CN101999071B - 用于制造微流控传感器的方法 - Google Patents

用于制造微流控传感器的方法 Download PDF

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Publication number
CN101999071B
CN101999071B CN2009801120900A CN200980112090A CN101999071B CN 101999071 B CN101999071 B CN 101999071B CN 2009801120900 A CN2009801120900 A CN 2009801120900A CN 200980112090 A CN200980112090 A CN 200980112090A CN 101999071 B CN101999071 B CN 101999071B
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CN
China
Prior art keywords
electrode
channel
fluid
substrate
layer
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Expired - Fee Related
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CN2009801120900A
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English (en)
Chinese (zh)
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CN101999071A (zh
Inventor
H·E·埃里夫
C·S·金
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EI Spectra LLC
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EI Spectra LLC
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Publication of CN101999071A publication Critical patent/CN101999071A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1056—Perforating lamina
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1062—Prior to assembly
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y10T29/49117—Conductor or circuit manufacturing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y10T29/49117—Conductor or circuit manufacturing
    • Y10T29/49124—On flat or curved insulated base, e.g., printed circuit, etc.
    • Y10T29/49155—Manufacturing circuit on or in base

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
CN2009801120900A 2008-04-07 2009-04-07 用于制造微流控传感器的方法 Expired - Fee Related CN101999071B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12324808P 2008-04-07 2008-04-07
US61/123,248 2008-04-07
US12412108P 2008-04-14 2008-04-14
US61/124,121 2008-04-14
PCT/US2009/002172 WO2009126257A1 (en) 2008-04-07 2009-04-07 Method for manufactiring a microfluidic sensor

Publications (2)

Publication Number Publication Date
CN101999071A CN101999071A (zh) 2011-03-30
CN101999071B true CN101999071B (zh) 2013-05-01

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CN2009801120900A Expired - Fee Related CN101999071B (zh) 2008-04-07 2009-04-07 用于制造微流控传感器的方法

Country Status (5)

Country Link
US (2) US8182635B2 (enExample)
EP (1) EP2265923A4 (enExample)
JP (1) JP5303028B2 (enExample)
CN (1) CN101999071B (enExample)
WO (1) WO2009126257A1 (enExample)

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JP5579537B2 (ja) * 2010-08-23 2014-08-27 株式会社堀場製作所 細胞分析用カートリッジ
GB2505126B (en) 2011-02-15 2017-07-05 Nat Res Council Canada 3D microfluidic devices based on open-through thermoplastic elastomer membranes
CN102522342A (zh) * 2011-12-27 2012-06-27 日月光半导体制造股份有限公司 半导体结构及其制造方法
JP5870716B2 (ja) * 2012-01-31 2016-03-01 コニカミノルタ株式会社 生化学検査装置
US9333502B1 (en) 2012-09-13 2016-05-10 E. I. Spectra, Llc Sample-acquiring microfluidic tester
US10261073B2 (en) 2012-10-10 2019-04-16 The Board Of Trustees Of The Leland Stanford Junior University Compartmentalized integrated biochips
JP5904958B2 (ja) 2013-03-07 2016-04-20 株式会社東芝 半導体マイクロ分析チップ及びその製造方法
JP5951527B2 (ja) 2013-03-07 2016-07-13 株式会社東芝 検体検出装置及び検出方法
JP6151128B2 (ja) * 2013-08-12 2017-06-21 株式会社東芝 半導体マイクロ分析チップ及びその製造方法
JP2015099031A (ja) * 2013-11-18 2015-05-28 株式会社東芝 半導体マイクロ分析チップ及びその製造方法
JP6189231B2 (ja) * 2014-02-26 2017-08-30 株式会社東芝 微粒子検査装置と微粒子検査システム及び微粒子検査方法
US10767219B2 (en) 2014-03-11 2020-09-08 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making and using same
KR101527768B1 (ko) * 2014-09-10 2015-06-12 주식회사 엑세스바이오코리아 미세유체 칩 및 진단기기
KR101724499B1 (ko) * 2015-12-11 2017-04-07 현대자동차 주식회사 입자상 물질 센서 및 이를 이용한 측정방법
WO2018163101A1 (en) 2017-03-09 2018-09-13 Ecole Polytechnique Federale De Lausanne (Epfl) Microfluidic sensor and method for obtaining such a sensor
CN109682878B (zh) * 2019-03-01 2024-07-05 南京岚煜生物科技有限公司 一种具有五层结构的多通道微流体凝血检测芯片
US11434747B2 (en) * 2020-07-24 2022-09-06 Baker Hughes Oilfield Operations Llc Down-hole tools comprising layers of materials and related methods
EP4462122A1 (en) * 2023-05-08 2024-11-13 Roche Diagnostics GmbH Method of manufacturing a plurality of analytical test elements
CN117511739B (zh) * 2024-01-04 2024-03-12 中日友好医院(中日友好临床医学研究所) 微流体骨类器官芯片的构建方法及装置

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Also Published As

Publication number Publication date
US20110030888A1 (en) 2011-02-10
CN101999071A (zh) 2011-03-30
US20120261067A1 (en) 2012-10-18
WO2009126257A1 (en) 2009-10-15
US8182635B2 (en) 2012-05-22
JP5303028B2 (ja) 2013-10-02
EP2265923A4 (en) 2016-05-04
JP2011516884A (ja) 2011-05-26
US8608891B2 (en) 2013-12-17
EP2265923A1 (en) 2010-12-29

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