CN101971991A - Process for producing mulberry leaf intestine-moistening cathartic capsules - Google Patents
Process for producing mulberry leaf intestine-moistening cathartic capsules Download PDFInfo
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- CN101971991A CN101971991A CN2010102556818A CN201010255681A CN101971991A CN 101971991 A CN101971991 A CN 101971991A CN 2010102556818 A CN2010102556818 A CN 2010102556818A CN 201010255681 A CN201010255681 A CN 201010255681A CN 101971991 A CN101971991 A CN 101971991A
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Abstract
The invention discloses a process for producing mulberry leaf intestine-moistening cathartic capsules, which comprises the following steps of: drying the picked mulberry leaves at the temperature of not more than 60 DEG C; crushing the dried mulberry leaves, then adding alcohol into the crushed mulberry leaves, and extracting the mixture by ultrasonic wave, wherein the concentration of the alcohol is 40 to 70 percent, the weight ratio of the material to the liquid is 1:15-1:20, the extraction time is 1 to 3 hours, the extraction temperature is 40 to 60 DEG C and the ultrasonic power is 1,000 to 1,200W; filtering the mixture to obtain extract, removing the alcohol, concentrating and centrifuging the extract to obtain supernatant, and freezing or spray-drying the supernatant to obtain raw material powder; and fully blending edible fiber and the raw material powder in a ratio of 1:4-1:19 uniformly, and filling the mixture into capsules to obtain the mulberry leaf intestine-moistening cathartic capsules. The mulberry leaf intestine-moistening cathartic capsules have the advantages of improving the functions of human intestinal tracts, promoting the absorption of the intestinal tracts on nutritive materials, increasing the moisture content of the intestines, accelerating intestinal tract peristalsis and softening excrement so as to empty the accumulated excrement in the body of a patient, change the functions of the intestinal tracts and prevent constipation.
Description
Technical field
The active medicinal matter that the present invention relates to a kind of integration of drinking and medicinal herbs leaves of plants (mulberry leaf) extracts and manufacturing process, products obtained therefrom includes abundant carbohydrate, polysaccharide, flavonoids, food fiber, multiple alkaloid and a large amount of mineral matter, be mainly used in effective human body intestinal canal function of improving, promote the absorption of enteron aisle to nutriment, make moisture increase in the intestines, quicken intestines peristalsis, softening ight soil, thereby make stool emptying in patient's body, the prevention constipation.
Background technology
Constipation is clinical common chronic digestible road symptom, shows as mainly that ight soil is dry and hard, matter is hard, defecation frequency minimizing, difficult defecation or defecation time prolong.Because of its incidence of disease height, cause of disease complexity is often brought many miseries and worry to the patient, has a strong impact on human health and quality of life.The viewpoint of generally acknowledging is at present: along with the increase at age, the incidence of constipation can increase gradually.Senescence phase should disease the incidence male sex can reach 9%-26%, the women can be up to 21%-34%, and simultaneous phenomenon also increase the weight of with advancing age and gradually (Deng Changsheng, Yu Xiqiu. constipation people at highest risk and special pathogenic factor thereof. medical science new knowledge magazine .2003; 13 (4): 187-188; Cai Yunqing, Wang Huijuan, Zhang Xu, Wang Yehuang, Gu Zhengwen, Wang Huaxing, Liu Yan. urban district, Nanjing constipation of old people illness rate and with the investigation of subhealth symptom relation. Chinese gerontology magazine .2004; 23 (4): 267-269; Qin Rong, Chen Yanqing, Liu Yunxing, Ceng Xuebin, Ye Minfu. the influence of mixture to constipation type mice with constipation bowel movement function due to the rice relaxes bowel. Yunnan traditional Chinese medicine magazine, 2009; 30 (7): 59-60).Prolonged constipation can cause sizable harm to body, discovers the relation that having of constipation and colorectal cancer is direct or indirect, and diseases such as hyperenteritis, hemorrhoid, anal fissure can also be brought out and add to constipation; Even can bring out or increase the weight of the state of an illness of cardiovascular patients such as coronary heart disease, angina pectoris, apoplexy, cause its sudden death (Qin Rong, Chen Yanqing, Liu Yunxing, Ceng Xuebin, Ye Minfu. the influence of mixture to constipation type mice with constipation bowel movement function due to the rice relaxes bowel. Yunnan traditional Chinese medicine magazine, 2009; 30 (7): 59-60).Although cause that the reason of constipation is a lot, the influence of diet structure can not be ignored.Modern's diet is too meticulous, higher fatty acid, high protein, and dietary fiber is taken in very few, long-term sitting, daily life system does not have rule, usually is that (Zhang Jie, Zhang Cong are scrupulously and respectfully for the main cause that causes constipation, Wang Qiushui. the research of food fiber preparation functions of loosening bowel relieving constipation, Henan preventive medicine magazine 2008; 19 (6): 416-418).
Western medicine does not still have major progress to this disease treatment at present, mainly to take cathartic, cures the symptoms, not the disease.The long-term contact class cathartic that uses easily produces the dependence of medicine, and can make constipation obstinate more.The Chinese medicine constipation has very big characteristic and advantage, when removing constipation, make disorderly gastrointestinal function obtain adjusting, and patient's physical condition is improved, and the Chinese medicine side effect is little, accepted (Qin Rong by the patient easily, Chen Yanqing, Liu Yunxing, Ceng Xuebin, Ye Minfu. the influence of mixture to constipation type mice with constipation bowel movement function due to the rice relaxes bowel. Yunnan traditional Chinese medicine magazine, 2009; 30 (7): 59-60).Mulberry leaf are a kind of first-class functional food materials, have suppress blood sugar rise, reduce cholesterol, suppress intestinal toxic bacterial reproduction, defaecation and keep with salubrious effect (Zhou Xiuqin. mulberry leaf are with healthy. today science and technology, 1998; 12:13).Contain a large amount of polysaccharide, flavonoids, mineral matter, food fiber and multiple alkaloid in the mulberry leaf, has the human body intestinal canal of improvement function, promote the absorption of enteron aisle to nutriment, make moisture increase in the intestines, quicken intestines peristalsis, function (Li Ruixue, Wang Taichu such as softening ight soil, Jia Hongying. mulberry leaf active component, bioactive research and Application and Development progress thereof. northern silkworm industry, 2009; 30 (2): 1-4).
Summary of the invention
The object of the present invention is to provide mulberry leaf capsule for relieving constipation production technology, main mulberry leaf carbohydrate, polysaccharide, flavonoids, food fiber, multiple alkaloid and a large amount of mineral matter by containing in the product, performance improves the human body intestinal canal function, promote the absorption of enteron aisle to nutriment, make moisture increase in the intestines, quicken intestines peristalsis, softening ight soil, thereby make stool emptying in patient's body, the prevention constipation.
In order to solve the problems of the technologies described above, the present invention is achieved by the following technical solutions: mulberry leaf capsule for relieving constipation production technology may further comprise the steps:
A. pluck: pluck mulberry leaf, annual May is to June;
B. dry: with the mulberry leaf drying of plucking, baking temperature is not more than 60 ℃;
C. pulverize: the mulberry leaf that drying is good are pulverized, grinding particle size 30 order to 50 orders;
D. extract: the mulberry leaf that crush are added alcohol, ultrasonic wave extraction, and alcohol concentration 40%～70%, the weight ratio of feed liquid are 1: 15～1: 20,1 to 3 hour extraction time, extract 40～60 ℃ of temperature, ultrasonic power: 1000～1200W filters and obtains extract;
E. make raw meal: the extract that step D is produced revolves and boils off except that alcohol, centrifugal speed 4000～8000rpm, concentrate, centrifugal after, supernatant, freezing or spray-drying obtains raw meal;
F. make capsule: with edibility fiber and raw meal ratio proportioning by weight 1: 4～1: 19, abundant mixing, by the capsule can promptly.
Preferably, the plucking time of mulberry leaf is annual late May in the described steps A; Grinding particle size 50 orders among the described step C; The alcohol concentration that adds among the described step D is 60%, 2 hours extraction times, extracts 60 ℃ of temperature; The ratio of edibility fiber and raw meal is 1: 9 in the described step F; Can reach the technological parameter of optimum efficiency.
Compared with prior art, advantage of the present invention is: with integration of drinking and medicinal herbs leaves of plants (mulberry leaf) is raw material, utilize modern extraction process, extracted the various active material, as: carbohydrate, polysaccharide, flavonoids, food fiber, multiple alkaloid and a large amount of mineral matter, aid in the edibility fibrous matter, the health food that relaxes bowel that exploitation makes new advances.Can bring into play and improve the human body intestinal canal function, promote the absorption of enteron aisle, make moisture increase in the intestines, quicken intestines peristalsis nutriment, softening ight soil, thus make stool emptying in patient's body, change function of intestinal canal, prevent constipation.Use plant because of raw materials used for food, therefore do not have bad side effect.Strongly professional, the good reproducibility of extracting method that this product technology is simple, set up, and use medicinal alcohol to extract, not only environmental protection, product safety is reliable simultaneously, is suitable for suitability for industrialized production.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Consult the process chart of Fig. 1, may further comprise the steps for mulberry leaf capsule for relieving constipation production technology of the present invention:
A. pluck 1: pluck 1 mulberry leaf, annual late May;
B. dry 2: will pluck 1 mulberry leaf drying 2, dry 2 temperature are not more than 60 ℃;
C. pulverize 3: dry 2 good mulberry leaf are pulverized 3, pulverize 3 granularities, 50 orders;
D. extract: will pulverize 3 good mulberry leaf and add alcohol, ultrasonic wave extraction 4, alcohol concentration 60%, the weight ratio of feed liquid are 1: 15～1: 20,2 hours extraction times, extract 60 ℃ of temperature, and ultrasonic power: 1000～1200W filters and obtains extract 5;
E. make raw meal 9: the extract 5 that step D is produced revolves and boils off except that alcohol, and centrifugal speed 4000～8000rpm concentrates, after centrifugal 6, supernatant 7, freezing or spray-drying 8 obtains raw meal 9;
F. make capsule 12: with the ratio proportioning of edibility fiber 10 and raw meal 9 by weight 1: 9, abundant mixing 11, by capsule 12 cans promptly.
Adopt the capsule of above-mentioned explained hereafter, every heavy 0.65 gram, active constituent content: carbohydrate 〉=40.0%, polysaccharide 〉=2.0%, flavonoids 〉=1.0%, food fiber 〉=10.0%, multiple alkaloid 〉=2.0%.Below be the effect experiment that adopts the product of this explained hereafter to carry out, and the concrete grammar list of references (Xie Cunzhi, Wang Yu, Sun Jinliang, Feng Dianjuan, Wang Shue. the animal experiment study of aloe poison expelling capsule defecating feces excretion. preventive medicine forum, 2009; 15 (7): 581-583).
1. test objective
Observe the bowel relaxing functions of the product of this explained hereafter to mice with constipation, for the product of this explained hereafter to improving function of intestinal canal, the effect of prevention, treatment constipation provides preliminary experimental basis.
2. be subjected to the reagent thing
The capsule raw material of this explained hereafter, shape: pale brown toner end, lot number: 090607, storage procedures: lucifuge, drying, normal temperature (below 25 ℃) are preserved, compound method: face with preceding under aseptic condition with 0.9% physiological saline solution to desired concn.
3. experimental animal
Cultivars and strains: ICR mouse, rank: SPF level, sex: male and female half and half, body weight: 20 ± 1g, quantity: 120, the source: Shanghai Experimental Animal Center/Shanghai Slac Experimental Animal Co., Ltd. of the Chinese Academy of Sciences [production licence: SCXK (Shanghai) 2007-0005], buy the back and adapt to a week in the laboratory.According to mouse body weight level, be divided into 10 groups at random, 12 every group, wherein 60 are carried out the intestinal motility experiment, other 60 determination experiments of arranging first grain melena time and stool weight, and observe its ight soil proterties.5 experimental group (blank group, model control group and 3 dosage groups) are all established in two experiments.
4. experiment condition
Barrier system experiment receptacle, temperature: 22 ± 1 ℃, humidity: 50-70%, illumination: 150-200Lx, light and shade replaced in 12 hours, noise＜50dB, occupancy permit: SYXK (Zhejiang) 2003-0003.
Drinking-water: the tap water filter sterilization places autoclaved drinking-water bottle freely to drink.
Feed: full nutrition pellet.
Feeding manner: free diet, give sufficient feed and water in the mouse rearging cage, every single cage of mouse is raised.
5. dosage is selected and is tried thing to give mode
People's recommended amounts is 2.6g/d, i.e. 0.043g/kgbw (with the 60kg batheroom scale) determines basic, normal, high 3 groups of dosage by 5 times, 10 times and 20 times that are equivalent to the human body recommended amounts, is respectively 0.215,0.43,0.86g/kgbw.Use the dissolved in distilled water given the test agent, give, irritate the long-pending 0.2ml/10gbw that presses of body of stomach to irritate the stomach mode.Control group gavages the distilled water of isodose.
6. instrument and reagent
Operating scissors, ophthalmology tweezers, ruler, AG204-electronic analytical balance (Switzerland, METTLER company), activated carbon powder, gum arabic (Beijing nandina birdseed product additive Co., Ltd, 090106), R-1132 (universal love pharmaceutcal corporation, Ltd product, lot number: 09041307) lot number:.
7. experimental technique
7.1 intestinal motility experiment
Each experimental group gives given the test agent by the 0.2ml/10bw per os, and two control groups give the distilled water of equivalent, every day 1 time, gives given the test agent 10d continuously.Last gives respectively to organize the mouse fasting behind the given the test agent can't help water 16h after, model control group and 3 dosage groups are irritated stomaches and are given compound diphenoxylate (5mg/kgbw), the blank group gives distilled water.After giving compound diphenoxylate 0.5h, the dosage group contains the prepared Chinese ink (containing 5% activated carbon powder, 10% gum arabic) of corresponding given the test agent respectively, and normal and model control group is irritated stomach to prepared Chinese ink.Take off cervical vertebra behind the 25min immediately and put to death animal, open the abdominal cavity and separate mesenterium, clip upper end is the intestinal tube to ileocecus from pylorus, lower end, place on the pallet, gently small intestine is pulled into straight line, measure prepared Chinese ink head end displacement and small intestine total length (from pylorus to ileum) in intestinal tube, calculate small intestine and advance percentage.Advance distance/small intestine total length * 100% of percentage (%)=prepared Chinese ink front end and pylorus].
7.2 arrange the mensuration of first grain melena time and stool weight
Each experimental group gives given the test agent by the 0.2ml/10gbw per os, and two control groups give the distilled water of equivalent, every day 1 time, gives given the test agent 10d continuously.Last gives respectively to organize the mouse fasting behind the given the test agent can't help water 16h after, model control group and 3 dosage groups are irritated stomaches and are given compound diphenoxylate (10mg/kgbw), the blank group gives the distilled water of equivalent.After giving compound diphenoxylate 0.5h, model control group and blank group mouse give prepared Chinese ink and irritate stomach, and 3 dosage groups contain the prepared Chinese ink of corresponding given the test agent, pick up counting simultaneously.Every animal is all raised separately, normal drinking-water feed, and every animal of observed and recorded is arranged defecation weight in melena time, the 5h first.
8. experimental data is added up
Experimental data represents that with X ± SD statistical method is the multiple covariance analysis, and SPSS 12.0 statistical softwares handle.
9. result
9.1 the product of explained hereafter is to the influence of mouse body weight
The body weight difference not statistically significant (P＞0.05) of each treated animal.See Table 1,2.
The product of this explained hereafter of table 1 is to the initial body weight of intestinal motility experiment mice and finish the influence (X ± SD) of body weight
The product of this explained hereafter of table 2 is to the initial body weight of defecation experiment mice and finish the influence (X ± SD) of body weight
9.2 the product of this explained hereafter is to the influence of intestinal motility experiment mice
The statistical analysis of small intestine prepared Chinese ink propelling rate finds that the prepared Chinese ink propelling rate of model control group mouse significantly is lower than blank group (P＜0.01).Expression constipation model is set up; The prepared Chinese ink propelling rate of each dosage group mouse all is significantly higher than model control group (P＜0.05 or P＜0.01).The results are shown in Table 3.
The product of this explained hereafter of table 3 is to the influence of mouse small intestine motion (X ± SD)
Annotate: compare with the normal control group: # is P＜0.05, and ## is P＜0.01; Compare with model control group: * is P＜0.05, and * * is P＜0.01.
9.3 the product of this explained hereafter is to the influence of mouse first grain melena time and stool weight
After per os gave sample 10d, the first grain melena time of the mouse of model control group, the first grain melena time of each dosage group significantly was lower than model control group (P＜0.01) significantly greater than blank group (P＜0.01); The stool in mice weight of model control group significantly is lower than blank group (P＜0.01), and the stool weight of middle and high dosage group is significantly greater than model control group (P＜0.05, P＜0.01).The results are shown in Table 4.
The product of this explained hereafter of table 4 is to the influence of defecation time and the stool weight of mouse (X ± SD)
Annotate: compare with the normal control group: # is P＜0.05, and ## is P＜0.01; Compare with model control group: * is P＜0.05, and * * is P＜0.01.
9.4 the product of this explained hereafter is to the influence of stool in mice proterties
Per os gives respectively to organize the product 10d of this explained hereafter of mouse various dose, the ight soil of each dosage group mouse of blank group, model control group and experiment is oval just granular between feeding period, but the model group stool in mice is obviously dry and hard, and each dosed administration group does not find that the diarrhoea phenomenon appears in animal.
10. conclusion
This experiment shows that per os has no adverse effects to weight of mice after giving the product of this explained hereafter of mouse various dose, can promote the small intestine ahead running of mice with constipation, shortens the first grain melena time of mice with constipation, increases just the weight of discharging feces.Results suggest this product capsule has certain bowel relaxing functions.
The above only is specific embodiments of the invention, but technical characterictic of the present invention is not limited thereto, and any those skilled in the art is in the field of the invention, and the variation of being done or modify all is encompassed among the claim of the present invention.
Claims (5)
1. mulberry leaf capsule for relieving constipation production technology is characterized in that: may further comprise the steps:
A. pluck (1): pluck (1) mulberry leaf, annual May is to June;
B. dry (2): will pluck the mulberry leaf drying (2) of (1), dry (2) temperature is not more than 60 ℃;
C. pulverize (3): the mulberry leaf that dry (2) are good are pulverized (3), pulverize (3) granularity 30 order to 50 orders;
D. extract: will pulverize (3) good mulberry leaf and add alcohol, ultrasonic wave extraction (4), alcohol concentration 40%～70%, the weight ratio of feed liquid are 1: 15～1: 20,1 to 3 hour extraction time, extract 40～60 ℃ of temperature, ultrasonic power: 1000～1200W filters and obtains extract (5);
E. make raw meal (9): the extract (5) that step D is produced revolves and boils off except that alcohol, and centrifugal speed 4000～8000rpm concentrates, after centrifugal (6), supernatant (7), freezing or spray-drying (8) obtains raw meal (9);
F. make capsule (12): with edibility fiber (10) and raw meal (9) ratio proportioning by weight 1: 4～1: 19, abundant mixing (11), by capsule (12) can promptly.
2. mulberry leaf capsule for relieving constipation production technology as claimed in claim 1 is characterized in that: the harvesting of mulberry leaf (1) time is annual late May in the described steps A.
3. mulberry leaf capsule for relieving constipation production technology as claimed in claim 1 is characterized in that: pulverize (3) granularity 50 orders among the described step C.
4. mulberry leaf capsule for relieving constipation production technology as claimed in claim 1 is characterized in that: the alcohol concentration that adds among the described step D is 60%, 2 hours extraction times, extracts 60 ℃ of temperature.
5. mulberry leaf capsule for relieving constipation production technology as claimed in claim 1 is characterized in that: the ratio of edibility fiber (10) and raw meal (9) is 1: 9 in the described step F.
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| CN2010102556818A CN101971991A (en) | 2010-08-13 | 2010-08-13 | Process for producing mulberry leaf intestine-moistening cathartic capsules |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178245A (en) * | 2011-04-07 | 2011-09-14 | 华南农业大学 | Extraction method for folium mori dietary fibers |
| CN105535112A (en) * | 2015-12-29 | 2016-05-04 | 浙江省农业科学院 | Extraction technology of hypoglycemic medicinal active substances of mulberry leaves and mulberries and formula |
| CN116602412A (en) * | 2023-06-02 | 2023-08-18 | 广东省农业科学院蚕业与农产品加工研究所 | Constipation-resistant composition, and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451290A (en) * | 2002-04-13 | 2003-10-29 | 弘荣食品株式会社 | Chewing gum contg. mulberry leaf function component and process for preparing same |
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2010
- 2010-08-13 CN CN2010102556818A patent/CN101971991A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451290A (en) * | 2002-04-13 | 2003-10-29 | 弘荣食品株式会社 | Chewing gum contg. mulberry leaf function component and process for preparing same |
Non-Patent Citations (2)
| Title |
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| 《江苏调味副食品》 20091231 毛红骞;等 桑叶的主要成分、功能及其在食品中的应用 30－33，36 1－5 第26卷, 第1期 * |
| 《结直肠肛门外科》 20100630 祝利；等 膳食纤维与便秘的关系研究进展 193－195页 1-5 第16卷, 第03期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178245A (en) * | 2011-04-07 | 2011-09-14 | 华南农业大学 | Extraction method for folium mori dietary fibers |
| CN105535112A (en) * | 2015-12-29 | 2016-05-04 | 浙江省农业科学院 | Extraction technology of hypoglycemic medicinal active substances of mulberry leaves and mulberries and formula |
| CN116602412A (en) * | 2023-06-02 | 2023-08-18 | 广东省农业科学院蚕业与农产品加工研究所 | Constipation-resistant composition, and preparation method and application thereof |
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Application publication date: 20110216 |