RU2516027C2 - Комбинация противораковых агентов - Google Patents
Комбинация противораковых агентов Download PDFInfo
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- RU2516027C2 RU2516027C2 RU2010139840/14A RU2010139840A RU2516027C2 RU 2516027 C2 RU2516027 C2 RU 2516027C2 RU 2010139840/14 A RU2010139840/14 A RU 2010139840/14A RU 2010139840 A RU2010139840 A RU 2010139840A RU 2516027 C2 RU2516027 C2 RU 2516027C2
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- Russia
- Prior art keywords
- lucanton
- pemetrexed
- administered
- therapeutically effective
- cancer
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/33—Heterocyclic compounds
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US3283108P | 2008-02-29 | 2008-02-29 | |
| US61/032,831 | 2008-02-29 | ||
| PCT/US2009/034629 WO2009108573A1 (en) | 2008-02-29 | 2009-02-20 | Combination anti-cancer agents |
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| RU2010139840A RU2010139840A (ru) | 2012-04-10 |
| RU2516027C2 true RU2516027C2 (ru) | 2014-05-20 |
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| EP (1) | EP2257285A1 (https=) |
| JP (1) | JP5590560B2 (https=) |
| KR (1) | KR20100126453A (https=) |
| CN (1) | CN102014895A (https=) |
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| RU (1) | RU2516027C2 (https=) |
| WO (1) | WO2009108573A1 (https=) |
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| BR112012022243A8 (pt) | 2010-03-08 | 2021-11-09 | Spectrum Pharmaceuticals Inc | Uso de um inibidor de autofagia baseado em tioxantona e de um composto indutor de autofagia para terapia de câncer, composição farmacêutica e kit farmacêutico |
| EP2425830A1 (en) | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synergistic drug combination for the treatment of cancer |
| WO2023114245A2 (en) * | 2021-12-14 | 2023-06-22 | Radin Daniel Pierce | Compositions and methods for treating cancers of the central nervous system (cns), including glioblastoma and chemoresistant cns tumors, and related compositions and methods for inhibiting and eliminating cns cancer stem cells |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391911B1 (en) * | 1999-02-26 | 2002-05-21 | Robert E. Bases | Coadministration of lucanthone and radiation for treatment of cancer |
| US6562363B1 (en) * | 1997-09-26 | 2003-05-13 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| WO2007071970A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of azd2171 and pemetrexed |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007071958A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of zd6474 and pemetrexed |
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- 2009-02-20 RU RU2010139840/14A patent/RU2516027C2/ru not_active IP Right Cessation
- 2009-02-20 BR BRPI0908398-7A patent/BRPI0908398A2/pt not_active Application Discontinuation
- 2009-02-20 EP EP09714301A patent/EP2257285A1/en not_active Withdrawn
- 2009-02-20 KR KR1020107021665A patent/KR20100126453A/ko not_active Abandoned
- 2009-02-20 WO PCT/US2009/034629 patent/WO2009108573A1/en not_active Ceased
- 2009-02-20 JP JP2010548807A patent/JP5590560B2/ja not_active Expired - Fee Related
- 2009-02-20 AU AU2009219464A patent/AU2009219464B2/en not_active Ceased
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- 2009-02-20 CA CA2717100A patent/CA2717100A1/en not_active Abandoned
- 2009-02-20 CN CN2009801154644A patent/CN102014895A/zh active Pending
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2010
- 2010-08-27 ZA ZA2010/06123A patent/ZA201006123B/en unknown
- 2010-08-29 IL IL207859A patent/IL207859A/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562363B1 (en) * | 1997-09-26 | 2003-05-13 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| RU2234337C2 (ru) * | 1997-09-26 | 2004-08-20 | Ноувен Фамэсьютикэлз, Инк. | Биоадгезивная композиция (варианты), способ ее получения (варианты), устройство для доставки через слизистую оболочку активного агента, способ пролонгированного местного введения одного или более активных агентов субъекту (варианты) и способ сокращения времени, требуемого для приклеивания композиции к слизистой ткани |
| US6391911B1 (en) * | 1999-02-26 | 2002-05-21 | Robert E. Bases | Coadministration of lucanthone and radiation for treatment of cancer |
| WO2007071970A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of azd2171 and pemetrexed |
Non-Patent Citations (2)
| Title |
|---|
| HANAUSKE A.R. et al., Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors, Oncologist, 2001, 6(4):363-73, Abstract, найдено из PubMed: http://www.ncbi.nlm.nih.gov/pubmed/11524555. MEIHUA LUO et al., Inhibition of the human apurinic/apyrimidinic endonuclease (Ape 1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone, anticancer research 24: 2127-2134 (2004), найдено из интернет: http://ar.iiarjournals.org/content/24/4/2127.full.pdf+html. FOSSELLA F.V., Pemetrexed for treatment of advanced non small cell lung cancer, Semin Oncol. 2004 Feb,31(1 Suppl 1):100-5, Abstract, найдено из PubMed: http://www.ncbi.nlm.nih.gov/pubmed/14981587 * |
| ГУТУРОВ С.Л., Современные позиции гемцитабина и пеметрекседа в лечении немелкоклеточного рака легкого, 2006, найдено из интернет: http://netoncology.ru/press/articles/673/674/. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2257285A1 (en) | 2010-12-08 |
| MX2010009502A (es) | 2010-11-10 |
| IL207859A (en) | 2015-09-24 |
| AU2009219464A1 (en) | 2009-09-03 |
| CA2717100A1 (en) | 2009-09-03 |
| RU2010139840A (ru) | 2012-04-10 |
| AU2009219464B2 (en) | 2015-04-09 |
| ZA201006123B (en) | 2011-05-25 |
| BRPI0908398A2 (pt) | 2015-08-11 |
| JP5590560B2 (ja) | 2014-09-17 |
| KR20100126453A (ko) | 2010-12-01 |
| WO2009108573A1 (en) | 2009-09-03 |
| US20090221615A1 (en) | 2009-09-03 |
| JP2011513315A (ja) | 2011-04-28 |
| IL207859A0 (en) | 2010-12-30 |
| CN102014895A (zh) | 2011-04-13 |
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