CN101874853B - Pills for treating ulcerative colitis and preparation process thereof - Google Patents
Pills for treating ulcerative colitis and preparation process thereof Download PDFInfo
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- CN101874853B CN101874853B CN201010186781.XA CN201010186781A CN101874853B CN 101874853 B CN101874853 B CN 101874853B CN 201010186781 A CN201010186781 A CN 201010186781A CN 101874853 B CN101874853 B CN 101874853B
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Abstract
The invention provides Chinese medicinal pills for treating ulcerative colitis, which are prepared by processing the following medicaments in part by weight: 9 to 11 parts of honeysuckle, 9 to 11 parts of mongolian dandelion herb, 9 to 11 parts of szechwon tangshen root, 7 to 9 parts of astragalus, 7 to 9 parts of Chinese angelica, 4 to 6 parts of liquorice root, 4 to 6 parts of weeping forsythia, 4 to 6 parts of catechu, 1 to 3 parts of mongolian snakegourd root, 1 to 3 parts of angelica dahurlica, 1 to 3 parts of chicken's gizzard-membrane, 2 to 4 parts of charred rehmanniae praeparatum and 2 to 4 parts of charred largetrifoliolious bugbane rhizome. Aiming at symptoms such as ulcerative colitis, hypofunction of the spleen and the stomach and endoretention of damp heat, the pills have the effects of tonifying the spleen and qi, clearing away heat and toxic materials, cooling blood and hemostasis and stopping diarrhea, and the medicaments are selected and combined according to the method. The Chinese medicinal pills have the advantages of definite curative effect, no side effect, safety and reliability.
Description
technical field:
The invention belongs to Chinese medicine preparation technical field, be specifically related to a kind of medicine pill and preparation method for the treatment of ulcerative colitis.
background technology:
Ulcerative colitis (UC) is one of main hazard factor of colon tumor generation, and its sickness rate is in rising trend, to become the emphasis of digestive system disease research.The canceration rate of colitis is higher 5～20 times than normal person, and the sickness rate of colon cancer has leapt to the 3rd in cancer at present, and the whole world approximately has 1,000,000 people to be diagnosed as this disease every year, nearly 500,000 people so and dead.Therefore ，Bei World Health Organization (WHO) classifies one of modern difficult treatment as.Medicine modern medicine is mainly applied sulfonamides, immunosuppressant, adrenocortical hormone etc. at present, and side effect is many, and easily recurrence.Clinical symptoms performance be take mucopurulent bloody stool, stomachache, diarrhoea or tenesmus as main; As treatment not in time, the ectocolon of meeting complicated with acute, perforated ulcer, colon cancer and intestinal obstruction etc., cause mortality rate high.The difficult pertinacious disease of Chinese medicine has unique advantage, and the traditional Chinese medical science thinks that morbidity is to take weakness of the spleen and stomach as this, take damp-heat accumulation, stagnation of blood stasis as due to the gastrointestinal dysfunction that index rises, and belongs to the disease of deficiency in origin and excess in superficiality.Existing Chinese patent medicine exists dosage large, and patient's long-term taking is difficult to adhere to etc. shortcoming particularly lack determined curative effect, low toxicity, high-efficiency preparation.
summary of the invention:
Technical problem to be solved by this invention is to address the above problem, and develops a kind of novel determined curative effect, low toxicity, treats efficiently the medicine pill of ulcerative colitis.
Said preparation is by Flos Lonicerae, Herba Taraxaci, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Fructus Forsythiae, catechu, Radix Trichosanthis, the Radix Angelicae Dahuricae, Endothelium Corneum Gigeriae Galli, fresh rehmannia charcoal, the medicine pill that Rhizoma Cimicifugae charcoal processes from strand.Its weight consists of: Flos Lonicerae 9-11 part, Herba Taraxaci 9-11 part, Radix Codonopsis 9-11 part, Radix Astragali 7-9 part, Radix Angelicae Sinensis 7-9 part, Radix Glycyrrhizae 4-6 part, catechu 4-6 part, Fructus Forsythiae 4-6 part, Radix Trichosanthis 1-3 part, Radix Angelicae Dahuricae 1-3 part, Endothelium Corneum Gigeriae Galli 1-3 part, fresh rehmannia charcoal 2-4 part, Rhizoma Cimicifugae charcoal 2-4 part.
The weight of said preparation forms: 10 parts of Flos Loniceraes, 10 parts of Herba Taraxacis, Radix Codonopsis 10
Part, 8 parts of the Radixs Astragali, 8 parts of Radix Angelicae Sinensis, 5 parts, Radix Glycyrrhizae, 5 parts, catechu, 5 parts of Fructus Forsythiaes, 2 parts of Radix Trichosanthis, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Endothelium Corneum Gigeriae Galli, 3 parts of fresh rehmannia charcoals, 3 parts of Rhizoma Cimicifugae charcoals.
A kind of preparation method that is used for the treatment of the medicine pill of ulcerative colitis provided by the invention is: match well by weight extracting honeysuckle, Herba Taraxaci, the Radix Astragali, Radix Glycyrrhizae, Fructus Forsythiae, catechu, Radix Trichosanthis mixing, add 10 times of water gagings to extract 3 times, each 2 hours, filter, filtrate decompression is concentrated, be dried to extractum, pulverize, cross 100 mesh sieves; Get by weight Radix Angelicae Sinensis, Radix Codonopsis, Endothelium Corneum Gigeriae Galli, the Radix Angelicae Dahuricae, fresh rehmannia charcoal, Rhizoma Cimicifugae charcoal pulverizing again, cross 100 mesh sieves, wherein Endothelium Corneum Gigeriae Galli is processed with the 60Co-radiation gamma of 6kGy after pulverizing; With mixer, the powder after sieving is mixed again, with pellet processing machine, make pill.
Technical scheme of the present invention is according to theory of Chinese medical science, and insufficiency of the spleen leading to overabundance of dampness is the key factor that causes ulcerative colitis to occur.Exopathogenic factor and damp and hot relation are maximum, and damp is invaded, impairing the spleen and stomach, dysfunction of the spleen in transportation and transformation, so-called " domination of damp bringing about watery diarrhea.In damp and hot obstruction intestinal, the QI and blood knot of fighting mutually with it, makes intestinal conduction mistake department, and venation is injured, coagulation of QI-blood, corruption turn to pus and blood and under dysentery red in vain; Mechanism of qi retardance, FU QI being obstructed is suffered from abdominal pain, tenesmus.Endogenous cause of ill is close with insufficiency of the spleen relation, insufficiency of the spleen mistake fortune, indigestion is precise and tiny, endogenous damp formation, mix and under.Insufficiency of the spleen mistake fortune can cause wet Sheng, and the latter can affect the transporting of spleen again, insufficiency of the spleen and wetly contains the reciprocal causation that influences each other.Therefore, ulcerative colitis is to take weakness of the spleen and stomach as this, take the gastrointestinal dysfunction that damp-heat accumulation, stagnation of blood stasis rise as index, belongs to the disease of deficiency in origin and excess in superficiality, belongs to the sick categories such as the traditional Chinese medical science is had loose bowels, dysentery.
This prescription founds the method for invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, cooling blood for hemostasis, antidiarrheal, and selects accordingly medicine prescription for ulcerative colitis weakness of the spleen and stomach, retention of damp-heat in the interior card.
With Radix Codonopsis, Radix Astragali the kidney invigorating gas, replenishing QI and blood, spleen invigorating and in, inspire healthy energy with anti-heresy, take Herba Taraxaci, Flos Lonicerae mutual reinforcement between is use, removing summer-heat gastrointestinal pyretic toxicity, is combined into monarch drug.Get Fructus Forsythiae, catechu, Radix Trichosanthis, heat-clearing and toxic substances removing, cooling blood for hemostasis, detumescence sore, " except chronic heat in the intestines and stomach ", the Radix Rehmanniae, Rhizoma Cimicifugae are got charcoal for using, be intended to strengthen the merit of cooling blood for hemostasis, dysentery relieving, when division " all pains of trusted subordinate ", Endothelium Corneum Gigeriae Galli " eliminating dampness by diuresis evil " with only " dysentery "; Radix Angelicae Dahuricae detumescence and apocenosis and pain relieving, Radix Glycyrrhizae eliminating fire and detoxication, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, department makes the duty of medicine.All 13 tastes in full side, eliminating evilly take into account with righting, stress eliminating evilly, and the cold temperature of medicine is use mutually, without eliminating evil wound just, righting loves the anxiety of heresy.All medicines match well, and play altogether the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, cooling blood for hemostasis, antidiarrheal.Due to weakness of the spleen and stomach, retention of damp-heat in the interior, have loose bowels, disease is seen diarrhoea, bloody purulent stool, stomachache, tenesmus, burning sensation of the anus, dark coloured urine, red tongue with yellowish and greasy fur, slippery and rapid pulse; Ulcerative colitis is shown in above-mentioned patient.
Tool of the present invention has the following advantages: (1) determined curative effect; (2) have no side effect.
the specific embodiment:
embodiment 1:
Flos Lonicerae 10g, Herba Taraxaci 10g, Radix Codonopsis 10g, Radix Astragali 8g, Radix Angelicae Sinensis 8g, Radix Glycyrrhizae 5g, Fructus Forsythiae 5g, catechu 5g, Radix Trichosanthis 2g, Radix Angelicae Dahuricae 2g, Endothelium Corneum Gigeriae Galli 2g, fresh rehmannia charcoal 3g, Rhizoma Cimicifugae charcoal 3g.
Match well by weight extracting honeysuckle, Herba Taraxaci, the Radix Astragali, Radix Glycyrrhizae, Fructus Forsythiae, catechu, Radix Trichosanthis and mix, add 10 times of water gagings to extract 3 times, each 2 hours, to filter, filtrate decompression is concentrated, is dried to extractum, pulverizes, and crosses 100 mesh sieves; Get by weight Radix Angelicae Sinensis, Radix Codonopsis, Endothelium Corneum Gigeriae Galli, the Radix Angelicae Dahuricae, fresh rehmannia charcoal, Rhizoma Cimicifugae charcoal pulverizing again, cross 100 mesh sieves, wherein Endothelium Corneum Gigeriae Galli is processed with the 60Co-radiation gamma of 6kGy after pulverizing; With mixer, the powder after sieving is mixed again, with pellet processing machine, make pill.Every 100 balls nearly weigh 6g.
Instructions of taking: every day twice, each 2-4g.
Embodiment 2:
Flos Lonicerae 9g, Herba Taraxaci 11g, Radix Codonopsis 10g, Radix Astragali 7g, Radix Angelicae Sinensis 7g, Radix Glycyrrhizae 6g, Fructus Forsythiae 4g, catechu 6g, Radix Trichosanthis 1g, Radix Angelicae Dahuricae 1g, Endothelium Corneum Gigeriae Galli 1g, fresh rehmannia charcoal 2g, Rhizoma Cimicifugae charcoal 2g.
Preparation method is with embodiment 1.
Instructions of taking: every day twice, each 2-4g.
Embodiment 3:
Flos Lonicerae 11g, Herba Taraxaci 11g, Radix Codonopsis 9g, Radix Astragali 9g, Radix Angelicae Sinensis 9g, Radix Glycyrrhizae 4g, Fructus Forsythiae 6g, catechu 4g, Radix Trichosanthis 3g, Radix Angelicae Dahuricae 3g, Endothelium Corneum Gigeriae Galli 3g, fresh rehmannia charcoal 4g, Rhizoma Cimicifugae charcoal 4g.
Preparation method is with embodiment 1.
Instructions of taking: every day twice, each 2-4g.
embodiment 4:clinical trial
Model case 1:
Week X X, man, 50 years old, existing 4 years ulcerative colitis medical histories, took our embodiment 1 pill one month, fully recover.
Model case 2:
Liu X X, female, 31 years old, suffer from 5 years medical histories of chronic ulcerative colitis, take our embodiment 1 pill 5 weeks, fully recover.
Typical case 3:
Zhao X X, man, 60 years old, suffer from 8 years medical histories of ulcerative colitis, take our embodiment 1 two months, fully recover.
Typical case 4:
King X X, man, 40 years old, suffer from 4 years medical histories of ulcerative colitis, take our embodiment 2 pill 5 weeks, fully recover.
Typical case 5:
Open X X, man, 52 years old, suffer from 7 years medical histories of ulcerative colitis, take our embodiment 2 pill 9 weeks, fully recover.
Typical case 6:
Lee X X, female, 32 years old, suffer from 3 years medical histories of ulcerative colitis, take our embodiment 3 pill 4 weeks, fully recover.
Typical case 7:
Grandson X X, man, 68 years old, suffer from 8 years medical histories of ulcerative colitis, take our embodiment 3 pill 10 weeks, fully recover.
Claims (3)
1. a pill for the treatment of ulcerative colitis, is characterized in that: it is by following weight component
Preparation of raw material form: Flos Lonicerae 9-11 part, Herba Taraxaci 9-11 part, Radix Codonopsis 9-11 part, Radix Astragali 7-9 part, Radix Angelicae Sinensis 7-9 part, Radix Glycyrrhizae 4-6 part, catechu 4-6 part, Fructus Forsythiae 4-6 part, Radix Trichosanthis 1-3 part, Radix Angelicae Dahuricae 1-3 part, Endothelium Corneum Gigeriae Galli 1-3 part, fresh rehmannia charcoal 2-4 part, Rhizoma Cimicifugae charcoal 2-4 part.
2. a kind of pill for the treatment of ulcerative colitis according to claim 1, is characterized in that:
It is that preparation of raw material by following weight component forms: 10 parts of Flos Loniceraes, 10 parts of Herba Taraxacis, 10 parts of Radix Codonopsis, 8 parts of the Radixs Astragali, 8 parts of Radix Angelicae Sinensis, 5 parts, Radix Glycyrrhizae, 5 parts, catechu, 5 parts of Fructus Forsythiaes, 2 parts of Radix Trichosanthis, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Endothelium Corneum Gigeriae Galli, 3 parts of fresh rehmannia charcoals, 3 parts of Rhizoma Cimicifugae charcoals.
3. an a kind of preparation method for the treatment of the pill of ulcerative colitis as claimed in claim 1,
It is characterized in that: this pill is that the raw material of select is carried out to screening, clean, dry; Match well by weight extracting honeysuckle, Herba Taraxaci, the Radix Astragali, Radix Glycyrrhizae, Fructus Forsythiae, catechu, Radix Trichosanthis and mix, add 10 times of water gagings to extract 3 times, each 2 hours, to filter, filtrate decompression is concentrated, is dried to extractum, pulverizes, and crosses 100 mesh sieves; Get by weight Radix Angelicae Sinensis, Radix Codonopsis, Endothelium Corneum Gigeriae Galli, the Radix Angelicae Dahuricae, fresh rehmannia charcoal, Rhizoma Cimicifugae charcoal pulverizing again, cross 100 mesh sieves, wherein Endothelium Corneum Gigeriae Galli is processed with the 60Co-radiation gamma of 6kGy after pulverizing; With mixer, the powder after sieving is mixed again, then with pellet processing machine, make medicine pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010186781.XA CN101874853B (en) | 2010-05-31 | 2010-05-31 | Pills for treating ulcerative colitis and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010186781.XA CN101874853B (en) | 2010-05-31 | 2010-05-31 | Pills for treating ulcerative colitis and preparation process thereof |
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| Publication Number | Publication Date |
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| CN101874853A CN101874853A (en) | 2010-11-03 |
| CN101874853B true CN101874853B (en) | 2014-01-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010186781.XA Active CN101874853B (en) | 2010-05-31 | 2010-05-31 | Pills for treating ulcerative colitis and preparation process thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705646B (en) * | 2013-12-29 | 2016-08-17 | 齐达春 | A kind of Chinese medicinal enema treating ulcerative colitis |
| CN103800597B (en) * | 2014-02-24 | 2016-07-06 | 杜翠云 | A kind of Chinese medicine treating retention of damp-heat in the interior type ulcerative colitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428165A (en) * | 2001-12-28 | 2003-07-09 | 北京中惠药业有限公司 | Chinese medicine positioning preparation for curing ulcerative colitis |
| CN1857453A (en) * | 2006-03-03 | 2006-11-08 | 延边大学 | Chinese medicine composition for treating ulcerative colitis and its preparing method |
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2010
- 2010-05-31 CN CN201010186781.XA patent/CN101874853B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1428165A (en) * | 2001-12-28 | 2003-07-09 | 北京中惠药业有限公司 | Chinese medicine positioning preparation for curing ulcerative colitis |
| CN1857453A (en) * | 2006-03-03 | 2006-11-08 | 延边大学 | Chinese medicine composition for treating ulcerative colitis and its preparing method |
Non-Patent Citations (4)
| Title |
|---|
| 刘进等.溃疡性结肠炎中医综合疗法概况.《世界中西医结合杂志》.2009,第4卷(第10期),753-754,758. |
| 溃疡性结肠炎中医综合疗法概况;刘进等;《世界中西医结合杂志》;20091031;第4卷(第10期);753-754,758 * |
| 田振国等.通腑宁颗粒治疗结肠炎性疾病解析.《中国中医药现代远程教育》.2004,第2卷(第01期),26-27. |
| 通腑宁颗粒治疗结肠炎性疾病解析;田振国等;《中国中医药现代远程教育》;20040131;第2卷(第01期);26-27 * |
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| CN101874853A (en) | 2010-11-03 |
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