CN109674927A - A kind of Jinling Oral Liquor and preparation method thereof - Google Patents
A kind of Jinling Oral Liquor and preparation method thereof Download PDFInfo
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- CN109674927A CN109674927A CN201910101258.3A CN201910101258A CN109674927A CN 109674927 A CN109674927 A CN 109674927A CN 201910101258 A CN201910101258 A CN 201910101258A CN 109674927 A CN109674927 A CN 109674927A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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Abstract
The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of Jinling Oral Liquor and preparation method thereof.Jinling Oral Liquor provided by the invention includes following component and its parts by weight: 6-8 parts of Rehmannia glutinosa, 3-4 parts of Chinese yam, 2-3 parts of Poria cocos, 2-3 parts of cortex moutan, 2-3 parts of rhizoma alismatis, 2-3 parts of Radix Polygalae, 5-7 parts of calcined Dragon's bone, 3-4 parts of the fruit of glossy privet, stir-baked CORTEX PHELLODENDRI with salt solution 2-3 points, 0.5-1.5 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, 0.5-1.5 parts of Schisandra chinensis, 3-4 parts of rhizoma acori graminei, 1-2 parts of benzoic acid, 1-2 parts of Tween-80,1-3 parts of sorbic acid, 1-3 parts of bacteriostatic agent, 1-3 parts of tremella powder, 10-15 parts of sucrose.Jinling Oral Liquor preparation method provided by the invention is simple, to the nonirritant effect of human body, can effectively treat and move multi-lingual, impulsion wilfulness, the symptoms such as difficulty of learning more.
Description
Technical field
The invention belongs to field of traditional Chinese medicine preparations, and in particular to a kind of Jinling Oral Liquor and preparation method thereof.
Background technique
Jinling Oral Liquor is used to treat a kind of drug of children ADHD, children ADHD cognition, mood, self-control,
The exception of will and personality etc. to patient and people around's bring pain and influences.The best side of taking of Jinling Oral Liquor
Method is to be administered at empty stomach, i.e., half an hour or 2 hours after meal take before meals.During taking Jinling Oral Liquor, pungent stimulation food need to be avoided
Object.During taking Jinling Oral Liquor, there is the case where exogenous disease fever, need to suspend use, table disease more after can continue to take.But
It is that conventional Jinling Oral Liquor long-term use will appear the adverse reactions such as insomnia, dry, constipation, appetite stimulator.
Chinese patent application CN105726904A discloses a kind of preparation side of traditional Chinese medicine oral liquid for treating children ADHD
Method.The oral solution include Rehmannia glutinosa 8-11 parts, 3-6 parts of the fruit of glossy privet, 3-5 parts of Chinese yam, 1-3 parts of Schisandra chinensis, 6-9 parts of keel, Radix Polygalae
2-5 parts, 3-5 parts of rhizoma acori graminei, 1-3 parts of rhizoma anemarrhenae, 2-5 parts of Cortex Phellodendri, 2-4 parts of cortex moutan, 2-5 parts of rhizoma alismatis, 2-5 parts of Poria cocos；Although taste
Preferably, for treating the significant effect of children ADHD, still, this oral solution fungistatic effect is limited, in storage of finished products mistake for sense
Cheng Zhonghui causes PH to decline due to microbial fermentation, and more serious person will cause bottle explosion accident, keeps product unqualified.
In summary, generally existing bacteriostasis is poor in oral solution in the prior art, and the storage of finished products phase is short, easily causes PH
Decline, affects the treatment and causes finished product unqualified.
Summary of the invention
For disadvantage existing in the prior art, the object of the present invention is to provide a kind of Jinling Oral Liquor and its preparation sides
Method.Jinling Oral Liquor good antimicrobial effect provided by the invention, it is without side-effects to human body, and environment will not be caused in preparation process
Damage.
In order to achieve the above object, the technical scheme adopted by the invention is as follows:
A kind of Jinling Oral Liquor, including the following raw material and its parts by weight: 6-8 parts of Rehmannia glutinosa, 3-4 parts of Chinese yam, Poria cocos 2-3
Part, 2-3 parts of cortex moutan, 2-3 parts of rhizoma alismatis, 2-3 parts of Radix Polygalae, 5-7 parts of calcined Dragon's bone, 3-4 parts of the fruit of glossy privet, stir-baked CORTEX PHELLODENDRI with salt solution 2-3 points, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution
0.5-1.5 parts, 0.5-1.5 parts of Schisandra chinensis, 3-4 parts of rhizoma acori graminei, 1-2 parts of benzoic acid, 1-2 parts of Tween-80,1-3 parts of sorbic acid, suppression
1-3 parts of microbial inoculum, 1-3 parts of tremella powder, 10-15 parts of sucrose.
Further, the Jinling Oral Liquor is made of the following raw material and its parts by weight: 7 parts of Rehmannia glutinosa, Chinese yam 3.5
Part, 2.5 parts of Poria cocos, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, 3.5 parts of the fruit of glossy privet, stir-baked CORTEX PHELLODENDRI with salt solution 2.5
Part, 1.0 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 1.5 parts of Tween-80,2 parts of sorbic acid, suppression
2 parts of microbial inoculum, 2 parts of tremella powder, 13 parts of sucrose.
Further, the bacteriostatic agent is by sodium lactate, propylparaben and dehydroactic acid sodium 1-3 in mass ratio:
4-7:6-9 composition.
Further, the bacteriostatic agent is by sodium lactate, propylparaben and dehydroactic acid sodium 2:5:8 in mass ratio
Composition.
The present invention also provides the preparation methods of the Jinling Oral Liquor, include the following steps:
S1, calcined Dragon's bone is pounded into fritter, above-mentioned 9-12 times of calcined Dragon's bone weight of water is added, be heated to 60-70 DEG C, decocted
50-70min obtains keel decoction liquor；
S2, Rehmannia glutinosa, Chinese yam, Poria cocos, cortex moutan, rhizoma alismatis, Radix Polygalae, glossy privet is added into keel decoction liquor obtained by step S1
Son, stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis, rhizoma acori graminei decoct twice, and the additive amount of first time water is that above-mentioned ten a herbs material is total
7-9 times of weight, the additive amount of second of water are 5-7 times of above-mentioned ten a herbs material total weight, decoct 100- for the first time
150min, second of decoction 80-100min, collecting decoction, filtration obtain filtrate；
S3, filtrate obtained by step S2 is cooled to 55-65 DEG C, being then concentrated under reduced pressure into relative density is 1.05-1.08, cold
But to 20-25 DEG C, concentrate is obtained；
S4, sucrose is prepared into simple syrup, it is spare；By benzoic acid, sorbic acid is configured to benzoic acid ethanol, sorb respectively
Sour ethanol, it is spare；
S5, tremella powder is taken, 5-8 times of warm water of 40-50 DEG C is added, impregnated 1 hour, heating is boiled, and keeps slightly boiled 1 in small fire
Hour, filtering takes decoction liquor, obtains tremella extract；
S6, simple syrup obtained by step S4, benzoic acid ethanol, sorbic acid second are sequentially added into concentrate obtained by step S3
Alcohol liquid, step S5 gained tremella extract, bacteriostatic agent and Tween-80, stir evenly, stand 22-26h, filtration adds sterile water extremely
1000mL is stirred evenly, packing to get.
Further, sucrose is prepared into the concrete operations of simple syrup are as follows: purified water 154.85L is taken to boil in the step S4
Boiling adds sucrose 292.50kg to stir, makes it dissolve, continue to be heated to 100 DEG C, adds suitable hot purified water to enough, and stirring is equal
It is even, be cooled to room temperature to get.
Further, by benzoic acid in the step S4, sorbic acid is configured to benzoic acid ethanol, sorbic acid ethyl alcohol respectively
The concrete operations of liquid are as follows: take benzoic acid 2250g, be dissolved in ethyl alcohol, be made into 20% benzoic acid ethanol 11250mL, sorbic acid 1500g
Be dissolved in ethyl alcohol, be made into 8% sorbic acid ethanol 18750mL to get.
In the present invention, sodium lactate, propylparaben and the dehydroactic acid sodium with bactericidal effect is added, these three
Substance is natural bactericidal agent, is added in Jinling Oral Liquor, and any stimulation will not be caused to human body, meanwhile, this hair
It is bright to joined Tween-80, the dissolubility of certain macromolecular drug ingredients can be increased, prevent from into analyzing and cause to precipitate and influence
Drug clarity.
Further, tremella powder is also added into the present invention, tremella powder itself has whitening spot-removing, wrinkle resistant, tonifying spleen appetizing,
QI invigorating gut purge, sleeping stomach invigorating and other effects；The present invention is found surprisingly that tremella powder and Chinese yam, the fruit of glossy privet are mixed in a certain amount of ratio
It closes and uses, the curative effect of Jinling Oral Liquor treatment children ADHD, and lasting medicine can be dramatically increased, pair will not be caused to human body
Effect is more suitable for children taking in addition, the mouthfeel of Jinling Oral Liquor can also be significantly improved by increasing tremella extract.
Specific embodiment
The present invention is further explained combined with specific embodiments below, it is noted that following embodiment is only
To explain the present invention, and it cannot be used to limit the present invention, all technical solutions same or similar with the present invention are in this hair
Within bright protection scope.Unless otherwise specified, what technological means used in embodiment was well known to those skilled in the art
Conventional means, raw materials used is commercial goods.
The tremella powder is purchased from the sapphire blue Biotechnology Co., Ltd in Deqing.
A kind of Jinling Oral Liquor of embodiment 1
The Jinling Oral Liquor is made of following component and its parts by weight: 6 parts of Rehmannia glutinosa, 3 parts of Chinese yam, and 2 parts of Poria cocos,
2 parts of cortex moutan, 2 parts of rhizoma alismatis, 2 parts of Radix Polygalae, 5 parts of calcined Dragon's bone, 3 parts of the fruit of glossy privet, stir-baked CORTEX PHELLODENDRI with salt solution 2 divides, and 0.5 part of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis 0.5
Part, 3 parts of rhizoma acori graminei, 1 part of benzoic acid, 1 part of Tween-80,1 part of sorbic acid, 1 part of bacteriostatic agent, 1 part of tremella powder, 10 parts of sucrose；It is described
Bacteriostatic agent is made of sodium lactate, propylparaben and dehydroactic acid sodium 1:4:6 in mass ratio.
The Jinling Oral Liquor, the preparation method is as follows:
S1, calcined Dragon's bone is pounded into fritter, the water of 9 times of above-mentioned calcined Dragon's bone weight is added, be heated to 60 DEG C, decocted 50min, obtain
Keel decoction liquor；
S2, Rehmannia glutinosa, Chinese yam, Poria cocos, cortex moutan, rhizoma alismatis, Radix Polygalae, glossy privet is added into keel decoction liquor obtained by step S1
Son, stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis, rhizoma acori graminei decoct twice, and the additive amount of first time water is that above-mentioned ten a herbs material is total
7 times of weight, the additive amount of second of water are 5 times of above-mentioned ten a herbs material total weight, for the first time decoction 100min, second
Secondary decoction 80min, collecting decoction, filtration obtain filtrate；
S3, filtrate obtained by step S2 is cooled to 55 DEG C, being then concentrated under reduced pressure into relative density is 1.05, is cooled to 20
DEG C, obtain concentrate；
S4, it takes purified water 154.85L to boil, adds sucrose 292.50kg to stir, make it dissolve, continue to be heated to 100 DEG C, add
Suitable hot purified water is stirred evenly, is cooled to room temperature, prepare simple syrup to enough, spare；Benzoic acid 2250g will be taken, it is molten
In ethyl alcohol, it is made into 20% benzoic acid ethanol 11250mL, sorbic acid 1500g and is dissolved in ethyl alcohol, be made into 8% sorbic acid ethanol
18750mL, it is spare；
S5, tremella powder being taken, 5 times of warm water of 40 DEG C is added, impregnated 1 hour, heating is boiled, it is kept for slightly boiled 1 hour in small fire,
Filtering, takes decoction liquor, obtains tremella extract；
S6, simple syrup obtained by step S4, benzoic acid ethanol, sorbic acid second are sequentially added into concentrate obtained by step S3
Alcohol liquid, tremella extract obtained by S5, bacteriostatic agent and Tween-80, stir evenly, and stand 22h, filtration, add purified water to 1000mL,
Stir evenly, packing to get.
A kind of Jinling Oral Liquor of embodiment 2
The Jinling Oral Liquor is made of following component and its parts by weight: 8 parts of Rehmannia glutinosa, 4 parts of Chinese yam, and 3 parts of Poria cocos,
3 parts of cortex moutan, 3 parts of rhizoma alismatis, 3 parts of Radix Polygalae, 7 parts of calcined Dragon's bone, 4 parts of the fruit of glossy privet, stir-baked CORTEX PHELLODENDRI with salt solution 3 divides, and 1.5 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis 1.5
Part, 4 parts of rhizoma acori graminei, 2 parts of benzoic acid, 2 parts of Tween-80,3 parts of sorbic acid, 3 parts of bacteriostatic agent, 3 parts of tremella powder, 15 parts of sucrose；By cream
Sour sodium, propylparaben and dehydroactic acid sodium 3:7:9 in mass ratio composition.
The Jinling Oral Liquor, the preparation method is as follows:
S1, calcined Dragon's bone is pounded into fritter, the water of 12 times of above-mentioned calcined Dragon's bone weight is added, be heated to 70 DEG C, decoct 70min,
Obtain keel decoction liquor；
S2, Rehmannia glutinosa, Chinese yam, Poria cocos, cortex moutan, rhizoma alismatis, Radix Polygalae, glossy privet is added into keel decoction liquor obtained by step S1
Son, stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis, rhizoma acori graminei decoct twice, and the additive amount of first time water is that above-mentioned ten a herbs material is total
9 times of weight, the additive amount of second of water are 7 times of above-mentioned ten a herbs material total weight, for the first time decoction 150min, second
Secondary decoction 100min, collecting decoction, filtration obtain filtrate；
S3, filtrate obtained by step S2 is cooled to 65 DEG C, being then concentrated under reduced pressure into relative density is 1.08, is cooled to 25
DEG C, obtain concentrate；
S4, it takes purified water 154.85L to boil, adds sucrose 292.50kg to stir, make it dissolve, continue to be heated to 100 DEG C, add
Suitable hot purified water is stirred evenly, is cooled to room temperature, prepare simple syrup to enough, spare；Benzoic acid 2250g will be taken, it is molten
In ethyl alcohol, it is made into 20% benzoic acid ethanol 11250mL, sorbic acid 1500g and is dissolved in ethyl alcohol, be made into 8% sorbic acid ethanol
18750mL, it is spare；
S5, tremella powder being taken, 8 times of warm water of 50 DEG C is added, impregnated 1 hour, heating is boiled, it is kept for slightly boiled 1 hour in small fire,
Filtering, takes decoction liquor, obtains tremella extract；
S6, simple syrup obtained by step S4, benzoic acid ethanol, sorbic acid second are sequentially added into concentrate obtained by step S3
Alcohol liquid, tremella extract obtained by S5, bacteriostatic agent and Tween-80, stir evenly, and stand 26h, filtration, add purified water to 1000mL,
Stir evenly, packing to get.
A kind of Jinling Oral Liquor of embodiment 3
The Jinling Oral Liquor is made of following component and its parts by weight: 7 parts of Rehmannia glutinosa, 3.5 parts of Chinese yam, and Poria cocos 2.5
Part, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, 3.5 parts of the fruit of glossy privet, 2.5 parts of stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution
1.0 parts, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 1.5 parts of Tween-80,2 parts of sorbic acid, 2 parts of bacteriostatic agent, silver
2 parts of ear powder, 13 parts of sucrose；The bacteriostatic agent is by sodium lactate, propylparaben and dehydroactic acid sodium 2:5:8 in mass ratio
Composition.
The Jinling Oral Liquor the preparation method comprises the following steps:
S1, calcined Dragon's bone is pounded into fritter, the water of 11 times of above-mentioned calcined Dragon's bone weight is added, be heated to 65 DEG C, decoct 60min,
Obtain keel decoction liquor；
S2, Rehmannia glutinosa, Chinese yam, Poria cocos, cortex moutan, rhizoma alismatis, Radix Polygalae, glossy privet is added into keel decoction liquor obtained by step S1
Son, stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis, rhizoma acori graminei decoct twice, and the additive amount of first time water is that above-mentioned ten a herbs material is total
8 times of weight, the additive amount of second of water are 6 times of above-mentioned ten a herbs material total weight, for the first time decoction 120min, second
Secondary decoction 90min, collecting decoction, filtration obtain filtrate；
S3, filtrate obtained by step S2 is cooled to 60 DEG C, being then concentrated under reduced pressure into relative density is 1.06, is cooled to 22
DEG C, obtain concentrate；
S4, it takes purified water 154.85L to boil, adds sucrose 292.50kg to stir, make it dissolve, continue to be heated to 100 DEG C, add
Suitable hot purified water is stirred evenly, is cooled to room temperature, prepare simple syrup to enough, spare；Benzoic acid 2250g will be taken, it is molten
In ethyl alcohol, it is made into 20% benzoic acid ethanol 11250mL, sorbic acid 1500g and is dissolved in ethyl alcohol, be made into 8% sorbic acid ethanol
18750mL, it is spare；
S5, tremella powder being taken, 6 times of warm water of 45 DEG C is added, impregnated 1 hour, heating is boiled, it is kept for slightly boiled 1 hour in small fire,
Filtering, takes decoction liquor, obtains tremella extract；
S6, simple syrup obtained by step S4, benzoic acid ethanol, sorbic acid second are sequentially added into concentrate obtained by step S3
Alcohol liquid, step S5 gained tremella extract, bacteriostatic agent and Tween-80, stir evenly, stand for 24 hours, filtration adds sterile water extremely
1000mL is stirred evenly, packing to get.
A kind of Jinling Oral Liquor of comparative example 1
The Jinling Oral Liquor is made of following component and its parts by weight: 7 parts of Rehmannia glutinosa, 3.5 parts of Chinese yam, and Poria cocos 2.5
Part, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, 3.5 parts of the fruit of glossy privet, 2.5 parts of stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution
1.0 parts, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 2 parts of sorbic acid, 2 parts of bacteriostatic agent, 2 parts of tremella powder, sucrose
13 parts；The bacteriostatic agent is made of sodium lactate, propylparaben and dehydroactic acid sodium 2:5:8 in mass ratio.
The preparation method of the Jinling Oral Liquor is similar to Example 3；
Difference with embodiment 3 is, Tween-80 is not included in comparative example 1.
A kind of Jinling Oral Liquor of comparative example 2
The Jinling Oral Liquor is made of following component and its parts by weight: 7 parts of Rehmannia glutinosa, 3.5 parts of Chinese yam, and Poria cocos 2.5
Part, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, 3.5 parts of the fruit of glossy privet, 2.5 parts of stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution
1.0 parts, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 1.5 parts of Tween-80,2 parts of sorbic acid, 2 parts of tremella powder, sugarcane
13 parts of sugar.
The preparation method of the Jinling Oral Liquor is similar to Example 3；
Difference with embodiment 3 is, bacteriostatic agent is not included in comparative example 2.
A kind of Jinling Oral Liquor of comparative example 3
The Jinling Oral Liquor is made of following component and its parts by weight: 7 parts of Rehmannia glutinosa, 3.5 parts of Chinese yam, and Poria cocos 2.5
Part, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, 3.5 parts of the fruit of glossy privet, 2.5 parts of stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution
1.0 parts, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 1.5 parts of Tween-80,2 parts of sorbic acid, 2 parts of bacteriostatic agent, silver
2 parts of ear powder, 13 parts of sucrose.
The preparation method of the Jinling Oral Liquor is similar to Example 3；
Difference with embodiment 3 is that bacteriostatic agent is by sodium lactate, propylparaben and dehydrogenation second in comparative example 3
Sour sodium 1:1:1 in mass ratio composition.
A kind of Jinling Oral Liquor of comparative example 4
The Jinling Oral Liquor is made of following component and its parts by weight: 7 parts of Rehmannia glutinosa, 3.5 parts of Chinese yam, and Poria cocos 2.5
Part, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, 3.5 parts of the fruit of glossy privet, 2.5 parts of stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution
1.0 parts, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 1.5 parts of Tween-80,2 parts of sorbic acid, 2 parts of bacteriostatic agent, sugarcane
13 parts of sugar；The bacteriostatic agent is made of sodium lactate, propylparaben and dehydroactic acid sodium 2:5:8 in mass ratio.
The preparation method of the Jinling Oral Liquor is similar to Example 3；
Difference with embodiment 3 is, does not include tremella powder in comparative example 4, in the Jinling Oral Liquor preparation process not
Include step S5.
The test of 1 antibiotic property of test example
1. test specimen: Jinling Oral Liquor made from embodiment 1-3 and comparative example 1-4；Staphylococcus aureus；Yeast
Bacterium；Candida albicans.
2. test method: using the anti-microbial property of paper disk method detection test specimen, in an aseptic environment, the circle scraps of paper being soaked
Afterwards, test specimen is picked respectively, and the circle scraps of paper are sticked to respectively then and fill staphylococcus aureus, saccharomycete, Candida albicans
Agar plate on, the size of its antibacterial circle diameter is observed and recorded after overnight incubation (as antibacterial circle diameter >=10mm, Jing Lingkou
It is antibacterial effectively to take liquid, as antibacterial circle diameter < 10mm, Jinling Oral Liquor is antibacterial invalid).
3. test result: specific test result is shown in Table 1.
The fungistatic effect of 1 different tests sample of table
As shown in Table 1, the antibacterial circle diameter for picking the circle scraps of paper of Jinling Oral Liquor made from 1-3 of the embodiment of the present invention exists
20mm or so has preferable antibacterial action, straight to the inhibition zone of three kinds of strains when especially picking 3 test specimen of embodiment
Diameter is in 22mm or more, and therefore, embodiment 3 is highly preferred embodiment of the present invention.And in comparative example 1-4, due to changing component,
Antibacterial action significantly reduces, especially the sample of comparative example 2-3, and due to changing bacteriostatic agent, bacteriostasis is significantly reduced.
The test of 2 therapeutic effect of test example
1. test specimen: Jinling Oral Liquor made from embodiment 1-3 and comparative example 1-4.
2. subjects: choosing introduction stage Rats Exposed To Hypoxia model mice 140, be randomly divided into 7 groups, every group 20, distinguish
Jinling Oral Liquor made from 1-3 of the embodiment of the present invention and comparative example 1-4 is taken, is taken in the morning and evening daily, each taking
1mL continuously takes 10 days.Recovery situation, and follow-up 6 months are observed, see whether recurrence occur.
Criterion:
Cure: cardinal symptom such as memory impairment, the symptoms such as hyperactivity disappear, and attention is concentrated；
Effective: cardinal symptom mostly disappears, and dispersion attention problem has larger improvement of terms；
Effective: cardinal symptom partial disappearance is improved, and attention concentration problem makes moderate progress but unstable；
Invalid: each symptom of mouse is not improved.
3. test result: specific test result is shown in Table 2, table 3.
Table 2 takes the therapeutic effect of different tests sample
The healing time of 3 different tests sample of table
| Test specimen | Reach efficient time/day |
| Embodiment 1 | 15 |
| Embodiment 2 | 16 |
| Embodiment 3 | 12 |
| Comparative example 1 | 21 |
| Comparative example 2 | 20 |
| Comparative example 3 | 20 |
| Comparative example 4 | 27 |
As shown in Table 2, the mouse model of Jinling Oral Liquor made from 1-3 of the embodiment of the present invention is taken, is cured efficient equal
Up to 90% or more, therapeutic effect is extremely significant, and especially in embodiment 3, only 1 invalid, effective percentage up to 95%, in conjunction with table
Different samples are taken in 3 and reach the efficient time, can be played a role within 12 days in embodiment 3, and therefore, embodiment 3 is this hair
Bright most preferred embodiment.And the therapeutic effect in comparative example 1-4 is significantly lower than the therapeutic effect of the embodiment of the present invention 3, especially
Embodiment 4 eliminates tremella powder, and effective time is extended to 27 days, and effective percentage is significantly reduced, and only 55%, further demonstrate,prove
The mutual synergistic effect between each component of the present invention is illustrated.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although elaborating referring to preferred embodiment to the present invention, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (7)
1. a kind of Jinling Oral Liquor, which is characterized in that including the following raw material and its parts by weight: 6-8 parts of Rehmannia glutinosa, Chinese yam 3-4
Part, 2-3 parts of Poria cocos, 2-3 parts of cortex moutan, 2-3 parts of rhizoma alismatis, 2-3 parts of Radix Polygalae, 5-7 parts of calcined Dragon's bone, 3-4 parts of the fruit of glossy privet, stir-baked CORTEX PHELLODENDRI with salt solution 2-
3 points, 0.5-1.5 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, 0.5-1.5 parts of Schisandra chinensis, 3-4 parts of rhizoma acori graminei, 1-2 parts of benzoic acid, 1-2 parts of Tween-80, sorb
It is 1-3 parts sour, 1-3 parts of bacteriostatic agent, 1-3 parts of tremella powder, 10-15 parts of sucrose.
2. Jinling Oral Liquor as described in claim 1, which is characterized in that be made of the following raw material and its parts by weight: radix rehmanniae preparata
It is 7 parts yellow, 3.5 parts of Chinese yam, 2.5 parts of Poria cocos, 2.5 parts of cortex moutan, 2.5 parts of rhizoma alismatis, 2.5 parts of Radix Polygalae, 6 parts of calcined Dragon's bone, the fruit of glossy privet 3.5
Part, 2.5 parts of stir-baked CORTEX PHELLODENDRI with salt solution, 1.0 parts of stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, 1.0 parts of Schisandra chinensis, 3.5 parts of rhizoma acori graminei, 1.5 parts of benzoic acid, 1.5 parts of Tween-80,
2 parts of sorbic acid, 2 parts of bacteriostatic agent, 2 parts of tremella powder, 13 parts of sucrose.
3. Jinling Oral Liquor as claimed in claim 1 or 2, which is characterized in that the bacteriostatic agent is by sodium lactate, para hydroxybenzene first
Propyl propionate and dehydroactic acid sodium 1-3:4-7:6-9 in mass ratio composition.
4. Jinling Oral Liquor as claimed in claim 1 or 2, which is characterized in that the bacteriostatic agent is by sodium lactate, para hydroxybenzene first
Propyl propionate and dehydroactic acid sodium 2:5:8 in mass ratio composition.
5. a kind of preparation method of Jinling Oral Liquor according to any one of claims 1-4, which is characterized in that including walking as follows
It is rapid:
S1, calcined Dragon's bone is pounded into fritter, above-mentioned 9-12 times of calcined Dragon's bone weight of water is added, be heated to 60-70 DEG C, decoct 50-
70min obtains keel decoction liquor；
S2, it is added Rehmannia glutinosa into keel decoction liquor obtained by step S1, Chinese yam, Poria cocos, cortex moutan, rhizoma alismatis, Radix Polygalae, the fruit of glossy privet,
Stir-baked CORTEX PHELLODENDRI with salt solution, stir-baked RHIZOMA ANEMARRHENAE before sprinking salt solution, Schisandra chinensis, rhizoma acori graminei decoct twice, and the additive amount of first time water is above-mentioned ten a herbs material total weight
7-9 times, the additive amount of second of water is 5-7 times of above-mentioned ten a herbs material total weight, for the first time decoction 100-150min,
Second of decoction 80-100min, collecting decoction, filtration obtain filtrate；
S3, filtrate obtained by step S2 is cooled to 55-65 DEG C, being then concentrated under reduced pressure into relative density is 1.05-1.08, is cooled to
20-25 DEG C, obtain concentrate；
S4, sucrose is prepared into simple syrup, it is spare；By benzoic acid, sorbic acid is configured to benzoic acid ethanol, sorbic acid second respectively
Alcohol liquid, it is spare；
S5, tremella powder is taken, 5-8 times of warm water of 40-50 DEG C is added, impregnated 1 hour, heating is boiled, small in small fire holding slightly boiled 1
When, filtering takes decoction liquor, obtains tremella extract；
S6, simple syrup obtained by step S4, benzoic acid ethanol, sorbic acid ethyl alcohol are sequentially added into concentrate obtained by step S3
Liquid, step S5 gained tremella extract, bacteriostatic agent and Tween-80, stir evenly, stand 22-26h, filtration adds purified water extremely
1000mL is stirred evenly, packing to get.
6. the preparation method of Jinling Oral Liquor as claimed in claim 5, which is characterized in that prepare sucrose in the step S4
At the concrete operations of simple syrup are as follows: take purified water 154.85L to boil, add sucrose 292.50kg to stir, make it dissolve, continue to heat
To 100 DEG C, suitable hot purified water is added to stir evenly to enough, be cooled to room temperature to get.
7. the preparation method of Jinling Oral Liquor as claimed in claim 5, which is characterized in that by benzoic acid in the step S4,
Sorbic acid is configured to benzoic acid ethanol, the concrete operations of sorbic acid ethanol respectively are as follows: and benzoic acid 2250g is taken, ethyl alcohol is dissolved in,
It is made into 20% benzoic acid ethanol 11250mL, sorbic acid 1500g and is dissolved in ethyl alcohol, be made into 8% sorbic acid ethanol 18750mL, i.e.,
?.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879268A (en) * | 2010-07-13 | 2010-11-10 | 辽宁东方人药业有限公司 | Method for preparing Chinese medicinal oral liquid for treating attention deficit hyperactivity disorder |
| CN103800636A (en) * | 2012-11-09 | 2014-05-21 | 李忠久 | Oral liquid for treating children hyperactivity |
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2019
- 2019-01-31 CN CN201910101258.3A patent/CN109674927A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879268A (en) * | 2010-07-13 | 2010-11-10 | 辽宁东方人药业有限公司 | Method for preparing Chinese medicinal oral liquid for treating attention deficit hyperactivity disorder |
| CN103800636A (en) * | 2012-11-09 | 2014-05-21 | 李忠久 | Oral liquid for treating children hyperactivity |
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| Title |
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| 国家药典委员会: "《中华人民共和国药典临床用药须知》", 30 September 2017, 中国医药科技出版社 * |
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Application publication date: 20190426 |