CN101883789B - 特异于流感病毒h5亚型或者n1亚型的血凝素和神经氨酸酶的单克隆抗体及其应用 - Google Patents

特异于流感病毒h5亚型或者n1亚型的血凝素和神经氨酸酶的单克隆抗体及其应用 Download PDF

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Publication number
CN101883789B
CN101883789B CN200880115546.4A CN200880115546A CN101883789B CN 101883789 B CN101883789 B CN 101883789B CN 200880115546 A CN200880115546 A CN 200880115546A CN 101883789 B CN101883789 B CN 101883789B
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mab
antibody
monoclonal antibody
subtype
virus
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Chinese (zh)
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CN101883789A (zh
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钱红亮
F·和
H-S·康
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Temasek Life Sciences Laboratory Ltd
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Temasek Life Sciences Laboratory Ltd
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    • C07K16/108—
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880115546.4A 2007-09-13 2008-09-12 特异于流感病毒h5亚型或者n1亚型的血凝素和神经氨酸酶的单克隆抗体及其应用 Expired - Fee Related CN101883789B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97205907P 2007-09-13 2007-09-13
US60/972,059 2007-09-13
PCT/SG2008/000347 WO2009035420A1 (en) 2007-09-13 2008-09-12 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210506817.7A Division CN103214570B (zh) 2007-09-13 2008-09-12 特异于流感病毒h5亚型或者n1亚型的血凝素和神经氨酸酶的单克隆抗体及其应用

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CN101883789A CN101883789A (zh) 2010-11-10
CN101883789B true CN101883789B (zh) 2014-10-08

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CN200880115546.4A Expired - Fee Related CN101883789B (zh) 2007-09-13 2008-09-12 特异于流感病毒h5亚型或者n1亚型的血凝素和神经氨酸酶的单克隆抗体及其应用
CN201210506817.7A Expired - Fee Related CN103214570B (zh) 2007-09-13 2008-09-12 特异于流感病毒h5亚型或者n1亚型的血凝素和神经氨酸酶的单克隆抗体及其应用

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Country Status (7)

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US (3) US8383121B2 (enExample)
EP (2) EP2947094B1 (enExample)
JP (1) JP5490696B2 (enExample)
CN (2) CN101883789B (enExample)
AU (1) AU2008297594B2 (enExample)
SG (2) SG183031A1 (enExample)
WO (1) WO2009035420A1 (enExample)

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EP2265947A4 (en) * 2008-03-20 2011-03-30 Abay Sa MULTI-LENGTH WAVE LENGTH ANALYSIS OF SOL-PARTICULATE SPECIFIC BINDING TESTS
AU2010247530B2 (en) * 2009-05-11 2016-10-13 Janssen Vaccines & Prevention B.V. Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof
CN102869379B (zh) * 2010-04-30 2015-04-15 淡马锡生命科学研究院有限公司 H5n1谱系的通用疫苗
WO2012054745A1 (en) * 2010-10-20 2012-04-26 New York Blood Center, Inc. Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection
JP2013087069A (ja) * 2011-10-17 2013-05-13 Toyobo Co Ltd Ｈ５亜型インフルエンザウイルスを特異的に認識するモノクローナル抗体
WO2013105896A1 (en) * 2012-01-12 2013-07-18 Temasek Life Sciences Laboratory Limited Monoclonal antibodies targeting neutralizing epitopes on h5 influenza virus of clade 2.3
TW201346040A (zh) * 2012-03-30 2013-11-16 田中貴金屬工業股份有限公司 流行性感冒ａ型病毒檢驗用套組
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
SG11201503878XA (en) * 2012-11-19 2015-06-29 Temasek Life Sciences Lab Ltd Monoclonal antibodies targeting neutralizing epitopes on h7 influenza viruses
CN104407133A (zh) * 2014-11-03 2015-03-11 清华大学深圳研究生院 A型流感病毒检测方法及其试剂盒
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
US20170240617A1 (en) 2016-02-24 2017-08-24 Visterra, Inc. Formulations of antibody molecules to influenza virus
PL238020B1 (pl) 2016-09-12 2021-06-28 Inst Biotechnologii I Antybiotykow Kompozycja przeciwciał monoklonalnych przeciwko hemaglutyninie wirusów grypy serotypu H5 i jej zastosowanie, hybrydomy produkujące rzeczone przeciwciała, sposób diagnozowania infekcji wirusami grypy serotypu H5 oraz zestawy diagnostyczne
CN106399265B (zh) * 2016-09-19 2018-03-02 中国动物卫生与流行病学中心 一种提高禽流感疫苗毒株增殖滴度的方法
CA3088194A1 (en) 2018-01-26 2019-08-01 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN110483637B (zh) * 2019-07-22 2022-06-10 扬州大学 一种抗禽流感病毒神经氨酸酶n2单克隆抗体、编码基因及其应用
CN112574297B (zh) * 2019-09-27 2022-06-24 上海生物制品研究所有限责任公司 抗神经氨酸酶的单克隆抗体及其应用
WO2021201677A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting influenza
JP2023551667A (ja) * 2020-11-23 2023-12-12 ヴィア・バイオテクノロジー・インコーポレイテッド 抗－インフルエンザ抗体及びその組合せ
KR102605065B1 (ko) * 2021-10-14 2023-11-22 원광대학교산학협력단 고병원성 조류 인플루엔자 바이러스 h5n1에 특이적인 단클론항체 및 이를 이용한 신속 진단 키트

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WO2007089753A2 (en) * 2006-01-26 2007-08-09 Hx Diagnostics, Inc. Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof

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WO2009035412A1 (en) * 2007-09-13 2009-03-19 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof

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Publication number Publication date
AU2008297594A1 (en) 2009-03-19
AU2008297594B2 (en) 2013-06-20
EP2201039A1 (en) 2010-06-30
US20130004496A1 (en) 2013-01-03
CN103214570B (zh) 2014-12-10
SG183032A1 (en) 2012-08-30
US8540996B2 (en) 2013-09-24
WO2009035420A1 (en) 2009-03-19
EP2947094A1 (en) 2015-11-25
EP2201039A4 (en) 2012-04-11
US8574581B2 (en) 2013-11-05
US20100266585A1 (en) 2010-10-21
JP2010539162A (ja) 2010-12-16
EP2947094B1 (en) 2018-11-14
JP5490696B2 (ja) 2014-05-14
WO2009035420A8 (en) 2009-05-07
EP2201039B1 (en) 2015-07-15
SG183031A1 (en) 2012-08-30
CN101883789A (zh) 2010-11-10
CN103214570A (zh) 2013-07-24
US8383121B2 (en) 2013-02-26
US20130004497A1 (en) 2013-01-03

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