CN1018825B - 制备聚-4-氨基吡咯-2-甲酰胺基衍生物的方法 - Google Patents

制备聚-4-氨基吡咯-2-甲酰胺基衍生物的方法

Info

Publication number
CN1018825B
CN1018825B CN86104787A CN86104787A CN1018825B CN 1018825 B CN1018825 B CN 1018825B CN 86104787 A CN86104787 A CN 86104787A CN 86104787 A CN86104787 A CN 86104787A CN 1018825 B CN1018825 B CN 1018825B
Authority
CN
China
Prior art keywords
formamido
methyl
pyrroles
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN86104787A
Other languages
English (en)
Chinese (zh)
Other versions
CN86104787A (zh
Inventor
费德里科·阿卡莫尼
尼科拉·蒙盖利
瑟吉奥·彼恩科
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517922A external-priority patent/GB8517922D0/en
Priority claimed from GB868613594A external-priority patent/GB8613594D0/en
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of CN86104787A publication Critical patent/CN86104787A/zh
Publication of CN1018825B publication Critical patent/CN1018825B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyamides (AREA)
CN86104787A 1985-07-16 1986-07-16 制备聚-4-氨基吡咯-2-甲酰胺基衍生物的方法 Expired CN1018825B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8517922 1985-07-16
GB858517922A GB8517922D0 (en) 1985-07-16 1985-07-16 Carboxamido derivatives
GB868613594A GB8613594D0 (en) 1986-06-04 1986-06-04 Poly-4-aminopyrrole-2-carboxamido derivatives
GB8613594 1986-06-04

Publications (2)

Publication Number Publication Date
CN86104787A CN86104787A (zh) 1987-02-18
CN1018825B true CN1018825B (zh) 1992-10-28

Family

ID=26289538

Family Applications (1)

Application Number Title Priority Date Filing Date
CN86104787A Expired CN1018825B (zh) 1985-07-16 1986-07-16 制备聚-4-氨基吡咯-2-甲酰胺基衍生物的方法

Country Status (26)

Country Link
JP (1) JPH0780843B2 (nl)
KR (1) KR930010496B1 (nl)
CN (1) CN1018825B (nl)
AT (1) AT387013B (nl)
AU (1) AU587841B2 (nl)
BE (1) BE905110A (nl)
CA (1) CA1285934C (nl)
CH (1) CH674206A5 (nl)
CS (1) CS276981B6 (nl)
DE (1) DE3623880A1 (nl)
DK (1) DK335986A (nl)
ES (1) ES2000502A6 (nl)
FI (1) FI83640C (nl)
FR (1) FR2585018B1 (nl)
GB (1) GB2178036B (nl)
GR (1) GR861841B (nl)
HU (1) HU205949B (nl)
IE (1) IE59073B1 (nl)
IL (1) IL79402A (nl)
IT (1) IT1196488B (nl)
NL (1) NL8601837A (nl)
NO (1) NO168826C (nl)
NZ (1) NZ216829A (nl)
PH (1) PH24714A (nl)
PT (1) PT82984B (nl)
SE (1) SE468642B (nl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1243389B (it) * 1990-11-22 1994-06-10 Menarini Farma Ind Derivati poliaminopirrolcarbossiamidici, processi di preparazione e composizioni farmaceutiche che li contengono.
AU1224392A (en) * 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
IT1247878B (it) * 1991-02-15 1995-01-05 Menarini Farma Ind Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
GB2260134A (en) * 1991-10-04 1993-04-07 Erba Carlo Spa Derivatives of poly-5-amino-3-carboxy-1-methyl compounds
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
AU6943796A (en) * 1995-09-12 1997-04-01 Kyowa Hakko Kogyo Co. Ltd. Compounds UCH 15
AU1596097A (en) * 1996-02-02 1997-08-22 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86210E (nl) 1963-04-04 1966-03-23
BR6461040D0 (pt) * 1963-07-26 1973-08-02 Farmaceutici Italia Processo para preparar novos derivados de pirrol
DE1795539A1 (de) * 1963-07-26 1972-01-13 Farmaceutici Italia Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
BE666612A (nl) * 1963-07-26 1965-11-03
NL130086C (nl) * 1964-07-14 1970-06-15
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法

Also Published As

Publication number Publication date
IE59073B1 (en) 1994-01-12
FI862959A (fi) 1987-01-17
FI83640B (fi) 1991-04-30
AT387013B (de) 1988-11-25
DK335986A (da) 1987-01-17
KR930010496B1 (ko) 1993-10-25
DK335986D0 (da) 1986-07-15
IT8621125A1 (it) 1988-01-15
IT1196488B (it) 1988-11-16
IE861875L (en) 1987-01-16
AU6020286A (en) 1987-01-22
NZ216829A (en) 1989-03-29
PT82984A (en) 1986-08-01
JPS6277362A (ja) 1987-04-09
PH24714A (en) 1990-10-01
CN86104787A (zh) 1987-02-18
SE8603098L (sv) 1987-01-17
NL8601837A (nl) 1987-02-16
ES2000502A6 (es) 1988-03-01
NO168826B (no) 1991-12-30
FI862959A0 (fi) 1986-07-16
AU587841B2 (en) 1989-08-31
NO168826C (no) 1992-04-08
NO862860L (no) 1987-01-19
FR2585018A1 (fr) 1987-01-23
CS276981B6 (en) 1992-11-18
PT82984B (pt) 1989-01-30
IT8621125A0 (it) 1986-07-15
BE905110A (fr) 1987-01-15
FR2585018B1 (fr) 1989-07-13
SE468642B (sv) 1993-02-22
SE8603098D0 (sv) 1986-07-11
CH674206A5 (nl) 1990-05-15
FI83640C (fi) 1991-08-12
IL79402A0 (en) 1986-10-31
DE3623880A1 (de) 1987-01-29
GB8617292D0 (en) 1986-08-20
GR861841B (en) 1986-11-18
KR870001201A (ko) 1987-03-12
GB2178036A (en) 1987-02-04
JPH0780843B2 (ja) 1995-08-30
NO862860D0 (no) 1986-07-15
HUT43088A (en) 1987-09-28
CS8605412A2 (en) 1991-03-12
IL79402A (en) 1991-06-10
HU205949B (en) 1992-07-28
GB2178036B (en) 1989-08-16
ATA188886A (de) 1988-04-15
CA1285934C (en) 1991-07-09

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C13 Decision
GR02 Examined patent application
C14 Grant of patent or utility model
GR01 Patent grant
C53 Correction of patent of invention or patent application
COR Change of bibliographic data

Free format text: CORRECT: PATENTEE; FROM: FARMITALIA CARLO ERBA S.R.L. TO: PHARMACIA + UPJOHN S.P.A.

CP01 Change in the name or title of a patent holder

Patentee after: The Upjohn Co.

Patentee before: Farmitalia Carlo Erba s.r.l.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee