CN101940252A - Application of anthraquinone compounds in Rumex patientia Linn. as feed additive and corresponding feeds - Google Patents

Application of anthraquinone compounds in Rumex patientia Linn. as feed additive and corresponding feeds Download PDF

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CN101940252A
CN101940252A CN2009100438744A CN200910043874A CN101940252A CN 101940252 A CN101940252 A CN 101940252A CN 2009100438744 A CN2009100438744 A CN 2009100438744A CN 200910043874 A CN200910043874 A CN 200910043874A CN 101940252 A CN101940252 A CN 101940252A
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analog compound
feed
anthraquinone analog
anthraquinone
tian
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贺喜
蔡鹏�
肖文军
伍小松
张石蕊
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Hunan Agricultural University
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Hunan Agricultural University
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Abstract

The invention relates to application of anthraquinone compounds in Rumex patientia Linn. as a feed additive and corresponding feeds, wherein the anthraquinone compounds in the Rumex patientia Linn. are directly and uniformly mixed and added or dissolved according to the ratio of feeding 1g to 200g of the anthraquinone compounds to every 1000kg of the feed, and then added to animal feeds in a spray way so as to prevent the feeds from mildewing, promote the growth of animals and enhance the conversion rate of the feed. The anthraquinone compounds in the Rumex patientia Linn. have the advantages of rich raw material resources, controllable production cost and great market requirement, and is suitable for industrialization development and production.

Description

Anthraquinone analog compound is as the purposes and the corresponding feed of feed addictive in the Ba Tian garden sorrel
Technical field:
The present invention relates to the application of anthraquinone analog compound in feed in the Ba Tian garden sorrel, particularly in the Ba Tian garden sorrel anthraquinone analog compound with form application in feed of feed addictive as mould inhibitor and growth accelerator.
Background technology:
Natural anthraquinone derivative extensively exists in plant, and many has been the active component of traditional Chinese herbal medicine, is used for human antibacterial, antiviral, antitumor, anti-inflammatory etc.The chemical constitution of anthraquinone analog compound is as follows:
Figure B2009100438744D0000011
Be in the various natural quinones quantity maximum also be a most important compounds.The natural anthraquinone compound mainly is present in the madder wort, and the content in high plants such as Rhamnaceae, pulse family (mainly being senna), polygonaceae, Zi Zangke, Verenaceae, Scrophulariaceae and Liliaceae is also higher.Be many with anthraquinone analog compound in aspergillus and the Penicillium in the mould.The animal kingdom has only in the marine animal of Dulicidae arthropod and Crinoidea and is found.Natural anthraquinone is divided into archen type and alizarin type.Natural archen type anthraquinone compounds design feature is that hydroxyl is distributed on the phenyl ring of both sides, and majority is pale brown look, all has in many important Chinese medicines such as rheum officinale, cassia seed, the giant knotweed etc. to contain this structure type anthraquinone.Archen is the most a kind of anthraquinone compounds that distributes, and from many moulds, lichens, higher plant and insect discovery is arranged all.Archen class anthraquinone is the active ingredient of many important Chinese medicine, has antibacterial, anti-inflammatory, protection liver kidney, suppresses platelet aggregation, improves microcirculation, anticancer etc., has using value preferably clinically.Natural alizarin has multiple biologically active such as promoting circulation of blood, hemostasis, and clearing and activating the channels and collaterals, effects such as the timid phlegm of cough-relieving can also be antibiotic, antiviral and anticancer etc.In addition, anthraquinone analog compound is at anti-inflammatory, antioxidation activity, to all useful effects such as cardiovascular and the circulatory system, intestines and stomach, research is also arranged on the bactericide of pesticide field such as anti-phytopathogen and uses.
Ba Tian garden sorrel (Rumex patientia Linn) another name Rumex patientia Linn, galvanized iron or tinned iron garden sorrel, field sowthistle herb belong to polygonaceae (Polygonaceae) Rumex (Rumex) plant, perennial herb, high 1-1.5 rice.Stem is upright, and is sturdy, and branch or branch do not have groove.Basal leaf has thick handle; Blade square circle shape lanceolar, long 15-30 centimetre, wide 4-8 centimetre, anxious point in top or circle are blunt, and base portion is circular or near heart-shaped, and full edge or edge are wavy; Upper leaf is little and narrow, nearly stockless; The ochrea tubular, membranous.Inflorescence is large-scale panicle, and give birth on the top or armpit is given birth to; The flower both sexes; Tapel 6 becomes 2 to take turns, when fruit in the wheel tapel increase, the shape of feeling relieved has reticulate pattern, full edge, one one or strumae is all arranged; Stamen 6; Column cap 3, penicillate.Achene is avette, 3 sharp is arranged, brown, light.Root contains tannin can obtain through refining tannin extract.Be distributed widely in height add entangle, Kazakhstan, Russia, Mongolia and European, in China northeast, North China, northwest, Shandong, Henan, Hunan, Hubei, Sichuan and Tibet growth is arranged also.Mainly grow in limit, village, roadside, flush with the limit, ditch.Be used as medicine with root, have hemostasis, heat-clearing, Li Shui, effects such as defaecation.
Be rich in anthraquinone analog compound (as archen, Chrysophanol, Physcion etc.) and flavone compound (as Kaempferol, Quercetin etc.) in the Ba Tian garden sorrel.Anthraquinone analog compound wherein is the effective ingredient of many Chinese medicines, has antibacterial, anti-inflammatory, protection liver kidney, suppresses blood platelet and focus on, improve microcirculation, effect such as anticancer, has using value preferably clinically.About the research of anthraquinone analog compound, mainly concentrate on the new drug development of the human field of Chinese medicines now.Chinese patent notification number CN1843340A, CN1843341A, CN1985898A are used as anti influenza and bird flu H 5 N 1 medication with anthraquinone analog compound, and Chinese notification number CN1927192A is then with the radiosensitizer of anthraquinone analog compound as cancer diagnosis.
Summary of the invention:
Technical problem to be solved by this invention is: at above-mentioned the deficiencies in the prior art, a kind of aboundresources, green health are provided, anthraquinone analog compound is as the purposes of feed addictive in the Ba Tian garden sorrel easy to use, provides in a kind of Ba Tian of being added with garden sorrel anthraquinone analog compound as the feed of mould inhibitor and growth accelerator simultaneously.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: anthraquinone analog compound is characterized in as the purposes of feed addictive in the Ba Tian garden sorrel: described anthraquinone analog compound plays anti-going mouldy, and somatotrophic effect.
Anthraquinone analog compound extracts acquisition in the Ba Tian garden sorrel of the present invention from the Ba Tian garden sorrel, and comprises by rules permissions and make an addition to carrier or matrix in animal feed or the feed addictive.Anthraquinone analog compound is a mixture in the Ba Tian garden sorrel, mainly contains archen, Chrysophanol, Physcion etc.From the Ba Tian garden sorrel, extract the method for anthraquinone analog compound, a lot of research is arranged both at home and abroad, as Su Yuezeng at document " anthraquinone analog compound in the Ba Tian garden sorrel " (" Northwest Normal University's journal " (natural science edition) P47, the 36th 2000 the 3rd phases of volume) introduced a kind of from the Ba Tian garden sorrel, the extraction and the method for separating anthraquinone compound, after being about to dried Ba Tian garden sorrel herb and being crushed to graininess, behind 95% ethanol cold soaking 3 times, get total medicinal extract after concentrating, after mixing a small amount of silica gel and waiing upon the residual ethanol volatilization, use benzinum successively, chloroform, ethyl acetate and extracting n-butyl alcohol, get the anthraquinone analog compound medicinal extract of respectively classifying, after carrying out the tonsure wash-out with different solvents successively again, alkali is molten respectively, the heavy back of acid chromatography goes out each concrete anthroic acid compounds, as archen (emodin), Chrysophanol (chrysophanol), Physcion (physcion) etc.Former sources etc. are at document " chemical composition of Ba Tian garden sorrel " (" CHINA JOURNAL OF CHINESE MATERIA MEDICA ", P256, the 26th the 4th phase of volume, calendar year 2001) introduced the another kind of method of from the Ba Tian garden sorrel, extracting anthraquinone analog compound, promptly get dry powder sample, with 80% ethanol cold soaking repeatedly, decompression concentrates, successively water and carrene, ethyl acetate, extracting n-butyl alcohol.Get concrete anthraquinone analog compound by the distinct methods wash-out.
Extracting method used in the present invention, concrete partial content with reference to document, after promptly pulverizing from the dry root of Ba Tian garden sorrel, use 95% ethanol to merge cooling bath behind the cold soaking 5 times repeatedly, concentrate total medicinal extract, after the medicinal extract microwave drying, pulverize, again with behind the petroleum ether extraction, put and be ground into 100% fine powder of crossing 80 mesh sieves after the vacuum drying chamber drying again, measure total anthraquinones content and be not less than 60%.
The ratio that anthraquinone analog compound in this Ba Tian garden sorrel adds the anthraquinone analog compound of 1-200 gram with per 1000 kilogram of feed is added in the feed.The addition manner that adopts is: anthraquinone analog compound is promptly directly mixed with feed in the mode that solid mixes, stir evenly and get final product; Or this anthraquinone analog compound added in the feed with spray pattern, be about to anthraquinone analog compound water-soluble after, the water that is dissolved with anthraquinone analog compound is sprayed on the feed.
Feed goods of the present invention are exactly to be added with anthraquinone analog compound in the Ba Tian garden sorrel as stated above as mould inhibitor, and the feed of growth accelerator.
Beneficial effect of the present invention is as follows: the mould fungus inhibition growth, and the prevention feed mold, the nutritional labeling in the protection feed prolongs the feed holding time; Promote growth of animal, improve food conversion ratio.
The specific embodiment:
Embodiment 1: anthraquinone analog compound is to the inhibition activity of common mould in the feed in the Ba Tian garden sorrel
Adopt punching medicament diffusion method, anthraquinone analog compound is to the inhibition activity of the common mould of feed in the mensuration Ba Tian garden sorrel.
Experiment material:
(1) anthraquinone analog compound 50 grams available from Hunan natural products Engineering Technical Research Centre, are demarcated total anthraquinones content 〉=60%.
(2) determination of activity fungal strain: aspergillus flavus (Aspergillus flavus Link), fusarium (Fusarium moniliforme), mould (Penicillium glaucum), Aspergillus ochraceus (Aspergillus ochraceus) is all taken from Hunan Inst. of Microbe, the above-mentioned bacterial strains long preservation is under-20 ℃, before determination of activity, on the LB flat board, carry out (28 ℃ of activation culture to supplying to try bacterium, secretly) 48h, picking list bacterium colony then, in the LB fluid nutrient medium, shake (28 ℃ of trainings, secretly, 150rpm) 24h, subculture is cultivated 8-12h then, and bacterial concentration reaches 10 9Cfu/mL promptly can be used for determination of activity.
(3) culture medium: adopt the LB agar medium (yeast extract 5g/L, peptone 10g/L, sodium chloride 5g/L, agar 20g/L, PH7.0) and the LB fluid nutrient medium (yeast extract 5g/L, peptone 10g/L sodium chloride 5g/L, PH7.0).
(4) antibacterial activity is measured: adopt punching medicament diffusion method to measure.Concrete determination step is: contain 3% water agar 10mL in the culture dish of 90mm diameter, add 15mL after the cooled and solidified and contain 150 μ L bacterium liquid (10 9Cfu/mL) LB culture medium (45 ℃), after treating that the upper strata is solidified, with aseptic card punch punching (diameter 5mm), adding concentration in every hole is the anthraquinone analog compound solution 10 μ L of 10mg/mL (preparing with DMSO) or aureomycin solution 10 μ L (positive control) or the DMSO solution 20 μ L (negative control) of 0.5mg/mL (preparing with DMSO), after cultivating 12h under 28 ℃, adopt the right-angled intersection method to measure the diameter in antibacterial zone.Each is handled and repeats 5 times.Result such as following table 1:
Anthraquinone analog compound is to the inhibition activity of common mould in the feed in the table 1 Ba Tian garden sorrel
Figure B2009100438744D0000041
Figure B2009100438744D0000051
Annotate: the amount of anthraquinone analog compound is 0.2mg in every hole, and the amount of aureomycin is 5 μ g.
The result shows: anthraquinone analog compound is to having better inhibited activity for the examination bacterium in the Ba Tian garden sorrel.
Embodiment 2: anthraquinone analog compound is to the anti-mold effect of mixed feed in the Ba Tian garden sorrel
Test material:
(1) anthraquinone analog compound:, demarcate total anthraquinones content 〉=60% available from Hunan natural products Engineering Technical Research Centre.
(2) aureomycin: commercially available, Inner Mongol Jin He bio tech ltd is produced, and demarcates content: 15%.
(3) Midew preventive for feed: commercially available, the Nantong imperial chemical industry of pine Co., Ltd produces.
(4) basal diet: according to the requirement of NRC (1998) about weaning stage piglet nutritional need, 4 kinds of different daily ration prescriptions of preparation on the basis of basal diet, basal diet is formed and trophic level sees Table 2 (trophic level is a calculated value in the table).
Table 2 experimental basis daily ration is formed and trophic level
The daily ration composition Content (%) Nutritive index Content
Corn C orn (CP7.8%) 55.5 DE(MJ/kg) 14.21
Big dregs of beans Soybean expanded (CP 45%) 15 CP(％) 20
Imported fish meal Fish meal (CP 64.5%) 3 Ca(％) 0.71
Low albumen whey powder Whey 7.5 Effective P (%) 0.48
In generation, is newborn precious 5 Lysine (%) 1.35
Pu Luobao 8.2 Methionine (%) 0.42
Tryptophan 0.06 Threonine (%) 0.9
Sucrose 1.5
Stone flour Limestone 0.66
Calcium monohydrogen phosphate Monocalcium phosphate 0.83
NaCl salt 0.13
Soybean oil 0.8
Premix Premix * 1
FE-5 L-Lysine.HCl 0.43
Methionine Met 0.19
Threonine Thr 0.17
Santoquin 0.03
Amount to Total 100
Annotate: *In daily ration, add (content in every kg daily ration): CuSO by premix 45H 2O, 19.84mg; KI, 0.2mg; FeSO 47H 2O, 400mg; NaSeO 3, 0.56mg; ZnSO 47H 2O, 358.74mg; MnSO 4H 2O, 10.17mg; VK 3, 5000mg; VB 1, 2000mg; VB 2, 15000mg; VB 12, 30mg; VA, 5,400 ten thousand IU; VD 3, 1,080 ten thousand IU; VE, 1.8 ten thousand IU; Choline Chloride 80mg; Antioxidant 20mg; 2. diets of different nutrition level is a calculated value.
Test site: the Hunan has breed Co., Ltd greatly
Experimental design: 4 kinds of mixed feeds of preparation on the basis of basal diet, processed group one is not added any other antibacterial mildew inhibitor, be negative control group, processed group two is added 50mg/kg aureomycin (positive controls 1), processed group three is added the commercially available Midew preventive for feed of 1g/kg (positive controls 2), and processed group four is added the 10mg/kg anthraquinone analog compound.
More than four groups respectively produce 1 ton of feed, adopt the molded grain of 2.5mm.The woven bag packing, 40kg/ bag, each 25 bags.Randomly draw 3 bags as mould proof test from every group, other are used to feed.
Test method: moisture determination is carried out in the feed grouping that will extract from four processed group, is respectively negative control group 12.3%, aureomycin group 12.1%, and Midew preventive for feed group 12.6%, anthraquinone analog compound group are 12.5%.Under 28 ℃, indoor stack 7 days, 15 days, 30 days respectively after, observe, and 15 days, 30 days according to the GB/T3092-2006 feed in the mensuration of total number of molds 2 groups of positive controls and anthraquinone analog compound group carried out total number of molds measure.Observe and measurement result such as table 3.
Table 3 anthraquinone analog compound is to the feedstuff mildew effect
Figure B2009100438744D0000071
The result shows: anthraquinone analog compound can prevent preferably that mixed feed from going mouldy.
Embodiment 3: anthraquinone analog compound is to the influence of weanling pig production performance
The mixed feed of test material: embodiment 2 preparations.
The test grouping: select 120 the 28 healthy weanling pigs of age in days, before on-test, fed 3 days with basal diet earlier, be divided into 12 hurdles at random by first starting weight, male and female principle half-and-half then, 10 piglets in every hurdle are divided into 3 processed group, every group 4 hurdle.Processed group one is the blank group basal diet of feeding, and processed group two positive control groups 1 are fed and added the daily ration of 50mg/kg aureomycin, and processed group three be the anthraquinone analog compound group, the daily ration of the interpolation 10mg/kg anthraquinone analog compound of feeding.
Test period: 30 days.Take by weighing body weight on an empty stomach in the 1st day morning and morning last day.
Daily management: have the test piglet to raise in closed animal house, the child care hurdle is high bed metal slatted floor iron cage, and the nipple-shape water fountain is freely drunk water.Other management more solitos such as sterilization, immunity are carried out.Manually add material, feed in 7:00,11:00,15:00 and 19:00 every day, guaranteeing there is not free choice feeding under the dyspeptic prerequisite, severe diarrhoea or disease treatment in time or superseded occurs.
The result is as shown in table 4 below:
Table 4 anthraquinone analog compound is to the influence (n=3) of piglet growth performance
Project The blank group The aureomycin group The anthraquinone analog compound group
Starting weight (kg) 8.56±0.21 8.59±0.24 8.50±0.12
End heavy (kg) 22.45±0.62a 23.49±0.81ab 23.95±0.55b
Average feed intake (g/d) 745.43±20.39a 794.56±37.15ab 803.4±21.45b
Average daily gain (g/d) 463.00±17.54a 496.67±23.33b 515.00±14.24b
Feedstuff-meat ratio 1.61±0.02a 1.60±0.01a 1.56±0.02b
Annotate: the complete person inequality of colleague's letter represents significant difference (P＜0.05) in the mark.
As seen from the above table, in piglet diet, add anthraquinone analog compound and blank group mutually specific energy improve feed intake 7.78%, daily gain 11.23%, reduction feedstuff-meat ratio 3.1%.Obtain the effect equal or better with aureomycin.The result shows: anthraquinone analog compound can effectively promote the weanling pig growth, obtains the effect suitable with aureomycin.
Embodiment 4: anthraquinone analog compound is to the influence of meat chicken production performance
Test site: fryer field, Ningxiang County Hua Ming building
The fast big fryer of experimental animal: Ai Weiyin
Experimental design: the single factor experiment design is adopted in this test, selects 600 the 1 fast big fryer of age in days Ai Wei mattress for use.For examination chicken well-grown, healthy anosis.The body weight basically identical.To try chicken and be divided into 4 groups at random, every group of 6 repetitions, each repeats 25 chickens.Experimental period is 49 days.Experiment is divided into 4 groups: processed group one is the blank group basal diet of feeding, and processed group two positive control groups 1 are fed and added the daily ration of 50mg/kg aureomycin, and handling three is the anthraquinone analog compound group, the daily ration of the interpolation 10mg/kg anthraquinone analog compound of feeding.Handling four is the compound group, feeds and adds the daily ration of 5mg/kg anthraquinone analog compound and 1g/kg Ba Tian garden sorrel plant powder.
Feeding and management:
The test hen house is open, and gravity-flow ventilation, illumination are 14L:10D.Write down temperature, humidity in the hen house every day.The examination chicken is adopted high bed to put down and supports, and measures quantity-unlimiting feeding; Freely drink water, scale of feeding is by recommending nutritional requirements to decide in conjunction with actual feed intake.Carry out hygienic cleaning and sterilization according to a conventional method.Experimental period, keep crib, tank sanitation and hygiene.
Record index and method
1. average daily gain (ADG): test chicken is that unit weighed on an empty stomach in the 21st, 49 mornings to repeat, to investigate per stage weightening finish, total augment weight and average daily gain;
2. average daily ingestion amount (ADFI): the daily ingestion amount that calculates every chicken;
3. feed conversion rate (FCR): average daily ingestion amount/average daily gain;
The result is as shown in table 5 below:
Table 5 anthraquinone analog compound is to growth of meat chicken Effect on Performance (n=4)
Project The blank group Positive controls Anthraquinone analog compound The compound group
D0 body weight (g) 45.1±0.6 44.9±0.71 45.2±0.62 45.0±0.21
D49 body weight (g) 2152.3±79.7 2163.6±97.6 2326.2±87.4 2332.7±74.2
Daily gain (g/d) 43.0±1.9 43.2±2.1 46.6±1.4 46.7±1.7
Average daily feed intake (g/d) 90.4±6.6 87.4±3.4 90.4±3.6 90.7±4.1
Feedstuff-meat ratio 2.1±0.1 2.0±0.1 1.9±0.4 1.9±0.2
Dead chicken number of full phase 12 7 5 5
As seen from the above table, the average daily ingestion amount of 3 processed group and average daily gain are followed successively by compound group, anthraquinone analog compound group, positive controls (aureomycin), blank group from high to low.Compare with the blank group, interpolation anthraquinone analog compound and Ba Tian garden sorrel vegetable material have improved average feed intake 0.3% in the daily ration; Average daily gain 8.60%; Feedstuff-meat ratio has descended 9.52%.The group of only adding anthraquinone analog compound is compared with the blank group and is then improved average daily gain 8.37%, and feedstuff-meat ratio 9.52%, two processed group that descended all effectively reduces the fryer death toll.
The result shows: in the fast big daily ration of broiler of Ai Wei mattress, add anthraquinone analog compound and can promote growth and raising fryer survival rate with Ba Tian garden sorrel vegetable material, obtain with aureomycin quite or better effect.

Claims (6)

1. anthraquinone analog compound is characterized in that as the purposes of feed addictive in the Ba Tian garden sorrel: described anthraquinone analog compound plays anti-going mouldy, and somatotrophic effect.
2. purposes as claimed in claim 1 is characterized in that: described anthraquinone analog compound is a Ba Tian garden sorrel plant extracts.
3. purposes as claimed in claim 1 or 2 is characterized in that: the ratio that anthraquinone analog compound adds the anthraquinone analog compound of 1-200 gram with per 1000 kilogram of feed is added in the feed.
4. purposes as claimed in claim 3 is characterized in that: anthraquinone analog compound is directly mixed with feed, stir evenly and get final product.
5. purposes as claimed in claim 3 is characterized in that: anthraquinone analog compound is added in the feed with spray pattern, be about to anthraquinone analog compound water-soluble after, the water that is dissolved with anthraquinone analog compound is sprayed on the feed.
6. be added with anthraquinone analog compound in the Ba Tian garden sorrel as mould inhibitor, and the feed of growth accelerator.
CN2009100438744A 2009-07-09 2009-07-09 Application of anthraquinone compounds in Rumex patientia Linn. as feed additive and corresponding feeds Pending CN101940252A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030925A (en) * 2015-09-12 2015-11-11 郭小川 Plant extract for treating blood stasis disease and pharmaceutic preparation
CN107712362A (en) * 2017-11-22 2018-02-23 广州傲农生物科技有限公司 A kind of feed addictive for preventing feed fat from aoxidizing and going mouldy and preparation method and application
CN112401106A (en) * 2020-10-10 2021-02-26 中国农业科学院草原研究所 Mildew preventive suitable for storing high-moisture natural pasture and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030925A (en) * 2015-09-12 2015-11-11 郭小川 Plant extract for treating blood stasis disease and pharmaceutic preparation
CN107712362A (en) * 2017-11-22 2018-02-23 广州傲农生物科技有限公司 A kind of feed addictive for preventing feed fat from aoxidizing and going mouldy and preparation method and application
CN112401106A (en) * 2020-10-10 2021-02-26 中国农业科学院草原研究所 Mildew preventive suitable for storing high-moisture natural pasture and preparation method thereof

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Application publication date: 20110112