CN101981045B - 改进的三氯半乳蔗糖提纯方法 - Google Patents

改进的三氯半乳蔗糖提纯方法 Download PDF

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Publication number
CN101981045B
CN101981045B CN200980110920.6A CN200980110920A CN101981045B CN 101981045 B CN101981045 B CN 101981045B CN 200980110920 A CN200980110920 A CN 200980110920A CN 101981045 B CN101981045 B CN 101981045B
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China
Prior art keywords
sucralose
chloride
aqueous solution
organic solvent
acetate
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CN200980110920.6A
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Chinese (zh)
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CN101981045A (zh
Inventor
罗伯特·詹森
戈登·沃克
约翰·克尔
安东尼·巴业达
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Tate and Lyle PLC
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Tate and Lyle PLC
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200980110920.6A 2008-04-03 2009-04-01 改进的三氯半乳蔗糖提纯方法 Active CN101981045B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4206808P 2008-04-03 2008-04-03
US61/042,068 2008-04-03
PCT/US2009/039105 WO2009124116A1 (en) 2008-04-03 2009-04-01 Improved sucralose purification process

Publications (2)

Publication Number Publication Date
CN101981045A CN101981045A (zh) 2011-02-23
CN101981045B true CN101981045B (zh) 2014-12-03

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ID=40940647

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CN200980110920.6A Active CN101981045B (zh) 2008-04-03 2009-04-01 改进的三氯半乳蔗糖提纯方法

Country Status (8)

Country Link
US (1) US8497367B2 (https=)
EP (1) EP2260050B1 (https=)
JP (1) JP5496181B2 (https=)
KR (1) KR20110003516A (https=)
CN (1) CN101981045B (https=)
AR (1) AR071580A1 (https=)
TW (1) TW200946686A (https=)
WO (1) WO2009124116A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101098971B (zh) * 2004-12-10 2010-04-21 V.B.医疗保险私人有限公司 有助于从含水反应混合物中选择性萃取4,1',6'三氯半乳蔗糖的盐
GB2469157B (en) 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
CN103012509B (zh) * 2012-12-13 2015-04-15 福建科宏生物工程有限公司 一种分离提纯三氯蔗糖-6-乙酸酯母液的方法
CN109467578B (zh) * 2018-03-14 2022-01-21 刘静 一种从多重母液里提取三氯蔗糖的方法
CN112480186A (zh) * 2020-11-30 2021-03-12 安徽金禾实业股份有限公司 一种三氯蔗糖一次母液的处理方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498709A (en) * 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
US5530106A (en) * 1993-03-12 1996-06-25 Mcneil-Ppc, Inc. Recovery of sucralose intermediates
CN1526716A (zh) * 2003-09-23 2004-09-08 李宝才 单脂法合成三氯蔗糖的方法

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39710A (en) 1972-06-19 1975-04-25 Imi Inst For Res & Dev Recovery of acids from aqueous solutions by solvent extraction
DE3062467D1 (en) * 1979-12-20 1983-04-28 Tate & Lyle Plc Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose
EP0043649B1 (en) 1980-07-08 1984-09-12 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
CA1183133A (en) * 1980-10-28 1985-02-26 Tate & Lyle Public Limited Company Sweet chlorine-substituted disaccharides
GB8525871D0 (en) * 1985-10-21 1985-11-27 Tate & Lyle Plc Chemical compound
GB8525954D0 (en) * 1985-10-21 1985-11-27 Mcneilab Inc Chlorination of carbohydrates &c alcohols
GB8622345D0 (en) * 1986-09-17 1986-10-22 Tate & Lyle Plc Sucrose derivatives
US4950746A (en) * 1988-07-18 1990-08-21 Noramco, Inc. Process for synthesizing sucrose derivatives by regioselective reaction
GB8822673D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Selective acylation of sugars
GB8822674D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Preparation of acylated sucrose derivatives
NZ234143A (en) * 1989-06-28 1991-10-25 Mcneil Ppc Inc Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
US4980463A (en) 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5034551A (en) * 1990-04-23 1991-07-23 Noramco, Inc. Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
NZ240818A (en) * 1990-12-14 1993-08-26 Mcneil Ppc Inc Liquid sucralose concentrate compositions containing preservative, buffer and liquid
GB9110931D0 (en) * 1991-05-21 1991-07-10 Tate & Lyle Plc Process for the preparation of sucrose 6-esters
US5272137A (en) * 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5397588A (en) * 1992-06-18 1995-03-14 Mcneil-Ppc, Inc. Reduced calorie fruit spreads
US5270071A (en) * 1992-06-18 1993-12-14 Mcneil-Ppc, Inc. Reduced calorie fruit spreads
US5354902A (en) * 1992-10-26 1994-10-11 Mcneil-Ppc, Inc. Stabilized sorbic acid or salt thereof
CA2110313C (en) * 1992-12-01 2004-10-26 Edward John Roche Pharmaceutical compositions containing a guanidinothiazole compound and antacids
IL108340A (en) * 1993-03-04 1996-10-16 Innova Sa Citric acid extraction
US5298611A (en) * 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production
CA2121435C (en) * 1993-04-16 2002-01-22 Sheila M. Ratnaraj Aqueous pharmaceutical suspension and process for preparation thereof
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
US5674522A (en) * 1993-10-07 1997-10-07 Mcneil-Ppc, Inc. Beverage concentrate for drug delivery
US5593696A (en) * 1994-11-21 1997-01-14 Mcneil-Ppc, Inc. Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders
US5902628A (en) * 1996-11-14 1999-05-11 Pepsico., Inc. Beverage with reduction of lingering sweet aftertaste of sucralose
EP0970096B1 (en) * 1997-02-13 2004-11-10 Tate & Lyle Public Limited Company Chromatographic purification of chlorinated sucrose
AU753587B2 (en) * 1997-11-14 2002-10-24 Johnson & Johnson Consumer Companies, Inc. Highly flavored dental floss
TR200100345T2 (tr) * 1998-07-07 2001-08-21 Mcneil Specialty Products Company, Division Of Mcneil- Sükraloza tat vermenin geliştirilmesine ilişkin metod
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
US6090401A (en) * 1999-03-31 2000-07-18 Mcneil-Ppc, Inc. Stable foam composition
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6258381B1 (en) * 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
US6277409B1 (en) * 2000-02-11 2001-08-21 Mcneil-Ppc, Inc. Protective coating for tablet
GB2365424B (en) * 2000-07-31 2002-06-26 Tate & Lyle Plc An improved method for the synthesis of sucrose-6-esters
CN1294139C (zh) * 2000-11-17 2007-01-10 塔特和莱利有限公司 改进的三氯蔗糖组合物及其制备方法
US6926810B2 (en) 2001-03-15 2005-08-09 A. E. Staley Manufacturing Co. Process for obtaining an organic acid from an organic acid ammonium salt, an organic acid amide, or an alkylamine organic acid complex
US6984293B2 (en) * 2001-03-15 2006-01-10 Tate & Lyle Ingredients Azeotropic distillation of cyclic esters of hydroxy organic acids
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US7049435B2 (en) * 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040030124A1 (en) * 2002-08-06 2004-02-12 Catani Steven J. Process for recovering chlorosucrose compounds
DE10260085A1 (de) 2002-12-19 2004-07-01 Basf Ag Verfahren zum Extrahieren von 2-Keto-L-gulonsäure (KGS) aus einem polaren, vorzugsweise wässrigen Lösungsmittel
WO2004056841A1 (de) * 2002-12-19 2004-07-08 Basf Aktiengesellschaft Verfahren zum extrahieren von 2-keto-l-gulonsäure (kgs) aus einem polaren, vorzugsweise wässrigen lösungsmittel
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
US6723877B1 (en) * 2003-06-16 2004-04-20 Air Products And Chemicals, Inc. Dimethylformamide synthesis via reactive distillation of methyl formate and dimethylamine
EA200601742A1 (ru) 2004-03-19 2007-02-27 Фармед Медикэр Прайвит Лимитед Усовершенствованный способ производства хлорированной сахарозы
WO2005090376A1 (en) 2004-03-19 2005-09-29 Pharmed Medicare Private Limited An improved process for producing chlorinated sucrose
GB2437442B (en) * 2004-12-10 2010-03-31 Pharmed Medicare Pvt Ltd Improved process for purification of 6 acetyl 4,1',6' trichlorogalactosucrose and 4,1'6' trichlorogalactosucrose by chromatography on silanized silica gel
CN101098971B (zh) 2004-12-10 2010-04-21 V.B.医疗保险私人有限公司 有助于从含水反应混合物中选择性萃取4,1',6'三氯半乳蔗糖的盐
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US20060205936A1 (en) * 2005-03-14 2006-09-14 Sl Laboratories, Llc Chlorination of Sucrose-6-esters
US20060276639A1 (en) 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
CN102124017A (zh) 2005-06-01 2011-07-13 V.B.医疗保险私人有限公司 利用溶剂萃取法纯化氯化蔗糖衍生物的方法
US20100197906A1 (en) 2005-06-06 2010-08-05 Pharmed Medicare Private Limited Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography
US7951937B2 (en) 2005-08-30 2011-05-31 V.B. Medicare Private Limited Process for purification of trichlorogalactosucrose based on direct extraction in organic solvent from reaction mixture followed by evaporative removal of solvent
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN100418976C (zh) * 2006-04-03 2008-09-17 广州科宏食品添加物有限公司 一种三氯蔗糖的制备方法
AU2006345862A1 (en) 2006-07-06 2008-01-10 Alembic Limited An improved process for the preparation of Sucralose of high purity
US20080227971A1 (en) 2007-01-19 2008-09-18 Leinhos Duane A Deacylation of sucralose-6-acylates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530106A (en) * 1993-03-12 1996-06-25 Mcneil-Ppc, Inc. Recovery of sucralose intermediates
US5498709A (en) * 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
CN1526716A (zh) * 2003-09-23 2004-09-08 李宝才 单脂法合成三氯蔗糖的方法

Also Published As

Publication number Publication date
US20090299054A1 (en) 2009-12-03
US8497367B2 (en) 2013-07-30
AR071580A1 (es) 2010-06-30
CN101981045A (zh) 2011-02-23
JP2011516491A (ja) 2011-05-26
EP2260050B1 (en) 2014-09-17
JP5496181B2 (ja) 2014-05-21
EP2260050A1 (en) 2010-12-15
WO2009124116A1 (en) 2009-10-08
TW200946686A (en) 2009-11-16
KR20110003516A (ko) 2011-01-12

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