CN101890144A - Medicament for treating hepatitis B and preparation method - Google Patents

Abstract

The invention relates to a medicament (hepatitis B kangtai pills) for treating hepatitis B. The medicament is easily taken water pills prepared from the Chinese medicaments such as parasitic loranthus, piece turmeric, fructus kochiae, phyllanthus emblica, amomum tsao-ko, coptis chinensis, isatis root, abrus herb, oriental wormwood, emilia sonchifolia, polygonum cuspidatum, cyrtomium fortunei, cantharides, eclipta alba, cordyceps sinensis, astragalus mongholicus, aloe barbadensis, heterophylly falsestarwort root, subprostrate sophora, Chinese angelica, licorice root and the like in a certain ratio. The medicament can effectively protect the liver, inhibit viruses, has a remarkable curative effect after short-term administration, can promote HBsAg, HBeAg and Anti-HBc positive, HBsAg, HBeAb and HBcAb-positive and HBV test to be converted into negative or normal, lighten or vanish symptom, has the effective rate of 98 percent and the cure rate of over 93 percent, and is an effective medicament for treating the hepatitis B at present.

Description

A kind of medicine and preparation method for the treatment of hepatitis B

Technical field:

The present invention is a kind of pure Chinese medicine watered pill for the treatment of hepatitis B, belongs to the technical field of Chinese medicine preparation and preparation method.

Background technology:

Hepatitis B, full name is a hepatitis B, is by hepatitis B virus (a kind of infectious disease that (HBV) causes.Developing country's sickness rate is higher, and according to statistics, China's hepatitis B patient and hepatitis B virus carriers account for 1.2 hundred million, and is most asymptomatic, wherein 1/3 clinical manifestation that hepatic injury occurs.At present, China has hepatitis B patient 5,000 ten thousand approximately.Because of onset is slow, much more common with subclinical type and chronic type.The easy chronicity of non-icteric type HbsAg lasting masculin patient.Primary disease mainly contacts with property by blood, mother and baby and propagates.The application of Hepatitis B virus vaccine at present just prevents and controls the effective measures of hepatitis B, but can not fundamentally solve the clinical treatment of current hepatitis B patient.

The pathogenesis of hepatitis B, its hepatocyte injury are not the results that HBV duplicates in hepatocyte, but are mediated by the T cytotoxic reaction.After the people infects HBV, cellular immunization and humoral immune reaction be can cause, and autoimmune response and immunoloregulation function disorder excited.These immunoreation are to the clinical manifestation of hepatitis B and lapse to significant.

One, acute hepatitis, behind the normal patient infection HBV of immunologic function, its cytotoxic T cell (Tc cell) is attacked the hepatocyte that is contaminted, be released into the HBV of blood by destructive hepatocyte, and by the combination of specific antibody institute, and the interferon generation is more, is eliminated and cause HBV, sb.'s illness took a favorable turn, after all recovery from illness.

Two, chronic active hepatitis sees immunologic function defectiveness and immunoregulatory disorder person.Infect behind the HBV because the Tc cell function is undesired, or specific antibody enclosure portion liver cell target antigen and restrict the T cytotoxic reaction, cause part of hepatocytes undermined, it is less that interferon produces, and HBV continues to duplicate.Specific antibody forms not enough hepatocyte and is invaded by HBV repeatedly, forms to infect chronicity.In addition, the special lipoprotein of liver plasma membrane (Lsp) forms autoantigen because of HBV infects, and stimulates the B cell to produce anti--lsp (lgp type), at suppressor T lymphocyte Ts cell) under the situation of active reduction, autoimmunity ADCC effect causes the hepatocyte progressive injury.

Three, chronic persistent hepatitis and asymptomatic HbsAg carrier can infect HBV when body's immunity is low, can not produce effective immunoreation, cause hepatocellular damage and hepatocellular damage slightly or not occurs.Especially asymptomatic HbeAg carrier, for want of interferon can not be removed virus, so that carries HBV for a long time.

Four, the generation of hepatitis gravis and acute severe hepatitis, because organism immune response is strong excessively, T cytotoxic reaction in a short time destroys the hepatocyte of a large amount of HBV of generation rapidly; Or forming antigen antibody complex in a short time in a large number, activating complement can cause the Schwartzmana reaction, makes hepatocyte that ischemic necrosis take place; In addition-cytokine such as a tumor necrosis factor (TNF-a), IL-I and leukotriene discharges by mononuclear phagocyte, impels hepatocyte injury.The subacute severe hepatitis pathogenesis is similar to acute severe hepatitis, but progress is slower.

Behind the hepatitis B virus infection human body, if passive protective physical fitness is strong, immunologic function is normal and treatment is timely, and hepatitis B virus can be eliminated very soon.The patient just can cure in acute stage.In case hepatitis B virus fails in time to remove, hepatitis B can transfer to chronic, and virus can be carried for a long time, haves a medical check-up to show as the hepatitis B antigen positive, Here it is our said hepatitis B virus carriers.If hepatitis B virus is movable in hepatocyte, breeding is duplicated, and then clinical symptoms can occur, and common symptom has: patient's uncomfortable liver area, have a dull ache, malaise, loss of appetite, feel sick, detest oil, diarrhoea.Patient is sometimes with the low grade fever, jaundice can appear in serious patient, if delay treatment, a few patients can develop into hepatitis gravis, showing as liver function injury sharply increases the weight of up to depletion, simultaneously with the infringement of multi-organ functions such as renal failure, the jaundice that continues to increase the weight of, oliguria, anuria, ascites, confusion, delirium, stupor can appear in the patient that is murdered.The chronic viral hepatitis B patient course of disease with the passing of time can be along the direction evolution of " hepatitis B-liver cirrhosis-hepatocarcinoma ", and Here it is " the hepatitis B trilogy " that it has often been said.

Hepatitis B does not still have specific drug at present in treatment, how to take the medicine and the interferon interventional therapy of antiviral, adjusting immunity, blood circulation promoting and blood stasis dispelling, fibrosis and promotion liver cell regeneration.The hepatitis B patient of being murdered is demanded a kind of effective medicine urgently and is come out.

Summary of the invention:

Purpose of the present invention just provide a kind of taking convenience, evident in efficacy, price is moderate, the medicine and the preparation method that have no side effect.

Medicine of the present invention by: Herba Taxilli, Rhizoma Wenyujin Concisum, the Fructus Kochiae, Fructus Phyllanthi, Fructus Tsaoko, Rhizoma Coptidis, Radix Isatidis, Herba Abri, Herba Artemisiae Scopariae, Herba Duchesneae Indicae, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Mylabris, Herba Ecliptae, Cordyceps, the Radix Astragali, Aloe, Radix Pseudostellariae, Radix Sophorae Tonkinensis, Radix Angelicae Sinensis, Radix Glycyrrhizae 20 Chinese medicine are simply formed.

The specific embodiment:

The per 250 gram watered pill (medicated powder is with Semen setariae) patent medicine contain by the dose proportioning: Herba Taxilli 20g, Rhizoma Wenyujin Concisum 9g, Fructus Kochiae 9g, Fructus Phyllanthi 3g, Fructus Tsaoko 3g, Rhizoma Coptidis 5g, Radix Isatidis 25g, Herba Abri 20g, Herba Artemisiae Scopariae 20g, Herba Duchesneae Indicae 15g, Rhizoma Polygoni Cuspidati 9g, Rhizoma Osmundae 9g, Mylabris 2g, Herba Ecliptae 15g, Cordyceps 8g, Radix Astragali 20g, Aloe 10g, Radix Pseudostellariae 9g, Radix Sophorae Tonkinensis 12g, Radix Angelicae Sinensis 9g, Radix Glycyrrhizae 6g, crude drug is 238g. altogether

Production technology may further comprise the steps:

1, with crude drug by the recipe quantity standard of weighing.

2, the 1000ml unboiled water is boiled, above full side's crude drug is put into container, pour boiled water into, stir, soaked 5 hours.

3, above medical material is pulled out put into the dehydrator dry for standby.

4, the dry medicine after will drying is put into medicinal material pulverizer, and pulverizing is that 120 order medicated powder are standby.

5, play mold forming with boiling naughty clean Semen setariae.

6, the general ball after the molding is put into pellet processing machine.

7, former soaking medicated liquid is added proper amount of white spirit.

8, be made into the watered pill by traditional handicraft.

9, the watered pill is taken out, put into dehydrator oven dry (also can dry) and package spare.

The present invention is is raw material with Chinese medicine, adopt the spy who strengthens drug effect to remove technology makes, and main excipient is a Chinese liquor.Though Chinese liquor itself is inviscid, but a good organic lyase of sterilization, the stickum in can dissolved substance, colloid etc., and can kill antibacterial in the medicated powder have antisepsis, and medicine is not gone mouldy in general system process, make the watered pill after moisture evaporation fast.

It is the main paathogenic factor that causes the hepatitis B morbidity that the epidemic disease poison infects.After hepatitis B epidemic disease poison infects human body, can cause the organs and tissues functional disorder of body, cause morbidity, live in seclusion in the intravital epidemic disease poison of female patient also by route infection babies such as childbirths.Therefore malicious infection of epidemic disease is the main pathogenic course that causes the hepatitis B morbidity, the treatment hepatitis B " generate heat because of evil, control not Zhi Qire of its heresy, and hot from going ", the damp and hot stasis of blood of epidemic disease poison is strongly fragrant, and liver spleen kidney loses supports, so hepatitis B disease position is mainly at liver spleen kidney.

The liver master dredges rushes down, the cloudy and positive usefulness of body, and the happiness bar reaches and dislikes depression.Edema with the liver involved is dredged soil, helps its fortuneization, and spleen soil battalion is wooden, and its catharsis of profit causes the heresy of the epidemic disease poison of hepatitis B to have and has a liking for the liver characteristic partially, makes stagnation of QI due to depression of the liver, and the criminal's of taking advantage of taste influence transformation and transportation of the spleen and stomach.Water paddy body fluid is reforming not, becomes to give birth to endogenous dampness, because the burning hot property of this tool of heresy of epidemic disease poison so whenever go into network for a long time with damp and hot glued ， Nightmare, forms the strongly fragrant disease of the epidemic disease caused by damp-heat pathogen poison stasis of blood, but sick hepatic depression fire-transformation for a long time, damp is accumulate living heat of a specified duration.The present invention earlier with Herba Duchesneae Indicae, Rhizoma Polygoni Cuspidati, Rhizoma Osmundae, Radix Isatidis, Herba Ecliptae, Herba Abri, Radix Sophorae Tonkinensis is antitoxin protects the liver, hepatitis B belongs to the disease of the hepatic and renal YIN deficiency mostly, compatibility Cordyceps, Radix Pseudostellariae, Herba Taxilli, the Radix Astragali are with health invigorating again, assistant is with Fructus Phyllanthi, the Fructus Kochiae, Rhizoma Coptidis, Rhizoma Wenyujin Concisum, Fructus Tsaoko, Radix Glycyrrhizae clearing away heat-fire, removing blood stasis detoxifcation, again with Herba Artemisiae Scopariae, Aloe, the Radix Angelicae Sinensis jaundice eliminating subcutaneous ulcer of invigorating blood circulation, with the Mylabris treating the poisonous disease with poisonous drugs, prevent that hepatopathy from further worsening is liver cirrhosis, hepatocarcinoma, again with solid the foundation of acquired constitution.

The medicine of complete side is auxilliary mutually to be usefulness, treating both the principal and secondary aspects of a disease, and clearing up letting out epidemic disease poison, eliminating pathogenic factor for supporting vital QI, to take good care of be to help.Have and suppress that virus, heat clearing away protect the liver, the effect of health invigorating, the present invention is applicable to treatment hepatitis B patient and hepatitis B virus carriers, clinical use for many years, total effective rate 98%, wherein cure rate is more than 93%, curative effect obviously is better than existing clinical treatment medication.

Embodiment: Tang Naijun, the man, 45 years old, be diagnosed as hepatitis B through hospital, medical history 7 years, hepatalgia, weak.The many places therapeutic effect is not obvious, after change clothes medicine of the present invention 90 days, transference cure, antisecosis, five indexes of hepatitis b, large and small three sun are turned out cloudy normally, can be engaged in heavy physical labour (at building stones factory breaking up stone), do not have recurrence so far in 3 years, reach the clinical cure purpose.

Claims (3)

1. medicine for the treatment of hepatitis B, it is characterized in that this invention medicine is is that raw material is formed with the Chinese herbal medicine, its crude drug is composed as follows: Herba Taxilli 20g, Rhizoma Wenyujin Concisum 9g, Fructus Kochiae 9g, Fructus Phyllanthi 3g, Fructus Tsaoko 3g, Rhizoma Coptidis 5g, Radix Isatidis 25g, Herba Abri 20g, Herba Artemisiae Scopariae 20g, Herba Duchesneae Indicae 15g, Rhizoma Polygoni Cuspidati 9g, Rhizoma Osmundae 9g, Mylabris 2g, Herba Ecliptae 15g, Cordyceps 8g, Radix Astragali 20g, Aloe 10g, Radix Pseudostellariae 9g, Radix Sophorae Tonkinensis 12g, Radix Angelicae Sinensis 9g, Radix Glycyrrhizae 6g, crude drug is 238g. altogether

2. a kind of medicine for the treatment of hepatitis B according to claim 1 is characterized in that through strengthening the watered pill that drug effect is handled.

3. according to the described a kind of medicine for the treatment of hepatitis B of claim 1--2, it is characterized in that preparation method of the present invention may further comprise the steps:

1) with crude drug by the recipe quantity standard of weighing.

2) the 1000ml unboiled water is boiled, above full side's crude drug is put into container, pour boiled water into, stir, soaked 5 hours.

3) above medical material is pulled out put into the dehydrator dry for standby.

4) the dry medicine after will drying is put into medicinal material pulverizer, and pulverizing is that 120 order medicated powder are standby.

5) play mold forming with boiling naughty clean Semen setariae.

6) the general ball after the molding is put into pellet processing machine.

7) former soaking medicated liquid is added proper amount of white spirit.

8) be made into the watered pill by traditional handicraft.

9) watered pill is taken out, put into dehydrator oven dry (also can dry) and package spare.