CN101918433B - 肝细胞癌细胞特异性的肽及其应用 - Google Patents

肝细胞癌细胞特异性的肽及其应用 Download PDF

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Publication number
CN101918433B
CN101918433B CN2008801247432A CN200880124743A CN101918433B CN 101918433 B CN101918433 B CN 101918433B CN 2008801247432 A CN2008801247432 A CN 2008801247432A CN 200880124743 A CN200880124743 A CN 200880124743A CN 101918433 B CN101918433 B CN 101918433B
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polypeptide
liposome
cancer
peptide
hcc
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CN101918433A (zh
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吴汉忠
林钦塘
阿尔伯特·洛
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Academia Sinica
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008801247432A 2007-11-20 2008-11-19 肝细胞癌细胞特异性的肽及其应用 Active CN101918433B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99648807P 2007-11-20 2007-11-20
US60/996,488 2007-11-20
PCT/US2008/084043 WO2009067520A2 (en) 2007-11-20 2008-11-19 Peptides specific for hepatocellular carcinoma cells and applications thereof

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CN101918433A CN101918433A (zh) 2010-12-15
CN101918433B true CN101918433B (zh) 2013-06-26

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US (1) US8541543B2 (enExample)
EP (1) EP2225262B1 (enExample)
JP (1) JP2011504361A (enExample)
CN (1) CN101918433B (enExample)
TW (1) TWI372866B (enExample)
WO (1) WO2009067520A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010138550A1 (en) * 2009-05-27 2010-12-02 Northeastern University Conjugated nanodelivery vehicles
CN102732522B (zh) * 2012-02-27 2014-04-09 南昌大学 一组肝癌血清核酸适配子
JP6335189B2 (ja) * 2012-12-17 2018-05-30 トリリアム・セラピューティクス・インコーポレイテッドＴｒｉｌｌｉｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． ＳＩＲＰアルファ−Ｆｃ融合体でのＣＤ４７＋疾患細胞の治療
CN103804473B (zh) * 2014-01-23 2016-01-20 浙江大学 一种多肽及包含该多肽的核酸药物纳米粒
CN103804472B (zh) * 2014-01-23 2016-06-08 浙江大学 一种紫杉烷类药物前体
CN104667290A (zh) * 2014-10-25 2015-06-03 中国科学技术大学 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用
CN105039333B (zh) * 2015-08-21 2018-07-24 天津医科大学 肝癌靶向肽及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1398187A (zh) * 2000-02-10 2003-02-19 加利福尼亚大学董事会 用于治疗肝细胞癌的方法和组合物

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US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) * 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4791192A (en) * 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5080891A (en) * 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US6663885B1 (en) * 1993-03-15 2003-12-16 A. Natterman & Cie Gmbh Aqueous liposome system and a method for the preparation of such a liposome system
AU683957B2 (en) * 1993-11-05 1997-11-27 Amgen, Inc. Liposome preparation and material encapsulation method
US6051251A (en) * 1997-11-20 2000-04-18 Alza Corporation Liposome loading method using a boronic acid compound
US6974884B2 (en) * 2002-06-07 2005-12-13 Wisconsin Alumni Research Foundation Chemical synthesis of reagents for peptide coupling
TWI262192B (en) * 2003-07-01 2006-09-21 Univ Nat Taiwan Labeling peptide for nasopharyngeal carcinoma (NPC) cells
US7501486B2 (en) * 2004-09-07 2009-03-10 Burnham Institute For Medical Research Peptides that selectively home to heart vasculature and related conjugates and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1398187A (zh) * 2000-02-10 2003-02-19 加利福尼亚大学董事会 用于治疗肝细胞癌的方法和组合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Du等.In vitro panning of a targeting peptide to hepatocarcinoma from a phage display peptide library.《Biochemical and Biophysical research communications》.2006,第12卷(第1期),956-962. *
Han Cliff等.Pathogenomic sequence analysis of Bacillus cereus and Bcillus thuringiensis isolates closely related to Bacillus anthracis.《Journal of Bacteriology》.2006,第188卷(第9期),3382-3390. *
Lauren R H等.The use of phage-displayed peptide libraries to develop tumor-targeting Drugs.《International Journal of peptide research and therapeutics》.2006,第12卷(第1期),79-91. *

Also Published As

Publication number Publication date
TWI372866B (en) 2012-09-21
WO2009067520A3 (en) 2009-09-03
EP2225262B1 (en) 2016-04-27
US8541543B2 (en) 2013-09-24
US20090136418A1 (en) 2009-05-28
TW200935055A (en) 2009-08-16
JP2011504361A (ja) 2011-02-10
EP2225262A2 (en) 2010-09-08
WO2009067520A2 (en) 2009-05-28
CN101918433A (zh) 2010-12-15

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