CN101961467A - Medicine for treating knee osteoarthritis and preparation method and application thereof - Google Patents
Medicine for treating knee osteoarthritis and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating knee osteoarthritis, which comprises the following components in parts by weight: 5-15 parts of monkshood, 5-15 parts of prepared cibot rhizome, 5-15 parts of human placenta, 5-15 parts of dogwood fruit, 5-15 parts of Sichuan cassia twig, 5-15 parts of morinda root, 10-20 parts of raw coix seed, 10-15 parts of prepared fleece-flower root, 5-15 parts of radix cyathulae and 5-10 parts of raw licorice. The invention also discloses a preparation method and application of the medicine for treating knee osteoarthritis. The medicine for treating knee osteoarthritis, which is provided by the invention, can be used for effectively treating knee osteoarthritis and has high cure rate, wide application range and no toxic side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound and its production and application, it is peaceful and its production and application to be specifically related to a kind of knee joint numbness.
Background technology
Knee joint osseous arthritis is the middle-aged and elderly people common clinical, and along with the aging of society, sickness rate is in rising trend.The cause of disease of primary disease is still not fully aware of, think that at present its generation is relevant with age, obesity, excessively heavy burden, wound and chronic injury, heredity, environment, immune dysfunction, biomechanics change etc.; pathological changes is from the knee cartilage degeneration; involve joint important structure such as subchondral bone matter, synovial membrane, joint capsule gradually; the hyperosteogeny that shows as limitation, carrying out property articular cartilage destruction and edge, joint on the pathomorphology forms more, and with struvite reparation and compensatory.
The traditional Chinese medical science think knee joint be Liver and kidney spleen three through direct bearing, be the conference of muscles and bones meat.Blood stored in the liver master muscle, kidney storing essence master bone, The spleen has the function to transport and transform nutrients closes meat." the Zhang Shi doctor is logical " cloud: " knee joint is a house of tendons, and gonalgia does not have to be had not because of the liver person who suffer from deficiency of kidney Yang, and void then wind and cold dampness is attacked it ".Primary disease is sent out in person in middle and old age well, and the man seven or eight, and the woman seventy-seven, and Liver and kidney gradually loses, and the slack lazy muscle of muscles and bones is lost blood foster, is difficult pliable and tough; Bone loses marrow and supports, and is difficult strong; Meat loses the spleen master, and weakness with emaciation is unable, causes not Shugu of muscle eventually, and knee joint loses lubricious, and venation is become estranged, and is all diseases.Strain for a long time in addition, the space between skin and muscles inanition, wind-cold damp pathogen is assorted extremely, the blood vessels that stagnate, two knee joint venations are obstructed, cause pain weighing, and delay is difficult.Disease is prolonged both of a specified duration, swelling pain, and difficulty in walking is walked lamely obviously.Therefore, the primary disease pathogenesis is mainly deficiency of the liver and kindey, deficiency of the spleen causing weakness of QI, and cold-dampness numbness, muscles and bones mistake is supported.In a word, forefathers explore through long-term, think that osteoarthritis and " void ", " heresy " are closely related.Caused by liver and kidney deficiency is the basic of pathological changes.Have the scholar that 892 routine knee joint osteoarthritis inpatient statistical analysiss are also drawn same conclusions, knee joint osseous arthritis serves as a basic card and clinical the most common with caused by liver and kidney deficiency, cold-damp resistance network.
NSAID (non-steroidal anti-inflammatory drug) is the Western medicine commonly used of treatment knee joint osseous arthritis, inflammatory to the osteoarthritis patient shows as arthralgia swelling, hydrops and the better curative effect of active receiving existence, but cartilage matrix synthetic there is inhibitory action, though prolonged application can be alleviated arthralgia, the basic lesion of osteoarthritis instead can increase the weight of.COX inhibitor 2 anti-inflammatory and analgesic effect is stronger, and gastrointestinal reaction and the less generation of Liver and kidney toxic and side effects, but takes the incidence rate that can increase the cardiovascular adverse events for a long time, awaits further clinical assessment.
Clinical Chinese medicine prescription is numerous and mixed and disorderly, actual efficacy is very different, and medicine typing lacks unified standard, and prescription is limited to a card one type mostly, or be limited to a ground one disease, naturopathy such as massage, acupuncture energy relief of symptoms lacks the value of applying, though can not effect a permanent cure by comprehensively regulating, patient's symptom is often delayed time and is sent out, patella replacement treatment price is high, and technical operation requires high-leveled and difficult to popularize the possibility that exists the second operation joint to overhaul after a period of time.Small number of patients has more serious postoperative complication threat to life.
Summary of the invention
It is peaceful that technical problem to be solved by this invention provides a kind of knee joint numbness for the treatment of knee joint osseous arthritis, its cure rate height, applied widely, have no side effect.
The technical problem that the present invention also will solve provides the peaceful preparation method of above-mentioned knee joint numbness.
The technical problem that the present invention will solve at last provides the rather application in preparation treatment knee joint osseous arthritis medicine of above-mentioned knee joint numbness.
A kind of knee joint numbness is peaceful, and it comprises the component of following parts by weight: 5～15 parts of RADIX ACONITI LATERALIS PREPARATAs, 5～15 parts of Rhizoma Cibotii of system, 5～15 parts of Placenta Hominiss, 5～15 parts of Fructus Corni, 5～15 parts of Ramulus Cinnamomis, 5～15 parts of Radix Morindae Officinaliss, 10～20 parts of Semen Coicis, 10～15 parts of Radix Polygoni Multiflori Preparata, 5～15 parts of Radix Cyathulaes, 5～10 parts of Radix Glycyrrhizae.
Above-mentioned knee joint numbness is peaceful, preferably comprises the component of following parts by weight: 10～15 parts of RADIX ACONITI LATERALIS PREPARATAs, 10～15 parts of Rhizoma Cibotii of system, 10～15 parts of Placenta Hominiss, 10～15 parts of Fructus Corni, 10～15 parts of Ramulus Cinnamomis, 10～15 parts of Radix Morindae Officinaliss, 10～15 parts of Semen Coicis, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Radix Cyathulaes, 5～10 parts of Radix Glycyrrhizae.
Above-mentioned knee joint numbness is peaceful, most preferably comprises the component of following parts by weight: 10 parts of RADIX ACONITI LATERALIS PREPARATAs, 10 parts of Rhizoma Cibotii of system, 10 parts of Placenta Hominiss, 10 parts of Fructus Corni, 10 parts of Ramulus Cinnamomis, 10 parts of Radix Morindae Officinaliss, 15 parts of Semen Coicis, 15 parts of Radix Polygoni Multiflori Preparata, 10 parts of Radix Cyathulaes, 10 parts of Radix Glycyrrhizae.
The peaceful preparation method of above-mentioned knee joint numbness, with RADIX ACONITI LATERALIS PREPARATA, system Rhizoma Cibotii, Placenta Hominis, Fructus Corni, Ramulus Cinnamomi, Radix Morindae Officinalis, Semen Coicis, Radix Polygoni Multiflori Preparata, Radix Cyathulae and Radix Glycyrrhizae mixing, add 2 times of volume water logging bubbles 10～20 minutes, after big fire is boiled, slow fire continues to decoct 30～40 minutes, leaches medicinal liquid; Two fry in shallow oil and add one times in water, and decocting time 15～20 minutes leaches medicinal liquid, mix with the head liquid of boiling medicine.
Above-mentioned knee joint numbness is the application in preparation treatment knee joint osseous arthritis medicine rather.
Wherein, described medicine, its dosage form is the oral dosage form that supplies on the pharmacy meaning, comprises water decoction, honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum and oral liquid, is preferably water decoction.
RADIX ACONITI LATERALIS PREPARATA in the prescription of the present invention, the Ramulus Cinnamomi kidney tonifying is supporing yang, a surname's numbness cold expelling, promoting the flow of QI in the collateral by warming the meridian are principal agent; With liver and kidney tonifying, relieving rigidity of joints increases the merit of expelling wind and removing dampness to minister with Placenta Hominis, Fructus Corni, Radix Morindae Officinalis, system Rhizoma Cibotii, Radix Polygoni Multiflori Preparata; Semen Coicis invigorating the spleen and benefiting QI dampness removing Shujin, and with Radix Achyranthis Bidentatae promoting blood circulation to restore menstrual flow conducting blood to flow downwards, assistant is with Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share, and gather replenishing QI and blood altogether, and invigorating the liver and kidney removes cold coagulation, the merit of the meridian dredging.Pharmacological research confirms that tonic can be regulated human immune system and hormonal system, stablizes interior environment, improves the Nutrition and Metabolism of subchondral bone and cartilage, delays regression, and has analgesia, antiinflammatory action.RADIX ACONITI LATERALIS PREPARATA, Placenta Hominis, Fructus Corni, Ramulus Cinnamomi, Radix Achyranthis Bidentatae etc. have the anticoagulant antiplatelet aggregative activity, can alleviate because of the caused intra-osteal pressure of primary disease increases, and symptom is eased.
Beneficial effect: the present invention compared with prior art has the following advantages:
1, the cure rate height is applied widely, and cure rate is applicable to all kinds cervical spondylotic radiculopathy disease patient in various degree up to 85%;
2, short treating period, instant effect is generally taken and can be taken effect in a week, the basic clinical symptoms of alleviating around taking;
3, said composition is pure Chinese medicinal preparation, and is cheap, has no side effect, and preparation, taking convenience are suitable for promoting the use of;
4, prescription is simple, and is easy to use, is suitable for medical institutions at different levels and uses.
The specific embodiment
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand that embodiment is described only to be used to illustrate the present invention, and should also can not limit the present invention described in detail in claims.
Embodiment 1:
Knee joint numbness is rather filled a prescription:
The component that comprises following parts by weight: 10 parts of RADIX ACONITI LATERALIS PREPARATAs, 10 parts of Rhizoma Cibotii of system, 10 parts of Placenta Hominiss, 10 parts of Fructus Corni, 10 parts of Ramulus Cinnamomis, 10 parts of Radix Morindae Officinaliss, 15 parts of Semen Coicis, 15 parts of Radix Polygoni Multiflori Preparata, 10 parts of Radix Cyathulaes, 10 parts of Radix Glycyrrhizae.
Concrete preparation technology: above-mentioned Chinese medicine medical material head is fried in shallow oil and is added 2 times in water, soaks 10 minutes, and after big fire was boiled, slow fire continued to decoct half an hour, leaches medicinal liquid; Two fry in shallow oil and add one times in water, and decocting time 15 minutes leaches medicinal liquid, mix with the head liquid of boiling medicine, water decoction.
Embodiment 2:
Knee joint numbness is rather filled a prescription:
The component that comprises following parts by weight: 15 parts of RADIX ACONITI LATERALIS PREPARATAs, 15 parts of Rhizoma Cibotii of system, 15 parts of Placenta Hominiss, 15 parts of Fructus Corni, 15 parts of Ramulus Cinnamomis, 15 parts of Radix Morindae Officinaliss, 20 parts of Semen Coicis, 15 parts of Radix Polygoni Multiflori Preparata, 15 parts of Radix Cyathulaes, 10 parts of Radix Glycyrrhizae.
Concrete preparation technology: above-mentioned Chinese medicine medical material head is fried in shallow oil and is added 2 times in water, soaks 20 minutes, and after big fire was boiled, slow fire continued to decoct half an hour, leaches medicinal liquid; Two fry in shallow oil and add one times in water, and decocting time 20 minutes leaches medicinal liquid, mix with the head liquid of boiling medicine.
Embodiment 3:
Knee joint numbness is rather filled a prescription:
The component that comprises following parts by weight: 10 parts of RADIX ACONITI LATERALIS PREPARATAs, 10 parts of Rhizoma Cibotii of system, 10 parts of Placenta Hominiss, 10 parts of Fructus Corni, 10 parts of Ramulus Cinnamomis, 10 parts of Radix Morindae Officinaliss, 15 parts of Semen Coicis, 15 parts of Radix Polygoni Multiflori Preparata, 10 parts of Radix Cyathulaes, 10 parts of Radix Glycyrrhizae.
Concrete preparation technology: above-mentioned Chinese medicine medical material head is fried in shallow oil and is added 2 times in water, soaks 10 minutes, decocting time half an hour, leaches medicinal liquid; Two fry in shallow oil and add one times in water, and decocting time 15 minutes leaches medicinal liquid, mix the back and divide and take for 2 times on the one with the head liquid of boiling medicine.
Embodiment 4:
Adopt the peaceful side of knee joint numbness (embodiment 1) treatment knee osteoarthritis 20 examples, treat 20 examples with diclofenac and contrast, observe the clinical efficacy of the peaceful side's treatment of knee joint knee joint osseous arthritis level walking pain.The criterion of therapeutical effect produce effects: pain, stiff disappearance in morning, the knee joint mobility is obviously improved, and does not influence orthobiosis and work, WOMAC index decreased＞2/3; Effectively: pain, morning, deadlock obviously alleviated the more preceding improvement of knee joint mobility, WOMAC index decreased＞1/3; Invalid: treatment back symptom does not have the alleviation or the person of increasing the weight of.
1. relatively to the 4th week carrying out efficacy evaluation after two groups of patient, treatment group total effective rate is 85.0% to short term effect, and the matched group total effective rate is 55.0%, and its difference not statistically significant shows that two groups of short term effects are similar.See Table 1.
Table 1 liang group short term effect comparison (example, %)
2. the 2nd, 4 all WOMAC indexes all obviously descend after two groups of patient of comparison of two groups of treatment back WOMAC index variations, the 2nd all matched group falls are more obvious, ease up to the 4th all matched group falls, treatment group fall increases, but difference compares difference not statistically significant, P＞0.05 before and after treating between two groups.Point out the variation of two groups of treatment back state of an illness integrations similar.See Table 2.
The comparison of table 2 liang group treatment back WOMAC index variation
Annotate: compare t check, * t=0.717, P＞0.05 with the same time point of matched group; * t=1.645, P＞0.05.
3. the 2nd, 4 all 100mmVAS all obviously descend after two groups of patient of comparison of two groups of treatment back level walking pain 100mmVAS variations, and the 2nd all matched group falls are more obvious, statistical significance arranged, P＜0.05 with treatment group comparison difference; Ease up to the 4th all matched group falls, treatment group fall increases, two groups treat before and after differences difference not statistically significants relatively, P＞0.05.The onset of prompting treatment group is slow than matched group, but the 4th all two groups of alleviating pain curative effects are similar.See Table 3.
The table 3 liang comparison that group treatment back level walking pain 100mmVAS changes
Annotate: compare t check, * t=2.24, P＜0.05 with the same time point of matched group; * t=0.367, P＞0.05.
4. relatively treatment group upper abdominal pain, burn feeling, the nauseating generation number of gastrointestinal reaction is starkly lower than matched group in two groups of therapeutic processes, and difference has statistical significance, P＜0.05.Show that the side reaction of treatment group medicine is lower than matched group.
Claims (6)
1. a knee joint numbness is peaceful, it is characterized in that it comprises the component of following parts by weight: 5～15 parts of RADIX ACONITI LATERALIS PREPARATAs, 5～15 parts of Rhizoma Cibotii of system, 5～15 parts of Placenta Hominiss, 5～15 parts of Fructus Corni, 5～15 parts of Ramulus Cinnamomis, 5～15 parts of Radix Morindae Officinaliss, 10～20 parts of Semen Coicis, 10～15 parts of Radix Polygoni Multiflori Preparata, 5～15 parts of Radix Cyathulaes, 5～10 parts of Radix Glycyrrhizae.
2. knee joint numbness according to claim 1 is peaceful, it is characterized in that it comprises the component of following parts by weight: 10～15 parts of RADIX ACONITI LATERALIS PREPARATAs, 10～15 parts of Rhizoma Cibotii of system, 10～15 parts of Placenta Hominiss, 10～15 parts of Fructus Corni, 10～15 parts of Ramulus Cinnamomis, 10～15 parts of Radix Morindae Officinaliss, 10～15 parts of Semen Coicis, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Radix Cyathulaes, 5～10 parts of Radix Glycyrrhizae.
3. knee joint numbness according to claim 2 is peaceful, it is characterized in that it comprises the component of following parts by weight: 10 parts of RADIX ACONITI LATERALIS PREPARATAs, 10 parts of Rhizoma Cibotii of system, 10 parts of Placenta Hominiss, 10 parts of Fructus Corni, 10 parts of Ramulus Cinnamomis, 10 parts of Radix Morindae Officinaliss, 15 parts of Semen Coicis, 15 parts of Radix Polygoni Multiflori Preparata, 10 parts of Radix Cyathulaes, 10 parts of Radix Glycyrrhizae.
4. the peaceful preparation method of the described knee joint numbness of claim 1, it is characterized in that RADIX ACONITI LATERALIS PREPARATA, system Rhizoma Cibotii, Placenta Hominis, Fructus Corni, Ramulus Cinnamomi, Radix Morindae Officinalis, Semen Coicis, Radix Polygoni Multiflori Preparata, Radix Cyathulae and Radix Glycyrrhizae mixing, add 2 times of volume water logging bubbles 10～20 minutes, after big fire is boiled, slow fire continues to decoct 30～40 minutes, leaches medicinal liquid; Two fry in shallow oil and add one times in water, and decocting time 15～20 minutes leaches medicinal liquid, mix with the head liquid of boiling medicine.
5. the rather application in preparation treatment knee joint osseous arthritis medicine of the described knee joint numbness of claim 1.
6. application according to claim 5, it is characterized in that described medicine, its dosage form is the oral dosage form that supplies on the pharmacy meaning, comprises water decoction, honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum and oral liquid.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622987A (en) * | 2015-03-04 | 2015-05-20 | 陈永华 | Pharmaceutical composition for treating chronic hepatitis and liver cirrhosis and application thereof |
| CN105326928A (en) * | 2014-08-17 | 2016-02-17 | 谢海雄 | External-use medicated wine for treating osteoarthritis in summer |
| CN106421291A (en) * | 2016-11-09 | 2017-02-22 | 佘鹏 | Traditional Chinese medicine for treating knee arthralgia |
-
2010
- 2010-10-21 CN CN2010105143253A patent/CN101961467B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 《中国骨伤》 20050430 王培民等 膝宁方治疗膝关节骨性关节炎平地行走疼痛的临床观察 240-241 第18卷, 第4期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326928A (en) * | 2014-08-17 | 2016-02-17 | 谢海雄 | External-use medicated wine for treating osteoarthritis in summer |
| CN104622987A (en) * | 2015-03-04 | 2015-05-20 | 陈永华 | Pharmaceutical composition for treating chronic hepatitis and liver cirrhosis and application thereof |
| CN104622987B (en) * | 2015-03-04 | 2017-10-10 | 陈永华 | A kind of pharmaceutical composition for treating chronic hepatitis liver cirrhosis and application |
| CN106421291A (en) * | 2016-11-09 | 2017-02-22 | 佘鹏 | Traditional Chinese medicine for treating knee arthralgia |
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| CN101961467B (en) | 2012-02-01 |
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