CN101983692A - Medicine for treating hyperlipemia and preparation method thereof - Google Patents

Medicine for treating hyperlipemia and preparation method thereof Download PDF

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Publication number
CN101983692A
CN101983692A CN2010105449593A CN201010544959A CN101983692A CN 101983692 A CN101983692 A CN 101983692A CN 2010105449593 A CN2010105449593 A CN 2010105449593A CN 201010544959 A CN201010544959 A CN 201010544959A CN 101983692 A CN101983692 A CN 101983692A
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herba
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CN101983692B (en
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许文成
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Abstract

The invention discloses a medicine for treating hyperlipemia. The medicine is mainly prepared by earthworm, scutellaria baicalensis, red paeony root, akebiaquinata, almond and solomon seal in a certain weight ratio, and the medicine can be prepared into any common oral preparation. The medicine of the invention has the effects of clearing away heat and toxic material, eliminating dampness and removing dampness through diuresis, eliminating blood stasis and reducing lipid and reducing blood viscosity, curative effect on hyperlipemia is quick, and curative ratio is high.

Description

A kind of medicine for the treatment of high fat of blood and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of high fat of blood and preparation method thereof, belong to the field of Chinese medicines.
Technical background
High fat of blood is common disease of middle-aged and elderly people and frequently-occurring disease, is " arch-criminal " of cardiovascular and cerebrovascular disease, has become one of principal disease that threatens middle-aged and elderly people health.This disease to the infringement of health be concealment, gradually, carrying out property and general, its direct infringement is to quicken systemic atherosclerosis, in case tremulous pulse is stopped up by atheromatous plaque, will cause serious consequence.Medically this disease is paid special attention in recent years, 90% medicine all is a Western medicine, though instant effect, but side effect is also being grown unconsciously, and in a single day most of fat-reducing medicaments are taken, and will accompany lifelong, and take Western medicine, the most tangible infringement for a long time to kidney.
Summary of the invention
Therefore people to curative effect preferably Chinese medicine have great demand, up to now, also do not find relevant report about medicine of the present invention.
The inventor has found the medicine that the radical cure of better curative effect high fat of blood is arranged finally, thereby has finished the present invention according to clinical research repeatedly and multiple authentication.
Purpose of the present invention just provides a kind of composition of medicine with radically treating hyperlipidemia.
Another object of the present invention has just provided this composition of medicine preparation method.
Medicament selection Pheretima of the present invention, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae, Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, Rhizoma Polygonati 32 flavor Chinese medicines make up; make each efficacy of drugs produce synergism these drug regimens, thereby effectively effect a radical cure the hyperlipidemia palindromia.Wherein select for use Pheretima to be because its nature and flavor are salty, cold, return liver, spleen, urinary bladder channel, the heat clearing away arresting convulsion is arranged, collateral dredging is relievingd asthma, and the diuretic function is controlled hyperpyrexia, coma, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension; Selecting Fructus Forsythiae for use is because its nature and flavor hardship, and the heart, liver, gallbladder meridian are gone in cold, and heat clearing away is arranged, detoxifcation, eliminating stagnation, the repercussive function, control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select for use Sargassum to be because its nature and flavor hardship is salty, cold, go into lung, spleen, kidney channel, softening the hard mass is arranged, expectorant, diuretic, the function that expels the heat-evil is controlled scrofula, and goiter is gathered, edema, beriberi, painful and swollen testis.Select for use Thallus Laminariae (Thallus Eckloniae) to be because its nature and flavor are salty, cold, return liver, stomach, kidney channel, hard masses softening and resolving is arranged, expectorant, the function of diuretic is controlled goiter, scrofula, painful and swollen testis, phlegm retention edema.Xuan Yong Gardenia is because its nature and flavor hardship is cold, goes into the heart, liver, lung, stomach warp, and heat clearing away is arranged, pathogenic fire purging, and the function of removing heat from blood is controlled the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.Select Radix Gentianae for use, the different name Radix Gentianae is because its nature and flavor hardship is cold, goes into liver, gallbladder meridian, and eliminating pathogen in the liver gallbladder excess-fire is arranged, remove the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat , Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the carbuncle skin infection, scrotum swells and ache, the pudendum pruritus due to damp pathogen.Select for use Radix Scutellariae to be because its nature and flavor hardship is cold, go into the heart, lung, gallbladder, large intestine channel, the removing the relative excess fire is arranged, except that damp and hot, hemostasis, antiabortive function is controlled the high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria is told, is defeated in battle, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.Selecting Herba Artemisiae Scopariae for use is that liver, spleen, urinary bladder channel are gone in cold, and the function of clearing away heat-damp and promoting diuresis is arranged, and control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies because of its nature and flavor toil.Select for use Radix Scrophulariae to be because its nature and flavor hardship is salty, lung, kidney channel are gone in cold, and YIN nourishing is arranged, pathogenic fire reducing, and relieving restlessness, the antidotal function is controlled the calentura excessive thirst, sends out speckle, the hectic fever due to YIN-deficiency consumptive fever, it is not peaceful to sleep night, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select for use Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid is controlled the calentura excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Select Radix Paeoniae Rubra for use, the different name Radix Paeoniae Rubra is that liver, spleen channel are gone in cold, and clots absorbing is arranged because its nature and flavor are bitter, pain relieving, and removing heat from blood, the repercussive function is controlled the stagnant amenorrhea of the stasis of blood, and the hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.Selecting Radix Et Caulis Acanthopanacis Senticosi for use is that temperature is returned spleen, kidney, heart channel, and replenishing QI to invigorate the spleen is arranged because of its nature and flavor suffering, little hardship, and the function that the kidney invigorating peace is examined is controlled deficiency of spleen-YANG and kidneyYANG, and body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.Select for use Radix Ilicis Pubescentis to be because its property mildly bitter flavor is sweet, property is flat, and is nontoxic, heat-clearing and toxic substances removing is arranged, and the function of blood circulation and channel invigorating is controlled anemopyretic cold, dyspnea and cough due to lung-heat, laryngeal edema, tonsillitis, hemiplegia due to the dysentery, coronary heart disease, cerebrovascular accident, thromboangiitis obliterans, erysipelas is scalded, central serous chorioretinopathy, uveitis, and skin acute suppurative inflammation.Select Radix Ophiopogonis for use, the different name Radix Ophiopogonis is because its property sweet and slightly bitter taste is cold, goes into lung, stomach, heart channel, and nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid is controlled dryness of the lung dry cough, spits blood spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, hinder in calentura Tianjin, dry mouth and throat, constipation.Select Radix Asparagi for use, the different name Radix Asparagi is because its nature and flavor sweetness and bitterness is cold, goes into lung, kidney channel, and YIN nourishing is arranged, moisturize, and lung heat clearing, the function of pathogenic fire reducing is controlled fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain is quenched one's thirst, constipation.Select for use Herba Artemisiae Annuae to be because the bitter little suffering of its nature and flavor is cold, go into liver, gallbladder meridian, heat clearing away is arranged, expelling summer-heat removes the function of steaming, and controls epidemic febrile disease, summer-heat, hectic fever due to YIN-deficiency consumptive fever, malaria, dysentery, jaundice, scabies, pruritus.Selecting Calculus Bovis for use is that the heart, Liver Channel are gone in cold because of its property bitter but sweet flavor, have to clear away heart-fire, and blood stasis dispelling, function of gallbladder promoting, calentura coma, delirium are controlled in relieving convulsion effect, and epilepsy is gone mad, and infantile convulsion is twitched, ulcerative gingivitis, larynx is swollen, aphtha of the mouth and tongue, carbuncle, furunculosis.Select for use Fel Ursi to be because its nature and flavor hardship is cold, go into liver, gallbladder, spleen, stomach warp, heat clearing away is arranged, spasmolytic makes eye bright, parasiticidal function, and it is yellow to control heat, diarrhea due to summer-heat, Xiao Jing Epilepsy, infantile malnutrition, ascarid pain, corneal nebula, sore throat, nose erosion, furuncle hemorrhoid malignant boil.Select for use Fel Sus domestica to be because its nature and flavor hardship is cold, go into liver, gallbladder, lung, large intestine channel, heat clearing away is arranged, moisturize, the antidotal function is controlled dry thirsty, the constipation of calentura interior-heat, jaundice, and pertussis, asthma is had loose bowels, dysentery, conjunctival congestion, sore throat, Ting ear, carbuncle furuncle.Selecting Flos Caryophylli for use is that temperature is gone into stomach, spleen, kidney channel, and warming middle-JIAO is arranged because of its nature and flavor suffering, warming the kidney, and the function of sending down the abnormal ascending QI is controlled singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, Xuan tinea, hernia, tinea disease.Selecting Radix Panacis Quinquefolii for use is that the heart, lung, kidney three warps are gone in cold because of its property sweet and slightly bitter taste, useful lung yin, and clear asthenic fire, the function of promoting the production of body fluid to quench thirst is controlled deficiency of the lung chronic cough, loses blood, dry throat and mouth, deficiency-heat is tired tired.Selecting Radix Pseudostellariae for use is that tepor is gone into the heart, spleen, lung three warps, and tonifying the lung is arranged because of its nature and flavor sweetness and bitterness, and the function of spleen invigorating is controlled the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, and the cardiopalmus spontaneous perspiration, spirit is tired.Selecting Semen Cassiae for use is that liver, kidney channel are gone in cold, and liver heat removing is arranged because of its property bitter but sweet flavor, make eye bright, and diuretic, the function of relieving constipation is controlled the wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation.Selecting Semen Armeniacae Amarum for use is because of its nature and flavor hardship, and temperature is poisonous, goes into lung, large intestine channel, and expelling phlegm for arresting cough is arranged, and relievings asthma, and the function of intestine moistening is controlled the exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select for use Herba Pteridis Multifidae to be because the light little hardship of its nature and flavor is cold in nature, go into kidney, stomach two warps, clearing away heat-damp and promoting diuresis is arranged, cooling blood for hemostasis, the function of subduing swelling and detoxicating is controlled icterohepatitis, enteritis, bacillary dysentery, stranguria with turbid discharge, leukorrhagia is spitted blood epistaxis, have blood in stool hematuria, tonsillitis, parotitis, carbuncle sore tumefacting virus, eczema.Select for use Herba Solani Nigri to be because its nature and flavor hardship is cold, heat clearing away is arranged, detoxifcation is invigorated blood circulation, and the repercussive function is controlled furuncle, carbuncle, erysipelas, osteopatia sprain, chronic tracheitis, acute nephritis.Select for use Herba Dianthi to be because its nature and flavor hardship is cold, go into the heart, kidney, small intestinal, urinary bladder channel, clearing away heat and promoting diuresis is arranged, the function that removing blood stasis stimulates the menstrual flow is controlled urinary obstruction, gonorrhea, and edema, amenorrhea, carbuncle, conjunctival congestion is hidden from view, the contamination sore.Selecting Caulis Akebiae for use is that the heart, small intestinal, urinary bladder channel are gone in cold, and pathogenic fire purging row water is arranged because of its nature and flavor hardship, and the function of promoting blood circulation is controlled hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Choosing is because its nature and flavor hardship is cold with Herba Polygoni Avicularis, goes into urinary bladder channel, and diuresis is arranged, heat clearing away, and parasiticidal function is controlled pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid, infantile malnutrition, hemorrhoid are swollen, eczema.Select for use Fructus Toosendan to be because its nature and flavor hardship is cold, poisonous, go into liver, stomach, small intestine meridian, have except that damp and hot, clearing away liver-fire, pain relieving, parasiticidal function is controlled epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.Select for use Herba Dendrobii to be because its property slightly sweet flavor is little salty, cold, go into stomach, lung, kidney channel, the stomach reinforcing of promoting the production of body fluid is arranged, the function of clearing away heat and nourishing YIN is controlled consumption of body fluid caused by febrile disease, the xerostomia excessive thirst, deficiency-heat after being ill, it is dark that the moon is hindered order.Select for use Rhizoma Polygonati to be because its nature and flavor are sweet, flat, go into spleen, lung, kidney channel, control invigorating the spleen and replenishing QI, the profit cardiopulmonary, the function of bone and muscle strengthening is controlled deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones weakness, rheumatalgia, the bright disease of wind leprosy.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each grouping all has better curative effect in following weight range:
Pheretima 6-12 gram Fructus Forsythiaes 10-18 gram Sargassums 8-18 grams
Thallus Laminariae (Thallus Eckloniae) 8-18 Ke Gardenia 10-18 cron Radix Gentianae 6-15 grams
Radix Scutellariae 10-18 gram Herba Artemisiae Scopariae 10-20 gram Radix Scrophulariaes 10-15 grams
Radix Rehmanniae 10-15 gram Radix Paeoniae Rubra 10-15 gram Radix Et Caulis Acanthopanacis Senticosis 10-20 grams
Radix Ilicis Pubescentis 15-30 gram 10-15 gram Radix Asparagis Radix Ophiopogonis 10-15 grams
Herba Artemisiae Annuae 10-30 gram Calculus Boviss 1-1.5 gram Fel Ursis 1-1.5 grams
Fel Sus domestica 1-2.0 gram Flos Caryophyllis 6-10 gram Radix Panacis Quinquefoliis 6-12 grams
Radix Pseudostellariae 10-15 gram Semen Cassiaes 10-15 gram Semen Armeniacae Amarums 10-15 grams
Herba Pteridis Multifidae 10-20 cron certain herbaceous plants with big flowers 6-12 gram Herba Dianthis 10-15 grams
Caulis Akebiae 10-15 Ke pivots hold 10-15 gram Fructus Toosendans, 8-15 grams
Herba Dendrobii 8-15 gram Rhizoma Polygonatis 10-15 grams
Be preferably:
Pheretima 10 gram Fructus Forsythiaes 15 gram Sargassums 15 grams
Thallus Laminariae (Thallus Eckloniae) 15 Ke Gardenia 15 cron Radix Gentianae 12 grams
Radix Scutellariae 15 gram Herba Artemisiae Scopariae 15 gram Radix Scrophulariaes 10 grams
Radix Rehmanniae 12 gram Radix Paeoniae Rubra 12 gram Radix Et Caulis Acanthopanacis Senticosis 15 grams
Radix Ilicis Pubescentis 20 gram 12 gram Radix Asparagis Radix Ophiopogonis 12 grams
Herba Artemisiae Annuae 20 gram Calculus Boviss 1.2 gram Fel Ursis 1.5 grams
Fel Sus domestica 1.5 gram Flos Caryophyllis 8 gram Radix Panacis Quinquefoliis 10 grams
Radix Pseudostellariae 12 gram Semen Cassiaes 12 gram Semen Armeniacae Amarums 12 grams
Herba Pteridis Multifidae 15 cron certain herbaceous plants with big flowers 10 gram Herba Dianthis 12 grams
Caulis Akebiae 12 Ke pivots hold 12 gram Fructus Toosendans, 12 grams
Herba Dendrobii 12 gram Rhizoma Polygonatis 12 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Pheretima: get crude drug, remove impurity, clean, moisten cutting, drying slightly;
2, Fructus Forsythiae: choose clean impurity, stranding is opened, and removes discarding stalk;
3, Sargassum: choose decontamination, water slightly floats, and dries in the air slightly, and cutting is dried;
4, Thallus Laminariae (Thallus Eckloniae): get crude drug, remove impurity, rinse, dry in the air slightly, shredding, drying;
5,, Gardenia: sieve dedust bits, choose decontamination, pulverize and sieve, or cut off two ends;
6, Radix Gentianae: choose decontamination, remove residual stem, clean, run through the back cutting, dry;
7, Radix Scutellariae: choose decontamination, remove residual stem, soak into or put to soak slightly in the boiled water and pull out, running through the back section and drying with cold water;
8, Herba Artemisiae Scopariae: sieve, choose decontamination, remove undesirable root, pulverize, remove clean spare after sieve;
9, Radix Scrophulariae: choose clean impurity, remove removing LU, clean running through, section is dried;
10, Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;
11, Radix Paeoniae Rubra: choose decontamination, separately size bar washes bubble about seven, eighty per cant with water thoroughly, pulls out to shine and dries in the air, and profit is even to inside and outside humidity, cuts into slices, and dries;
12, Radix Et Caulis Acanthopanacis Senticosi: get crude drug, remove impurity, big or small stepping soaks, and runs through, and cuts sheet, drying, and sieve removes chip;
13, Radix Ilicis Pubescentis: choose clean impurity, section is dried;
14, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
15, Radix Asparagi: choose decontamination, washing is clean, and moistening is even to inside and outside humidity, cutting, drying;
16, Herba Artemisiae Annuae: choose decontamination, remove undesirable root, water drenches just profit, and cutting is dried;
17, Calculus Bovis: be ground into superfine powder and use;
18, Fel Ursi: remove clean epithelium, pulverization is used;
19, Fel Sus domestica: after obtaining, hang-up is dried, or flattens slightly when half-dried, and is dry again;
20, Flos Caryophylli: select the high-quality Flos Caryophylli to put and do stir-fry in the iron pan, be coke yellow or burnt brown to the surface, rare black speck;
21, Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu profit 2 days, Winter-Spring profit 3 days is taken out section, dries;
22, Radix Pseudostellariae: choose decontamination, clean earth, dry;
23, Semen Cassiae: choose decontamination, sieve removes earth;
24, Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;
25, Herba Pteridis Multifidae: get crude drug, choose decontamination, dry;
26, Herba Solani Nigri: get crude drug, choose decontamination, dry;
27, Herba Dianthi: choose clean impurity, remove undesirable root, clean, stewing profit, cutting is dried;
28, Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
29,, Herba Polygoni Avicularis: remove clean impurity and root, clean, moisten softly, cutting is dried;
30, Fructus Toosendan: choose decontamination, clean, oven dry, grating or cleave in two;
31, Herba Dendrobii: get exsiccant Herba Dendrobii, approximately to eighty per cant saturating, stewing profit is removed undesirable root and black branch with blister, and the thin film is hit in cutting, dries;
32, Rhizoma Polygonati: clean earth, slightly profit is cut into slices, and dries.
Two, preparation
1, the preparation of capsule:
Pheretima with described weight; Fructus Forsythiae; Sargassum; Thallus Laminariae (Thallus Eckloniae) Gardenia; Radix Gentianae; Radix Scutellariae; Herba Artemisiae Scopariae; Radix Scrophulariae; Radix Rehmanniae; Radix Paeoniae Rubra; Radix Et Caulis Acanthopanacis Senticosi; Radix Ilicis Pubescentis; Radix Ophiopogonis; Radix Asparagi; Herba Artemisiae Annuae; Calculus Bovis; Fel Ursi; Fel Sus domestica; Flos Caryophylli; Radix Panacis Quinquefolii; Radix Pseudostellariae; Semen Cassiae; Semen Armeniacae Amarum; Herba Pteridis Multifidae; Herba Solani Nigri; Herba Dianthi; Caulis Akebiae Herba Polygoni Avicularis; Fructus Toosendan; Herba Dendrobii; Rhizoma Polygonati decocts with water twice; each amount of water is advisable to cover powder; merge decoction liquor twice; it is 1.35 extractum that filtering and concentrating becomes proportion; add 90-95% ethanol and carry out precipitate with ethanol; reclaim ethanol and concentrated; dry down at 45 ℃-50 ℃; it is ground into powder, incapsulates.
2, the preparation of tablet:
Pheretima with described weight; Fructus Forsythiae; Sargassum; Thallus Laminariae (Thallus Eckloniae) Gardenia; Radix Gentianae; Radix Scutellariae; Herba Artemisiae Scopariae; Radix Scrophulariae; Radix Rehmanniae; Radix Paeoniae Rubra; Radix Et Caulis Acanthopanacis Senticosi; Radix Ilicis Pubescentis; Radix Ophiopogonis; Radix Asparagi; Herba Artemisiae Annuae; Calculus Bovis; Fel Ursi; Fel Sus domestica; Flos Caryophylli; Radix Panacis Quinquefolii; Radix Pseudostellariae; Semen Cassiae; Semen Armeniacae Amarum; Herba Pteridis Multifidae; Herba Solani Nigri; Herba Dianthi; Caulis Akebiae Herba Polygoni Avicularis; Fructus Toosendan; Herba Dendrobii; Rhizoma Polygonati decocts with water twice; add for the first time 6 times of amounts of water; decocted 1.5 hours; add for the second time 4 times of amounts of water; decocted 1 hour; merge the extractum that twice decoction liquor is condensed into proportion 1.35; extractum added 90-95% ethanol; stir; precipitation reclaims ethanol and concentrates; dry down at 45 ℃-50 ℃; be ground into powder, add the adjuvant compacting in flakes.
3, the preparation of decocting liquid:
(1) Pheretima, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae, Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, the Rhizoma Polygonati with described weight decocts with water; add for the first time 2 times of amounts of water; intense fire decocts boiling 30 minutes; promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling.
(2) medicinal residues after will filtering for the first time add 1.5 times of amounts of water, decoct boiling, and the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient.
4, particulate preparation:
Pheretima with described weight; Fructus Forsythiae; Sargassum; Thallus Laminariae (Thallus Eckloniae) Gardenia; Radix Gentianae; Radix Scutellariae; Herba Artemisiae Scopariae; Radix Scrophulariae; Radix Rehmanniae; Radix Paeoniae Rubra; Radix Et Caulis Acanthopanacis Senticosi; Radix Ilicis Pubescentis; Radix Ophiopogonis; Radix Asparagi; Herba Artemisiae Annuae; Calculus Bovis; Fel Ursi; Fel Sus domestica; Flos Caryophylli; Radix Panacis Quinquefolii; Radix Pseudostellariae; Semen Cassiae; Semen Armeniacae Amarum; Herba Pteridis Multifidae; Herba Solani Nigri; Herba Dianthi; Caulis Akebiae Herba Polygoni Avicularis; Fructus Toosendan; Herba Dendrobii; Rhizoma Polygonati decocts with water twice; add for the first time 6 times of amounts of water; decocted 1.5 hours; add for the second time 4 times of amounts of water; decocted 1 hour; merging twice decoction liquor, to be condensed into proportion be 1.35 extractum; extractum added 90-95% ethanol; stir precipitation and reclaim ethanol and concentrated; dry down at 45 ℃-50 ℃; add adjuvant, make granule.
5, the preparation of unguentum:
Pheretima, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae, Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, the Rhizoma Polygonati of described weight are decocted with water twice; add for the first time 6 times of amounts of water; decocted 1.5 hours; add for the second time 4 times of amounts of water; decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum.
The active component of medicine of the present invention can add preparation required various conventional adjuvant during different dosage form, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as tablet, capsule, oral agents, granule, unguentum etc.
Medicine of the present invention has heat-clearing and toxic substances removing, the dampness dampness removing, and the blood stasis dispelling blood fat reducing, blood viscosity lowering strengthens blood blood flow degree etc., and curative effect is fast, the radical rate height.Below further set forth effective achievement of medicine of the present invention by testing example, these tests comprise that medicine of the present invention (to call quick-acting Xuezhikang in the following text) animal toxicity test and clinical observation test.
[test example 1] medicine of the present invention is to the toxicity test report of rabbit
Get 40 of West Germany does, body weight 2.0-2.5kg divides two groups, every group 20, wherein one group is the overdose test group, and another group is the normal amount test group, the super quantity group is 20ml/kg, normal amount is 10ml/kg, and administering mode is the administration by gavage administration, once a day, serve on January, observe administration reaction every day, the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data:
Accept out-patient's 1200 examples for medical treatment, 30-40 years old 800 age example, 40-50 years old 300 example, 100 examples more than 50 years old.
2, diagnostic criteria:
Light-duty hyperlipidemia morbidity 1-3 years, patient's dizziness, muddled, top-heavy, limbs fatigue, drowsiness, dreaminess is tested inspection through sanguification, extraordinary value that blood lipids index is slight.
Heavy hyperlipidemia morbidity 3-8 years, patient's diet poor appetite, weak all over, fidgety irritability, the night sweat bitter taste, dry pharynx, dryness of the tongue, nose heave desire is fallen, symptoms such as grogginess, the extraordinary value of lipid examination index height is obvious.
3, Therapeutic Method:
Decocting liquid: by measuring quick-acting Xuezhikang, put into the container herbal decoction routinely of boiling medicine, sooner or later service once every day twice, one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Tablet: oral three times of every day, each 12, one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Capsule: oral three times of every day, each 13, one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Granule: oral three times of every day, each 2 bags (6g), one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Unguentum: oral three times of every day, each 15ml, one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
4, efficacy assessment standard:
Produce effects: light, heavy hyperlipidemia this disease symptoms of patient after treating disappears, and it is normal that patient's body constitution is recovered, and through laboratory examination, in the blood fat normal value, follows up a case by regular visits to 1-3 years no recidivists.
Take a turn for the better: the hyperlipidemia symptom progressively alleviates or disappears, and the patient feels good, and it is normal that body constitution is recovered substantially.
Invalid: as not reach improvement standard person.
5, therapeutic outcome: (seeing the following form)
Figure 286138DEST_PATH_IMAGE001
In the treatment of a course of treatment, with light-duty hyperlipemic patients 1000 examples of Drug therapy of the present invention, produce effects 980 examples, 20 examples that take a turn for the better, total effective rate 100%; In the treatment of two courses of treatment, with heavy hyperlipemic patients 200 examples of Drug therapy of the present invention, produce effects 180 examples, 18 examples that take a turn for the better, invalid 2 examples, total effective rate is 90%.

Claims (3)

1. a medicine for the treatment of high fat of blood is characterized in that, it is to be made by the crude drug in the following weight scope:
Pheretima 6-12 gram Fructus Forsythiaes 10-18 gram Sargassums 8-18 grams
Thallus Laminariae (Thallus Eckloniae) 8-18 Ke Gardenia 10-18 cron Radix Gentianae 6-15 grams
Radix Scutellariae 10-18 gram Herba Artemisiae Scopariae 10-20 gram Radix Scrophulariaes 10-15 grams
Radix Rehmanniae 10-15 gram Radix Paeoniae Rubra 10-15 gram Radix Et Caulis Acanthopanacis Senticosis 10-20 grams
Radix Ilicis Pubescentis 15-30 gram 10-15 gram Radix Asparagis Radix Ophiopogonis 10-15 grams
Herba Artemisiae Annuae 10-30 gram Calculus Boviss 1-1.5 gram Fel Ursis 1-1.5 grams
Fel Sus domestica 1-2.0 gram Flos Caryophyllis 6-10 gram Radix Panacis Quinquefoliis 6-12 grams
Radix Pseudostellariae 10-15 gram Semen Cassiaes 10-15 gram Semen Armeniacae Amarums 10-15 grams
Herba Pteridis Multifidae 10-20 cron certain herbaceous plants with big flowers 6-12 gram Herba Dianthis 10-15 grams
Caulis Akebiae 10-15 Ke pivots hold 10-15 gram Fructus Toosendans, 8-15 grams
Herba Dendrobii 8-15 gram Rhizoma Polygonatis 10-15 grams.
2. medicine according to claim 1 is characterized in that: wherein the consumption of each crude drug is:
Pheretima 10 gram Fructus Forsythiaes 15 gram Sargassums 15 grams
Thallus Laminariae (Thallus Eckloniae) 15 Ke Gardenia 15 cron Radix Gentianae 12 grams
Radix Scutellariae 15 gram Herba Artemisiae Scopariae 15 gram Radix Scrophulariaes 10 grams
Radix Rehmanniae 12 gram Radix Paeoniae Rubra 12 gram Radix Et Caulis Acanthopanacis Senticosis 15 grams
Radix Ilicis Pubescentis 20 gram 12 gram Radix Asparagis Radix Ophiopogonis 12 grams
Herba Artemisiae Annuae 20 gram Calculus Boviss 1.2 gram Fel Ursis 1.5 grams
Fel Sus domestica 1.5 gram Flos Caryophyllis 8 gram Radix Panacis Quinquefoliis 10 grams
Radix Pseudostellariae 12 gram Semen Cassiaes 12 gram Semen Armeniacae Amarums 12 grams
Herba Pteridis Multifidae 15 cron certain herbaceous plants with big flowers 10 gram Herba Dianthis 12 grams
Caulis Akebiae 12 Ke pivots hold 12 gram Fructus Toosendans, 12 grams
Herba Dendrobii 12 gram Rhizoma Polygonatis 12 grams.
3. according to the preparation method of claim 1 or 2 described medicines, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) Pheretima: get crude drug, remove impurity, clean, moisten cutting, drying slightly;
(2) Fructus Forsythiae: choose clean impurity, stranding is opened, and removes discarding stalk;
(3) Sargassum: choose decontamination, water slightly floats, and dries in the air slightly, and cutting is dried;
(4) Thallus Laminariae (Thallus Eckloniae): get crude drug, remove impurity, rinse, dry in the air slightly, shredding, drying;
(5) Gardenia: sieve dedust bits, choose decontamination, pulverize and sieve, or cut off two ends;
(6) Radix Gentianae: choose decontamination, remove residual stem, clean, run through the back cutting, dry;
(7) Radix Scutellariae: choose decontamination, remove residual stem, soak into or put to soak slightly in the boiled water and pull out, running through the back section and drying with cold water;
(8) Herba Artemisiae Scopariae: sieve, choose decontamination, remove undesirable root, pulverize, remove clean spare after sieve;
(9) Radix Scrophulariae: choose clean impurity, remove removing LU, clean running through, section is dried;
(10) Radix Rehmanniae: get crude drug, remove impurity, clean, profit is cut sheet slightly, drying, and sieve removes chip;
(11) Radix Paeoniae Rubra: choose decontamination, separately size bar washes bubble about seven, eighty per cant with water thoroughly, pulls out to shine and dries in the air, and profit is even to inside and outside humidity, cuts into slices, and dries;
(12) Radix Et Caulis Acanthopanacis Senticosi: get crude drug, remove impurity, big or small stepping soaks, and runs through, and cuts sheet, drying, and sieve removes chip;
(13) Radix Ilicis Pubescentis: choose clean impurity, section is dried;
(14) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;
(15) Radix Asparagi: choose decontamination, washing is clean, and moistening is even to inside and outside humidity, cutting, drying;
(16) Herba Artemisiae Annuae: choose decontamination, remove undesirable root, water drenches just profit, and cutting is dried;
(17), Calculus Bovis: be ground into superfine powder and use;
(18) Fel Ursi: remove clean epithelium, pulverization is used;
(19) Fel Sus domestica: after obtaining, hang-up is dried, or flattens slightly when half-dried, and is dry again;
(20) Flos Caryophylli: select the high-quality Flos Caryophylli to put and do stir-fry in the iron pan, be coke yellow or burnt brown to the surface, rare black speck;
(21) Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu profit 2 days, Winter-Spring profit 3 days is taken out section, dries;
(22) Radix Pseudostellariae: choose decontamination, clean earth, dry;
(23) Semen Cassiae: choose decontamination, sieve removes earth;
(24) Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;
(25) Herba Pteridis Multifidae: get crude drug, choose decontamination, dry;
(26) Herba Solani Nigri: get crude drug, choose decontamination, dry;
(27) Herba Dianthi: choose clean impurity, remove undesirable root, clean, stewing profit, cutting is dried;
(28) Caulis Akebiae: water soaks slightly, and moistening is to saturating, and section is dried;
(29) Herba Polygoni Avicularis: remove clean impurity and root, clean, moisten softly, cutting is dried;
(30) Fructus Toosendan: choose decontamination, clean, oven dry, grating or cleave in two;
(31) Herba Dendrobii: get exsiccant Herba Dendrobii, approximately to eighty per cant saturating, stewing profit is removed undesirable root and black branch with blister, and the thin film is hit in cutting, dries;
(32) Rhizoma Polygonati: clean earth, slightly profit is cut into slices, and dries;
(2) preparation
(1) preparation of capsule:
Pheretima with described weight, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae) Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, Rhizoma Polygonati decocts with water twice, each amount of water is advisable to cover powder, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrated, dry down at 45 ℃-50 ℃, it is ground into powder, incapsulates;
(2) preparation of tablet:
Pheretima with described weight, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae) Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, Rhizoma Polygonati decocts with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merge the extractum that twice decoction liquor is condensed into proportion 1.35, extractum added 90-95% ethanol, stir, precipitation reclaims ethanol and concentrates, dry down at 45 ℃-50 ℃, be ground into powder, add the adjuvant compacting in flakes;
(3) preparation of decocting liquid:
1. Pheretima, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae, Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, the Rhizoma Polygonati with described weight decocts with water, add for the first time 2 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling;
2. the medicinal residues after will filtering for the first time add 1.5 times of amounts of water, decoct boiling, and the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient;
(4) particulate preparation:
Pheretima with described weight, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae) Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, Rhizoma Polygonati decocts with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45 ℃-50 ℃, add adjuvant, make granule;
(5) preparation of unguentum:
Pheretima, Fructus Forsythiae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Gardenia, Radix Gentianae, Radix Scutellariae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Rehmanniae, Radix Paeoniae Rubra, Radix Et Caulis Acanthopanacis Senticosi, Radix Ilicis Pubescentis, Radix Ophiopogonis, Radix Asparagi, Herba Artemisiae Annuae, Calculus Bovis, Fel Ursi, Fel Sus domestica, Flos Caryophylli, Radix Panacis Quinquefolii, Radix Pseudostellariae, Semen Cassiae, Semen Armeniacae Amarum, Herba Pteridis Multifidae, Herba Solani Nigri, Herba Dianthi, Caulis Akebiae, Herba Polygoni Avicularis, Fructus Toosendan, Herba Dendrobii, the Rhizoma Polygonati of described weight are decocted with water twice; add for the first time 6 times of amounts of water; decocted 1.5 hours; add for the second time 4 times of amounts of water; decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum.
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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101195001A (en) * 2007-12-03 2008-06-11 门连社 Chinese medicine prescription for treating hypertension, hypercholesterolemia and hyperglycemia

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101195001A (en) * 2007-12-03 2008-06-11 门连社 Chinese medicine prescription for treating hypertension, hypercholesterolemia and hyperglycemia

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