CN101978983B - Chinese medicinal composition for treating acute upper respiratory infection and preparation method thereof - Google Patents
Chinese medicinal composition for treating acute upper respiratory infection and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating acute upper respiratory infection and a preparation method thereof, belongs to the technical field of Chinese medicaments, and aims to provide a medicament for treating acute upper respiratory infection with effects of expelling wind, relieving superficies, clearing heat and detoxifying. The Chinese medicament is a preparation prepared from the following Chinese medicinal raw materials in percentage by weight: 8 to 30 percent of incised notopterygium rhizome, 12 to 48 percent of sweet wormwood herb, 12 to 48 percent of pubescent holly root, 12 to 48 percent of native achyranthes root, 10 to 32 percent of rough-haired holly root and 10 to 32 percent of south indigowoad root. The preparation method comprises the following steps of: (1) weighing the raw materials in percentage by weight for later use; (2) decocting the raw materials for two times by adding water, filtering the decoction, combining two times of filtrate, and concentrating the combined filtrate into thin paste I with relative density of 1.10 to 1.12 at 60 DEG C; and (3) adding ethanol into the thin paste I till the ethanol content is 65 percent, standing the mixture over night, taking the supernatant, concentrating the supernatant into thin paste II with relative density of 1.30 to 1.40 at 60 DEG C under reduced pressure, and then preparing the thin paste II into the proper Chinese medicinal preparation. The Chinese medicament is used for treating the acute upper respiratory infection.
Description
Technical field
The present invention relates to a kind of Chinese medicine, more particularly, it relates to a kind of Chinese medicine composition that is used to treat acute upper respiratory tract infection, the invention still further relates to the method for preparing of above-mentioned Chinese medicine composition.
Background technology
Acute upper respiratory tract infection (AURTI) is meant the general title of nasal cavity, pharynx or acute throat inflammation, is modal a kind of respiratory infectious disease.The patient is of all ages, sex, occupation and regional.Primary disease not only has stronger infectiousness, but also can cause severe complication, should actively prevent and treat.Primary disease all can be fallen ill the whole year, is the high-incidence season with the winter-spring season, and mostly it can be to distribute through the spittle or contaminated hands and the apparatus propagation that contains virus, but can be popular when abrupt change of climate.Because the type of virus is more, the immunity that human body produces after to various viral infection is more weak and of short duration, does not have cross immunity, simultaneously the virus carrier is arranged in healthy population, falls ill so a people can have in 1 year repeatedly.As risk factors such as suffering from cold, drench with rain, be overtired; When whole body or respiratory tract local defense function are reduced; Former virus or the antibacterial that has been present in upper respiratory tract or has invaded from the external world can breed rapidly; Cause primary disease, especially old germling is weak or chronic respiratory tract disease such as nasosinustis, tonsillitis person are arranged, and more is prone to suffer from.
Primary disease has 70-80% to be caused by virus approximately, and minority causes by antibacterial, mainly contains influenza virus (first, second, third), parainfluenza virus, respiratory tract and closes spore virus, adenovirus, rhinovirus, echovirus, Coxsackie virus, Measles virus, rubella virus etc.Bacterial infection can directly or after viral infection take place, and for seeing, is hemophilus influenza, streptococcus pneumoniae and staphylococcus etc. with Hemolytic streptococcus secondly more.Accidental gram negative bacilli.Its infection mainly show as rhinitis, pharyngolaryngitis or tonsillitis etc.Can concurrent acute sinusitis, otitis media, tracheitis and bronchitis, but part patient also secondary rheumatism, glomerulonephritis and myocarditis etc., so should attract great attention.
Modern medicine does not still have special antiviral drugs for upper respiratory tract infection, how with anti symptom treatment, have a rest, quit smoking, polydipsia water, to keep the room air circulation, prevent and treat the secondary bacterial infection be main.Symptomatic treatment can be selected antipyretic-antalgic for use and reduce the congested anti-flu complexing agent with secretions of nasopharynx as being main to acetamido phenol (acetaminophen), the numb sheet class medicine of bis-phenol puppet etc.; Bacterial infection is arranged, can select responsive antibacterials for use according to pathogen, medicines such as penicillin, first generation cephalosporin, Macrolide or quinolones are often selected in the experience medication for use.
Chinese medicine has complicated component but few side effects, the medicine source is abundant, cheap and action target spot is many characteristics.And pay attention to pathogen-body-Chinese medicine three's determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs relation; Pathogen is a purpose in the body to remove; Improve the animal economy state simultaneously; Particularly can have the virus replication of inhibition, stop pathological changes caused by virus, regulate immunologic function through transferring the ability that body specificity and non-specific immunity strengthen antiviral, bacterial-infection resisting, comprehensive effect such as analgesic, analgesia, antiinflammatory.
The Chinese medicine of resisiting influenza virus is main with heat-clearing and detoxifying herb; To the existing more research of the Chinese medicine of this type; Confirm that it has preferably directly antivirus action; Single medicinal material has Folium Isatidis, Radix Isatidis, Fructus Forsythiae, Rhizoma Osmundae, Herba Houttuyniae etc., and it is main with heat and toxic materials clearing away medicine also that the medicine of compound recipe is formed, like Lonicerae and Forsythiae Powder, the clear pestilence capsule of Flos Nelumbinis etc.Though every flavor Chinese medicine constituent more complicated; The Chinese medicinal formulae mechanism of action is also more complicated; But Chinese herbal medicine resisiting influenza virus approach mainly contains two: directly suppress virus 1.: the absorption of blocking virus reproductive process, penetrate, duplicate, a certain link in the maturation, thereby reach the purpose of viral infection resisting.At present the more clearly composition to the mechanism research of Chinese herbal medicine viral infection resisting has two types: the one, and polyphenols proves that it can suppress influenza virus protein matter and synthesize with RNA, the while also can be suppressed the adsorption of influenza virus; Another kind of is Flavonoid substances, and its mechanism is to suppress the activity and the film fusion of influenza virus sialidase.2. indirectly suppress virus: Chinese herbal medicine has immunosuppressive action, can improve the defensive enginery of body, thereby reaches the effect of " healthy energy deposit in, heresy can not be done ".
Summary of the invention
The purpose of this invention is to provide a kind of have expelling pathogenic wind from the body surface, heat-clearing toxin-expelling functions, be used to treat the Chinese medicine composition of acute upper respiratory tract infection.
Another object of the present invention provides a kind of method for preparing of above-mentioned Chinese medicine composition.
Last technical scheme of the present invention is such: a kind of Chinese medicine composition of treating acute upper respiratory tract infection is the medicament of being processed by the raw material of Chinese medicine of following weight percentage ratio: Rhizoma Et Radix Notopterygii 8～30%, Herba Artemisiae Annuae 12～48%, Radix Ilicis Pubescentis 12～48%, Radix Achyranthis 12～48%, Radix Ilicis Asprellae 10～32%, Rhizoma Et Radix Baphicacanthis Cusiae 10～32%.
Further; In above-mentioned a kind of Chinese medicine composition of treating acute upper respiratory tract infection, the percentage by weight of said raw material of Chinese medicine is good with following ratio: Rhizoma Et Radix Notopterygii 10～18%, Herba Artemisiae Annuae 14～28%, Radix Ilicis Pubescentis 14～28%, Radix Achyranthis 14～28%, Radix Ilicis Asprellae 12～24%, Rhizoma Et Radix Baphicacanthis Cusiae 12～24%.
In above-mentioned a kind of Chinese medicine composition of treating acute upper respiratory tract infection, described medicament can be the common formulations in the important preparation, like any one of tablet, granule, pellet, oral liquid or capsule etc.; But with oral liquid or granule is good, and particularly granule is better.
The Rhizoma Et Radix Notopterygii acrid in the mouth is bitter, warm in nature in the present invention's prescription, expelling pathogenic wind from the body surface, removing damp and stopping pain; Herba Artemisiae Annuae clearing up internal heat by using drugs of bitter in taste and cold in nature, Xin Xiang pass through and loose, and have good analgesic antipyretic effect, are usually used in fever caused by exogenous pathogens.Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae compatibility, just in because the pathogenesis of diseases such as the upper respiratory tract infection finding fever with chills due to the wind heat, pathogenic wind-warm, pyretic toxicity etc., systemic pain, so be monarch drug.Radix Ilicis Pubescentis bitter in the mouth, cold in nature, heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Radix Achyranthis sweet-bitter flavor, property are put down, and pharynx-clearing throat-benefiting, heat-clearing and toxic substances removing, swelling diuretic, dissipating blood stasis dispel the wind.Radix Ilicis Pubescentis and Radix Achyranthis two medicines can be assisted monarch drug, and treatment is because diseases such as the heating that primary disease causes due to the pathogenic wind-warm, wind heat, pyretic toxicity, laryngopharynx swelling and pain, dry mouth with bitter taste, so be ministerial drug.Radix Ilicis Asprellae bitter in the mouth, property are sweet cold, heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, relieving sore throat and diminishing swelling; Rhizoma Et Radix Baphicacanthis Cusiae bitter in the mouth, cold in nature, heat clearing away, detoxifcation, removing heat from blood; Radix Ilicis Asprellae and Rhizoma Et Radix Baphicacanthis Cusiae can assist to strengthen the effect of monarch drug, ministerial drug heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling, are adjuvant.More than all medicines share, can be directed against the basic pathogenesis of primary disease wind, temperature, heat, poison, select medicine to take into account tradition and strong south of the Five Ridges characteristic, dredge, separate, clearly, sharp and usefulness, be total to long memorial wind, induce sweat, the merit of heat clearing away, detoxifcation, can obtain good effect so treat acute upper respiratory tract infection.
Back of the present invention one technical scheme is such: a kind of method for preparing of treating the Chinese medicine composition of acute upper respiratory tract infection may further comprise the steps:
(1) above-mentioned Six-element medical material is weighed by raw material percentage ratio, and is subsequent use;
(2) the medical material decocte with water is 2 times, and decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I;
(3) in clear paste I, adding ethanol is 65% to containing the alcohol amount; Hold over night; Get supernatant; Concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II, and clear paste II according to handle the adjuvant commonly used that this kind preparation is added in the back without the requirement of preparation, is processed granule or oral liquid or pellet or capsule or tablet at last.
Further, in the method for preparing of above-mentioned a kind of Chinese medicine composition of treating acute upper respiratory tract infection, add 8 times of water yields for the first time during decoction described in the step (2), add 6 times of water yields for the second time, decocted 1 hour at every turn.
Above-mentioned Chinese medicine composition of the present invention is a clinical proved recipe; Be used to treat acute upper respiratory tract infection; Disease is seen heating, aversion to cold, laryngopharynx swelling and pain, systemic pain, cough, watery nasal discharge, xerostomia, headache person, and its main pathogenesis is pathogenic wind-warm, pyretic toxicity, and method of treatment is expelling pathogenic wind from the body surface, heat-clearing and toxic substances removing.The south of the Five Ridges genuine medicinal materials Radix Achyranthis of the selected tool antipyretic and antidote functions of prescription, Radix Ilicis Asprellae, Rhizoma Et Radix Baphicacanthis Cusiae, Radix Ilicis Pubescentis; Compatibility Rhizoma Et Radix Notopterygii, Herba Artemisiae Annuae expelling pathogenic wind from the body surface, its determined curative effect, preparation technology is easy to stable uniform simultaneously; Quality controllable, meet the developing direction of modernization of cmm.
Positive beneficial effect of the present invention is: the Chinese medicine composition of treatment acute upper respiratory tract infection of the present invention is to the basic pathogenesis of wind, temperature, heat, poison; Select medicine to take into account tradition and strong south of the Five Ridges characteristic; Dredge, separate, clearly, sharp and use; Be total to the merit of long memorial wind, relieving exterior syndrome, heat-clearing and toxic substances removing, the preparation of the Chinese medicine composition of treatment acute upper respiratory tract infection of the present invention has the taking convenience of carrying, quality controllable, eutherapeutic characteristics.
The specific embodiment
Mode through embodiment further specifies the present invention below, but does not therefore limit the present invention among the described embodiment.
A kind of Chinese medicine composition of treating acute upper respiratory tract infection of the present invention; The medicament that the raw material of Chinese medicine of employing following weight percentage ratio is processed all has curative effect preferably: Rhizoma Et Radix Notopterygii 8～30%, Herba Artemisiae Annuae 12～48%, Radix Ilicis Pubescentis 12～48%, Radix Achyranthis 12～48%, Radix Ilicis Asprellae 10～32%, Rhizoma Et Radix Baphicacanthis Cusiae 10～32%.
The method of preparation comprises the steps:
(1) above-mentioned Six-element medical material is weighed by raw material percentage ratio, and is subsequent use;
(2) the medical material decocte with water is 2 times, and decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I;
(3) in clear paste I, adding ethanol is 65% to containing the alcohol amount; Hold over night; Get supernatant; Concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II, and clear paste II according to handle the adjuvant commonly used that this kind preparation is added in the back without the requirement of preparation, is processed granule or oral liquid or pellet or capsule or tablet at last.
Wherein:
A. the preparation of granule
Clear paste II carries out drying, is ground into fine powder, adds adjuvant, processes granule, and drying is used the compositing aluminium bag packing, promptly gets.
B. the preparation of oral liquid
Clear paste II thin up adds antiseptic commonly used and correctives again, supplies full dose with water and processes oral liquid.
C. the preparation of pellet
Clear paste II carries out drying, dried cream powder, suitable excipients pulverize separately are become fine powder after, mix in proportion, place the micropill machine, starting device adds an amount of second alcohol and water, extrudes suitable wet granular, and is round as a ball, drying, the screening, promptly get micropill.
D. the preparation of capsule
Clear paste II carries out drying, is ground into fine powder, adds suitable excipients, processes granule, incapsulates, and promptly gets.
E. the preparation of tablet
Clear paste II carries out drying, and the powder that gets dry extract is pulverized, and adds appropriate amount of auxiliary materials, processes granule, drying, and tabletting, packing again behind slice, thin piece packing or the bag film-coat promptly gets.
One of preparation of embodiment 1 granule
Raw medicinal material prescription: Rhizoma Et Radix Notopterygii 160g, Herba Artemisiae Annuae 960g, Radix Ilicis Pubescentis 240g, Radix Achyranthis 240g, Radix Ilicis Asprellae 200g, Rhizoma Et Radix Baphicacanthis Cusiae 200g.
Method for preparing:
(1) decocte with water of Six-element medical material is 2 times, adds 8 times of water yields for the first time, adds 6 times of water yields for the second time, decocts 1 hour at every turn;
(2) decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I;
(3) in clear paste I, adding ethanol is 65% to containing the alcohol amount, and hold over night is got supernatant, and concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II;
(4) clear paste II carries out drying, is ground into fine powder, adds adjuvant, processes granule, and drying is used the compositing aluminium bag packing, promptly gets.
The specification of the granule that makes is: the 8g/ bag.Usage and dosage is: oral, one time 1 bag, 3 times on the one.
Two of the preparation of embodiment 2 granules
Raw medicinal material prescription: Rhizoma Et Radix Notopterygii 200g, Herba Artemisiae Annuae 300g, Radix Ilicis Pubescentis 300g, Radix Achyranthis 300g, Radix Ilicis Asprellae 240g, Rhizoma Et Radix Baphicacanthis Cusiae 240g.
Method for preparing is with embodiment 1.
Three of the preparation of embodiment 3 granules
Raw medicinal material prescription: Rhizoma Et Radix Notopterygii 360g, Herba Artemisiae Annuae 360g, Radix Ilicis Pubescentis 300g, Radix Achyranthis 280g, Radix Ilicis Asprellae 240g, Rhizoma Et Radix Baphicacanthis Cusiae 300g.
Method for preparing is with embodiment 1.
Four of the preparation of embodiment 4 granules
Raw medicinal material prescription: Rhizoma Et Radix Notopterygii 320g, Herba Artemisiae Annuae 400g, Radix Ilicis Pubescentis 500g, Radix Achyranthis 280g, Radix Ilicis Asprellae 240g, Rhizoma Et Radix Baphicacanthis Cusiae 260g.
Method for preparing is with embodiment 1.
The preparation of embodiment 5 oral liquids
Prescription by embodiment 1 takes by weighing the Six-element medical material, and decocte with water 2 times adds 8 times of water yields for the first time, adds 6 times of water yields for the second time, decocts 1 hour at every turn; Decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I; In clear paste I, adding ethanol is 65% to containing the alcohol amount, and hold over night is got supernatant, and concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II; Clear paste II thin up adds antiseptic commonly used and correctives again, supplies full dose with water and processes oral liquid.
The preparation of embodiment 6 micropills
Prescription by embodiment 1 takes by weighing the Six-element medical material, and decocte with water 2 times adds 8 times of water yields for the first time, adds 6 times of water yields for the second time, decocts 1 hour at every turn; Decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I; In clear paste I, adding ethanol is 65% to containing the alcohol amount, and hold over night is got supernatant, and concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II; Clear paste II carries out drying, dried cream powder, suitable excipients pulverize separately are become fine powder after, mix in proportion, place the micropill machine, starting device adds an amount of second alcohol and water, extrudes suitable wet granular, and is round as a ball, drying, the screening, promptly get micropill.
The preparation of embodiment 7 capsules
Prescription by embodiment 1 takes by weighing the Six-element medical material, and decocte with water 2 times adds 8 times of water yields for the first time, adds 6 times of water yields for the second time, decocts 1 hour at every turn; Decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I; In clear paste I, adding ethanol is 65% to containing the alcohol amount, and hold over night is got supernatant, and concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II; Clear paste II carries out drying, is ground into fine powder, adds suitable excipients, processes granule, incapsulates, and promptly gets.
The specification of the capsule that makes is: the 0.3g/ grain.Usage and dosage is: oral, one time 3,3 times on the one.
The preparation of embodiment 8 tablets
Prescription by embodiment 1 takes by weighing the Six-element medical material, and decocte with water 2 times adds 8 times of water yields for the first time, adds 6 times of water yields for the second time, decocts 1 hour at every turn; Decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I; In clear paste I, adding ethanol is 65% to containing the alcohol amount, and hold over night is got supernatant, and concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II; Clear paste II carries out drying, and the powder that gets dry extract is pulverized, and adds appropriate amount of auxiliary materials, processes granule, drying, and tabletting, packing again behind slice, thin piece packing or the bag film-coat promptly gets.
The specification of the tablet that makes is: the 0.3g/ sheet.Usage and dosage is: oral, one time 3,3 times on the one.
Experimental example 1
Chinese medicine composition of the present invention is to the influence of rabbit heating due to the Typhoid-Paratyphoid triple vaccine
Select healthy rabbits; Preliminary election body temperature in 38.0～39.5 ℃ of scopes and every day fluctuation be no more than 0.2 ℃ 30 of new zealand rabbits; Earlier surveyed the animal basal body temperature 2 times the same day, its average as pyrogenicity before normal value, by ear vein injection Typhoid-Paratyphoid vaccine 0.5ml/kg; Select behind the 1h its body temperature rise more than 1.0 ℃ the person be divided into Chinese medicine composition high dose group of the present invention, middle dose groups, low dose group, positive controls and blank group at random; Every group 6, gastric infusion 5ml/kg, the blank group is given and is waited the capacity normal saline.Every after the administration at a distance from 1 body temperature of 1h measurement, survey altogether 6 times.Chinese medicine composition of the present invention as a result has significant antipyretic effect to rabbit heating due to the Typhoid-Paratyphoid three mattress Seedlings, sees table 1.
Table 1 Chinese medicine composition of the present invention is to the influence
of rabbit heating due to the triple vaccine
Annotate: compare with the normal saline group,
*P＜0.05,
*P＜0.01; The t check.
Experimental example 2
Chinese medicine composition of the present invention is to the influence of thermostimulation induced mice pain
Choose 75 of the male mice of the basic threshold of pain between 5～30s (from mice is placed hot plate temperature be 55 ± 0.5 ℃ go up to time that mice begins to lick metapedes as the basic threshold of pain) be divided into 5 groups at random, i.e. blank group, positive controls, the high, medium and low dose groups of Chinese medicine composition of the present invention are irritated stomach and are given corresponding medicine for every group then; The blank group gives isometric normal saline; Every day 1 time, the administration volume is 10ml/kg, for three days on end; Behind last administration 1.0, the 2.0h; Measure the mice threshold of pain, and calculate the threshold of pain and improve percentage rate, relatively each group difference.Percentage rate=(threshold of pain behind the medicine-basic the threshold of pain)/basic threshold of pain * 100% is improved in the threshold of pain, and Chinese medicine composition of the present invention as a result can obviously improve the mice pain threshold that hot plate causes, sees table 2.
Table 2 Chinese medicine composition of the present invention is to the influence of thermostimulation induced mice pain (`X ± S)
Annotate: compare with the normal saline group, * P 0.05, * * P < 0.01; The t check.
Experimental example 3
The influence of xylol induced mice auricle edema
Get 75 of NIH mices, body weight 18 ~ 22g, male, be divided into 5 groups at random, i.e. blank group, positive drug matched group, the high, medium and low dose groups of Chinese medicine composition of the present invention.Every group of filling stomach gives corresponding medicine then, and the blank group gives isometric normal saline, every day 1 time; For three days on end, behind the last administration 1h, 50 μ l drip in the mouse right ear two sides with xylene; Left side ear is not coated with and compares, and behind 0.5 h mice is taken off cervical vertebra and puts to death, and lays round auricle at the same position of left and right ear respectively with diameter 6mm card punch; Accurate weighing, with the difference of left and right auricle weight as the swelling degree, each group difference relatively.The result shows that Chinese medicine composition of the present invention can suppress xylene induced mice auricle inflammatory swelling, sees table 3.
The influence of table 3 Chinese medicine composition xylol of the present invention induced mice auricle edema (`X ± S)
Annotate: compare with the normal saline group, * P 0.05, * * P < 0.01
Experimental example 4
The characteristic case
Case 1
Chen, the man, 7 years old, infant continued hyperpyrexia 5 days, companion's aversion to cold, headache, dry pharynx, red tongue, yellow fur, floating and rapid pulse.After treated with intravenous drips such as ceftizoxime, virazoles the outer court, the state of an illness did not have obvious improvement, health check-up: 39.5 ℃ of body temperature; Pharyngeal congestion, bilateral amygdala silght enlargement, haemanalysis: WBC6.4X10e9/L; Neutrality 0.53, lymphocyte 0.44, the conducting lung X-ray examination inspection is no abnormal; Western medicine diagnose is a viral upper respiratory tract infection, and Chinese medical discrimination is a pathogenic wind-warm.With expelling pathogenic wind from the body surface, heat-clearing and toxic substances removing is method.With Rhizoma Et Radix Notopterygii 5g, Herba Artemisiae Annuae 8g, Radix Ilicis Pubescentis 8g, Radix Achyranthis 8g, Radix Ilicis Asprellae 8g, Rhizoma Et Radix Baphicacanthis Cusiae 8g, give three doses of tops, every day, potion was decocted in water for oral dose twice.It is quiet and pacify that infant heat is moved back body behind three doses of the clothes tops.
Case 2
Infant, the woman, 3 years old, main cause 3 d that generate heat went to a doctor.Infant heating 3d, body temperature fluctuates at 37～39 ℃, the wake tears, sneeze, cough, the head of a family is from giving treatments such as " Merrill Lynch ", " BANLANGEN CHONGJI ", and temporary transient heat is stepped back recurrence.The back, still generates heat with cephalo-type and quiet 2 d of SHUANGHUANLIAN to the outer court, and body temperature rises to 39.8 ℃.Have a medical check-up: pharyngeal congestion (++ ++), the enlargement of tonsil I degree; Routine blood test: WBC 3.3 * 10e9/L, granulocyte percentage ratio 0.285, neutrophil cell percentage ratio 0.178, lymphocyte percentage ratio 0.537.Be diagnosed as viral upper respiratory tract infection.Chinese medical discrimination is an anemopyretic cold.With Rhizoma Et Radix Notopterygii 3g, Herba Artemisiae Annuae 5g, Radix Ilicis Pubescentis 5g, Radix Achyranthis 5g, Radix Ilicis Asprellae 5g, Rhizoma Et Radix Baphicacanthis Cusiae 5g, after the top was taken two doses, all cards disappeared clinical cure.
Case 3
The week certain, the man, 48 years old, generated heat 1 day, aversion to wind, slight headache, flushing, thirsty, the time cough is arranged, indigestion and loss of appetite, dry stool yellowish urine, red tongue with thin and yellow fur, floating and rapid pulse.Body is looked into: T38.8 ℃, and pharyngeal congestion, the cardiopulmonary inspection is no abnormal, routine blood test: WBC5.2X10e9/L, N:0.51, L:0.49.Western medicine diagnose is a upper respiratory tract infection, and Chinese medical discrimination is that the epidemic febrile disease heresy is being defended branch.Give Rhizoma Et Radix Notopterygii 10g, Herba Artemisiae Annuae 10g, Radix Ilicis Pubescentis 15g, Radix Achyranthis 15g, Radix Ilicis Asprellae 15g, Rhizoma Et Radix Baphicacanthis Cusiae 12g.Take medicine after twice, patient's sweating is more, and body temperature gradually falls, and body temperature is reduced to normally behind the 24h, no headache, and cough disappears basically, and is just smooth, and recovery from illness after 2 doses continues to take medicine.
Case 4
Gong, the women, 42 years old, heating, pharyngalgia, itching throat, cough 4 days, obvious when pharyngalgia is swallowed, the itching throat QI rising in reverse order is then coughed, and expectorant is yellow turbid and amount is many, and xerostomia is bitter, red tongue with yellowish and greasy fur, slippery and rapid pulse.Health check-up: 38.9 ℃ of body temperature, the enlargement of bilateral amygdala II degree is also suppurated.Western medicine diagnose: suppurative tonsillitis.Chinese medical discrimination: wind-heat invading the lung.With expelling pathogenic wind from the body surface, heat-clearing and toxic substances removing is method.With Rhizoma Et Radix Notopterygii 10g, Herba Artemisiae Annuae 15g, Radix Ilicis Pubescentis 30g, Radix Achyranthis 20g, Radix Ilicis Asprellae 20g, Rhizoma Et Radix Baphicacanthis Cusiae 30g, take medicine that the heating of patient's pharyngalgia obviously alleviates after 1 dose, cough takes a turn for the better.The patient does not have cough, no pharyngalgia itching throat after 4 doses, and body temperature is normal.
Case 5
Liu, the male, 22 years old, the back fever aversion to cold of drenching with rain, 38.6 ℃, generalized muscle ache and weakness, cough, the expectorant yellow sputum is thick, bitter taste, yellowish urine.Red tongue with yellow fur, slippery and rapid pulse.From clothes Bufferin Cold, Amoxicillin Capsules etc., unsatisfactory curative effect.Chinese medical discrimination is an anemopyretic cold.With expelling pathogenic wind from the body surface, heat-clearing and toxic substances removing is method.With Rhizoma Et Radix Notopterygii 15g, Herba Artemisiae Annuae 15g, Radix Ilicis Pubescentis 30g, Radix Achyranthis 15g, Radix Ilicis Asprellae 15g, Rhizoma Et Radix Baphicacanthis Cusiae 30g, take medicine and cure after 3 doses.
Claims (6)
1. a Chinese medicine composition of treating acute upper respiratory tract infection is characterized in that the medicament of being processed by the raw material of Chinese medicine of following weight percentage ratio: Rhizoma Et Radix Notopterygii 8～30%, Herba Artemisiae Annuae 12～48%, Radix Ilicis Pubescentis 12～48%, Radix Achyranthis 12～48%, Radix Ilicis Asprellae 10～32%, Rhizoma Et Radix Baphicacanthis Cusiae 10～32%.
2. a kind of Chinese medicine composition of treating acute upper respiratory tract infection according to claim 1; It is characterized in that the percentage by weight of said raw material of Chinese medicine is: Rhizoma Et Radix Notopterygii 10～18%, Herba Artemisiae Annuae 14～28%, Radix Ilicis Pubescentis 14～28%, Radix Achyranthis 14～28%, Radix Ilicis Asprellae 12～24%, Rhizoma Et Radix Baphicacanthis Cusiae 12～24%.
3. a kind of Chinese medicine composition of treating acute upper respiratory tract infection according to claim 1 is characterized in that, described medicament is any one in tablet or granule or pellet or oral liquid or the capsule.
4. a kind of Chinese medicine composition of treating acute upper respiratory tract infection according to claim 3 is characterized in that described medicament is oral liquid or granule.
5. the arbitrary described a kind of method for preparing of treating the Chinese medicine composition of acute upper respiratory tract infection of claim 1 to 3 is characterized in that may further comprise the steps:
(1) above-mentioned Six-element medical material is weighed by raw material percentage ratio, and is subsequent use;
(2) the medical material decocte with water is 2 times, and decoction liquor filters, and merges filtrating twice, and being condensed into and recording relative density at 60 ℃ is 1.10～1.12 clear paste I;
(3) in clear paste I, adding ethanol is 65% to containing the alcohol amount; Hold over night; Get supernatant; Concentrating under reduced pressure becomes that to record relative density at 60 ℃ be 1.30～1.40 clear paste II, and clear paste II is handled the adjuvant commonly used that this kind preparation is added in the back according to the requirement of different preparations, processes granule or oral liquid or pellet or capsule or tablet at last.
6. a kind of method for preparing of treating the Chinese medicine composition of acute upper respiratory tract infection according to claim 5 is characterized in that, adds 8 times of water yields during decoction described in the step (2) for the first time, adds 6 times of water yields for the second time, decocts 1 hour at every turn.
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| DE202011103697U1 (en) * | 2011-07-25 | 2012-11-15 | Ottmar W. Geiger | Compositions of the plant Artemisia annua |
| CN104324072A (en) * | 2014-10-20 | 2015-02-04 | 四川金堂海纳生物医药技术研究所 | Oral medicine for treating postoperative pain of tonsils and preparation method thereof |
| CN104666535A (en) * | 2015-02-15 | 2015-06-03 | 广西双蚁药业有限公司 | Traditional Chinese medicinal preparation for treating acute upper respiratory infection and preparation method of traditional Chinese medicinal preparation |
| CN106267052A (en) * | 2015-06-03 | 2017-01-04 | 天津药物研究院有限公司 | A kind of medicine treating infantile acute upper respiratory infection and preparation method thereof |
| CN112451556A (en) * | 2020-12-24 | 2021-03-09 | 广东康明医院管理有限公司 | Oral liquid for treating common cold and preparation method thereof |
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| CN101138614A (en) * | 2007-08-25 | 2008-03-12 | 尹克华 | Traditional Chinese Medicine for Treating Exogenous Fever |
| CN101147788A (en) * | 2007-04-11 | 2008-03-26 | 秦庆吉 | Medicine for treating cold and upper respiratory tract infection and its lung inflammation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101147788A (en) * | 2007-04-11 | 2008-03-26 | 秦庆吉 | Medicine for treating cold and upper respiratory tract infection and its lung inflammation |
| CN101138614A (en) * | 2007-08-25 | 2008-03-12 | 尹克华 | Traditional Chinese Medicine for Treating Exogenous Fever |
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