CN102008560B - Thalictrum foeniculaceum extractive and application thereof in preparing drugs for treating oral ulcer - Google Patents
Thalictrum foeniculaceum extractive and application thereof in preparing drugs for treating oral ulcer Download PDFInfo
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- CN102008560B CN102008560B CN2010105758351A CN201010575835A CN102008560B CN 102008560 B CN102008560 B CN 102008560B CN 2010105758351 A CN2010105758351 A CN 2010105758351A CN 201010575835 A CN201010575835 A CN 201010575835A CN 102008560 B CN102008560 B CN 102008560B
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Abstract
The invention relates to a plant extractive as well as a preparation method and an application thereof, in particular to a thalictrum foeniculaceum extractive, an application thereof in preparing drugs for treating oral ulcer and a preparation method thereof. The extractive is obtained through carrying out water extract or direct pulping extract on thalictrum foeniculaceum as raw materials. Long-term outpatient observation shows that the drugs prepared by thalictrum foeniculaceum extractive have obvious analgesic and healing effects on various oral ulcer diseases, have the advantages of shortmedication time, fast and long-lasting effects, wide application, thus being superior to existing drugs for treating oral ulcers with the total effective rate exceeding 90%.
Description
Technical field
The present invention relates to a kind of plant extract, be specifically related to a kind of Thalictrum foeniculaceum extract and the Use and preparation method in the preparation stomatocace medicine thereof.
Background technology
The Thalictrum ranunculaceae plant; It is the exclusive a kind of pharmaceutical plant of China; Generally have effects such as anticancer, anti-inflammation, antiviral, blood pressure lowering, heat-clearing and toxic substances removing, analgesia, the Thalictrum of record has more than 60 kind approximately at present, mainly concentrates on the southwest.Thalictrum foeniculaceum (goes out for three times three; Thalictrum foeniculaceumBunge) be special kind in the Thalictrum aquilegifolium L. var. sibiricum Regel, included by " Chinese Plants will " in 2010, abundant according to investigating this kind wild resource; Vitality is strong, is convenient to artificial establishing in large scale, cultivation.For a long time, Thalictrum foeniculaceum is not familiar with by people always, in a large number as cattle, sheep feedstuff and be not used as the herbal development utilization.The inventor once repeatedly to relevant department's this kind name of seeking knowledge, had entrusted Plant Inst.'s verification until in November, 2010 since 1980 find this kind, just obtain " Thalictrum foeniculaceum " and rectify name.The inventor attempts according to the principle of Chinese materia medica " four natures and five flavors of drug " meridian distribution of property and flavor through the experience of practising medicine oneself decades, and it is returned through being: gas suffering, slightly sweet flavor, property are flat nontoxic, GUIXIN spleen, kidney channel.And confirm that further this kind Thalictrum foeniculaceum has the effect of treatment oral ulcer, and definite effect, long-term observation does not have obvious adverse reaction.Single component can reach the effect of treatment oral ulcer, instant effect, taking convenience, and the side effect such as zest pain that do not exist existing oral ulcer class medicine to exist.
Summary of the invention
The technical problem that the present invention will solve is: overcomes the deficiency of prior art, a kind of Thalictrum foeniculaceum extract that can effectively treat the oral ulcer symptom is provided, and this Thalictrum foeniculaceum preparation method of extract and the application in the preparation stomatocace medicine.
The technical solution adopted for the present invention to solve the technical problems is: the application of this Thalictrum foeniculaceum extract in preparation treatment stomatocace medicine.
This Thalictrum foeniculaceum extract, uses it separately or is used with other drug as active component with it on pharmaceutical preparation is used, and prepares powder or tablet with the conventional dose process.Its effective dose adopts routine dose to use, and one is 150～200mg/ time.Preferably, get the Thalictrum foeniculaceum aerial parts, do not influence the diauxic growth of Thalictrum foeniculaceum after the harvesting as raw material.
The Thalictrum foeniculaceum preparation method of extract is characterized in that, adopts following steps: 1) with said Thalictrum foeniculaceum at 30～60 ℃ of oven drying at low temperatures; 2) pulverize 1: 10 ratio in back and water and decoct, decoct 2～3 times, each 1～3 hour, merge extractive liquid, also filtered, and becoming concentration at concentrating under reduced pressure below 60 ℃ is the clear paste of 7.5mg/ml; 3) do dried after the purification clear paste is cooled to room temperature, break into fine powder, make extract.
Preferably, said concentrating under reduced pressure temperature is 40 ℃～60 ℃.
Preferably, said filtrating is filtered through 30～60 mesh sieves.
Said Thalictrum foeniculaceum extract is characterized in that, adopts direct slurrying extracting mode to obtain; Concrete steps are: get the bright article of Thalictrum foeniculaceum and pulverize pulping; The squeezing extracting juice staticly settles juice 10～20 hours, gets supernatant and filters through 30～60 mesh sieves; 40 ℃～60 ℃ oven dry pulverizing down, make extract.
The valid density of said Thalictrum foeniculaceum extract is 0.5mg/ml.
Active constituent content is high in the Thalictrum foeniculaceum, even do not extract, only at back 30 ℃～60 ℃ oven drying at low temperatures of collection, directly is ground into smalls, also can reach the efficacious therapy purpose.The smalls of directly pulverizing behind 30～60 mesh sieves, is used separately or with other drug, makes medicament or food and get final product.Also can the smalls of directly pulverizing be added in the said extracted thing simultaneously and mix, make medicament or food again, can further improve the Thalictrum foeniculaceum property of medicine.
Compared with prior art, Thalictrum foeniculaceum extract of the present invention and its production and use the beneficial effect that had be:
1, this Thalictrum foeniculaceum extract preparation is convenient, and raw material is easy to get, and the pharmacy cost is low;
2, obvious to oral cavity ulcerate disease shape therapeutic effect, clinical trial does not have obvious adverse reaction.
Clinical observation statistical result: 100 oral ulcer of picked at random or oral lichen planus patient, patient symptom is the skin ulcer pale complexion before the treatment; Open sore part size is trembled like foxtail millet; Powder formulation 150～the 200mg of external application Thalictrum foeniculaceum extract of the present invention preparation behind the skin ulcer face, 1 minute pain relief, one irritable food of feed is painless basically after several minutes; Medication every day 1～2 time, recovery from illness in 2～7 days.92 examples are significantly effective among the 100 routine patients, and 5 examples are basic to be improved, and only 3 example nothings are obviously improved effect, and total effective rate is 97%.Cure back patient in 1～March and do not have recurrence.
Long-term outpatient service is observed and is shown; Thalictrum foeniculaceum extract of the present invention prepares medicine has obvious pain relieving and healing effect to various oral ulcer class diseases; Administration time is short, rapid-action, persistent, and applied range is superior to existing various treatment oral ulcer class medicines.
The specific embodiment
Embodiment 1
Thalictrum foeniculaceum is used the drying oven oven drying at low temperature at 30 ℃～40 ℃, pulverize the back, obtain extracting solution in ratio decocte with water in 1: 10 3 hours.Filter extracting solution with 60 mesh sieves, become the clear paste of 7.5mg/ml. at 60 ℃ of concentrating under reduced pressure, clear paste is done dried, break into fine powder, make extract filtrating.
With extract obtained adding starch, fully mixing, granulation, drying, granulate, be pressed into the 100mg tablet.This tablet directly is contained in the mouth, or external application and open sore part place, 1 minute pain relief, one irritable food of feed is painless basically after several minutes, medication every day 1～2 time, recovery from illness in 2～7 days.
Embodiment 2
With said Thalictrum foeniculaceum at 50～60 ℃ of oven drying at low temperatures; 1: 10 ratio in back and water of pulverizing decocts, and decocts 2～3 times, and each 1～2 hour, merge extractive liquid, also filtered, and becoming concentration at 50 ℃ of concentrating under reduced pressure is the clear paste of 7.5mg/ml.; Do dried after the purification clear paste is cooled to room temperature, break into fine powder, make extract.
With extract obtained be the powder more than 120 orders drying, be ground into granularity under the aseptic condition, directly use as powder.Get 150mg/ the external application of powder and the open sore part, 1 minute pain relief, one irritable food of feed is painless basically after several minutes, medication every day 1～2 time, recovery from illness in 2～7 days.
Embodiment 3
The bright article of Thalictrum foeniculaceum are pulverized pulping, squeeze extracting juice, juice was staticly settled 10～20 hours, get supernatant and filter,, make extract 40 ℃～60 ℃ oven dry pulverizing down through 30～60 mesh sieves.
With extract obtained adding starch, fully mixing, granulation, drying, granulate, be pressed into the 100mg tablet.This tablet directly is contained in the mouth, or external application and open sore part place, 1 minute pain relief, one irritable food of feed is painless basically after several minutes, medication every day 1～2 time, recovery from illness in 2～7 days.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (6)
1. the application of Thalictrum foeniculaceum extract in preparation treatment stomatocace medicine is characterized in that, said Thalictrum foeniculaceum extract adopts the mode of water extraction to obtain, and step is following: 1) with said Thalictrum foeniculaceum at 30～60 ℃ of oven drying at low temperatures; 2) pulverize 1: 10 ratio in back and water and decoct, decoct 1～3 time, each 1～3 hour, merge extractive liquid, also filtered, and becoming concentration at concentrating under reduced pressure below 60 ℃ is the clear paste of 7.5mg/ml; 3) do dried after the purification clear paste is cooled to room temperature, break into fine powder, make extract.
2. the application of Thalictrum foeniculaceum extract according to claim 1 in preparation treatment stomatocace medicine, it is characterized in that: said concentrating under reduced pressure temperature is 40 ℃～60 ℃.
3. the application of Thalictrum foeniculaceum extract according to claim 1 in preparation treatment stomatocace medicine, it is characterized in that: said filtrating is filtered through 30～60 mesh sieves.
4. the application of Thalictrum foeniculaceum extract in preparation treatment stomatocace medicine is characterized in that said Thalictrum foeniculaceum extract adopts direct slurrying extracting mode to obtain; Concrete steps are: get the bright article of Thalictrum foeniculaceum and pulverize pulping; The squeezing extracting juice staticly settles juice 10～20 hours, gets supernatant and filters through 30～60 mesh sieves; 40 ℃～60 ℃ oven dry pulverizing down, make extract.
5. according to claim 1 or the application of 4 described Thalictrum foeniculaceum extracts in preparation treatment stomatocace medicine, it is characterized in that: described medicine refers to adopt the powder or the tablet of practice of pharmacy preparation.
6. the application of Thalictrum foeniculaceum in preparation treatment stomatocace medicine is characterized in that said Thalictrum foeniculaceum is at back 30 ℃～60 ℃ oven drying at low temperatures of collection, the powder that directly is ground into.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105758351A CN102008560B (en) | 2010-12-04 | 2010-12-04 | Thalictrum foeniculaceum extractive and application thereof in preparing drugs for treating oral ulcer |
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| CN2010105758351A CN102008560B (en) | 2010-12-04 | 2010-12-04 | Thalictrum foeniculaceum extractive and application thereof in preparing drugs for treating oral ulcer |
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| Publication Number | Publication Date |
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| CN102008560A CN102008560A (en) | 2011-04-13 |
| CN102008560B true CN102008560B (en) | 2012-07-11 |
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| CN2010105758351A Expired - Fee Related CN102008560B (en) | 2010-12-04 | 2010-12-04 | Thalictrum foeniculaceum extractive and application thereof in preparing drugs for treating oral ulcer |
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Granted publication date: 20120711 Termination date: 20181204 |