CN101982198A - Perfusion medicinal oil for treating hysteritis of cow and preparation method thereof - Google Patents
Perfusion medicinal oil for treating hysteritis of cow and preparation method thereof Download PDFInfo
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- CN101982198A CN101982198A CN 201010519121 CN201010519121A CN101982198A CN 101982198 A CN101982198 A CN 101982198A CN 201010519121 CN201010519121 CN 201010519121 CN 201010519121 A CN201010519121 A CN 201010519121A CN 101982198 A CN101982198 A CN 101982198A
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Abstract
The invention relates to perfusion medicinal oil for treating hysteritis of a cow and a preparation method thereof, belonging to the veterinary medicine technology. The oil is prepared by the following raw materials of eucalyptus oil, turpentine oil, methylsalicylate, camphor, menthol, decanoylacetal behyde, chymotrypsin for injection and aluminum stearate, and the raw materials are adjusted to 100ml by soybean oil for injection. The preparation method comprises the following steps: weighing the raw materials; adding the eucalyptus oil, the turpentine oil, the methylsalicylate, the camphor, the menthol and the decanoylacetal behyde to 20ml of the soybean oil for injection to obtain the medicinal oil; adding the aluminum stearate to 20ml of the soybean oil for injection, and heating to 120 DEG C; stirring, dissolving and keeping the temperature for 1 hour; slowly adding 50ml of the soybean oil for injection to obtain oil glue; mixing the medicinal oil and the oil glue, and adding the soybean oil for injection for adjusting to 100ml; uniformly stirring, filtering and sterilizing under a moist heat condition at 121 DEG C; adding the chymotrypsin for injection; placing the obtained mixture in a colloid mill to be grinded into suspension; and sub-packaging to obtain the product. The medicinal oil has the advantages of strong adhesion, good medicine effect and high bioavailability.
Description
Technical field
The invention belongs to the veterinary drug technology, relate generally to metritic perfusion oil preparation of a kind of treatment milch cow and preparation method thereof.
Background technology
Metritis is one of the most common disease of milch cow, can be divided into 3 kinds of acute, chronic and recessive metritiss according to clinical symptoms, generally cause by the bacterial infection Uterus wall, if untimely treatment metritis, inflammation just diffuses to form myometritis, parametritis etc. easily, and transfer chronic inflammatory disease to, and become milch cow and join the one of the main reasons infertile, that breeding potential is low repeatly, seriously can cause death.Examination per vagina, cervix uteri is opened a business slightly, has secretions to discharge sometimes; Seriously ill person uterus secretions mostly is deep red color or brown, discharges stench, water sample vaginal discharge when lying down; Cornua uteri is bigger than normal during examination per rectum, palace wall thickness, clinical symptoms such as uterine contraction habituation.
Be vein or intramuscular injection antibiotic whole body therapeutic, uterus perfusion therapy at metritic main therapeutic modality at present.General antibiotic therapy can kill or suppress the breeding of antibacterial fast, and instant effect, but milk is because of antibiotic remains is discarded and the treatment cost is increased.Existing intrauterine perfusion therapy medicament mostly is water soluble medicament, if intrauterine has a large amount of hydrops, suppurative fragment can directly influence therapeutic effect.
Summary of the invention
The object of the present invention is to provide metritic perfusion oil preparation of a kind of treatment milch cow and preparation method thereof, this agent has the effect of cleaning suppuration wound surface, blood clot dissolving, pus and slough, anti-inflammation, blood circulation promoting and blood stasis dispelling, antipyretic-antalgic, reaches nonreactive, noresidue, good drug efficacy, purpose that bioavailability is high.
Another object of the present invention provides the preparation method of said medicine preparation.
Technical scheme of the present invention is:
The metritic perfusion oil preparation of a kind of treatment milch cow is prepared from by following materials of weight proportions:
Eucalyptus oil 0.5-2g, Oleum Terebinthinae 0.1-1g, methyl salicylate 0.5-4g, Camphora 1-4g, Mentholum 0.5-1g, houttuynine sodium bisulfite 0.1-1g, injection Chymotrypsin 0.02-0.1g, aluminium stearate 1-4g transfer to 100ml with the injection soybean oil.
The present invention also provides the preparation method of the metritic perfusion oil preparation of treatment milch cow, comprises the steps:
1. take by weighing the raw material that contains above-mentioned weight ratio; 2. eucalyptus oil, Oleum Terebinthinae, methyl salicylate, Camphora, Mentholum, houttuynine sodium bisulfite are joined in the 20ml injection soybean oil, stirring and dissolving makes patent medicine oil; 3. aluminium stearate is joined 20ml injection soybean oil, heat to 120 ℃, stir, dissolving is incubated 1 hour, slowly adds 50ml injection soybean oil again, and stirring makes into factice; 4. medicine oil and factice are mixed, add the injection soybean oil, stir to 100ml, the filtration of G3 sintered filter funnel, 121 ℃ of moist heat sterilizations 20 minutes add the injection Chymotrypsin in sterile working's mode, and insert and grind to form suspensoid in the colloid mill, packing, promptly.
Advantage of the present invention and beneficial effect are:
1. the suspendible oil preparation can be preserved the Chymotrypsin activity, uses posthydrolysis to play a role, and blood clot dissolving, pus and slough are removed the factor that blood pus hinders the drug effect performance.
2. active ingredient is Chinese medicine and traditional medicine volatile oil, and nonreactive, noresidue avoid abandoning in the therapeutic process milk loss.
3. suspendible oil preparation adhesion is strong, and Surface Permeability is strong, good drug efficacy, bioavailability height.
The specific embodiment
Below in conjunction with embodiment this bright technical scheme is described in detail.
Embodiment 1:
Take by weighing eucalyptus oil 1g, Oleum Terebinthinae 0.1g, methyl salicylate 2g, Camphora 1g, Mentholum 0.5g, houttuynine sodium bisulfite 0.2g, injection Chymotrypsin 0.04g, aluminium stearate 2g; Eucalyptus oil, Oleum Terebinthinae, methyl salicylate, Camphora, Mentholum, houttuynine sodium bisulfite are joined in the 20ml injection soybean oil, and stirring and dissolving makes patent medicine oil; Aluminium stearate is joined the 20ml injection soybean oil of getting in addition, heat to 120 ℃, stir, dissolving is incubated 1 hour, slowly adds 50ml injection soybean oil again, and stirring makes into factice; Medicine oil and factice are mixed, add the injection soybean oil and transfer to 100ml, stir, the filtration of G3 sintered filter funnel, 121 ℃ of moist heat sterilizations 20 minutes add the injection Chymotrypsin in sterile working's mode, and insert and grind to form suspensoid in the colloid mill, packing, promptly.
Embodiment 2:
Take by weighing eucalyptus oil 2g, Oleum Terebinthinae 0.1g, methyl salicylate 0.5g, Camphora 4g, Mentholum 1g, houttuynine sodium bisulfite 0.1g, injection Chymotrypsin 0.02g, aluminium stearate 1g; Eucalyptus oil, Oleum Terebinthinae, methyl salicylate, Camphora, Mentholum, houttuynine sodium bisulfite are joined in the 20ml injection soybean oil, and stirring and dissolving makes patent medicine oil; Aluminium stearate is joined the 20ml injection soybean oil of getting in addition, heat to 120 ℃, stir, dissolving is incubated 1 hour, slowly adds 50ml injection soybean oil, and stirring makes into factice; Medicine oil and factice are mixed, add the injection soybean oil and transfer to 100ml, stir, the filtration of G3 sintered filter funnel, 121 ℃ of moist heat sterilizations 20 minutes add the injection Chymotrypsin in sterile working's mode, and insert and grind to form suspensoid in the colloid mill, packing, promptly.
Embodiment 3:
Take by weighing eucalyptus oil 0.5g, Oleum Terebinthinae 1g, methyl salicylate 4g, Camphora 1g, Mentholum 0.5g, houttuynine sodium bisulfite 1g, injection Chymotrypsin 0.1g, aluminium stearate 3g; Eucalyptus oil, Oleum Terebinthinae, methyl salicylate, Camphora, Mentholum, houttuynine sodium bisulfite are joined in the 20ml injection soybean oil, and stirring and dissolving makes patent medicine oil; Aluminium stearate is joined the 20ml injection soybean oil of getting in addition, heat to 120 ℃, stir, dissolving is incubated 1 hour, slowly adds 50ml injection soybean oil, and stirring makes into factice; Medicine oil and factice are mixed, add the injection soybean oil and transfer to 100ml, stir, the filtration of G3 sintered filter funnel, 121 ℃ of moist heat sterilizations 20 minutes add the injection Chymotrypsin in sterile working's mode, and insert and grind to form suspensoid in the colloid mill, packing, promptly.
To treat the metritic Chinese medicine and western medicine compound filling agent of milch cow and carry out following test:
1, content of effective determination test:
The quality standard assay item of said preparation be chosen as houttuynine sodium bisulfite and Chymotrypsin.Adopt spectrophotometry to tire and should be 90.0%～110.0% of labelled amount.
| Lot number | Angle raw meat grass plain (labelled amount %) | Chymotrypsin (labelled amount %) |
| 080601 | 99.25 | 98.45 |
| 080602 | 99.78 | 98.36 |
| 080603 | 99.10 | 99.52 |
Above-mentioned three batches of preparations are same preparation technology embodiment product, and the production inventory is 105% of a recipe quantity.But, character reasonable by above-mentioned data product technology stablized, and can produce in batches.
2, stability test: three batches of products are packaged in by finished product under the condition of 25 ℃ ± 2 ℃ of temperature, relative humidity 60% ± 10% and placed 12 months, sampling in per 3 months once detected by stable high spot reviews project respectively at 0 month, 3 months, 6 months, 9 months, 12 months.After 12 months, carry out outward appearance, content, sterility test respectively at sampling in 18 months, 24 months.
Conclusion: character of the present invention, content detection, sterility test are all qualified, meet " People's Republic of China's veterinary drug allusion quotation 2005 editions " related request.
3, safety testing
Give the rat oral gavage administration every day with this product senior amount group 30ml/kgBW and low dose group 5ml/kgBW, in continuous 10 weeks, observe the reaction of rat physiological status.Activities in rats is normal as a result, and body weight, internal organs, blood preparation are compared no significant difference with matched group, and blood parameters does not have significant change, and the rat heart, liver, kidney, stomach are all normal through histological examination.
4, treatment purulence endometritis effect test
The inventor has carried out the therapeutic effect viewing test in Fructus Pruni forestry and animal husbandry cattle farm, Harbin to suffering from 50 of purulence endometritis.
(1) laboratory animal and grouping
Suffer from totally 50 of the milch cows of purulence endometritis, be divided into 2 groups at random, 25 of treatment groups, 25 of matched groups.
(2) test method
Adopt the dabbling dosing mode in uterus, every dispensing in 5 days 1 time, 3 times is a course of treatment, offers medicine and carries out the uterus examination per rectum in back 5 days, and the cattle of recovery from illness stops treatment, the Niu Jixu treatment of not curing.
The treatment group: preparation of the present invention pours into 50ml at every turn.
Matched group: the uterus is injected in penicillin 4,000,000 units, streptomycin 2,000,000 flat water 40mL dissolving back.
(3) criterion of cure: adopt the observation of examination per rectum and vaginal secretions to judge that the contractile response of uterus and cornua uteri is good, uterus quality softness, elasticity are good, and vaginal secretions is limpid, do not have the muddy recovery from illness that is.
(4) result of the test
| Group | Number | Cure a number | Cure rate (%) | Effective number | Effective percentage (%) | Invalid number | Inefficiency (%) |
| The treatment group | 25 | 22 | 88 | 25 | 100 | 0 | 0 |
| Matched group | 25 | 7 | 28 | 15 | 60 | 10 | 40 |
Result of the test shows that the effect of preparation for treating milch cow purulence endometritis of the present invention is better than the mycillin therapeutic effect, mainly be because matched group penicillin and streptomycin medicinal liquid is intercepted by intrauterine pus and clot, fragment of tissue, medicament can not fully affact the inflammatory surface, do not bring into play whole drug effects, and blood clot dissolving, pus and slough after the Chymotrypsin hydrolysis among the present invention, remove the factor that blood pus hinders the drug effect performance, thereby drug effect is brought into play efficiently.
Claims (2)
1. treat the metritic perfusion oil preparation of milch cow for one kind, it is characterized in that: this agent is prepared from by following proportion raw material: eucalyptus oil 0.5-2g, Oleum Terebinthinae 0.1-1g, methyl salicylate 0.5-4g, Camphora 1-4g, Mentholum 0.5-1g, houttuynine sodium bisulfite 0.1-1g, injection Chymotrypsin 0.02-0.1g, aluminium stearate 1-4g transfer to 100ml with the injection soybean oil.
2. the metritic perfusion oil preparation of an a kind of treatment milch cow as claimed in claim 1 preparation method is characterized in that this method comprises the steps: 1. to take by weighing the raw material that contains above-mentioned weight ratio; 2. eucalyptus oil, Oleum Terebinthinae, methyl salicylate, Camphora, Mentholum, houttuynine sodium bisulfite are joined in the 20ml injection soybean oil, stirring and dissolving makes patent medicine oil; 3. aluminium stearate is joined 20ml injection soybean oil, heat to 120 ℃, stir, dissolving is incubated 1 hour, slowly adds 50ml injection soybean oil again, and stirring makes into factice; 4. medicine oil and factice are mixed, add the injection soybean oil and transfer to 100ml, stir, the filtration of G3 sintered filter funnel, 121 ℃ of moist heat sterilizations 20 minutes add the injection Chymotrypsin in sterile working's mode, and insert and grind to form suspensoid in the colloid mill, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105191219A CN101982198B (en) | 2010-10-26 | 2010-10-26 | Perfusion medicinal oil for treating hysteritis of cow and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105191219A CN101982198B (en) | 2010-10-26 | 2010-10-26 | Perfusion medicinal oil for treating hysteritis of cow and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101982198A true CN101982198A (en) | 2011-03-02 |
| CN101982198B CN101982198B (en) | 2012-07-04 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103976947A (en) * | 2014-06-05 | 2014-08-13 | 段明星 | Enzyme oil suspended agent as well as preparation method and application thereof |
| CN108721611A (en) * | 2018-04-23 | 2018-11-02 | 周华锋 | A kind of hydrophobic proteins enzyme oil formulation and its preparation method and application |
| CN111671888A (en) * | 2020-08-03 | 2020-09-18 | 山东利邦牧业股份有限公司 | Composition for preventing postpartum metritis of sow |
-
2010
- 2010-10-26 CN CN2010105191219A patent/CN101982198B/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 《中国中西医结合杂志》 20070731 张翔，张建波 鱼腥草素钠灌洗治疗慢性上颌窦炎内镜术后的临床观察 661-662 1-2 第27卷, 第7期 * |
| 《中国兽医科技》 19971231 杜爱芳等 合成鱼腥草素对奶牛乳房炎致病菌的抑菌作用 37-38 1-2 第27卷, 第3期 * |
| 《浙江农业学报》 19971231 杜爱芳等 合成鱼腥草素治疗奶牛临床型乳房炎的研究 165-168 1-2 第9卷, 第3期 * |
| 《浙江农业学报》 19971231 蔡渭明等 合成鱼腥草素对牛奶中性白细胞吞噬活性的影响 315-319 1-2 第9卷, 第6期 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103976947A (en) * | 2014-06-05 | 2014-08-13 | 段明星 | Enzyme oil suspended agent as well as preparation method and application thereof |
| CN103976947B (en) * | 2014-06-05 | 2016-08-17 | 段明星 | A kind of containing enzyme oil-suspending agent and preparation method and application |
| CN108721611A (en) * | 2018-04-23 | 2018-11-02 | 周华锋 | A kind of hydrophobic proteins enzyme oil formulation and its preparation method and application |
| CN111671888A (en) * | 2020-08-03 | 2020-09-18 | 山东利邦牧业股份有限公司 | Composition for preventing postpartum metritis of sow |
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| CN101982198B (en) | 2012-07-04 |
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Granted publication date: 20120704 Termination date: 20191026 |