CN102014895A - 组合抗癌剂 - Google Patents

组合抗癌剂 Download PDF

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Publication number
CN102014895A
CN102014895A CN2009801154644A CN200980115464A CN102014895A CN 102014895 A CN102014895 A CN 102014895A CN 2009801154644 A CN2009801154644 A CN 2009801154644A CN 200980115464 A CN200980115464 A CN 200980115464A CN 102014895 A CN102014895 A CN 102014895A
Authority
CN
China
Prior art keywords
lucanthone
antimetabolite
treatment
administration
effective dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801154644A
Other languages
English (en)
Chinese (zh)
Inventor
古鲁·雷迪
路吉·莱纳兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spectrum Pharmaceuticals Inc
Original Assignee
Spectrum Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrum Pharmaceuticals Inc filed Critical Spectrum Pharmaceuticals Inc
Publication of CN102014895A publication Critical patent/CN102014895A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN2009801154644A 2008-02-29 2009-02-20 组合抗癌剂 Pending CN102014895A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3283108P 2008-02-29 2008-02-29
US61/032,831 2008-02-29
PCT/US2009/034629 WO2009108573A1 (en) 2008-02-29 2009-02-20 Combination anti-cancer agents

Publications (1)

Publication Number Publication Date
CN102014895A true CN102014895A (zh) 2011-04-13

Family

ID=40566524

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801154644A Pending CN102014895A (zh) 2008-02-29 2009-02-20 组合抗癌剂

Country Status (13)

Country Link
US (1) US20090221615A1 (https=)
EP (1) EP2257285A1 (https=)
JP (1) JP5590560B2 (https=)
KR (1) KR20100126453A (https=)
CN (1) CN102014895A (https=)
AU (1) AU2009219464B2 (https=)
BR (1) BRPI0908398A2 (https=)
CA (1) CA2717100A1 (https=)
IL (1) IL207859A (https=)
MX (1) MX2010009502A (https=)
RU (1) RU2516027C2 (https=)
WO (1) WO2009108573A1 (https=)
ZA (1) ZA201006123B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012022243A8 (pt) 2010-03-08 2021-11-09 Spectrum Pharmaceuticals Inc Uso de um inibidor de autofagia baseado em tioxantona e de um composto indutor de autofagia para terapia de câncer, composição farmacêutica e kit farmacêutico
EP2425830A1 (en) 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synergistic drug combination for the treatment of cancer
WO2023114245A2 (en) * 2021-12-14 2023-06-22 Radin Daniel Pierce Compositions and methods for treating cancers of the central nervous system (cns), including glioblastoma and chemoresistant cns tumors, and related compositions and methods for inhibiting and eliminating cns cancer stem cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL135258A0 (en) * 1997-09-26 2001-05-20 Noven Pharma Bioadhesive compositions and methods for topical administration of active agents
US6391911B1 (en) * 1999-02-26 2002-05-21 Robert E. Bases Coadministration of lucanthone and radiation for treatment of cancer
WO2007071958A2 (en) * 2005-12-22 2007-06-28 Astrazeneca Ab Combination of zd6474 and pemetrexed
ATE502641T1 (de) * 2005-12-22 2011-04-15 Astrazeneca Ab Kombination aus azd2171 und pemetrexed

Also Published As

Publication number Publication date
EP2257285A1 (en) 2010-12-08
MX2010009502A (es) 2010-11-10
IL207859A (en) 2015-09-24
AU2009219464A1 (en) 2009-09-03
RU2516027C2 (ru) 2014-05-20
CA2717100A1 (en) 2009-09-03
RU2010139840A (ru) 2012-04-10
AU2009219464B2 (en) 2015-04-09
ZA201006123B (en) 2011-05-25
BRPI0908398A2 (pt) 2015-08-11
JP5590560B2 (ja) 2014-09-17
KR20100126453A (ko) 2010-12-01
WO2009108573A1 (en) 2009-09-03
US20090221615A1 (en) 2009-09-03
JP2011513315A (ja) 2011-04-28
IL207859A0 (en) 2010-12-30

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20110413