CN101953770B - Cream for resisting aging and improving climacteric symptoms - Google Patents
Cream for resisting aging and improving climacteric symptoms Download PDFInfo
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- CN101953770B CN101953770B CN201010514618A CN201010514618A CN101953770B CN 101953770 B CN101953770 B CN 101953770B CN 201010514618 A CN201010514618 A CN 201010514618A CN 201010514618 A CN201010514618 A CN 201010514618A CN 101953770 B CN101953770 B CN 101953770B
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a cream for resisting aging and improving climacteric symptoms and a preparation method thereof, in particular to pasty cosmetic prepared from dioscorea villosa, metallothionein (MT) and other auxiliary plant extracts, and a preparation method thereof. The cream comprises the following components: the dioscorea villosa, the MT, ginsenoside, chamomile, oyster, black cohosh, stinging nettle, rosemary oil, vitamin E oil, collagen, grape seed oil, jojoba oil, capo and distilled water and is a dioscorea villosa-MT balancing cream used for balancing human body internal secretion, resisting oxidation, keeping human body skin smooth and delicate, promoting metabolism and improving physiological aging of human bodies. When the cream is applied to the skin surface, the dioscorea villosa and the MT are absorbed by the skin through massage, so the cream can stimulate the blood flow of the human bodies, increase hormone secreted by the human bodies, restore the human bodies to a balancing state when a user is young, achieve the effect of resisting aging, and is convenient to popularize and apply.
Description
Technical field
This utility model relates to a kind of mastic cosmetics for external use, specifically a kind ofly contains the cosmetics that Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass, metallothionein (MT) and other auxiliary plant extraction are processed cream frost state.
Background technology
Climate change at present, environmental change, ambient air pollute to the mankind and cause very big pollution, cause human senility, some symptoms that enter into the climacteric period in advance and reflected.
Research shows; The pollution of environment, air quality is low, causes human free radical and other biological active substance; To macromole infringement in the human body; Main cause is polluted in the lesion development process, physiological effect occurs, and damage biology and human skin and climacteric shift to an earlier date form change and radiation electromagnetic radiation disease state etc.All can regard a series of Secondary cases effects of radical pair body injury or indirect effect as, under air quality and contamination, water produces excited state water through exciting in the body; Or just be understood as with molecule and an ion of positive lotus, resolve into then and have the high activity free radical, though have the free radical of removing ability system in the body; But ultraviolet; It is superfluous that electromagnetic radiation, air pollution produce interior free yl, and these superfluous free radicals just destroy the health biomacromolecule.Like protein, undersaturated fatty acid, cause human body senilism to occur, the lost of life, tumor and hematopathy take place, even the influence gene, are to prevent human senility and the important measures of climacteric symptom so antagonism air pollution, radiation produce free radical.Minimizings such as general people use cosmetics, Orally taken health article or postpone the generation of this above symptom, but externally-applied health-care products is few only, and cosmetics to preserve moisture with skin moistening separately be main, the change that it brings is of short duration.
Experiment finds, Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT contains and enriches competent cell or tissue can be resisted human body sorrow old tissue, because of air pollution, the concrete strong free radical resisting of electromagnetic radiation; Prevent that cell membrane receives free radical and air pollution to resist Aging Damage; Can play the blood circulation of releiving, eliminate the climacteric obstacle and have the effect of conditioning skin and losing slow down aging, suitably replenishing MT can antioxidation, can improve the chemicotherapy repairing effect for tumor disease patient; For the endocrine disturbance cytoactive of recovery oxygen content is arranged; Improve bone density, prevention breast body of gland cyst is kept endometrium function equivalent fruit.
Summary of the invention
The object of the invention provides a kind of defying age, improves cream of menopause syndrome and preparation method thereof, and it is that a kind of balance human endocrine antioxidation improves the smooth exquisiteness of human skin, enhances metabolism; Improve the old and feeble Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT equilibrium cream of Human Physiology; This cream is spread upon skin surface, make Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT, can stimulate the blood of human body circulation through the massage Transdermal absorption; Increase self secreting hormone; Make health return back to poised state at an early age, and then reach the defying age effect, be convenient to promote and use.
Technical solution of the present invention is that to contain Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass (powder) 0.3-8 part purity be that 93% (following priority scheme has used 8 parts; So here, should be more than or equal to 8 parts), MT (metallothionein) (granule) 0.01-0.09 part purity is 85%, ginsenoside's (powder) 1-10 part purity is 95%, Flos Matricariae chamomillae (powder) 10-30 part purity is 96%, Concha Ostreae (powder) 1-15 part purity is 95%, Cimicifuga racemosa (powder) 1-30 part purity is 85%, big-sting nettle (powder) 0.5-10 part purity is 95%, oil of rosemary (pure liquid) 1-15 part purity is 98%, VE (vitamin E) oil (pure liquid) 0.1-10 part purity is 98%, collagen protein (pure liquid) 1-9 part purity is 95%, Oleum Vitis viniferae (pure liquid) 1-8 part purity is 95%, Jojoba oil (pure liquid) 0.9-5 part purity is 95%, card ripple (pure liquid) 2-8 part purity is 95%, distilled water 750-1000 part.
Preferred version is 8 parts of Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass, 0.03 part of MT (metallothionein), 8 parts of ginsenosides, 10 parts of Flos Matricariae chamomillae, 7 parts of Concha Ostreaes, 4 parts of Cimicifuga racemosas, 6 parts of big-sting nettles, 5 parts of oil of rosemary, 7 parts of collagen protein, 6 parts of Oleum Vitis viniferaes, 1.5 parts of Jojoba oils, 4 parts in ripple of card, 800 parts of distilled water.3 parts of VE oil.
More than method for preparing according to the invention carry out according to following steps:
1. get Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass, MT (metallothionein), ginsenoside and Flos Matricariae chamomillae by above-mentioned formulation weight; With 2000-4000 rev/min of speed homogenizing 4-12 minute; And be heated to 80-100 ℃, then with 35-55 rev/min of insulated and stirred 10-30 branch, get A phase solution;
2. get Cimicifuga racemosa, big-sting nettle, collagen protein, card ripple by above-mentioned formulation weight; Concha Ostreae and distilled water were with 2000-4000 rev/min of speed homogenizing 4-12 minute; And be heated to 75-95 ℃, then with 35-55 rev/min of insulated and stirred 10-30 divide B phase solution;
3. above-mentioned formulation weight meter is got oil of rosemary, VE oil, Jojoba oil; With rotating speed 2000-4000 rev/min homogenizing 3-10 minute, and be heated to 75-95 ℃, stir with 35-55 rev/min then and A phase, B phase solution mixed after 10-20 minute; Again with 35-55 rev/min of speed; After keeping stirring in 20-40 minute, to be cooled to room temperature, process Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT balance cream.
Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass contains the precursor of hormone, and Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass elite similar in appearance to human body lutein molecular structure has activating cell, and it is best suited for the hormone raw material of human body, therefore stimulates the human endocrine cell to produce hormone.MT (metallothionein) has the function of removing free radical to make it in processes such as defying age, antioxidation pressure and apoptosis, bring into play important effect; MT is a kind of potential apoptosis negative regulatory factor, biological activity protein is arranged and in chemotherapy, normal body cell is had the certain protection effect.The ginsenoside is the main active of from Araliaceae Radix Ginseng, stem, leaf, extracting, and has leukocyte increasing quantity, improves body immunity, promotes substance metabolism, resisting fatigue, the anti-ageing effect of waiting for a long time.Flos Matricariae chamomillae has Cure for insomnia, brings high blood pressure down, and can invigorate, refresh oneself, effects such as memory reinforcing, cholesterol reducing.Concha Ostreae contains various trace elements such as calcium, zinc, plays adjustment human internal environment's balance effect.Cimicifuga racemosa can play swelling and ache that the rheumatism of releiving causes, and helps body and mind lax, removes muscle spasm, alleviating neuropathic pain, and antitussive, and help bronchus to loosen, help production process to wait effect smoothly.Big-sting nettle cures mainly rheumatic arthritis, puerperal convulsion, infantile convulsion, poliomyelitis sequela, hypertension, dyspepsia, constipation; Control urticaria from the beginning of, venom etc., Herba Urticae Cannabinae itself is a kind of natural diuretic, also is antiinflammatory agents.Oil of rosemary has stronger astriction, nurses one's health greasy unclean skin, blood circulation promoting, and stimulating hair regeneration makes the lax skin in fat-reducing back more solid.VE (vitamin E) oil can be used as antioxidant, and vitamin e helps and prevents that polybasic unsaturated fatty acid and phospholipid are oxidized, so can keep the integrity of cell membrane; Can protect the not oxidated destruction of Vitamin A, and strengthen its effect, vitamin E can prevent the relevant symptom of vitamin E deficiency to take place; Prevent that the lipid peroxide in the blood from increasing, reduce the incidence rate suffer from heart disease, coronary artery disease, can give protection against cancer, aging resistance; Prevent the excessive coagulation of platelet, it is stable and erythrocytic synthetic to promote the erythrocyte film, reduces the effect that causes because of air pollution; And then the injury of lungs is reduced, and keep Cellular respiration, reduce the deposition of senile plaque.Collagen protein is to keep the indispensable important component of health normal activity, simultaneously also is to make health keep young, prevent aged material, can prevent disease, improve body constitution, and all helpful to beauty treatment and health.Oleum Vitis viniferae can reduce cholesterol in the blood, prevents thrombosis, and the blood vessel dilating effect has nourishing brain cell simultaneously, regulates neuro vegetative effect, effectively prevents the various diseases that cardiovascula sclerosis causes.Jojoba oil has good stable property, very easily merges with skin, has non-oxidizability free from worldly cares, contains and enriches vitamin, has the effect of nourishing softening skin.The card ripple plays thickening, suspension effect, makes this product form the cream frost of good stability.
The invention has the advantages that:
1, this kind cream improves the smooth exquisiteness of human skin through balance human endocrine antioxidation, enhances metabolism, and improves the old and feeble Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT equilibrium cream of Human Physiology;
2, this cream does not need orally, as long as spread upon skin surface, makes Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT through the massage Transdermal absorption, can reduce surplus materials and deposit in vivo, and reduce side effect, is convenient to promote and use yet;
3, this cream reasonably matches various effective ingredient through after repeatedly testing, and can make every kind of effective ingredient performance effect effectively, and reaching stimulates the blood of human body circulation, increases self secreting hormone, makes health return back to poised state at an early age, and then defying age.
The specific embodiment:
Embodiment 1
Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass 0.3-7 part, MT (metallothionein) 0.01-0.09 part, ginsenoside 1-10 part, Flos Matricariae chamomillae 10-30 part, Concha Ostreae 1-15 part, Cimicifuga racemosa 1-30 part, big-sting nettle 0.5-10 part, oil of rosemary 1-15 part, the oily 0.1-10 part of VE (vitamin E), collagen protein 1-9 part, Oleum Vitis viniferae 1-8 part, Jojoba oil 0.9-5 part, card ripple 2-8 part or distilled water 750-1000 part.
Embodiment 2
Identical with embodiment 1, be 8 parts of Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass, 0.03 part of MT (metallothionein), 8 parts of ginsenosides, 10 parts of Flos Matricariae chamomillae, 7 parts of Concha Ostreaes, 4 parts of Cimicifuga racemosas, 6 parts of big-sting nettles, 5 parts of oil of rosemary, 7 parts of collagen protein, 6 parts of Oleum Vitis viniferaes, 1.5 parts of Jojoba oils, 4 parts in ripple of card, 800 parts of distilled water.3 parts of VE
Embodiment 3-10
Identical with embodiment 1, just content is respectively shown in the following table:
| Raw material | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 |
| Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass (g) | 7 | 5 | 4 | 3 | 2 | 6 | 5 | 4 |
| MT(g) | 0.02 | 0.01 | 0.015 | 0.075 | 0.05 | 0.09 | 0.03 | 0.035 |
| Life saponin (g) | 6 | 4 | 3 | 8 | 7 | 6 | 3 | 1.5 |
| Flos Matricariae chamomillae (g) | 22 | 15 | 18 | 20 | 19 | 25 | 27 | 21 |
| Concha Ostreae (g) | 7 | 9 | 8 | 4 | 3 | 7 | 6 | 8 |
| Cimicifuga racemosa (g) | 3 | 15 | 20 | 5 | 23 | 25 | 26 | 26 |
| Big-sting nettle (g) | 4 | 3 | 3.5 | 4 | 0.8 | 2 | 1 | 1 |
| Oil of rosemary (g) | 4 | 3.5 | 2 | 3 | 0.9 | 7 | 5 | 3 |
| V.E oil (g) | 0.6 | 0.7 | 1 | 2 | 3 | 4 | 4 | 2 |
| Collagen protein (g) | 0.8 | 1.1 | 1.5 | 3 | 2 | 6 | 3 | 2 |
| Oleum Vitis viniferae (g) | 1.1 | 1.5 | 1.3 | 1.2 | 1 | 1.5 | 2 | 3 |
| Jojoba oil (g) | 0.9 | 1.2 | 1.5 | 1.8 | 1.7 | 2 | 4 | 3 |
| Card ripple 941 | 5 | 4 | 6 | 2 | 4 | 7 | 6 | 4.5 |
| Distilled water (g) | 800 | 750 | 800 | 750 | 895 | 950 | 1000 | 850 |
Each different product of above embodiment 1-10 content carries out headspace gas chromatography and clinical visual method carries out:
1, headspace gas chromatography test TOSC value:
1.1 instrument and reagent: gas chromatograph (Tianjin, island GC-4B), 20mL hardtops empty bottle (Agilent company), constant-temperature shaking water bath (device company of Shanghai section).2,2 ' other reagent are homemade analytical pure for two (the 2 one amidine propane) dihydrochlorides (ABAP) of azo (Japanese WakoChemical company), 4 methyl mercapto 2 butanone acid sodium-salt (KMBA) (Sig-ma company).1.2 experimental principle: pyrolysis ABAP produces a large amount of oxygen-derived free radicals in airtight head space bottle, attacks KMBA and produces ethylene; Antioxidant and KMBA competition oxygen-derived free radicals can reduce the generation of ethylene, calculate the TOSC value of institute's test sample article from the reduction of ethylene.
1.3 chromatographic condition: GDX-502 glass packed column (2 m * 3 mm i.d.); Injector, chromatographic column, detector temperature are respectively 150,60 and 200 ℃; Carrier gas (N :), hydrogen, air velocity are respectively 40,50 and 500 mL/min; Detector is flame ionization detector (FID).
1.4 TOSC measures: (be and face the time spent and join at present with 0.1 mol/L phosphate buffer (PBS) preparation, 0.2 mol/LABAP, 0.25 mmol/LKMBA; 4 ℃ of lucifuges are stored); In the head space bottle, add KMBA 0.8 mL and PBS 0.1 mL as control valve; Add KMBA 0.8mL and appearance liquid 0.1 mL as sample cell, seal the back respectively and inject 0.1 mLABAP with syringe, making the solution final volume is 1mL.The head space bottle is put 35 ℃ of water-bath oscillating reactions 60 min of people, extract head space gas 0.6mL immediately by " 1.3 " joint condition sample introduction.The TOSC computing formula is: TOSC=100-(As/Ac) * 100 (As and Ac are respectively the ethylene peak area of sample cell and control valve).
1.5 sample analysis: the product of embodiment 1-10, use a spot of dissolve with ethanol earlier, reuse PBS is 100 times of stepwise dilution (0.1mg/L) under ultra-sonic dispersion.Each 0.1 mL of 10 kinds of sample solutions that gets after the above-mentioned dilution handles by " 1.4 " joint condition.
The result: 10 parts of parallel sample are measured result such as following table
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| The TOSC value | 98．1 | 99.2 | 98.5 | 98.3 | 98.2 | 98.1 | 98 | 97 | 97.3 | 97.7 |
The result shows that the TOSC value of each embodiment sample all near 100, proves that the sample oxidation resistance is stronger.
2, the Clinical detection method is divided into that 1. skin of forearm contact test and biopsy model are screened 2. complete facial testing evaluation.
1. skin of forearm contact test and biopsy model screen: the volunteer that selects 10 30-50 years; One side skin of forearm of each volunteer uses product to reach for 3 weeks; The another side forearm does not use any product, visually rank erythema situation after normal 3 weeks of sunshine.Use the skin of forearm of various embodiments of the present invention product the erythema situation all not occur, do not use the forearm of any product erythema then to occur.
2. complete facial testing evaluation: select the volunteer in 10 30-50 year, each volunteer half face under more normal operating position uses each second half face of embodiment product not use any product, after normal 5 weeks of sunshine, is carrying out experimenter's self assessment.Assessment result all shows, uses half face of each embodiment product of each volunteer assessment of the present invention not have microgroove and wrinkle pigmentation and mottle also not to occur, does not use second half face of any product microgroove or mottle then to occur.
Embodiment 11
Take off each material of face by the weight of embodiment 1-10:
1. Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass, MT (metallothionein), ginsenoside and Flos Matricariae chamomillae with 3000 rev/mins of speed homogenizing 8 minutes, and are heated to 90 ℃, then with 45 rev/mins of insulated and stirred 20 minutes, A phase solution;
2. Cimicifuga racemosa, big-sting nettle, collagen protein, card involve distilled water, with 3000 rev/mins of speed homogenizing 8 minutes, and are heated to 85 ℃, then with 45 rev/mins of insulated and stirred 20 minutes, B phase solution;
3. oil of rosemary, VE oil, Jojoba oil with 3000 rev/mins of speed homogenizing of rotating speed 7 minutes, and are heated to 85 ℃; A phase, B phase solution are mixed after 15 minutes with 45 rev/mins of stirrings then; After keeping stirring in 30 minutes with 45 rev/mins of speed again, be cooled to room temperature, process Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass MT balance cream.
Embodiment 12
Identical with embodiment 11, just 1. in the step with 2000 rev/mins of speed homogenizing 12 minutes, and be heated to 100 ℃, then with 55 rev/mins of insulated and stirred 30 minutes;
Embodiment 13
Identical with embodiment 11, just 1. in the step,, and be heated to 80 ℃, then with 35 rev/mins of insulated and stirred 10 minutes with 4000 rev/mins of speed homogenizing 4 minutes;
Embodiment 14
Identical with embodiment 11, just 2. in the step,, and be heated to 95 ℃, then with 55 rev/mins of insulated and stirred 30 minutes with 2000 rev/mins of speed homogenizing 12 minutes;
Embodiment 15
Identical with embodiment 11, just 2. in the step,, and be heated to 75 ℃, then with 35 rev/mins of insulated and stirred 10 minutes with 4000 rev/mins of speed homogenizing 4 minutes;
Embodiment 16
Identical with embodiment 11, just 3. in the step,, and be heated to 75 ℃ with 4000 rev/mins of homogenizing of rotating speed 3 minutes, stir with 35 rev/mins then and A phase, B phase solution are mixed after 10 minutes, again with 35 rev/mins of speed, keeps stirring in 20 minutes.
Embodiment 17
Identical with embodiment 11, just 3. in the step,, and be heated to 95 ℃ with 2000 rev/mins of homogenizing of rotating speed 10 minutes, stir with 55 rev/mins then and A phase, B phase solution are mixed after 20 minutes, again with 55 rev/mins of speed, keeps stirring in 40 minutes.
Claims (1)
- A defying age, improve the cream of menopause syndrome; It is characterized in that it contains that Miscanthus sacchariflorus (Maxim) Benth et Hook f reed grass 0.3-8 part purity is 93%, metallothionein 0.01-0.09 part purity is 85%, ginsenoside 1-10 part purity is 95%, Flos Matricariae chamomillae 10-30 part purity is 96%, Concha Ostreae 1-15 part purity is 95%, Cimicifuga racemosa 1-30 part purity is 85%, big-sting nettle 0.5-10 part purity is 95%, oil of rosemary 1-15 part purity is 98%, vitamin E oil 0.1-10 part purity is 98%, collagen protein 1-9 part purity is 95%, Oleum Vitis viniferae 1-8 part purity is 95%, Jojoba oil 0.9-5 part purity is 95%, card ripple 2-8 part purity is 95%, distilled water 750-1000 part.
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| CN102198073B (en) * | 2011-06-08 | 2012-10-03 | 浙江欧诗漫集团有限公司 | Preparation process of pearl whitening essence |
| CN103599063B (en) * | 2013-11-28 | 2016-01-20 | 杭州贞尔生物科技有限公司 | A kind of anti-aging face cream |
| CN103690434B (en) * | 2013-12-18 | 2016-03-30 | 郑州市嘉蓓丽生物科技有限公司 | Pu' er tea anti-aging cream and preparation method thereof |
| CN103690468A (en) * | 2013-12-30 | 2014-04-02 | 董玉国 | Anti-aging cream for improving climacteric physical symptoms, and preparation method of cream |
| FR3029418B1 (en) * | 2014-12-09 | 2018-03-09 | Michel Frey | COMPOSITION FOR SLOWING THE SIGNS OF PATHOLOGICAL OR PHYSIOLOGICAL AGING. |
| CN104921109B (en) * | 2015-05-27 | 2018-03-13 | 广州市圣鑫生物科技有限公司 | A kind of antisenescence health product and its detection method |
| CN105903002A (en) * | 2016-06-17 | 2016-08-31 | 孙和平 | Emulsion for eliminating breast distending pain and breast nodules and preparation method thereof |
| CN108635255A (en) * | 2018-04-28 | 2018-10-12 | 广东巴松那生物科技有限公司 | It is a kind of to activate plant skin cream of Telomerase and preparation method thereof |
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