CN101869107A - Scopoletin lactone plant miticide and purposes thereof - Google Patents
Scopoletin lactone plant miticide and purposes thereof Download PDFInfo
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- CN101869107A CN101869107A CN201010212770A CN201010212770A CN101869107A CN 101869107 A CN101869107 A CN 101869107A CN 201010212770 A CN201010212770 A CN 201010212770A CN 201010212770 A CN201010212770 A CN 201010212770A CN 101869107 A CN101869107 A CN 101869107A
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- scopolactone
- scopoletin
- emulsifier
- lactone
- weight portion
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Abstract
The invention provides plant miticide prepared by taking scopoletin lactone as the main raw material and then adding in solvent, solubilizer and/or emulsifier, is environmental-friendly harmonious pesticide which is safety to human beings and animals, and has profound significance in the long-termed development of the ecological environment, the health of human beings and the integrated control of diseases. Compared with traditional pesticide, the scopoletin lactone plant miticide is characterized in and has the advantages that: 1. the scopoletin lactone exists in nature is a large amount, has low toxicity, is easy to degrade and is safety to the ecological environment; 2. the scopoletin lactone extraction method is simpler; 3. the scopoletin lactone can be also synthesized manually, has low cost and is easily applied to industrial large-scale production; 4. the scopoletin lactone can be solved in various solvent, is easy to be mixed with other anti-mite components to prepare medicine, and can play the role of improving the anti-mite effect; and 5. the scopoletin lactone can inhibit cellular signal transduction, is good neuromuscular blocking agent, and can quickly palsies harmful mites.
Description
Technical field
The present invention relates to the new purposes of a kind of scopolactone plant acaricide and scopolactone.
Background technology
Scopolactone (Scopoletine) has another name called Scopoletin, scopolactone, scopolin unit, scopoletin, henbane phenol, scopoletin, 7-hydroxyl-6-methoxyl group-2H-1-chromen-2-one; Molecular formula: C
10H
8O
4, molecular weight: 192.17; Needle-like or prism-shaped crystallization; Can reduce Fei Linshi solution; Be dissolved in the glacial acetic acid of dimethylbenzene, hot ethanol or heat, be slightly soluble in chloroform, water or cold ethanol, be dissolved in benzene hardly; Its ethanolic solution is blue-fluorescence, 204 ℃ of fusing points; Maximum absorption wavelength 230,254,260,298,346nm; Excitant is arranged.Scopolactone belongs to coumarin kind compound, medicine such as Chang Zuowei analgesia, anti-inflammatory, hypotensive and relieve muscle spasms.But still there be not the application report of scopolactone in preparation plant resource miticide in the existing document; Still do not have at present a kind of good with environment compatibility, to the harmonious agricultural chemicals of mammalian safe.
Summary of the invention
The object of the invention is to disclose a kind of scopolactone plant acaricide, and order of the present invention also is the new purposes of open scopolactone in the preparation plant acaricide.
The present invention seeks to be achieved through the following technical solutions:
The application of scopolactone in the preparation plant acaricide.
Scopolactone is added conventional auxiliary material, according to common process, make various forms of miticides: missible oil, suspending agent, pulvis or spray.
Wherein, auxiliary material is a solvent, can also add solubilizer and/or emulsifier.Solvent is acetone, chloroform, benzene and/or dimethylbenzene, preferred dimethylbenzene; Solubilizer, emulsifier are spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent.
Wherein, the raw material of missible oil consists of in the scopolactone miticide of the present invention:
Scopolactone 20-60 weight portion dimethylbenzene 30-70 weight portion emulsifier 5-15 weight portion.
The raw material of missible oil composition is preferably in the scopolactone miticide of the present invention:
Scopolactone 50 weight portion dimethylbenzene 40 weight portion emulsifier 10 weight portions.
The raw material of missible oil composition is preferably in the scopolactone miticide of the present invention:
Scopolactone 30 weight portion dimethylbenzene 60 weight portion emulsifier 10 weight portions.
The raw material of missible oil composition is preferably in the scopolactone miticide of the present invention:
Scopolactone 40 weight portion dimethylbenzene 50 weight portion emulsifier 10 weight portions.
Wherein, emulsifier is that the HLB value is 15 Tween-80.
The preparation method of missible oil is in the scopolactone miticide of the present invention: with the scopolactone xylene soluble, add emulsifier therein again, dissolving promptly can be used for mite extremely.
Wherein, described mite can be a Tetranychus cinnabarinus.
The invention provides a kind ofly, the comprehensive regulation of ecotope long term growth, human beings'health and disease is all had profound significance person poultry safety, environmentally friendly harmonious agricultural chemicals.Scopolactone plant acaricide of the present invention is compared with traditional agricultural chemicals, have following characteristics and advantage: 1, scopolactone exists in a large number at occurring in nature, and especially content is higher in plant, animal, and its toxicity is low, easily degraded, and to ecological environment security; 2, the scopolactone extracting method is comparatively simple, can pass through ion exchange resin or supercritical CO
2Technologies such as extraction are extracted; 3, scopolactone also can pass through synthetic, and its cost is low, is easy for large-scale industrialization production; 4, scopolactone can be dissolved in multiple solvent because its physics and chemical characteristic, easily kills the acaricidal composition pharmaceutical mixture with other, can play the effect of raising miticidal effect; 5, scopolactone can suppress cell signalling, is good neuromuscular blocking agents, can benumb harmful mite rapidly.Compare with the plant resource acaricidal activity material that Celastrus angulatus etc. is known, scopolactone can be anaesthetized in 30 minutes when concentration is 2mg/mL and be surpassed 90% harmful mite; 6, in addition, the missible oil in the scopolactone plant acaricide of the present invention has used dimethylbenzene as solvent, can increase the solvability of scopolactone in water, and has the effect that promotes agricultural chemicals infiltration plant epidermis concurrently.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1 scopolactone plant acaricide of the present invention is to the inhibition experiment of Tetranychus cinnabarinus.
Prepare scopolactone plant acaricidal missible oil of the present invention according to the embodiment of the invention 1 described raw material and method, and dilute, carry out the inhibition experiment of Tetranychus cinnabarinus then by table 1.Experimental result sees Table 2, table 3 and table 4:
The table 1 concentration dilution multiple table of comparisons
Table 2 scopolactone missible oil is to the Tetranychus cinnabarinus effect (24 hours) of tagging
Table 3 scopolactone missible oil is to inhaling effect (24 hours) in the Tetranychus cinnabarinus
Table 4 concentration is that the scopolactone missible oil of 2mg/mL is to Tetranychus cinnabarinus anesthetic effect (2mg/mL)
Experimental result shows that scopolactone plant acaricide of the present invention has tag significantly effect and interior suction effect to Tetranychus cinnabarinus, and scopolactone can be anaesthetized the harmful mite above 90% in 30 minutes when concentration is 2mg/mL.
The screening experiment of experimental example 2 solvents of the present invention.
Dimethylbenzene, chloroform and 3 kinds of solvents of ethanol are adopted in this experiment respectively, are the 2mg/mL effect experiment of tagging according to table 1 preparation scopolactone content respectively, and preparation scopolactone content is to inhale effect experiment in 24mg/mL carries out.This experiment is intended to the optimum solvent of scopolactone is screened.Experiment adopts Tetranychus cinnabarinus to tag and systemic activity is measured, and the results are shown in Table 5 and table 6.The result shows that preferred solvent is a dimethylbenzene.
The scopolactone of table 5 different solvents is to the contact toxicity of the female one-tenth mite of Tetranychus cinnabarinus
Annotate: different lowercases represent to reach 5% horizontal significant difference in the same column.
The scopolactone of table 6 different solvents is to the systemic activity of the female one-tenth mite of Tetranychus cinnabarinus
Annotate: different lowercases represent to reach 5% horizontal significant difference in the same column.
Following embodiment all can realize the described effect of above-mentioned experimental example.
Embodiment
Embodiment 1: scopolactone plant acaricidal missible oil of the present invention
Scopolactone 50kg dimethylbenzene 40kg HLB value is 15 Tween-80 10kg.
With the scopolactone xylene soluble, add the HLB value therein again and be 15 Tween-80, dissolving can be adopted spray pattern control Tetranychus cinnabarinus.
Embodiment 2: scopolactone plant acaricidal missible oil of the present invention
Scopolactone 30kg dimethylbenzene 60kg HLB value is 15 Tween-80 10kg.
With the scopolactone xylene soluble, add emulsifier therein again, dissolving can be adopted spray pattern control Tetranychus cinnabarinus.
Embodiment 3: scopolactone plant acaricidal missible oil of the present invention
Scopolactone 40kg dimethylbenzene 50kg HLB value is 15 Tween-80 10kg.
With the scopolactone xylene soluble, add emulsifier therein again, dissolving can be adopted spray pattern control Tetranychus cinnabarinus.
Embodiment 4: scopolactone plant acaricidal suspending agent of the present invention
Scopolactone added in the solvent acetone dissolve, add Arlacel-20 again, make scopolactone plant acaricidal suspending agent, adopt the spraying mode to prevent and treat plant evil mite according to common process.
Embodiment 5: scopolactone plant acaricidal pulvis of the present invention
According to common process, add conventional auxiliary material, scopolactone is made pulvis, adopt the spraying mode to prevent and treat plant evil mite.
Embodiment 6: scopolactone plant acaricidal spray of the present invention
Scopolactone added in the solvent chloroform dissolve, add ethylene glycol again, make scopolactone plant acaricidal spray, adopt the spraying mode to prevent and treat plant evil mite according to common process.
Claims (10)
1. scopolactone plant acaricide is characterized in that this acaricidal raw material consists of:
Scopolactone 20-60 weight portion dimethylbenzene 30-70 weight portion emulsifier 5-15 weight portion.
2. miticide as claimed in claim 1 is characterized in that this acaricidal raw material consists of:
Scopolactone 50 weight portion dimethylbenzene 40 weight portion emulsifier 10 weight portions;
Or
Scopolactone 30 weight portion dimethylbenzene 60 weight portion emulsifier 10 weight portions;
Or
Scopolactone 40 weight portion dimethylbenzene 50 weight portion emulsifier 10 weight portions.
3. miticide as claimed in claim 1 or 2 is characterized in that wherein said emulsifier is that the HLB value is 15 Tween-80.
4. as the arbitrary described acaricidal preparation method of claim 1-3, it is characterized in that this method is:
With the scopolactone xylene soluble, add emulsifier therein again, dissolving promptly can be used for mite extremely.
5. prevent and treat application in the plant mites medicine as the arbitrary described miticide of claim 1-3 in preparation.
6. the application of scopolactone in the preparation plant acaricide.
7. as claim 5 or 6 described application, it is characterized in that wherein said plant mites is a Tetranychus cinnabarinus.
8. as claim 6 or 7 described application, it is characterized in that when the preparation plant acaricide, scopolactone being added conventional auxiliary material, according to common process, make various forms of miticides: missible oil, suspending agent, pulvis or spray.
9. application as claimed in claim 8 is characterized in that wherein said auxiliary material is a solvent: acetone, chloroform, benzene and/or dimethylbenzene.
10. application as claimed in claim 9 is characterized in that wherein said auxiliary material also adds solubilizer and/or emulsifier; Solvent is that solubilizer, emulsifier are spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010212770A CN101869107A (en) | 2010-06-22 | 2010-06-22 | Scopoletin lactone plant miticide and purposes thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010212770A CN101869107A (en) | 2010-06-22 | 2010-06-22 | Scopoletin lactone plant miticide and purposes thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101869107A true CN101869107A (en) | 2010-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010212770A Pending CN101869107A (en) | 2010-06-22 | 2010-06-22 | Scopoletin lactone plant miticide and purposes thereof |
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| CN (1) | CN101869107A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102771483A (en) * | 2011-05-09 | 2012-11-14 | 北京农学院 | Novel plant acaridal application of racanisodamine hydrochloride |
| CN102907427A (en) * | 2012-11-21 | 2013-02-06 | 西南大学 | Scopoletin and di-bisdemethoxycurcumin complex suspending agent |
| CN105994327A (en) * | 2016-05-31 | 2016-10-12 | 刘雨 | Composition for preventing and treating Chinese cabbage white spot disease and preparation method thereof |
| CN108902149A (en) * | 2018-05-31 | 2018-11-30 | 沈阳农业大学 | Scopoletin excites the purposes and application method of the broad spectrum resistance of plant immune |
| WO2021213484A1 (en) * | 2020-04-24 | 2021-10-28 | 珠海岐微生物科技有限公司 | Application of radix gentianae macrophyllae and monomer compound thereof in killing mites |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1450062A (en) * | 2003-05-15 | 2003-10-22 | 中国科学院上海有机化学研究所 | Coumarin group compound, synthesis process and use thereof |
-
2010
- 2010-06-22 CN CN201010212770A patent/CN101869107A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1450062A (en) * | 2003-05-15 | 2003-10-22 | 中国科学院上海有机化学研究所 | Coumarin group compound, synthesis process and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张永强: "黄花蒿杀螨物质活性追踪及杀螨作用机理研究", 《中国博士学位论文全文数据库》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102771483A (en) * | 2011-05-09 | 2012-11-14 | 北京农学院 | Novel plant acaridal application of racanisodamine hydrochloride |
| CN102907427A (en) * | 2012-11-21 | 2013-02-06 | 西南大学 | Scopoletin and di-bisdemethoxycurcumin complex suspending agent |
| CN105994327A (en) * | 2016-05-31 | 2016-10-12 | 刘雨 | Composition for preventing and treating Chinese cabbage white spot disease and preparation method thereof |
| CN108902149A (en) * | 2018-05-31 | 2018-11-30 | 沈阳农业大学 | Scopoletin excites the purposes and application method of the broad spectrum resistance of plant immune |
| CN108902149B (en) * | 2018-05-31 | 2020-07-21 | 沈阳农业大学 | Application and using method of scopoletin in stimulating broad-spectrum disease resistance of plant immunity |
| WO2021213484A1 (en) * | 2020-04-24 | 2021-10-28 | 珠海岐微生物科技有限公司 | Application of radix gentianae macrophyllae and monomer compound thereof in killing mites |
| CN115607589A (en) * | 2020-04-24 | 2023-01-17 | 珠海岐微生物科技有限公司 | Application of gentiana macrophylla and monomer compound thereof in mite killing |
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Application publication date: 20101027 |