CN101879268B - Method for preparing Chinese medicinal oral liquid for treating attention deficit hyperactivity disorder - Google Patents
Method for preparing Chinese medicinal oral liquid for treating attention deficit hyperactivity disorder Download PDFInfo
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Abstract
The invention relates to a method for preparing Chinese medicinal oral liquid for treating attention deficit hyperactivity disorder, which comprises the two steps of preparing liquor and preparing finished oral liquid. The Chinese medicinal oral liquid mainly regulates the maladjustment problem of the viscera function by a mode of balancing yin and yang, has good taste, and is suitable for the administration of children; and simultaneously, active ingredients in the raw material medicament can be extracted as far as possible, and the Chinese medicinal oral liquid has obvious curative effect.
Description
Technical field
The present invention relates to a kind of method for preparing that is used to treat the Chinese medicine oral liquid of childhood hyperkinetic syndrome.
Background technology
Childhood hyperkinetic syndrome, hyperkinetic syndrome (hyperkinetic syndrome of childhood) are a kind of common children's behavior abnormal problems; Modern medicine with its be referred to as Cerebral function slight maladjustment or minimal brain dysfunction syndrome (minimal brain dysfunction, MBD).Because the intelligence of this type infant is normally or normal basically, but study, behavior and emotion aspect defectiveness show as difficult concentrating, note of short duration, hyperactivity, emotion is inflammable so that influence child's orthobiosis and study.Show that according to the ASSOCIATE STATISTICS data prevalence of existing childhood hyperkinetic syndrome accounts for 1～10% of child's sum.
This type of disease of western medical treatment is mainly used resist melancholy agent, psychosis, Anti-epileptics etc., is common drug with central nervous excitation agent methylphenidate or dextro-amphetamine generally.But this type of Western medicine is bigger to the human body side effect, and effect is not fairly obvious, so this type of disease of western medical treatment awaits to inquire into and research.
Chinese medicine is acted on the equilibrium between yin and yang theory; Theoretically formulate the pathogeny of this type of disease, " element ask vital QI of the body connecting with natural QI opinion " cloud: " YIN and YANG in a relative equilibrium, life activities being normally maintained "; Human body normal activities and mind state; Be the result that negative and positive keep the united and coordinating relation, otherwise imbalance of YIN and YANG then is one of unusual basic pathology of body mind.And that the hyperkinetic syndrome cardinal symptom is god is not peaceful, the will lack perseverance, and feelings are variable, impatient hot-tempered, are to change the system of losing to some extent by sound, and promptly due to the imbalance of YIN and YANG, and imbalance of YIN and YANG is embodied in the imbalance of function, relates to the heart, liver,spleen,kidney four is dirty.
No. 1772176 disclosed names of Chinese patent are called the prescription that " a kind of method for preparing and method of quality control of treating the granule of childhood hyperkinetic syndrome " proposes to utilize the treatment by Chinese herbs childhood hyperkinetic syndrome.This patent with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Cortex Moutan, Rhizoma Alismatis, Radix Polygalae, Os Draconis (calcined), Fructus Ligustri Lucidi, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei as crude drug; And through extract after twice decoction filtrating merge; And the relative density that filtrating is concentrated into 80 ℃ the time is the clear paste of 1.30-1.35, adds conventional adjuvant again and processes granule.Though this kind granule has certain curative effect for the treatment childhood hyperkinetic syndrome; But, be difficult to swallow, particularly for the child because the sense of taste of Chinese medicine is strange; Directly take very difficulty of Chinese medicine; And the Chinese medicine granules of the treatment child heart hyperkinetic syndrome that this patent proposed does not take to improve the measure of Chinese medicine sense of taste, so this kind granule is not suitable for children taking; In addition; Though the active ingredient that can extract in the crude drug to be contained through the mode that decocts, because of the active ingredient extraction time in each crude drug incomplete same, with regard to the crude drug of this kind compatibility; Some crude drug such as Os Draconis; Decoct and be difficult for for twice leaching the active ingredient in it is most of, and the active ingredient in the crude drug of Chinese medicine can not effectively utilize, and can directly influence the curative effect of patent medicine.
Summary of the invention
The purpose of this invention is to provide a kind of mode that changes dosage form of utilizing and solve the take medicine method for preparing of Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome of difficult problem of child.
The method for preparing of the Chinese medicine oral liquid of treatment child heart hyperkinetic syndrome proposed by the invention, this oral liquid is made up of following weight portion raw material: 8-11 parts of Radix Rehmanniae Preparata, 3-6 parts of Fructus Ligustri Lucidi, 3-5 parts of Rhizoma Dioscoreaes; 1-3 parts of Fructus Schisandrae Chinensis, 6-9 parts of Os Draconis, 2-5 parts of Radix Polygalaes, 3-5 parts of Rhizoma Acori Graminei; 1-3 parts of the Rhizoma Anemarrhenaes, 2-5 parts of Cortex Phellodendris, 2-4 parts of Cortex Moutans; 2-5 parts of Rhizoma Alismatis, 2-5 parts in Poria may further comprise the steps when making oral liquid:
Produce medicinal liquid: at first Os Draconis Powder is broken to the thin piece below the 2.5cm, then with thin block Os Draconis and above-mentioned ten simply Chinese medicine put into extraction pot together, and in extraction pot, add the 6-9 water doubly that quality is the Chinese medicine quality summation; Again extraction pot being carried out the heating first time decocted 0.8-1.2 hour; The taking-up decoction liquor is carried out the second time and decoction for the third time by the method for decoction for the first time, and is overanxious after merging with three decoction liquor overanxious back merging or with three decoction liquor; To maybe will merge the overanxious decoction liquor in back through the decoction liquor after overanxious at last concentrates and alcohol extraction; The density that is about to decoction liquor after filtering is concentrated into 1.07-1.09 earlier, in concentrated solution, adds ethanol again, when the ethanol content in the concentrated solution reaches 45%-55%; Stop to add ethanol; Leave standstill after 24 hours and extract supernatant, the density of supernatant is concentrated into 1.05-1.09 is medicinal liquid, and in extracting the supernatant process, reclaim ethanol simultaneously; Produce the finished product oral liquid: will place centrifuge to filter through spissated medicinal liquid; Then medicinal liquid is after filtering placed in the Agitation Tank; Adding syrup and distilled water stir in Agitation Tank again; Put into sterilization tank after syrupy medicinal liquid stirs and sterilize when adding, at last to adding benzoic acid ethanol liquid and sorbic acid ethanol liquid in the sugared medicinal liquid lentamente through containing of sterilization, and to make the pH value that contains in the sugared medicinal liquid be 3.9-5.0; Relative density is 1.05-1.09, and resulting liquid is the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome proposed by the invention.The present invention selects Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis as the primary raw material medicine, and intention is to make the effect of under these a few flavor medicine synergism, playing the tonification human body, and childhood hyperkinetic syndrome is seen from traditional Chinese medical science angle; Mainly be that yin and yang imbalance causes internal organs growth promoter defective, Radix Rehmanniae Preparata has the effect that nourishing YIN and supplementing blood, beneficial essence are filled out marrow, and Fructus Ligustri Lucidi has the effect of the liver and the kidney tonifying; Rhizoma Dioscoreae is put down in writing according to Compendium of Material Medica: " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery; the saliva that reduces phlegm, profit fur.", Fructus Schisandrae Chinensis has supplementing QI for promoting the production of body fluid, the effect of kidney calming, and the insufficient effect of tonification human internal organ is played in the combined effect of complementing each other of this four Chinese medicine; Adding Os Draconis, Radix Polygalae, Rhizoma Acori Graminei in the crude drug again and play the effect of tranquillizing and allaying excitement, mainly is in the tonification human internal organ, and stable human five internal organs's six internal organs and each great circulation system make each big system physiological activity of human body be tending towards harmonious; Add the Rhizoma Anemarrhenae, Cortex Phellodendri, Cortex Moutan again, mainly play the effect of heat-clearing and toxic substances removing, removing heat from blood heat radiation, childhood hyperkinetic syndrome is on the pathological characters basis of internal organs defective; Also stop up stifled with interior-heat; The characteristic that exopathogen is prone to invade is so the medicine of selecting heat-clearing and toxic substances removing for use to its toxin expelling that dispels the heat, alleviates the human body burden to reach; More help the medicine effect of tonification human body; Last the present invention adds the effect that Rhizoma Alismatis, Poria mainly play " promoting diuresis to eliminate damp pathogen ", and this two flavors medicine plays and promotes the metabolic effect of human body, helps the human body toxin and effluxes.It is thus clear that the selected crude drug ability of this oral liquid balance human body negative and positive can be separated resolution, liver,spleen,kidney four visceral dysfunction problems; Simultaneously, these crude drug are obtained through refining into oral liquid through three water, can make oral liquid promptly be suitable for children taking the most of leaching of the active ingredient in the crude drug basically, again good relatively curative effect can be arranged.
Said producing also comprises before the finished product oral liquid and produces syrupy step; In this step, after the distilled water of at first getting some boils, sugaring and make the sugar dissolving in this distilled water again through stirring; With absorbent cotton liquid glucose is filtered then, gained filtrating is syrup.
The Chinese medicine oral liquid of treatment child heart hyperkinetic syndrome proposed by the invention is mainly come the imbalance of function through the mode of Yin Yang balancing; And sense of taste is better relatively; Be suitable for children taking, can also as much as possible the active ingredient in the crude drug be leached simultaneously, it is evident in efficacy.
Utilize the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome proposed by the invention to be and treated 557 infants, these infants are from school census and outpatient service at random, its infant; Male's 454 examples, women's 103 examples, wherein; Age reckling 4 years old, the maximum 16 years old, course of disease phase 0.5-14.When taking, take secondary every day, give various dose according to the size at age, like 10ml every day in 4-5 year, every day in 6-14 year 20ml, more than 15 years old every day 30ml, and during taking this Chinese medicine oral liquid all the time the end add with treatment this sick other medicines or therapy.Its therapeutic outcome is following: in the infant of 557 examples, and clinical cure 144 examples; Produce effects 127 examples; Effective 246 examples; Invalid 40 examples.Total significant figure is 517 examples, and total effective rate is 92.8%, the fastest person 6 days of wherein taking effect, and the slowest person 60 days of taking effect, and after curing the case drug withdrawal, observe more than 6 months, find to have the recidivist.
The Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome according to the invention is in drug toxicity experiment, and the result shows and has no side effect.In animal model experiment, its result: the one, there are significant anti-excited and many actions to use; The 2nd, obvious reinforcement memory is arranged and strengthen the intelligence effect.
The specific embodiment
Embodiment 1
Get 16 kilograms of Radix Rehmanniae Preparata, 12 kilograms of Fructus Ligustri Lucidi, 9 kilograms of Rhizoma Dioscoreaes, 2 kilograms of Fructus Schisandrae Chinensis, 16 kilograms of Os Draconis, 4 kilograms of Radix Polygalaes, 9 kilograms of Rhizoma Acori Graminei, 2 kilograms of the Rhizoma Anemarrhenaes, 4 kilograms of Cortex Phellodendris, 8 kilograms of Cortex Moutans, 9 kilograms of Rhizoma Alismatis, Poria 9.When the preparation oral liquid, be divided into and produce medicinal liquid and produce two steps of finished product oral liquid.At first the Os Draconis Powder with above-mentioned weight is broken to the thin piece below the 2.5cm, then with thin block Os Draconis and above-mentioned weight ten simply Chinese medicine put into extraction pot together, in extraction pot, add 700 kilograms water again; Extraction pot is carried out heating decoction 0.8 hour the first time, take out decoction liquor, the water that in extraction pot, adds 600 kilograms again carries out the heating decoction second time; Decoct and take out decoction liquor after 1 hour, the water that in extraction pot, adds 600 kilograms again heats decoction for the third time, decocts and takes out decoction liquor after 1 hour; The overanxious back of three decoction liquor is merged, concentrate when the decoction liquor after merging is dropped to 50-70 ℃, when the decoction liquor after merging is concentrated into relative density and is 1.07-1.09; Promptly obtain concentrated solution, in concentrated solution, add ethanol again, ethanol content is generally 95%; Also can adopt content is the ethanol of 85-98%, and when adding ethanol, adopts the mode of adding while stirring; When the ethanol content in the concentrated solution stops to add ethanol during at 45-55%; To contain alcoholic acid concentrated solution and leave standstill after 24 hours and extract supernatant, and the density of supernatant will be concentrated into 1.05-1.09 be medicinal liquid, and in extracting the supernatant process, reclaim ethanol simultaneously.
In the step of producing the finished product oral liquid; To place centrifuge to filter through spissated medicinal liquid earlier, and then medicinal liquid after filtering placed in the Agitation Tank, the distilled water that in Agitation Tank, adds syrup and capacity again stirs; Stir after 12-18 minute; Sterilize when adding the mode of putting into sterilization tank employing heating decoction after syrupy medicinal liquid stirs, decocting time is 0.5-1 hour, at last to adding benzoic acid ethanol liquid and sorbic acid ethanol liquid in the sugared medicinal liquid lentamente through containing of sterilization; And making the pH value that contains in the sugared medicinal liquid is 3.9-5.0; Relative density is 1.05-1.09, and resulting liquid is the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome proposed by the invention, and to make the sugar content in the oral liquid be 19-20%.
Above-mentioned syrup adopts following mode to produce: after at first getting 1000ml distilled water heated and boiled, in this distilled water, add 850g sugar again, and make the sugar dissolving through stirring, with absorbent cotton liquid glucose is filtered postcooling then, gained filtrating is syrup.
Embodiment 2
Get 22 kilograms of Radix Rehmanniae Preparata, 6 kilograms of Fructus Ligustri Lucidi, 6 kilograms of Rhizoma Dioscoreaes, 6 kilograms of Fructus Schisandrae Chinensis; 12 kilograms of Os Draconis, 10 kilograms of Radix Polygalaes, 6 kilograms of Rhizoma Acori Graminei; 6 kilograms of the Rhizoma Anemarrhenaes, 10 kilograms of Cortex Phellodendris, 4 kilograms of Cortex Moutans; 6 kilograms of Rhizoma Alismatis, 6 kilograms in Poria is processed the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome proposed by the invention according to the method for embodiment 1.In producing the medicinal liquid step, the amount of water that heating for the first time decocts is 900 kilograms, and decocting time is 1.2 hours, is 700 kilograms with the amount of water that decocts for the third time for the second time, and decocting time is 1 hour.
Embodiment 3
Get 20 kilograms of Radix Rehmanniae Preparata, 8 kilograms of Fructus Ligustri Lucidi, 8 kilograms of Rhizoma Dioscoreaes, 4 kilograms of Fructus Schisandrae Chinensis; 16 kilograms of Os Draconis, 6 kilograms of Radix Polygalaes, 8 kilograms of Rhizoma Acori Graminei; 4 kilograms of the Rhizoma Anemarrhenaes, 6 kilograms of Cortex Phellodendris, 6 kilograms of Cortex Moutans; 8 kilograms of Rhizoma Alismatis, 6 kilograms in Poria is processed the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome proposed by the invention according to the method for embodiment 1.In producing the medicinal liquid step, the amount of water that heating for the first time decocts is 800 kilograms, and decocting time is 1 hour, is 600 kilograms with the amount of water that decocts for the third time for the second time, and decocting time is 1 hour.
Embodiment 4
Get 18 kilograms of Radix Rehmanniae Preparata, 10 kilograms of Fructus Ligustri Lucidi, 8 kilograms of Rhizoma Dioscoreaes, 6 kilograms of Fructus Schisandrae Chinensis; 14 kilograms of Os Draconis, 8 kilograms of Radix Polygalaes, 6 kilograms of Rhizoma Acori Graminei; 6 kilograms of the Rhizoma Anemarrhenaes, 8 kilograms of Cortex Phellodendris, 6 kilograms of Cortex Moutans; 6 kilograms of Rhizoma Alismatis, 4 kilograms in Poria is processed the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome proposed by the invention according to the method for embodiment 1.In producing the medicinal liquid step, the amount of water that heating for the first time decocts is 800 kilograms, and decocting time is 1.1 hours, is 700 kilograms with the amount of water that decocts for the third time for the second time, and decocting time is 1 hour.
The discrimination method of the Chinese medicine oral liquid of treatment child heart hyperkinetic syndrome of the present invention is the thin layer differential method, comprises discrimination method:
1. get 2000-6000 parts of the composition solutions that prepared, be concentrated into thick paste, add 1000-3000 parts of chloroforms while hot; Stir, filter and filtrating is concentrated into 50-150 parts and obtain need testing solution A, other gets 50-150 parts of Cortex Phellodendri control medicinal materials; Decocte with water 2 hours is filtered and filtrating is condensed into thick paste, adds 1000-3000 parts of chloroforms while hot; Stir and filter, filtrating is concentrated into 50-150 parts obtains the control medicinal material solution B, according to the thin layer chromatography test as control medicinal material solution; Each 1-3 parts of draw solution A and solution B are put respectively in same and are contained on the silica gel g thin-layer plate that 0.5% sodium carboxymethyl cellulose is a binding agent, and (ratio is: upper solution 5:1:4) is developing solvent with n-butyl alcohol-acetic acid-water; Launch, take out, dry, place under the ultra-violet lamp (254nm) and inspect, in the test sample chromatograph; With control medicinal material chromatograph relevant position on, show the fluorescence speckle of same color.
2. get 5000-15000 parts of the composition solutions that prepared, heating is concentrated into 3000-9000 parts, with twice of water saturated n-butanol extraction; Each 2000-6000 parts; Merge n-butyl alcohol liquid, with the saturated water washing twice of n-butyl alcohol, each 2000-6000 parts; With n-butyl alcohol liquid evaporate to dryness, residual residue is added 100-300 parts of dissolve with methanol obtain need testing solution A; Other gets the peoniflorin reference substance, adds methanol and processes per 100-300 parts of solution that contain 10-30 parts of peoniflorins as reference substance solution B, according to the thin layer chromatography test; Draw 2-6 parts of above-mentioned need testing solution A, draw 1-3 parts of reference substance solution B, put respectively in same be on the silica gel g thin-layer plate of binding agent preparation with the sodium carboxymethyl cellulose; Lower floor's solution with chloroform, methanol, water (ratio is 13:7:2) is developing solvent; Launch, take out, dry, spray is with 5% vanillin sulfuric acid solution, and it is clear to be heated to speckle colour developing at 105 ℃; In the test sample chromatograph with reference substance chromatograph relevant position on, show the speckle of same color.
Assay adopts berberine hydrochloride and shines high effective liquid chromatography for measuring, and step is following:
1. system suitability test: use octadecylsilane chemically bonded silica to be filler; Contain 170-510 parts of potassium dihydrogen phosphates in 50000-150000 parts in acetonitrile-water (47:53) and be mobile phase for 85-255 parts with sodium lauryl sulphate; The detection wavelength is 345nm; Number of theoretical plate calculates by the berberine hydrochloride peak and should be not less than 40000/m, and berberine hydrochloride peak and RRT are that the separating degree at 0.88 unknown component peak should meet the requirements.
2. the preparation of reference substance solution: precision takes by weighing at 105 ℃ of berberine hydrochloride reference substances that are dried to constant weight an amount of, adds methanol and is mixed with per 50-150 parts of solution B that contain 4-12 parts of berberine hydrochloride.
3. the preparation of need testing solution: precision takes by weighing 250-750 parts of the composition solutions that prepare, places measuring bottle, after adding that methanol is an amount of and mixing, is diluted to maximum scale with methanol, shakes up then with exsiccator and filters, and discards filtrating just, and it is subsequent use to get subsequent filtrate.
4. algoscopy: accurate each 1-3 parts of the reference substance solution and need testing solution of drawing, inject high performance liquid chromatograph respectively, measure peak area, get final product with external standard method calculating.
The hydrochloric berberine of these article must not be less than 20 μ g/ml.Berberine hydrochloride is used for measuring the content of Cortex Phellodendri in this Chinese medicine oral liquid.
Claims (2)
1. treat the method for preparing of the Chinese medicine oral liquid of childhood hyperkinetic syndrome, this oral liquid is made up of following weight portion raw material: 8-11 parts of Radix Rehmanniae Preparata, 3-6 parts of Fructus Ligustri Lucidi, 3-5 parts of Rhizoma Dioscoreaes; 1-3 parts of Fructus Schisandrae Chinensis, 6-9 parts of Os Draconis, 2-5 parts of Radix Polygalaes, 3-5 parts of Rhizoma Acori Graminei; 1-3 parts of the Rhizoma Anemarrhenaes, 2-5 parts of Cortex Phellodendris, 2-4 parts of Cortex Moutans, 2-5 parts of Rhizoma Alismatis; 2-5 parts in Poria is characterized in that, the system oral liquid may further comprise the steps:
Produce medicinal liquid: at first Os Draconis Powder is broken to the thin piece below the 2.5cm, then with thin block Os Draconis and above-mentioned ten simply Chinese medicine put into extraction pot together, and in extraction pot, add the 6-9 water doubly that quality is the Chinese medicine quality summation; Again extraction pot being carried out the heating first time decocted 0.8-1.2 hour; The taking-up decoction liquor is carried out the second time and decoction for the third time by the method for decoction for the first time, and is overanxious after merging with three decoction liquor overanxious back merging or with three decoction liquor; To maybe will merge the overanxious decoction liquor in back through the decoction liquor after overanxious at last concentrates and alcohol extraction; The density that is about to decoction liquor after filtering is concentrated into 1.07-1.09 earlier, in concentrated solution, adds ethanol again, when the ethanol content in the concentrated solution reaches 45%-55%; Stop to add ethanol; Leave standstill after 24 hours and extract supernatant, the density of supernatant is concentrated into 1.05-1.09 is medicinal liquid, and in extracting the supernatant process, reclaim ethanol simultaneously;
Produce the finished product oral liquid: will place centrifuge to filter through spissated medicinal liquid; Then medicinal liquid is after filtering placed in the Agitation Tank; Adding syrup and distilled water stir in Agitation Tank again; Put into sterilization tank after syrupy medicinal liquid stirs and sterilize when adding, at last to adding benzoic acid ethanol liquid and sorbic acid ethanol liquid in the sugared medicinal liquid lentamente through containing of sterilization, and to make the pH value that contains in the sugared medicinal liquid be 3.9-5.0; Relative density is 1.05-1.09, and resulting liquid is the Chinese medicine oral liquid of treatment childhood hyperkinetic syndrome.
2. the method for preparing of Chinese medicine oral liquid according to claim 1; It is characterized in that: said producing also comprises before the finished product oral liquid and produces syrupy step; In this step, after the distilled water of at first getting some boils, sugaring and make the sugar dissolving in this distilled water again through stirring; With absorbent cotton liquid glucose is filtered then, gained filtrating is syrup.
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| CN102205032B (en) * | 2011-05-31 | 2012-07-25 | 山东省农业科学院农产品研究所 | Golden mushroom oral liquid for treating hyperactivity disease |
| CN103301368B (en) * | 2013-06-14 | 2014-07-02 | 刘宗银 | Medicament for treating hyperactivity |
| CN105726904A (en) * | 2016-04-05 | 2016-07-06 | 辽宁东方人药业有限公司 | Method for preparing traditional-Chinese-medicine oral liquid for treating child hyperactivity |
| CN108355043B (en) * | 2018-05-17 | 2020-12-29 | 辽宁东方人药业有限公司 | Preparation method of traditional Chinese medicine oral liquid, traditional Chinese medicine oral liquid for treating attention deficit hyperactivity disorder and preparation method of traditional Chinese medicine oral liquid |
| CN109674927A (en) * | 2019-01-31 | 2019-04-26 | 辽宁东方人药业有限公司 | A kind of Jinling Oral Liquor and preparation method thereof |
| CN111840454A (en) * | 2020-09-07 | 2020-10-30 | 辽宁东方人药业有限公司 | Traditional Chinese medicine oral liquid medicine composition for treating attention deficit hyperactivity disorder and preparation method thereof |
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| CN1803180A (en) * | 2005-01-13 | 2006-07-19 | 北京凯瑞创新医药科技有限公司 | Medicine composition and its preparation method and quality control method |
| CN100998744A (en) * | 2006-12-26 | 2007-07-18 | 王巨先 | Chinese patent drug for treating infantile hyperkinetic syndrome |
| CN101011521A (en) * | 2006-01-26 | 2007-08-08 | 烟台大洋制药有限公司 | Chinese patent drug for nourishing liver and kidney, tranquilizing the mind and developing intelegence and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1803180A (en) * | 2005-01-13 | 2006-07-19 | 北京凯瑞创新医药科技有限公司 | Medicine composition and its preparation method and quality control method |
| CN101011521A (en) * | 2006-01-26 | 2007-08-08 | 烟台大洋制药有限公司 | Chinese patent drug for nourishing liver and kidney, tranquilizing the mind and developing intelegence and its preparation method |
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