CN101912109B - Health-care food with hypoxia tolerance function and preparation method thereof - Google Patents
Health-care food with hypoxia tolerance function and preparation method thereof Download PDFInfo
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- CN101912109B CN101912109B CN2010102219231A CN201010221923A CN101912109B CN 101912109 B CN101912109 B CN 101912109B CN 2010102219231 A CN2010102219231 A CN 2010102219231A CN 201010221923 A CN201010221923 A CN 201010221923A CN 101912109 B CN101912109 B CN 101912109B
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Abstract
The invention discloses health-care food with hypoxia tolerance function and a preparation method thereof. The health-care food is prepared from the following raw materials comprising olive leaves and green tea. The health-care preparation provided by the invention can improve the normal-pressure hypoxia tolerance survival time of mice, improve the sodium nitrate poisoning survival time of the mice and improve the acute hypoxic-ischemic gasp time of the mice, and has good hypoxia tolerance health-care function. The health-care food takes a homologous medicament-food natural plant as a main raw material, and has stable and controllable preparation process and product quality and remarkable curative effect; and the provided formulation is convenient to take and suitable for all people to eat.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof, belong to health product technology field with anoxia tolerance function.
Background technology
In kownledge economy, the market economy New Times of high speed development, rhythm of life is accelerated, and social competition is fierce; People also grow with each passing day in the face of the pressure of each side; Many crowds that are in sub-health state because working strength strengthens, produce the not enough phenomenon of oxygen supply gradually.The crowd of anaerobic environment work is more and more wider, and like the crowd of tourism, office building, market, basement etc. are than the personnel of confined space life, work, computernik; Be in student in the test period, accounting, scientific research personnel; Writer, the sportsman of strenuous exercise, the elderly etc.China always payes attention to integration of drinking and medicinal herbs, and health food receives numerous crowds' welcome deeply.Therefore, develop a kind of good effect, can improve anoxia endurance, be easy to just seem more and more urgent for the health food that the Chinese common people accept.
The share that the present health food of anti-the anoxic occupies in health food market is increasing; Data according to health-product market Working Committee of China health care association; So far; Ratify kind surplus the anoxia tolerance function health food 200 altogether, homemade health food in being mainly, mostly its main component is shark alkene, rhodiola root, American ginseng etc.From application market, mainly in the face of following crowd: (1) student.The student belongs to the heavy crowd of mental labour, especially in the test period.(2) the elderly.On the one hand, said like before, middle-aged and old histocytes obtain the ability drop of oxygen, and on the other hand, a lot " anti-anoxic " health foods have enhance immunity power concurrently, constitutional effect simultaneously.(3) need improve the adult of energy.(4) crowd who works, travels to the plateau.In the traditional health care culture of China, anti-hypoxia health product has unique status, and the resource that can develop is very abundant, and therefore, the health food of studying anti-anoxic has the vast market development prospect.
The homemade health products that are used for anti-anoxic in the market have three general Rhodiola rosea capsules (compound sky sour jujube capsule), Rhodiola rosea capsules, Nuodikang capsule, sharp capsules " Weishukang " for curing; General safranine capsule, beneficial glad recovering capsule, safflower micro powder capsules; Hundred power capsules, the strong waist capsule of consumption pizzle, the glad recovering capsule of fat etc.Although anti-hypoxia health product a multitude of names, advertising is powerful, and the health products that can obtain consumers in general's approval are few; Also lack desirable anti-hypoxia health product in the market, its weak point mainly is that active constituent content is low; Onset is slow, DeGrain, and product price is relatively more expensive.
This product is the basic foundation of product design with traditional methods to keep in good health's theory, and the natural plants of using biologically active is a primary raw material.Wherein olive growing leaves has been widely used in cosmetics and food supplement and the medicine in American-European market, and the Tea Polyphenols in the green tea is the natural antioxidative food additive of Ministry of Public Health's approval.This product component reasonable mixture ratio, active constituent content is high, has the significant health care of anti-the anoxic, has the good market competitiveness.
Summary of the invention
The objective of the invention is to: a kind of health food with anoxia tolerance function and preparation method thereof is provided.
The natural plants that health products of the present invention are used integration of drinking and medicinal herbs is a primary raw material, and preparation technology and constant product quality are controlled, and be evident in efficacy, and the formulation that is provided is carried, taking convenience, and it is edible to be fit to all kinds of crowds.
The present invention constitutes like this: a kind of health food with anoxia tolerance function, according to listed as parts by weight, it is that raw material is processed for 100～200 parts with green tea for 80～150 parts with olive growing leaves.
Described health products are oral formulations, are preferably capsule.
Preparation method with health food of anoxia tolerance function of the present invention is: take by weighing feedstock oil olive leaf and green tea in proportion, extract 1～3 time with 6～10 times of alcohol refluxs of measuring 60～90% concentration, extracted 1～3 hour at every turn; Filter, merging filtrate is behind the decompression recycling ethanol; Be evaporated to the medicinal extract of 60 ℃ of relative densities 1.10～1.15, medicinal extract is carried out spray-drying (EAT is 150～180 ℃, and leaving air temp is 60～90 ℃); Obtain the spray-drying fine powder, add an amount of auxiliary material, mix 10～60min; With the material filled capsules that mixes, packing promptly gets.
The auxiliary material that adds among the preparation method of said health products is starch or lactose or dextrin, and the spray-drying fine powder with add auxiliary material weight ratio be 0.8～1.5.
Health products of the present invention are primary raw material with olive growing leaves and green tea, are prepared from through reasonable process.
Olive growing leaves: the leaf that belongs to Oleaceae (Oleaceae), Olea (Olea) aiphyllium.Research in recent years shows, contains simple phenolic compound such as a large amount of secoiridoid (representative species oleuropein), hydroxytyrosol, lignan class, caffeoyl benzyl carbinol glycoside, flavonoids etc. in the olive growing leaves.Wherein polyphenol compound is its main physiologically active ingredient.Research shows that the olive polyphenol has significant anti-oxidant and resisting oxygen lack, can remove free radical effectively, can alleviate the degree of oxidation of low-density lipoprotein, prevention coronary heart disease, atherosclerotic generation; Enhancing body immunity and antineoplastic action are arranged; Has the vascular smooth muscle of releiving, the ability that brings high blood pressure down.
The olive growing leaves polyphenol is to be extracted by natural green plants to form; Chinese scholars has been carried out various pharmacological experiment studies such as acute and chronic toxicity test, AMES test, anti-mutant test, anticancer change test, micronucleus test to it, the result show the olive polyphenol have no side effect, safe.The external olive growing leaves polyphenol extract of standard of having produced, its active constituent content is high, is used for cosmetics and food supplement and medicine.At present France, Italy, Israel are existing is that the cosmetics and the medicine of Main Ingredients and Appearance appears on the market with the olive growing leaves polyphenol extract, receives consumer and patient's favorable comment.
Green tea: the bud-leaf that belongs to Theaceae Camellia tea plant.The main chemical compositions of green tea comprises: compositions such as Tea Polyphenols, tea polysaccharide, amino acid, Tea Pigment, caffeine.Wherein the major physiological active material is a Tea Polyphenols.Tea Polyphenols is a kind of natural health-care products of traditional integration of drinking and medicinal herbs, in existing about 5000 history of China.Research shows that Tea Polyphenols has significant anti-anoxic property and non-oxidizability, can remove free radical, delay senility; But enhancing body immunity, the auxiliary tumour that suppresses; The effect of blood-fat-decreasing, blood sugar, inhibition atherosclerotic, fat-reducing is arranged; Antibiotic in addition, antiviral, radiation hazradial bundle had multiple efficacies such as assistant protection function.Tea Polyphenols is the natural antioxidative food additive of Ministry of Public Health approval, and it is classified as the sanitary standard that food additives use and is GB2760-86.Chinese scholars has been carried out various pharmacological experiment studies such as acute and chronic toxicity test, AMES test, anti-mutant test, anticancer change test, micronucleus test to Tea Polyphenols, the result shows that Tea Polyphenols is a kind of novel safe, nontoxic, green natural anti-oxidant.
Because Tea Polyphenols is the material that directly from tealeaves, extracts, and belongs to natural additive, and is harmless to human non-toxic, safety and sanitation, and human body had plurality of health care functions, thereby be the natural additive for foodstuff with very big development and application prospect.Tea Polyphenols is at food additives, daily-use chemical industry, and be used widely in fields such as Medicines and Health Product, and the domestic and international market is good, and development prospect is tempting.At present some are that the Medicines and Health Product processed of raw material is of a great variety with the Tea Polyphenols, like Chinese medicine capsule, and green tea effervescence piece, Tea Polyphenols capsule, Tea Polyphenols sheet etc.The U.S. has ratified the green tea capsule as the clinical application thing.
Health products of the present invention are functional component with the total polyphenols, test through function test, hygiene and the quality stability of security toxicological test, anti-anoxic to show this health products safety non-toxic, the health care with significant anti-anoxic.
The specific embodiment
Below further set forth the preparation method that the present invention has the health food of anoxia tolerance function through embodiment.
Embodiment 1: the raw material of getting following weight portion: 120 parts of olive growing leaves, and 100 parts of green tea extract 2 times with 7 times of alcohol refluxs of measuring 70% concentration, extract 2 hours at every turn; Filter, merging filtrate is behind the decompression recycling ethanol; Be evaporated to the medicinal extract of 60 ℃ of relative densities 1.10～1.15, medicinal extract is carried out spray-drying (EAT is 180 ℃, and leaving air temp is 70 ℃); Obtain the spray-drying fine powder, add an amount of supplementary product starch (weight ratio of spray-drying fine powder and starch is 0.9), mix 40min; With the material filled capsules that mixes, packing promptly gets.
Embodiment 2: the raw material of getting following weight portion: 150 parts of olive growing leaves, and 150 parts of green tea extract 3 times with 7 times of alcohol refluxs of measuring 80% concentration, extract 2 hours at every turn; Filter, merging filtrate is behind the decompression recycling ethanol; Be evaporated to the medicinal extract of 60 ℃ of relative densities 1.10～1.15, medicinal extract is carried out spray-drying (EAT is 170 ℃, and leaving air temp is 90 ℃); Obtain the spray-drying fine powder, add an amount of auxiliary material lactose (weight ratio of spray-drying fine powder and lactose is 1.2), mix 20min; With the material filled capsules that mixes, packing promptly gets.
Embodiment 3: the raw material of getting following weight portion: 100 parts of olive growing leaves, and 100 parts of green tea extract 2 times with 6 times of alcohol refluxs of measuring 70% concentration, extract 2.5 hours at every turn; Filter, merging filtrate is behind the decompression recycling ethanol; Be evaporated to the medicinal extract of 60 ℃ of relative densities 1.10～1.15, medicinal extract is carried out spray-drying (EAT is 160 ℃, and leaving air temp is 80 ℃); Obtain the spray-drying fine powder, add an amount of auxiliary material dextrin (weight ratio of spray-drying fine powder and dextrin is 1.5), mix 30min; With the material filled capsules that mixes, packing promptly gets.
Embodiment 4: the raw material of getting following weight portion: 130 parts of olive growing leaves, and 200 parts of green tea extract 2 times with 9 times of alcohol refluxs of measuring 60% concentration, extract 1.5 hours at every turn; Filter, merging filtrate is behind the decompression recycling ethanol; Be evaporated to the medicinal extract of 60 ℃ of relative densities 1.10～1.15, medicinal extract is carried out spray-drying (EAT is 180 ℃, and leaving air temp is 90 ℃); Obtain the spray-drying fine powder, add an amount of auxiliary material dextrin (weight ratio of spray-drying fine powder and dextrin is 1.0), mix 40min; With the material filled capsules that mixes, packing promptly gets.
The health food active constituent content with anoxia tolerance function and the quality of producing according to this technological process are all very stable.The security and the function test of these health products being carried out through authoritative department Jiangsu Province Center for Disease Control, result show that this health products safety non-toxic has significant resisting oxygen lack.Concrete content of the test and result are following:
One, safety testing
The toxicity safety test in the I of these health products and II stage shows: this product safety is nontoxic.Jiangsu Prov. Disease Preventing and Controlling Center shows the I and the safety test of II stage toxicity of these health products:
(1) chmice acute per os toxicity test, male and female its mouse oral MTD value show that greater than 20000mg/kg b.wt these health products belong to nontoxic level.
(2) Salmonella reversion test: flat board mixes method, and dosage reaches 5000 μ g/ wares, adds and do not add S9, and standard testing bacterium TA97, TA98, TA100 and TA102 are not all detected tangible MA.
(3) PCEMNR micronucleus test: dosage reaches 10000mg/kg b.wt, does not detect the micronucleus effect that causes to the male and female PCEMNR.
(4) mouse sperm deformity test: dosage reaches 10000mg/kg b.wt, does not detect the MA to the male mice sperm.
Therefore, these health products do not have teratogenesis, mutagenesis and carcinogenic.
(5) 30 days feeding trials; Sample is with 1600,2000 and 2400mg/kg b.wt dosage (when being equivalent to the actual intake of 80,100 and 120 times of RDs); Fed rat 30 days; Rat growthing development and hematology, biochemical pathological index all do not detect obvious illeffects, do not see obvious harmful effect.It is 2400mg/kg/d that the maximum of 30 days feeding trials of this sample is not observed illeffects dosage (NOAEL value).
Two, anoxia tolerance function test
To the health food of anti-anoxic function assessment evaluation criterion, show that through zoopery health food of the present invention has significant anoxia tolerance function according to Ministry of Public Health's " health food check and assessment technique standard " (2003 editions).
1. experimental animal: female healthy ICR mouse, cleaning level, body weight 18～22g.Shanghai Slac Experimental Animal Co., Ltd. provides, the quality certification number: SCXK (Shanghai) 2007-0005.The SPF level animal used as test environmental facility quality certification number: SYXK (Soviet Union) 2007-0020.All sterilize mouse feed and aqua sterilisa of all animals freely taken.
2. dosage is selected and tried thing to give mode: every test all establishes 600,200 and three dose groups of 100mg/kg (be respectively referrer's daily intaking amount 30,10,5 times), establish a solvent control group simultaneously; Animal respectively is divided into 4 groups by body weight at random, every group of 12 mouse.Taking by weighing sample 1200,400,200mg respectively adds distilled water and is mixed with to 40ml and respectively receives amount of reagent, preparation on the same day.Every day, per os was irritated stomach once, irritated gastric capacity and was the 20ml/kg body weight, was tried thing 30d continuously.Solvent control group is irritated stomach equivalent distilled water every day.
3. carry out data with the SPSS statistical software.This experiment gained data are measurement data; Initial data is carried out test of normality and homogeneity test of variance earlier; Satisfy the requirement of " variance is neat " and " normal distribution "; (ANOVA) adds up with the one-way analysis of variance method, and the data of P＜0.05 are carried out statistical disposition with the comparative approach in twos of mean between a plurality of experimental group and control group.
4. test procedure
4.1 normal pressure hypoxia endurance test: last is irritated behind the stomach 1h mouse is put into the 250ml port grinding bottle that fills the 5g soda lime (capacity error ± 1ml) respectively; Be coated with vaseline sealing bottleneck; And timing immediately, be index to cease breathing, observe and the record mouse anti-anoxic time-to-live of normal pressure.
4.2 natrium nitrosum poisoning survival test: last pursues a lumbar injection natrium nitrosum (injection volume is the 0.1ml/10g body weight) with mouse by 220mg/kg b.w. dosage after irritating stomach 1h, and timing immediately is an index with the breath stopped, the record mouse time-to-live.
4.3 acute cerebral ischemia property anoxic survival test: last pursues only broken end with mouse from neck after irritating stomach 1h, with dehiscing the time of breathing behind the stopwatch record mouse broken end.
5. result
5.1 body weight and time-to-live are seen table 1 before and after each the treated animal experiment of mouse normal pressure hypoxia endurance test.
Table 1 this health products mouse normal pressure hypoxia endurance test result
Visible by table 1: as not have group difference (P＞0.05) with test back the weight of animals before the test.Compare each dose groups prolonged survival period with control group, middle and high dose groups all has significant difference (P＜0.05, P＜0.01).
5.2 body weight and time-to-live are seen table 2 before and after each the treated animal experiment of natrium nitrosum poisoning experiment.
Table 2 this health products mouse natrium nitrosum poisoning experiment result
Visible by table 2: as not have group difference (P＞0.05) with test back the weight of animals before the test.Compare each dose groups time-to-live all prolongs with control group, and utmost point significant difference (P＜0.01) is all arranged.
5.3 body weight and the time of breathing are seen table 3 before and after each the treated animal experiment of chmice acute cerebral ischemia hypoxia test.
Table 3 this health products chmice acute cerebral ischemia hypoxia test result
Visible by table 3: as not have group difference (P＞0.05) with test back the weight of animals before the test.Comparing each dose groups time of breathing with control group all has prolongation, and high dose group has significant difference (P＜0.05).
6. brief summary: this sample has the effect of natrium nitrosum poisoning time-to-live of raising mouse; Have and improve the breathe effect of time of chmice acute cerebral ischemia anoxic; Has the effect that improves the mouse anti-anoxic time-to-live of normal pressure; According to improving the criterion of anoxia tolerant function experimental result, this sample has the effect that improves anoxia tolerant function.
Claims (6)
1. the health food with anoxia tolerance function is characterized in that the weight portion proportioning of raw material is: 80～150 parts of olive growing leaves, 100～200 parts of green tea.
2. according to the described health food with anoxia tolerance function of claim 1, it is characterized in that: described health food is an oral formulations.
3. according to the described health food with anoxia tolerance function of claim 2, it is characterized in that: described oral formulations is a capsule.
4. like each said preparation method among the claim 1-3, it is characterized in that: take by weighing feedstock oil olive leaf and green tea in proportion, extract 1～3 time, extracted 1～3 hour at every turn with 6～10 times of alcohol refluxs of measuring 60～90% concentration with health food of anoxia tolerance function; Filter, merging filtrate behind the decompression recycling ethanol, is evaporated to the medicinal extract of 60 ℃ of relative densities 1.10～1.15; Medicinal extract is carried out spray-drying, and EAT is 150～180 ℃, and leaving air temp is 60～90 ℃; Obtain the spray-drying fine powder, add an amount of auxiliary material, mix 10～60min; With the material filled capsules that mixes, packing promptly gets.
5. according to the preparation method of the health food that has anoxia tolerance function described in the claim 4, it is characterized in that: the auxiliary material that is added is starch or lactose or dextrin.
6. according to the preparation method of the health food that has anoxia tolerance function described in the claim 4, it is characterized in that: the spray-drying fine powder is 0.8～1.5 with the weight ratio of add auxiliary material.
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104621657B (en) * | 2014-12-26 | 2016-08-24 | 深圳市贝沃德克生物技术研究院有限公司 | The pure natural drinks that applicable Hypertensive Population based on health promotion is drunk |
| CN105011162A (en) * | 2015-07-02 | 2015-11-04 | 罗新华 | Olive leaf essence as well as making technology and application thereof |
| CN107227223A (en) * | 2017-06-27 | 2017-10-03 | 易门县康蓉油橄榄农业种植专业合作社 | Olive oil oil expression waste material brewages the brewing method of olive wine |
| CN114748532B (en) * | 2022-04-28 | 2023-08-18 | 云南油橄榄大健康产业创新研究发展有限公司 | A component prepared from fructus Canarii albi with anoxia resisting activity and its application |
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| CN1806649A (en) * | 2006-01-24 | 2006-07-26 | 邱国祥 | Health-caring tea made by olive leaf and preparation method thereof |
| CN101049328A (en) * | 2007-05-23 | 2007-10-10 | 陇南田园油橄榄科技开发有限公司 | Technique for producing extractive of olive growing leaves |
| CN101084945A (en) * | 2007-07-02 | 2007-12-12 | 北京市科威华食品工程技术有限公司 | Olive leaves extraction and preparation method thereof |
| CN101142958A (en) * | 2006-12-13 | 2008-03-19 | 唐文荣 | Olive tea |
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- 2010-07-09 CN CN2010102219231A patent/CN101912109B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806649A (en) * | 2006-01-24 | 2006-07-26 | 邱国祥 | Health-caring tea made by olive leaf and preparation method thereof |
| CN101142958A (en) * | 2006-12-13 | 2008-03-19 | 唐文荣 | Olive tea |
| CN101049328A (en) * | 2007-05-23 | 2007-10-10 | 陇南田园油橄榄科技开发有限公司 | Technique for producing extractive of olive growing leaves |
| CN101084945A (en) * | 2007-07-02 | 2007-12-12 | 北京市科威华食品工程技术有限公司 | Olive leaves extraction and preparation method thereof |
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