CN101984314A - Preparation method for dry extract of total saponins of rehmannia leaves - Google Patents
Preparation method for dry extract of total saponins of rehmannia leaves Download PDFInfo
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- CN101984314A CN101984314A CN201010514049.0A CN201010514049A CN101984314A CN 101984314 A CN101984314 A CN 101984314A CN 201010514049 A CN201010514049 A CN 201010514049A CN 101984314 A CN101984314 A CN 101984314A
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Abstract
The invention provides a preparation method for a dry extract of total saponins of rehmannia leaves, which comprises the following steps: a microwave drying machine is used to dry a rehmannia leaf extract under a vacuum condition, and water evaporates and is drawn out by vacuum after the rehmannia leaf extract absorbs microwave energy. The whole drying process has the advantages of short time and low environmental temperature, and the obtained dry extract is a medium with uniform and loose pores and has the advantages of light color, low water content, good solubility and the like. The method has the advantages of short operating process and convenient cleaning, facilitates the production of multiple batches and multiple varieties and meets the GMP requirements. The preparation method provided by the invention can realize that microwave drying power can be automatically selected to dry the extract in different periods in the drying process and the vacuum degree can be simultaneously subjected to on-line adjustment in the drying process. Compared with the common vacuum hot-air oven method, the quality of the dry extract of total saponins of rehmannia leaves obtained by the invention is greatly improved, thereby being beneficial to the subsequent preparation operation. Besides, the drying time is greatly shortened, the labor intensity is lowered, and the production efficiency is improved.
Description
Technical field
The invention belongs to the Chinese medical concrete technical field of drying, the preparation method who relates to a kind of adhesive rehmannia leaf total glycoside extract dry product, the adhesive rehmannia leaf total glycoside extract dry product that obtains by this method has that moisture content is low, dissolubility good, be characteristics such as porosity and looseness shape, and product quality improves a lot than vacuum hot-air oven method.
Background technology
Adhesive rehmannia leaf is the dried leaves of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa Libosch).The adhesive rehmannia leaf main product also has wild on China Shaanxi, Hebei and other places and cultivation in celebrating area, bosom, Henan Province.Modern pharmacology studies show that contained main component is the total glycosides of adhesive rehmannia leaf in the adhesive rehmannia leaf, has enriching yin and nourishing kidney, and cooling and activating blood is taken the photograph effects such as smart hemostasis, can be used for treating diseases such as albuminuria, blood urine, CGN.The drying of adhesive rehmannia leaf total glycoside extract is one of key link in the total glycosides formulation production process of adhesive rehmannia leaf, and product quality is had bigger influence.The drying means of adhesive rehmannia leaf total glycoside extract mainly contains vacuum dehydrating at lower temperature and spray-drying at present.Patent 200610021877.4 " adhesive rehmannia leaf extract and its production and use, with the medicine of this extract preparation " adopts spray-drying and vacuum hot-air oven method to carry out drying, 200610104355.0 " preparation technology who has the acteoside of treatment CGN effect in the adhesive rehmannia leaf " adopts the cryogenic vacuum oven method.Spray drying process baking temperature height wherein, the densification of gained dry powder and poorly water-soluble, and color is darker, the effective component loss is bigger, because the dry thing of part can adhere on the spray dryer inwall, so this method yield is lower.Vacuum hot-air oven method baking temperature is lower, but its drying time is long, and desciccate easily lumps, poorly water-soluble, and the quality instability, production efficiency is low.The shortcoming that these methods exist has considerable influence to the quality and the curative effect of the total glycosides formulation product of adhesive rehmannia leaf.
Summary of the invention
The objective of the invention is to problem, a kind of adhesive rehmannia leaf total glycoside extract dry product preparation method be provided, be achieved through the following technical solutions at present adhesive rehmannia leaf total glycoside extract dry poor product quality:
Equipment of the present invention adopts KMZ-2000 type microwave vacuum dryer, and this drying machine comprises that vacuum meter, drying machine door closure, microwave generator, commentaries on classics basket, material holding tray, condenser, cooling water inlet pipe and cooling water outlet pipe, vacuum regulatory function module, power program design function module, intermittence are than critical pieces such as time set module, rotating shaft and vacuum pump switch;
Getting water content to be dried and be 45%～75% adhesive rehmannia leaf total glycoside extract packs in the material holding tray, control medicinal extract laying depth is no more than 1/3 of material holding tray height, then material holding tray is put into the commentaries on classics basket of microwave dryer, close and lock the drying machine door closure, open the vavuum pump cooling water, when the PLC control panel shows " can start shooting ", open vacuum pump switch, when the vacuum meter reading arrive to set vacuum values-0.09～-0.08MPa after, cooling water inlet pipe on the open cold condenser and the valve on the cooling water outlet pipe, open microwave generator then, take out material holding tray after arriving setting-up time 8～32min, dry thing is scraped collection back sealed storage, and it is qualified that the moisture content of adhesive rehmannia leaf extract dry product is lower than at 5.0% o'clock.The power of the microwave generator described in the invention can be provided with by the programmable functionality module, the adjustable range of microwave power is 50W-3000W, make the dry run different time sections select microwave drying power that medicinal extract is carried out drying automatically, thereby vacuum can be set and realize that vacuum is online adjustable when simultaneously dry by vacuum regulatory function module.The volume containing the sample of adhesive rehmannia leaf medicinal extract is elected 50g～150g as, and best volume containing the sample is 70g.Change the rotating speed of basket and elect 10 rev/mins-90 rev/mins as, optimum speed is 90 rev/mins.Intermittently, best intermittently than being 3, intermittently than the ratio that is meant microwave opening time ON and shut-in time OFF than being 1～4.
The microwave vacuum drying method that the present invention adopts, heat time heating time is short, and the heating globality is more even, and environment temperature is lower than 80 ℃, and firing rate is fast, and effectively energy savings reaches more than 2/3rds.This method heating is the selectivity heating, and it only directly heats the material that absorbs microwave, so the environment thermal losses is low, pollution-free; Whole dry run has realized Automatic Control, not only reduces labour intensity, enhances productivity, and meets the GMP requirement of modernized pharmaceutical production management.Method gained adhesive rehmannia leaf total glycoside extract dry product provided by the invention is a kind of porous, loose medium, has lighter color, moisture is low, dissolubility is good advantage, is a kind of comparatively desirable adhesive rehmannia leaf total glycoside extract dry technology.Compare with existing adhesive rehmannia leaf total glycoside extract dry method, the invention has the beneficial effects as follows:
(1) under vacuum condition, utilize microwave energy that the glutinous rehmannia leaf total glycoside extract is carried out drying, whole dry run environment temperature is low, drying time short, the rerum natura that can keep material to greatest extent, the dry thing that obtains by this method have that lighter color, moisture are low, porosity and looseness, characteristics that dissolubility is good.
(2) the dry thing of gained porosity and looseness has crystallization effect to a certain degree, pulverizes the mobile fine of back powder, can direct tablet compressing or can capsule; Because dry thing has the porous loose structure of microcosmic, its instant capacity is better, helps mixing with auxiliary material simultaneously.
(3) this method is extremely short drying time, and rate of drying is fast, is tens of times of vacuum conduction type heat driers; And the dry run material is in rotary state always, and drying is very even, gives birth to outer burnt phenomenon in can not producing.
(4) microwave energy that adopts of this method is selectivity heating means always, and the moisture of material inside can absorb microwave energy consumingly, and material absorption itself is less, so the material self-temperature is not high, has improved the effective component retention rate greatly.
(5) equipment that this method adopted possesses the condensation function, discharges after the steam that microwave drying process is produced in time is condensed, and prevents that steam from condensing into fog and influencing drying effect in cavity.Possess the microwave power gradual change simultaneously and can be in harmonious proportion the vacuum adjustable function,, not only enlarged the scope of application of this method, can improve the desciccate quality simultaneously at the dry Object Selection of different cultivars different vacuum and microwave power program.
(6) this method device therefor volume is little, and floor space is little, and is easy and simple to handle, and is easy to clean GMP compatible.Because drying time is short, cleaning is convenient, is particularly suitable for multiple batches of continuous production.
Description of drawings
Fig. 1 is a device structure schematic diagram of the present invention.
The specific embodiment
The invention will be further described in conjunction with the accompanying drawings and embodiments in the present invention.
Embodiment 1:
Referring to Fig. 1, equipment of the present invention adopts KMZ-2000 type microwave vacuum dryer, and this drying machine comprises vacuum meter 1, drying machine door closure 2, microwave generator 3, changes basket 4, material holding tray 5, condenser 6, cooling water inlet pipe 7 and cooling water outlet pipe 8, vacuum regulatory function module 9, power program design function module 10, intermittence than critical pieces such as time set module 11, rotating shaft 12 and vacuum pump switch 13;
Getting initial water content and be 45% adhesive rehmannia leaf total glycoside extract 100g packs in the material holding tray 5, put into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 50 rev/mins, and vacuum is-0.09Mpa, adopt uninterrupted heating mode, be 20min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 1KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 7.24%, and rate of drying is 0.122kg/h.Power is too low, and the product moisture content is higher, and is defective.
Embodiment 2:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 100g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 50 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 20min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 1.72%, and rate of drying is 0.132kg/h.Production capacity increases than embodiment 1, and moisture content descends significantly than embodiment 1.
Embodiment 3:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 100g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 50 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 20min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 3KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 0.38%, and rate of drying is 0.134kg/h.Production capacity increases than embodiment 2, and moisture content descends to some extent than embodiment 2.
Embodiment 4:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 70 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 8min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 7.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 6.18%, and rate of drying is 0.155kg/h.
Embodiment 5:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 70 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 32min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 2.26%, and rate of drying is 0.041kg/h.
Embodiment 6:
Equipment is with embodiment 1, gets initial water content and is 55% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 90 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 2.32%, and rate of drying is 0.055kg/h.
Embodiment 7:
Equipment is with embodiment 1, gets initial water content and is 65% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 90 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 2.71%, and rate of drying is 0.054kg/h.
Embodiment 8:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 70g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 90 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 1.64%, and rate of drying is 0.077kg/h.Production capacity increases than embodiment 7.
Embodiment 9:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 150g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 90 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 1.07%, and rate of drying is 0.167kg/h.Production capacity increases than embodiment 8.
Embodiment 10:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 10 rev/mins, vacuum is-0.09Mpa, adopts uninterrupted heating mode, and be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 2.81%, and rate of drying is 0.054kg/h.Moisture content increases to some extent than embodiment 6.
Embodiment 11:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 10 rev/mins, vacuum is-0.08Mpa, adopts uninterrupted heating mode, and be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.08Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 4.76%, and rate of drying is 0.041kg/h.Desciccate sweat rate increases to some extent than embodiment 10 and rate of drying descends to some extent.
Embodiment 12:
Equipment is with embodiment 1, getting initial water content and be 45% adhesive rehmannia leaf total glycoside extract 70g packs in the material holding tray 5, put into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 10 rev/mins, vacuum is-0.09Mpa, intermittently than being 1 (ON 30s, OFF 30s), be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 1.64%, and rate of drying is 0.077kg/h.
Embodiment 13:
Equipment is with embodiment 1, getting initial water content and be 45% adhesive rehmannia leaf total glycoside extract 70g packs in the material holding tray 5, put into the commentaries on classics basket 4 of microwave dryer after the shop is even, setting commentaries on classics basket 4 rotating speeds is 10 rev/mins, vacuum is-0.09Mpa, intermittently than being 3 (ON 45s, OFF 15s), be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.09Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Regulating microwave power is that 2KW carries out drying, and behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 1.48%, and rate of drying is 0.084kg/h.
Embodiment 14:
Equipment is with embodiment 1, gets initial water content and is 45% adhesive rehmannia leaf total glycoside extract 50g and pack in the material holding tray 5, puts into the commentaries on classics basket 4 of microwave dryer after the shop is even, sets that to change basket 4 rotating speeds be 10 rev/mins, and vacuum is-0.09Mpa that be 24min drying time.Close and lock drying machine door closure 2, open the vavuum pump cooling water, open vavuum pump again, behind vacuum table 1 reading arrival-0.08Mpa, cooling water inlet pipe 7 on the open cold condenser 6 and the valve on the cooling water outlet pipe 8.Adopt the microwave power gradual-change mode to carry out drying (0-18min, 2KW; 18-24min, 1KW), behind the arrival setting-up time, material holding tray 5 is taken out in emptying, collects dry thing.With reference to " aquametry first method is measured in the Chinese pharmacopoeia 2005 editions, and prepared adhesive rehmannia leaf total glycoside extract dry product moisture content is 3.26%, and rate of drying is 0.048kg/h.
Claims (6)
1. the preparation method of an adhesive rehmannia leaf total glycoside extract dry product, adopt KMZ-2000 type microwave vacuum dryer, this drying machine mainly comprises vacuum meter (1), drying machine door closure (2), microwave generator (3), changes basket (4), material holding tray (5), condenser (6), cooling water inlet pipe (7) and cooling water outlet pipe (8), vacuum regulatory function module (9), power program design function module (10), intermittence than time set module (11), rotating shaft (12) and vacuum pump switch (13), it is characterized in that, be achieved through the following technical solutions:
Getting water content to be dried and be 45%～75% adhesive rehmannia leaf total glycoside extract packs in the material holding tray (5), then material holding tray is put into the commentaries on classics basket (4) of microwave dryer, close and lock drying machine door closure (2), open the vavuum pump cooling water, when the PLC control panel shows " can start shooting ", open vacuum pump switch (13), when vacuum table (1) reading arrive to set vacuum values-0.09～-0.08MPa after, the cooling water inlet pipe (7) on the open cold condenser (6) and the valve of cooling water outlet pipe (8), open microwave generator (3) again, take out material holding tray (5) after arriving setting-up time 8～32min, dry thing is scraped collection back sealed storage, and it is qualified that the moisture content of adhesive rehmannia leaf extract dry product is lower than at 5.0% o'clock.
2. the preparation method of a kind of adhesive rehmannia leaf total glycoside extract dry product according to claim 1 is characterized in that, control medicinal extract laying depth is no more than 1/3 of material holding tray height in the material holding tray (5).
3. the preparation method of a kind of adhesive rehmannia leaf total glycoside extract dry product according to claim 1 is characterized in that, the adjustable range of the microwave power of described microwave generator (3) is 50W-3000W.
4. the preparation method of a kind of adhesive rehmannia leaf total glycoside extract dry product according to claim 1 is characterized in that, the volume containing the sample of adhesive rehmannia leaf medicinal extract is elected 50g～150g as.
5. the preparation method of a kind of adhesive rehmannia leaf total glycoside extract dry product according to claim 1 is characterized in that, the rotating speed that changes basket (4) is 10 rev/mins-90 rev/mins.
6. the preparation method of a kind of adhesive rehmannia leaf total glycoside extract dry product according to claim 1 is characterized in that, microwave switch is intermittently than being 1～4.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102445055A (en) * | 2011-12-07 | 2012-05-09 | 河南科技大学 | Method for drying traditional Chinese medicine materials in mixing mode through microwave vacuum and hot air |
| CN102564074A (en) * | 2011-12-27 | 2012-07-11 | 黄山锦峰实业有限公司 | Equipment and method for drying triglycidyl isocyanurate |
| CN103245170A (en) * | 2013-05-21 | 2013-08-14 | 锡矿山闪星锑业有限责任公司 | Ethylene glycol antimony acetate vacuum microwave drying method |
| CN107823896A (en) * | 2017-09-09 | 2018-03-23 | 广东湛江吉民药业股份有限公司 | A kind of vacuum dehydrating at lower temperature method of bone glue |
| WO2022067880A1 (en) * | 2020-09-30 | 2022-04-07 | 南京中科药业有限公司 | Microwave vacuum drying device and drying process thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1947757A (en) * | 2006-09-16 | 2007-04-18 | 四川美大康药业股份有限公司 | Leave of glutinous rehmannia extractive, its prepn. method and use, medicines prepd. with said extractives |
| CN101121740A (en) * | 2006-08-09 | 2008-02-13 | 中国中医科学院中药研究所 | Technique for preparing verbascoside with function of curing chronic glomerulonephritis in glutinous rehmannia leaf |
| CN101700314A (en) * | 2009-11-13 | 2010-05-05 | 四川美大康药业股份有限公司 | Traditional Chinese medicine extract drying method for preparing drug for curing osteoporosis |
| CN101703613A (en) * | 2009-11-03 | 2010-05-12 | 四川美大康药业股份有限公司 | Preparation method of rehmannia leaf total glycoside extract dry product |
-
2010
- 2010-10-19 CN CN201010514049.0A patent/CN101984314B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121740A (en) * | 2006-08-09 | 2008-02-13 | 中国中医科学院中药研究所 | Technique for preparing verbascoside with function of curing chronic glomerulonephritis in glutinous rehmannia leaf |
| CN1947757A (en) * | 2006-09-16 | 2007-04-18 | 四川美大康药业股份有限公司 | Leave of glutinous rehmannia extractive, its prepn. method and use, medicines prepd. with said extractives |
| CN101703613A (en) * | 2009-11-03 | 2010-05-12 | 四川美大康药业股份有限公司 | Preparation method of rehmannia leaf total glycoside extract dry product |
| CN101700314A (en) * | 2009-11-13 | 2010-05-05 | 四川美大康药业股份有限公司 | Traditional Chinese medicine extract drying method for preparing drug for curing osteoporosis |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102445055A (en) * | 2011-12-07 | 2012-05-09 | 河南科技大学 | Method for drying traditional Chinese medicine materials in mixing mode through microwave vacuum and hot air |
| CN102564074A (en) * | 2011-12-27 | 2012-07-11 | 黄山锦峰实业有限公司 | Equipment and method for drying triglycidyl isocyanurate |
| CN102564074B (en) * | 2011-12-27 | 2014-12-10 | 黄山锦峰实业有限公司 | Equipment and method for drying triglycidyl isocyanurate |
| CN103245170A (en) * | 2013-05-21 | 2013-08-14 | 锡矿山闪星锑业有限责任公司 | Ethylene glycol antimony acetate vacuum microwave drying method |
| CN107823896A (en) * | 2017-09-09 | 2018-03-23 | 广东湛江吉民药业股份有限公司 | A kind of vacuum dehydrating at lower temperature method of bone glue |
| CN107823896B (en) * | 2017-09-09 | 2020-05-22 | 广东湛江吉民药业股份有限公司 | Vacuum low-temperature drying method of bovine bone glue |
| WO2022067880A1 (en) * | 2020-09-30 | 2022-04-07 | 南京中科药业有限公司 | Microwave vacuum drying device and drying process thereof |
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