AU2008297594B2 - Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof - Google Patents

Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof Download PDF

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Publication number
AU2008297594B2
AU2008297594B2 AU2008297594A AU2008297594A AU2008297594B2 AU 2008297594 B2 AU2008297594 B2 AU 2008297594B2 AU 2008297594 A AU2008297594 A AU 2008297594A AU 2008297594 A AU2008297594 A AU 2008297594A AU 2008297594 B2 AU2008297594 B2 AU 2008297594B2
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AU
Australia
Prior art keywords
antibody
subtype
mab
virus
binding
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Ceased
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AU2008297594A
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English (en)
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AU2008297594A1 (en
Inventor
Fang He
Hwei-Sing Kwang
Hong Liang Qian
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Temasek Life Sciences Laboratory Ltd
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Temasek Life Sciences Laboratory Ltd
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Publication of AU2008297594A1 publication Critical patent/AU2008297594A1/en
Application granted granted Critical
Publication of AU2008297594B2 publication Critical patent/AU2008297594B2/en
Priority to AU2013224734A priority Critical patent/AU2013224734B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2008297594A 2007-09-13 2008-09-12 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof Ceased AU2008297594B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013224734A AU2013224734B2 (en) 2007-09-13 2013-09-06 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97205907P 2007-09-13 2007-09-13
US60/972,059 2007-09-13
PCT/SG2008/000347 WO2009035420A1 (en) 2007-09-13 2008-09-12 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013224734A Division AU2013224734B2 (en) 2007-09-13 2013-09-06 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof

Publications (2)

Publication Number Publication Date
AU2008297594A1 AU2008297594A1 (en) 2009-03-19
AU2008297594B2 true AU2008297594B2 (en) 2013-06-20

Family

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AU2008297594A Ceased AU2008297594B2 (en) 2007-09-13 2008-09-12 Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof

Country Status (7)

Country Link
US (3) US8383121B2 (enExample)
EP (2) EP2947094B1 (enExample)
JP (1) JP5490696B2 (enExample)
CN (2) CN103214570B (enExample)
AU (1) AU2008297594B2 (enExample)
SG (2) SG183031A1 (enExample)
WO (1) WO2009035420A1 (enExample)

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EP2155787A4 (en) * 2007-05-11 2010-06-16 Temasek Life Sciences Lab Ltd SPECIFIC TO THE H5-SUBTYPE BINDING PROTEINS SUITED TO THE DIAGNOSIS AND MONITORING OF THE H5 BIRGRAP
WO2009117510A2 (en) * 2008-03-20 2009-09-24 Abaxis, Inc. Multi-wavelength analyses of sol-particle specific binding assays
MX2011011331A (es) * 2009-05-11 2011-11-18 Crucell Holland Bv Moleculas de union humanas capaces de neutralizar el virus de la influenza h3n2 y usos de las mismas.
EP2563389B1 (en) * 2010-04-30 2015-07-08 Temasek Life Sciences Laboratory Limited Universal vaccine against h5n1 lineages
US8900585B2 (en) * 2010-10-20 2014-12-02 New York Blood Center, Inc. Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection
JP2013087069A (ja) * 2011-10-17 2013-05-13 Toyobo Co Ltd Ｈ５亜型インフルエンザウイルスを特異的に認識するモノクローナル抗体
US9233152B2 (en) 2012-01-12 2016-01-12 Temasek Life Sciences Laboratory Limited Monoclonal antibodies targeting neutralizing epitopes on H5 influenza virus of clade 2.3
TW201346040A (zh) * 2012-03-30 2013-11-16 田中貴金屬工業股份有限公司 流行性感冒ａ型病毒檢驗用套組
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
SG11201503878XA (en) * 2012-11-19 2015-06-29 Temasek Life Sciences Lab Ltd Monoclonal antibodies targeting neutralizing epitopes on h7 influenza viruses
CN104407133A (zh) * 2014-11-03 2015-03-11 清华大学深圳研究生院 A型流感病毒检测方法及其试剂盒
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
EP3419663A1 (en) 2016-02-24 2019-01-02 Visterra, Inc. Formulations of antibody molecules to influenza virus
PL238020B1 (pl) * 2016-09-12 2021-06-28 Inst Biotechnologii I Antybiotykow Kompozycja przeciwciał monoklonalnych przeciwko hemaglutyninie wirusów grypy serotypu H5 i jej zastosowanie, hybrydomy produkujące rzeczone przeciwciała, sposób diagnozowania infekcji wirusami grypy serotypu H5 oraz zestawy diagnostyczne
CN106399265B (zh) * 2016-09-19 2018-03-02 中国动物卫生与流行病学中心 一种提高禽流感疫苗毒株增殖滴度的方法
SG11202006379UA (en) 2018-01-26 2020-07-29 Regeneron Pharma Human antibodies to influenza hemagglutinin
CA3132521A1 (en) 2019-03-25 2020-10-01 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN110483637B (zh) * 2019-07-22 2022-06-10 扬州大学 一种抗禽流感病毒神经氨酸酶n2单克隆抗体、编码基因及其应用
CN112574297B (zh) * 2019-09-27 2022-06-24 上海生物制品研究所有限责任公司 抗神经氨酸酶的单克隆抗体及其应用
WO2021201677A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting influenza
CA3199429A1 (en) * 2020-11-23 2022-05-27 Davide Corti Anti-influenza antibodies and combinations thereof
KR102605065B1 (ko) * 2021-10-14 2023-11-22 원광대학교산학협력단 고병원성 조류 인플루엔자 바이러스 h5n1에 특이적인 단클론항체 및 이를 이용한 신속 진단 키트
CN120424203B (zh) * 2025-03-24 2026-04-17 华南农业大学 抗h5亚型禽流感病毒纳米抗体及其构建方法和用途

Citations (1)

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WO2008156763A2 (en) * 2007-06-15 2008-12-24 The Board Of Trustees Of The Leland Stanford Junior University Human neutralizing monoclonal antibodies to h5n1 influenza a virus

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US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP5525688B2 (ja) 2005-08-19 2014-06-18 株式会社ビーエル インフルエンザウイルスｈ５亜型の免疫検出法
CA2622603C (en) 2005-09-15 2014-06-17 Crucell Holland B.V. Method for preparing immunoglobulin libraries
WO2007089753A2 (en) * 2006-01-26 2007-08-09 Hx Diagnostics, Inc. Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof
EP2059532B1 (en) 2006-09-07 2012-12-26 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
EP2155787A4 (en) 2007-05-11 2010-06-16 Temasek Life Sciences Lab Ltd SPECIFIC TO THE H5-SUBTYPE BINDING PROTEINS SUITED TO THE DIAGNOSIS AND MONITORING OF THE H5 BIRGRAP
WO2009035412A1 (en) * 2007-09-13 2009-03-19 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof

Patent Citations (1)

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WO2008156763A2 (en) * 2007-06-15 2008-12-24 The Board Of Trustees Of The Leland Stanford Junior University Human neutralizing monoclonal antibodies to h5n1 influenza a virus

Non-Patent Citations (3)

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CHEN, JIANFENG ET AL. Journal of Veterinary Diagnostic Investigation. (1 May 2007) vol 19 issue 3 pages 155-160. *
NETTLES, V. ET AL. Avian Diseases (1985 Jul-Sep) Vol. 29, No. 3, pp. 733-41. *
YAN, JUYING ET AL. Diagnostic Microbiology and Infectious Disease (August 2007) Vol 58 issue 4 pag *

Also Published As

Publication number Publication date
WO2009035420A1 (en) 2009-03-19
WO2009035420A8 (en) 2009-05-07
US8540996B2 (en) 2013-09-24
EP2201039A1 (en) 2010-06-30
AU2008297594A1 (en) 2009-03-19
EP2201039A4 (en) 2012-04-11
CN103214570A (zh) 2013-07-24
US20130004497A1 (en) 2013-01-03
EP2947094A1 (en) 2015-11-25
EP2947094B1 (en) 2018-11-14
CN103214570B (zh) 2014-12-10
US8383121B2 (en) 2013-02-26
JP5490696B2 (ja) 2014-05-14
US8574581B2 (en) 2013-11-05
SG183032A1 (en) 2012-08-30
EP2201039B1 (en) 2015-07-15
CN101883789B (zh) 2014-10-08
JP2010539162A (ja) 2010-12-16
SG183031A1 (en) 2012-08-30
CN101883789A (zh) 2010-11-10
US20130004496A1 (en) 2013-01-03
US20100266585A1 (en) 2010-10-21

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired