-22 ノボ ノルディスク アクティーゼルスカブ 遅延作用プロファイルを有するｇｌｐ−１のｇｌｐ−１誘導体及びエキセンジン
WO1999058475A2 (en) * 1998-05-11 1999-11-18 Cambridge Combinatorial Limited Preparation of compounds using polymer supported reagents
US6902744B1 (en) 1999-01-14 2005-06-07 Amylin Pharmaceuticals, Inc. Exendin agonist formulations and methods of administration thereof
CZ20013018A3 (cs) 1999-03-17 2002-02-13 Novo Nordisk A/S Způsob pro acylování aminoskupiny peptidu nebo proteinu a sloučenina
SE0104462D0 (sv) * 2001-12-29 2001-12-29 Carlbiotech Ltd As Peptide purifcation (Peptidrening)
BRPI0413644A (pt) * 2003-08-21 2006-10-17 Novo Nordisk As métodos para separar as duas formas de um polipeptìdeo tendo uma única racemização de aminoácido, e para separar dois polipeptìdeos, produto de polipeptìdeo, e, composição farmacêutica
EP2181983A4 (en) * 2007-07-25 2013-01-02 Ajinomoto Kk METHOD FOR THE SELECTIVE REMOVAL OF A DIBENZOFULVENE DERIVATIVE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARTIN VIAU等: "Study of Solid-Phase Synthesis and Purification Strategies for the Preparation of Polyglutamine Peptides", 《PEPTIDE SCIENCE, WILEY INTERSCIENCE》 *

Also Published As

Publication number Publication date
US20120149868A1 (en) 2012-06-14
WO2009138488A1 (en) 2009-11-19
EP2280993A1 (en) 2011-02-09
JP2011520844A (ja) 2011-07-21

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Legal Events

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C04 Withdrawal of patent application after publication (patent law 2001)
WW01 Invention patent application withdrawn after publication

Application publication date: 20110420