CN101983205B - 催产素类似物 - Google Patents

催产素类似物 Download PDF

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Publication number
CN101983205B
CN101983205B CN200980111919.5A CN200980111919A CN101983205B CN 101983205 B CN101983205 B CN 101983205B CN 200980111919 A CN200980111919 A CN 200980111919A CN 101983205 B CN101983205 B CN 101983205B
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China
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compound
fmoc
manufacture
acid
medicament
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CN200980111919.5A
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English (en)
Chinese (zh)
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CN101983205A (zh
Inventor
苏达尔·阿拉加萨米
罗伯特·加雷因
卡齐米日·维希涅夫斯基
克劳迪奥·施泰加特
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Ferring BV
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Ferring BV
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN200980111919.5A 2008-03-31 2009-03-30 催产素类似物 Active CN101983205B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4097308P 2008-03-31 2008-03-31
US61/040,973 2008-03-31
EP08251739.2 2008-05-19
EP08251739 2008-05-19
PCT/IB2009/005351 WO2009122285A1 (en) 2008-03-31 2009-03-30 Oxitocin analogues

Publications (2)

Publication Number Publication Date
CN101983205A CN101983205A (zh) 2011-03-02
CN101983205B true CN101983205B (zh) 2015-08-19

Family

ID=39722695

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980111919.5A Active CN101983205B (zh) 2008-03-31 2009-03-30 催产素类似物

Country Status (20)

Country Link
US (1) US8673841B2 (enExample)
EP (2) EP2260053B1 (enExample)
JP (1) JP5539310B2 (enExample)
KR (1) KR101558404B1 (enExample)
CN (1) CN101983205B (enExample)
AU (1) AU2009233429B2 (enExample)
BR (1) BRPI0910345B1 (enExample)
CA (1) CA2718148C (enExample)
DK (1) DK2260053T3 (enExample)
ES (1) ES2488992T3 (enExample)
HR (1) HRP20140716T1 (enExample)
IL (1) IL208039A (enExample)
MX (1) MX2010010743A (enExample)
NZ (1) NZ587817A (enExample)
PL (1) PL2260053T3 (enExample)
PT (1) PT2260053E (enExample)
RU (1) RU2496788C2 (enExample)
SI (1) SI2260053T1 (enExample)
WO (1) WO2009122285A1 (enExample)
ZA (1) ZA201006733B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011147889A1 (en) 2010-05-25 2011-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of a feeding disorder with early-onset in a patient
JO3400B1 (ar) * 2010-09-30 2019-10-20 Ferring Bv مركب صيدلاني من كاربيتوسين
DK2935312T3 (en) 2012-12-21 2018-10-22 Hoffmann La Roche Peptides as oxytocin agonists
CA2949173A1 (en) * 2014-06-03 2015-12-10 Caterina Bissantz Peptides as oxytocin agonists
CR20160562A (es) * 2014-06-06 2017-01-06 Hoffmann La Roche Péptidos como agonistas de la oxitocina
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
FI3666258T3 (fi) * 2014-09-19 2024-02-09 Ferring Bv Menetelmä prader-willin oireyhtymän hoitamiseksi
CN106084015B (zh) * 2016-08-25 2020-01-31 成都圣诺生物制药有限公司 一种合成卡贝缩宫素的方法
WO2019032946A1 (en) 2017-08-11 2019-02-14 Ferring B.V. PROCESS FOR PRODUCING OXYTOCIN
WO2019030412A1 (en) * 2017-08-11 2019-02-14 Ferring B.V. PROCESS FOR PRODUCING PHARMACEUTICAL PREPARATION
CN107628975B (zh) * 2017-09-17 2019-10-29 贵州医科大学 赖氨酸衍生物类组蛋白去乙酰化酶抑制剂及其合成和应用
CN112969450B (zh) 2018-09-20 2023-05-30 阿卡蒂亚药品公司 卡贝缩宫素药物产品及用于制备其的方法
CA3112185C (en) 2018-09-20 2025-10-07 Acadia Pharmaceuticals Inc. STABLE INTRANASAL FORMULATIONS OF CARBETOCINE
WO2020137880A1 (ja) * 2018-12-27 2020-07-02 国立大学法人北海道大学 オキシトシン誘導体及びその使用
JP2023500763A (ja) * 2019-11-04 2023-01-11 フェリング ベスローテン フェンノートシャップ 泌乳の改善のためのメロトシンの鼻腔内投与
US20230265124A1 (en) * 2020-07-27 2023-08-24 Az. Bd. of Reg. on Behalf of the Univ. of Arizona Oxytocin analogues and methods for using the same
EP4313106B1 (en) 2021-03-26 2025-01-15 Ot4B Treatment of dysphagia
WO2024044633A2 (en) * 2022-08-23 2024-02-29 Seattle Children's Hospital (D/B/A Seattle Children's Research Institute) Oxytocin derivatives and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072597A1 (en) * 2002-02-27 2003-09-04 Ferring Bv Intermediates and methods for making heptapeptide oxytocin analogues

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9604341D0 (sv) * 1996-11-26 1996-11-26 Ferring Bv Hepta-peptide oxytocin analogue

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072597A1 (en) * 2002-02-27 2003-09-04 Ferring Bv Intermediates and methods for making heptapeptide oxytocin analogues

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Behavioral Effects of Intracerebroventricularly Administered Neurohypophyseal Hormone Analogs in Mice;GERHARD MEISENBERG AND WILLIAM H. SIMMONS;《Pharmacology Biochemistry & Behavior》;19821231;第16卷;819-825 *
Synthesis and Some Pharmacological Properties of [4-Threonine,7-sarcosine]oxytocin,a Peptide with High Oxytocic Potency, and of [ 4-Threonine,7-N-methylalanine]oxytocin;Zbigniew Grzonka et al;《J. Med. Chem.》;19831231;第26卷;1786-1787 *
Synthesis and Some Pharmacological Properties of Oxytocin and Vasopressin Analogues with Sarcosine or N-Met hyl-L-alanine in Position 7;Zbigniew Grzonka et al;《J. Med. Chem.》;19831231;第26卷;555-559 *

Also Published As

Publication number Publication date
MX2010010743A (es) 2010-11-04
WO2009122285A8 (en) 2009-12-10
WO2009122285A1 (en) 2009-10-08
JP2011516460A (ja) 2011-05-26
AU2009233429B2 (en) 2014-02-13
US20110044905A1 (en) 2011-02-24
KR20110005705A (ko) 2011-01-18
AU2009233429A1 (en) 2009-10-08
EP2260053B1 (en) 2014-05-14
BRPI0910345A2 (pt) 2015-10-06
IL208039A (en) 2016-03-31
EP2626364A1 (en) 2013-08-14
IL208039A0 (en) 2010-12-30
JP5539310B2 (ja) 2014-07-02
PL2260053T3 (pl) 2014-11-28
SI2260053T1 (sl) 2014-08-29
HRP20140716T1 (hr) 2014-08-29
ES2488992T3 (es) 2014-09-01
RU2496788C2 (ru) 2013-10-27
DK2260053T3 (da) 2014-06-23
RU2010139634A (ru) 2012-05-10
NZ587817A (en) 2012-05-25
PT2260053E (pt) 2014-08-29
CA2718148A1 (en) 2009-10-08
KR101558404B1 (ko) 2015-10-08
CA2718148C (en) 2017-11-07
US8673841B2 (en) 2014-03-18
HK1146064A1 (en) 2011-05-13
CN101983205A (zh) 2011-03-02
EP2260053A1 (en) 2010-12-15
BRPI0910345B1 (pt) 2021-08-17
ZA201006733B (en) 2011-06-29

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