CN101890100B - 一种治疗皮炎、湿疹的药物及其制备方法 - Google Patents
一种治疗皮炎、湿疹的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗皮炎、湿疹的外用药物,它是由黄柏、土荆皮、生大黄、冰片等原料药按一定比例配制而成的,本发明药物具有杀虫、解毒、去腐生肌的功能,用于治疗皮炎、湿疹、疗效好,治愈率高。
Description
技术领域:
本发明涉及一种治疗皮炎、湿疹的药物,属中药领域。
背景技术:
皮炎、湿疹是一种常见的皮炎性皮肤病,以皮疹损害处具有渗出潮湿倾向而得名。该病病程迁延难愈、易复发。目前市场上销售的各种治疗皮肤疾病的药物,大都制为膏剂使用,为防止药膏的干燥、变质,常配以油脂调和便于存放。这些油脂药膏抹擦皮肤表面,极易粘污衣物及被褥,形成油渍、污斑。同时,油脂堵塞毛孔造成皮肤不适,也影响疗效。
发明内容:
本发明的目的是克服上述缺陷,提供一种疗效显著,使用方便的中药药物。适用于季节性皮炎、神经性皮炎、钱币性湿疹,还可预防蚊虫叮咬,防止粘污衣物,而且具有止痒,修补表皮和保护表皮组织的作用。本发明的另一个目的就是提供了该中药药物的制备方法。
本发明药物是选择生大黄(异名大黄)、土荆皮(异名土槿皮)、黄柏、苯甲酸、樟脑、冰片、薄荷脑、香精、乙醇进行组合的,将这些药物组合,使得各药物功效产生协同作用,从而能够有效治疗皮炎、湿疹的复发。其中选用生大黄是由于其性味苦、寒。入胃、大肠、肝经。泻热毒,破积滞,行瘀血。治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,症瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用土荆皮是由于其性味辛,温,有毒。治癣疥。选用黄柏是由于其性味苦,寒。入肾、膀胱经。清热,燥湿,泻火,解毒。治热痢,泄泻,清渴,黄疸,痿,梦遗,淋浊,痔疮,便血,赤白带下,骨蒸劳热,目赤肿痛,口舌生疮,疮疡肿毒。选用樟脑是由于其性味辛,热。入心、脾经。通窍,杀虫,止痛,辟秽。治心腹胀痛,脚气,疮疡疥癣,牙痛,跌打损伤。选用冰片是由于其性味辛苦,凉,入心、肺经。有通诸窍,散郁火,去翳明目,消肿止痛的功能。治中风口噤,热病神昏,气闭耳聋,喉痹,口疮,痈肿痔疮,目赤翳膜。薄荷脑为薄荷的新鲜茎和叶经水蒸气蒸馏所得的薄荷油中得到的一种饱和环状醇。性味辛,凉。归肺经。芳香药、调味药及祛风药。用于皮肤或黏膜产生清凉感,以减轻不适及疼痛。苯甲酸外观鳞片状或针状结晶,具有苯或甲醛的臭味,用于浅部的真菌感染,也可作为食物或药品制剂的防腐剂。香精是由人工合成的模仿水果和天然香料气味的浓缩芳香油,它是一种人造香料,多用于制造食品、化妆品和卷烟等。选用酒精含量为95%的乙醇是由于乙醇性味甘、苦、辛、温,入心、肝、肺、胃、经,有通血脉、御寒气的功能,治风寒痹痛,筋脉挛急,心腹冷痛。
本发明药物组分的用量也是经过发明人进行大量摸索总结得出的,各组分用量在下述重量范围内都具有较好的疗效:
生大黄10-12克 土荆皮5-10克 黄柏10-15克
樟脑3-5克 薄荷脑8-10克 冰片8-10克
苯甲酸3-5克 乙醇800-1000毫升 香精0.3-0.8克
蒸馏水450-550毫升
优选为:生大黄11克、土荆皮9克、黄柏12克、樟脑4克、薄荷脑9克、冰片9克,苯甲酸4克、乙醇900毫升,香精0.5克,蒸馏水500毫升。
本发明药物的制备方法如下:
一、备料
1、生大黄:原药拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块,晒干;
2、土荆皮:拣去杂质,晒干;
3、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
4、薄荷脑:取原药材,除去杂质。
二、制备:
1、将上述重量的生大黄、土荆皮、黄柏研成粉状,加入酒精含量为95%的乙醇浸泡72小时后,过滤得上清液;
2、将冰片加入到上清液中,待冰片溶解后,加入苯甲酸、樟脑,混合搅拌溶解均匀;
3、将蒸溜水加热至50℃,加入薄荷脑进行溶解,搅拌均匀。与以上药液混合在一起,再加入香精,密封装瓶保存。
本发明药物具有清热,燥湿,杀虫,解毒的作用,用于治疗皮炎、湿疹疗效好,治愈率高。
具体实施方式:
以下通过试验例来进一步阐述本发明所述药物的有益效果。
[试验例1]动物试验报告
选用新西兰家兔10只,将10只家兔腹部兔毛拔光,每只家兔用本发明药物10克,涂抹脱毛后的兔腹处,用纱布包裹,每日三次,连用7天,检查兔腹正常,10只家兔均无任何不良反应。
通过对新西兰家兔的试验,结果表明,按正常量使用本发明药物治疗无任何毒副作用。
【试验例2】本发明药物治疗皮炎、湿疹的临床观察
1、一般资料
收治门诊患者共127例,其中男62例,女65例,其中年龄20-30岁32例,31-40岁30例,41-50岁34例,60岁以上31例。
2、诊断标准
皮炎、湿疹表现为皮肤发红,出现丘疹,或小米粒状红疹,顶端起水泡,痒,抓破后流水,浸淫成片,可结痂。
3、治疗方法
用温热水擦拭患处,取本发明药液涂抹于患处,8小时重新涂沫一次,涂抹7天为一疗程。
4、疗效评定标准
显效:皮损恢复正常,观察一年无复发者。
好转:80%皮损恢复正常,余下皮损有肥厚或极少液渗出,伴有瘙痒感,但尚能忍受。
无效:局部皮损达不到好转标准,或无改善,甚至恶化。
5、治疗结果
在上述的治疗中,用本发明药物治疗皮炎、湿疹患者127例,结果显效106例,显效率为83.46%,好转19例,好转率为14.96%,无效2例,总有效率为98.42%。
Claims (3)
1.一种治疗皮炎、湿疹的药物,其特征在于:它是由下列重量范围内的原料制成:
生大黄 10-12克 土荆皮 5-10克 黄柏 10-15克
樟脑 3-5克 薄荷脑 8-10克 冰片 8-10克
苯甲酸 3-5克 乙醇 800-1000毫升 香精 0.3-0.8克
蒸馏水 450-550毫升;
制备步骤:
(一)备料:
(1)生大黄:原药拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块,晒干;
(2)土荆皮:拣去杂质,晒干;
(3)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(4)薄荷脑:取原药材,除去杂质;
(二)制备:
(1)将生大黄、土荆皮、黄柏按上述剂量研成粉状,加入酒精含量为95%的乙醇浸泡72小时后,过滤得上清液;
(2)将冰片加入到上清液中,待冰片溶解后,加入苯甲酸、樟脑,混合搅拌溶解均匀;
(3)将蒸馏水加热至50℃,加入薄荷脑进行溶解,搅拌均匀,与以上药液混合在一起,再加入香精,密封装瓶保存。
2.根据权利要求1所述的药物,其中各原料的用量为:生大黄11克、土荆皮9克、黄柏12克、樟脑4克、薄荷脑9克、冰片9克,苯甲酸4克、乙醇900毫升,香精0.5克,蒸馏水500毫升。
3.根据权利要求1或2所述药物的制备方法,包括下列步骤:
(一)备料:
(1)生大黄:原药拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块,晒干;
(2)土荆皮:拣去杂质,晒干;
(3)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(4)薄荷脑:取原药材,除去杂质;
(二)制备:
(1)将生大黄、土荆皮、黄柏按权利要求1或2所述剂量研成粉状,加入酒精含量为95%的乙醇浸泡72小时后,过滤得上清液;
(2)将冰片加入到上清液中,待冰片溶解后,加入苯甲酸、樟脑,混合搅拌溶解均匀;
(3)将蒸馏水加热至50℃,加入薄荷脑进行溶解,搅拌均匀,与以上药液混合在一起,再加入香精,密封装瓶保存。
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