CN102872181A - Preparation method of gout treating medicine oral liquid - Google Patents
Preparation method of gout treating medicine oral liquid Download PDFInfo
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- CN102872181A CN102872181A CN2012103969465A CN201210396946A CN102872181A CN 102872181 A CN102872181 A CN 102872181A CN 2012103969465 A CN2012103969465 A CN 2012103969465A CN 201210396946 A CN201210396946 A CN 201210396946A CN 102872181 A CN102872181 A CN 102872181A
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- raphani
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Abstract
The invention relates to a preparation method of gout treating medicine oral liquid. The preparation method comprises the following steps that a, fresh radish roots or radish leaves or mixtures of the fresh radish roots or the radish leaves are selected; b, the fresh radish roots or the radish leaves or the mixtures of the fresh radish roots or the radish leaves are put into a fruit and vegetable ultramicro pulverizing machine to be pulverized; c, the pulverized solid and liquid mixture is subjected to solid and liquid separation; and d, supernatant fluid after solid and liquid separation is added with dimethyl sulfone and is then subjected to split charging. The supernatant fluid is clear liquid, good organ sense is realized in the aspect of appearance , the comfortable mouth feeling is realized during taking, the supernatant fluid can be received and taken by more patients for lightening the pain, and the mankind is benefited. The supernatant fluid comprises fresh radish medicinal ingredients and bioactive substances, in addition, the storage is easy, and after the split charging into small bottles, the carrying and the transportation are convenient, so the gout medicine is suitable for batch production, and market promotion values are realized.
Description
Technical field
The present invention relates to treat gout drug world technology, refer in particular to a kind of preparation method for the treatment of the gout medicine oral liquid.
Background technology
Fresh Radix Raphani is squeezed the juice to take and is used as the usefulness of falling blood uric acid, and effect is magical.Radix Raphani will be used plant as time-honored, has been found in recent years well to fall the blood uric acid effect, and without any side effects, can take for a long time by informal dress fully.
The gout that hyperuricemia causes, serious threat the healthy of people, and present medical science level still is helpless, and ventilating still is incurable disease.
If fresh Radix Raphani directly chews as eating fruit, the incidence rate of oral ulcer is very high, and taste is pungent, and a lot of people can't stand and refusing to eat.In the prior art, fresh Radix Raphani is pulverized, the juice after the pulverizing is directly oral, contain a large amount of solid residues in the juice after the pulverizing, not only seem to allow the people produce uncomfortable and refusing to eat, and directly the oral juice mouthfeel that contains solid residue is poor, so that a lot of people is reluctant long-term taking; The more important thing is, the fresh Radix Raphani juice that contains a large amount of solid residues also can only be preserved three months under 1 ~ 5 ℃ refrigerated condition, was unfavorable for long-term taking and marketing.
Summary of the invention
In view of this, the present invention is directed to the disappearance of prior art existence, its main purpose provides a kind of preparation method for the treatment of the gout medicine oral liquid, it not only possesses medicinal ingredient and the bioactive substance of fresh Radix Raphani, and have good sense organ and a comfortable mouthfeel, this gout medicine is easy to preserve simultaneously, has market popularization value.
For achieving the above object, the present invention adopts such as the purgation technical scheme: a kind of preparation method for the treatment of the gout medicine oral liquid includes following steps
A, select fresh Radix Raphani;
B, fresh Radix Raphani is put into the fruit and vegerable super micron mill pulverize;
C, the solidliquid mixture after will pulverizing carry out solid-liquid separation;
D, the supernatant after the solid-liquid separation is carried out packing.
A kind of preparation method for the treatment of the gout medicine oral liquid includes following steps
A, select fresh Folium Raphani;
B, fresh Folium Raphani is put into the fruit and vegerable super micron mill pulverize;
C, the solidliquid mixture after will pulverizing carry out solid-liquid separation;
D, the supernatant after the solid-liquid separation is carried out packing.
A kind of preparation method for the treatment of the gout medicine oral liquid includes following steps
A, select fresh Radix Raphani and Folium Raphani;
B, with fresh Radix Raphani with and Folium Raphani put into the fruit and vegerable super micron mill and pulverize;
C, the solidliquid mixture after will pulverizing carry out solid-liquid separation;
D, the supernatant after the solid-liquid separation is carried out packing.
In above three kinds of preparation methoies for the treatment of the gout medicine, described fruit and vegerable super micron mill is the pulverizer of high speed juice extractor and biological extracter and so on, and its rotating speed is more than 4000 rev/mins; The mixture of described Radix Raphani and Folium Raphani or Radix Raphani or the Folium Raphani grinding time in the fruit and vegerable super micron mill is in 60～120 seconds; The temperature of juice remains between 30～45 ° of C.Described solid-liquid separation is centrifugal sedimentation technique.The described conventional criteria that is packed as according to oral liquid or bottled fruit and vegetable juice liquid product is packaged into the bottle oral liquid, and the volume of every bottle of oral liquid is 30mL ~ 100mL.In pulverizing link, can in the mixture of Radix Raphani and Folium Raphani or Radix Raphani or Folium Raphani, add with water that its quality equates after pulverize again.
In above three kinds of preparation methoies for the treatment of the gout medicine, add dimethyl sulfone in supernatant, the mass ratio of this supernatant and dimethyl sulfone is 20 ~ 40:1.
The present invention compared with prior art has obvious advantage and beneficial effect, particularly, has such scheme as can be known:
Through after the micronizing, the cell wall of its plant cell is broken with fresh Radix Raphani, Folium Raphani, and the ingredient that it contains and bioactive substance have obtained discharging to greatest extent.Radix Raphani solidliquid mixture after the superfine powder pulverizing is carried out solid-liquid separation, after removing solid residue, carry out packing after obtaining supernatant, this supernatant is not only possessed medicinal ingredient and the bioactive substance of fresh Radix Raphani, and after removing solid residue, supernatant is clear liquor, seems to have good sense organ, has comfortable mouthfeel when taking.After supernatant carried out packing, this gout medicine not only was easy to carry about with one, and has greatly prolonged its shelf-life, so that more patient likes this medicine, promoted the well-being of mankind; This gout medicine also is suitable for producing in enormous quantities simultaneously, has market popularization value.
The specific embodiment
Embodiment 1
Select fresh Radix Raphani as raw material, be cut into particulate mass after fresh Radix Raphani is cleaned up; Fresh Radix Raphani is put into rotating speed above behind 4500 rev/mins the fruit and vegerable super micron mill, and the water of adding and fresh Radix Raphani equal in quality starts the fruit and vegerable super micron mill and pulverizes; The cell wall of its plant cell is broken, and the ingredient that it contains and bioactive substance have obtained discharging to greatest extent.
Solidliquid mixture after crushed contains solid residue, by centrifuging process solid residue is removed, and obtains supernatant and carries out packing as medicine.Specific as follows: specific as follows: the solidliquid mixture after will pulverizing is sent into juice clarification type centrifuge immediately, remove the residue of Radix Raphani solidliquid mixture by centrifugal sedimentation technique after, in supernatant, add dimethyl sulfone, the mass ratio of this supernatant and dimethyl sulfone is 20:1, at last obtained liquid is carried out the bottle encapsulation according to the conventional criteria packing of oral liquid or bottled fruit and vegetable juice liquid product and namely get the bottled oral liquid of gout medicine, every bottle contains the 30mL oral liquid.
Embodiment 2
Select fresh Folium Raphani as raw material, fresh Folium Raphani is cleaned up; Fresh Folium Raphani is put into rotating speed above behind 4500 rev/mins the fruit and vegerable super micron mill, and the water of adding and fresh Folium Raphani equal in quality starts the fruit and vegerable super micron mill and pulverizes; The cell wall of its plant cell is broken, and the ingredient that it contains and bioactive substance have obtained discharging to greatest extent.
Solidliquid mixture after crushed contains solid residue, by centrifuging process solid residue is removed, and obtains supernatant and carries out packing as medicine.Specific as follows: the solidliquid mixture after will pulverizing is sent into juice clarification type centrifuge immediately, remove the residue of Folium Raphani solidliquid mixture by centrifugal sedimentation technique after, in supernatant, add dimethyl sulfone, the mass ratio of this supernatant and dimethyl sulfone is 30:1, at last obtained liquid is carried out the bottle encapsulation according to the conventional criteria packing of oral liquid or bottled fruit and vegetable juice liquid product and namely get the bottled oral liquid of gout medicine, every bottle contains the 30mL oral liquid.
Embodiment 3
Select fresh Radix Raphani and Folium Raphani as raw material, be cut into blocky-shaped particle after fresh Radix Raphani is cleaned up; Fresh Radix Raphani blocky-shaped particle and Folium Raphani are put into rotating speed above behind 4500 rev/mins the fruit and vegerable super micron mill, and the water of adding and Radix Raphani and Folium Raphani equal in quality starts the fruit and vegerable super micron mill and pulverizes; The cell wall of its plant cell is broken, and the ingredient that it contains and bioactive substance have obtained discharging to greatest extent.
Solidliquid mixture after crushed contains solid residue, by centrifuging process solid residue is removed, and obtains supernatant and carries out packing as medicine.Specific as follows: the solidliquid mixture after will pulverizing is sent into juice clarification type centrifuge immediately, remove the residue of solidliquid mixture of Radix Raphani and Folium Raphani by centrifugal sedimentation technique after, in supernatant, add dimethyl sulfone, the mass ratio of this supernatant and dimethyl sulfone is 40:1, at last obtained liquid is carried out the bottle encapsulation according to the conventional criteria packing of oral liquid or bottled fruit and vegetable juice liquid product and namely get the bottled oral liquid of gout medicine, every bottle contains the 30mL oral liquid.
Be clear liquor by above-described embodiment 1 ~ 3 prepared supernatant, seem to have good sense organ, have comfortable mouthfeel when taking, can so that more patient accepts and takes with relieving the pain caused by diseases, promote the well-being of mankind.Supernatant is not only had medicinal ingredient and the bioactive substance of fresh Radix Raphani, and is easy to preserve, carry out the bottle packing after, easy to carry and transport so that this gout medicine is suitable for producing in enormous quantities, have market popularization value.
Adopt embodiment 1 ~ 3 prepared treatment gout medicine to patient with gout (totally 100 people) treatment of one month when tieing up, when edible, each serving with an above-mentioned packaged bottle Radix Raphani oral liquid, every bottle contains the 30mL oral liquid, twice of every day.Therapeutic effect is as follows:
Wherein evident in efficacyly refer to alleviate very significantly the gout symptom; Curative effect better refers to alleviate to a certain extent the gout symptom.
The above, it only is preferred embodiment of the present invention, be not that technical scope of the present invention is imposed any restrictions, therefore every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention any trickle modification, equivalent variations and modification that above embodiment makes.
Claims (10)
1. a preparation method for the treatment of the gout medicine oral liquid is characterized in that: include following steps
A, select fresh Radix Raphani;
B, fresh Radix Raphani is put into the fruit and vegerable super micron mill pulverize;
C, the solidliquid mixture after will pulverizing carry out solid-liquid separation;
D, the supernatant after the solid-liquid separation is carried out packing.
2. a preparation method for the treatment of the gout medicine oral liquid is characterized in that: include following steps
A, select fresh Folium Raphani;
B, fresh Folium Raphani is put into the fruit and vegerable super micron mill pulverize;
C, the solidliquid mixture after will pulverizing carry out solid-liquid separation;
D, the supernatant after the solid-liquid separation is carried out packing.
3. a preparation method for the treatment of the gout medicine oral liquid is characterized in that: include following steps
A, select fresh Radix Raphani and Folium Raphani;
B, with fresh Radix Raphani with and Folium Raphani put into the fruit and vegerable super micron mill and pulverize;
C, the solidliquid mixture after will pulverizing carry out solid-liquid separation;
D, the supernatant after the solid-liquid separation is carried out packing.
4. any one described a kind of preparation method for the treatment of the gout medicine oral liquid in 3 according to claim 1, it is characterized in that: add dimethyl sulfone in supernatant, the mass ratio of this supernatant and dimethyl sulfone is 20 ~ 40:1.
5. any one described a kind of preparation method for the treatment of the gout medicine oral liquid in 3 according to claim 1, it is characterized in that: described solid-liquid separation is centrifugal sedimentation technique.
6. any one described a kind of preparation method for the treatment of the gout medicine oral liquid in 3 according to claim 1, it is characterized in that: the described conventional criteria that is packed as according to oral liquid or bottled fruit and vegetable juice liquid product is packaged into the bottle oral liquid.
7. described a kind of preparation method for the treatment of the gout medicine oral liquid according to claim 6, it is characterized in that: the volume of every bottle of oral liquid is 30mL ~ 100mL.
8. any one described a kind of preparation method for the treatment of the gout medicine oral liquid in 3 according to claim 1, it is characterized in that: in pulverizing link, can in the mixture of Radix Raphani and Folium Raphani or Radix Raphani or Folium Raphani, add with water that its quality equates after pulverize again.
9. any one described a kind of preparation method for the treatment of the gout medicine oral liquid in 3 according to claim 1, it is characterized in that: the rotating speed of described fruit and vegerable super micron mill is more than 4000 rev/mins.
10. any one described a kind of preparation method for the treatment of the gout medicine oral liquid in 3 according to claim 1, it is characterized in that: the mixture of described Radix Raphani and Folium Raphani or Radix Raphani or the Folium Raphani grinding time in the fruit and vegerable super micron mill is in 60～120 seconds; The temperature of juice remains between 30～45 ° of C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012103969465A CN102872181A (en) | 2012-09-25 | 2012-10-18 | Preparation method of gout treating medicine oral liquid |
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| CN201210359960 | 2012-09-25 | ||
| CN201210359960.8 | 2012-09-25 | ||
| CN2012103969465A CN102872181A (en) | 2012-09-25 | 2012-10-18 | Preparation method of gout treating medicine oral liquid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9907751B2 (en) | 2016-03-10 | 2018-03-06 | RxOMEG Therapeutics LLC | Composition and method of use of colchicine oral liquid |
| US10226423B1 (en) | 2017-12-20 | 2019-03-12 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| CN111514207A (en) * | 2020-04-09 | 2020-08-11 | 单鹏翼 | Formula and preparation process of medicine for treating gout |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100696A (en) * | 2009-12-17 | 2011-06-22 | 许宏昌 | Bone joint maintenance composite containing dimethyl sulfone |
| CN102106516A (en) * | 2011-01-25 | 2011-06-29 | 天津科技大学 | Use of vegetable extract in inhibiting xanthine oxidase (XO) and application in preparing food for preventing and treating hyperuricemia or gout |
| CN102526159A (en) * | 2012-01-09 | 2012-07-04 | 东莞市驱风堂生物科技有限公司 | Preparation method for gout treatment medicament |
-
2012
- 2012-10-18 CN CN2012103969465A patent/CN102872181A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100696A (en) * | 2009-12-17 | 2011-06-22 | 许宏昌 | Bone joint maintenance composite containing dimethyl sulfone |
| CN102106516A (en) * | 2011-01-25 | 2011-06-29 | 天津科技大学 | Use of vegetable extract in inhibiting xanthine oxidase (XO) and application in preparing food for preventing and treating hyperuricemia or gout |
| CN102526159A (en) * | 2012-01-09 | 2012-07-04 | 东莞市驱风堂生物科技有限公司 | Preparation method for gout treatment medicament |
Non-Patent Citations (1)
| Title |
|---|
| 张 勇: "二甲基砜的合成及在保健食品和医药中的应用", 《广州食品工业科技》, vol. 20, no. 2, 31 December 2004 (2004-12-31), pages 136 - 139 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9907751B2 (en) | 2016-03-10 | 2018-03-06 | RxOMEG Therapeutics LLC | Composition and method of use of colchicine oral liquid |
| US10226423B1 (en) | 2017-12-20 | 2019-03-12 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| US10383820B2 (en) | 2017-12-20 | 2019-08-20 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| US10383821B2 (en) | 2017-12-20 | 2019-08-20 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| US11672759B2 (en) | 2017-12-20 | 2023-06-13 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| CN111514207A (en) * | 2020-04-09 | 2020-08-11 | 单鹏翼 | Formula and preparation process of medicine for treating gout |
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Application publication date: 20130116 |