CN101692821A - New application of stigmasterol - Google Patents
New application of stigmasterol Download PDFInfo
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- CN101692821A CN101692821A CN200910180614A CN200910180614A CN101692821A CN 101692821 A CN101692821 A CN 101692821A CN 200910180614 A CN200910180614 A CN 200910180614A CN 200910180614 A CN200910180614 A CN 200910180614A CN 101692821 A CN101692821 A CN 101692821A
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- stigmasterol
- emulsifier
- synergist
- solubilizer
- bleeding agent
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Abstract
The invention relates to a botanical acaricides applied to preventing mites on industrial crops, such as fruit trees, vegetables and the like as well as a preparation method and application thereof. The botanical acaricides is prepared from stigmasterol adding with surfactant, emulsifier, penetrant, synergist and the like, and has the characteristics of high efficiency, low toxicity, low residue, environment friendliness and the like.
Description
Technical field
The present invention relates to the new purposes of stigmasterol, particularly the new purposes of stigmasterol in the preparation plant acaricide.
Background technology
Stigmasterol English name: Stigmasterol, molecular formula: C
29H
48O, molecular weight: 412.69; Be soluble in chloroform, benzene, ethyl acetate, pyridine, can be dissolved in ethanol, acetone, water insoluble.Be commonly used for the steroid hormone synthesis material, the monomer stigmasterol is as a component in the phytosterol, it is important medicine intermediate, being used to produce steroid hormone, cholecalciferol etc. and showing that through medical research phytosterol has the important physical active function to human body, is the important steroid drugs and the raw materials for production of cholecalciferol.Because phytosterol has physiologically active, emulsifiability is good and stable, is used for multiple cosmetics abroad as the skin-nourishing agent, and the novel cosmetic of phytosterol is also contained in domestic manufacturer in the active development development.Phytosterol also is used to animal growth promoting agent and effect is obvious.At industrial circles such as chemical industry, weaving, papermaking, printings, phytosterol also has wide application prospect.Contain sitosterol in the phytosterol, multiple components such as campesterol, brassicasterol, stigmasterol, stigmasterol is a kind of of phytosterol, has the various character and the purposes of phytosterol, more outstanding is stigmasterol has stronger anti-inflammatory and antiinflammation and directly be used as anti-inflammatory drug.Beans paddy alcohol comes into one's own day by day as the main the most frequently used initiation material of producing steroid drugs key intermediate 4AD or ADD, also stigmasterol is used for cholesterol reducing as the raw material of health-oriented products in developed country.Phytophagous mites is the important pest in the agricultural production, and it has a very wide distribution, and the harm host is many, and it is big that area takes place, and medicine resistance ability is strong, and is serious and restive to the loss that agricultural production causes.But still there be not the application report of stigmasterol in the preparation plant acaricide in the existing document; Still do not have at present a kind of good with environment compatibility, to the harmonious miticide of mammalian safe.
Summary of the invention
The new purposes that the objective of the invention is to open stigmasterol; Another object of the present invention is to the new purposes of open stigmasterol in preparation plant resource miticide.
The present invention seeks to be achieved through the following technical solutions:
The application of stigmasterol in the preparation plant acaricide.Mite extremely of the present invention can be to kill the female one-tenth mite of Tetranychus cinnabarinus.Stigmasterol of the present invention adds conventional auxiliary material, according to common process, makes various forms of miticides, for example missible oil, suspending agent, pulvis, spray etc.
Prepare plant with the organic solvent lixiviate---chemical composition in the Inula britannica chinensis, according to extraction and chromatographic theory knowledge, chemical composition is divided into different material segments, and extract is by the separation of separation chromatography post, purifying active substance, and the pure active substance that obtains is accredited as stigmasterol through GC/MS; In the process of separation and purification material, follow the tracks of biological activity determination, active substance---stigmasterol has acaricidal activity to the laboratory test proof; From Singma company buy the pure product of standard---stigmasterol has acaricidal activity.
Stigmasterol miticide of the present invention is with the stigmasterol dissolution with solvents, can selectively add the dissolving of solubilizer, synergist, emulsifier, bleeding agent promotion stigmasterol therein, promptly can be used for mite extremely.
Among the acaricidal preparation method, solvent is selected from a kind of in water, ethanol, methyl alcohol, acetone, cyclohexanone, toluene, dimethylbenzene, benzinum, petroleum aromatic, the purified petroleum benzin; Solubilizer be neopelex, Potassium dodecylbenzenesulfonate, polysorbate, polyethylene glycol, sorbierite polyoxy ether, lignosulfonates, tea withered, take any in the Chinese honey locust; Synergist is any in Tea Saponin, 2-C1C6H4-N=OCH3SCH3, methylenedioxy benzene derivative, 6-vinyl capraldehyde, the Octachlorodipropyl Ether; Emulsifier is any in C15～17H31～37COONa, odium stearate, lauryl sodium sulfate, N-domiphen, APEO, polyethenoxy ether, paraoctyl phenol APEO, aliphatic alcohol polyethenoxy base ether, aliphatic acid polyethenoxy base ester, the alkylaryl sulfonates, can utilize the HLB value to select emulsifier, the HLB value obtains the good missible oil of emulsifiability between 15-18; Bleeding agent is any in emulsifier BP, azone, the triphen phosphorus.
The component of this missible oil is: stigmasterol 20%～50%, solubilizer 50%～20%, emulsifier 10%, synergist 10%, bleeding agent 10%. Preferably stigmasterol 50%, solubilizer 20%, emulsifier 10%, synergist 10%, bleeding agent 10%; Stigmasterol 40%, solubilizer 30%, emulsifier 10%, synergist 10%, bleeding agent 10% or stigmasterol 30%, solubilizer 40%, emulsifier 10%, synergist 10%, bleeding agent 10%; Stigmasterol 20%, solubilizer 50%, emulsifier 10%, synergist 10%, bleeding agent 10%.Adopt spray pattern control herbivore mite, it is 4mg/ml that the pure stigmasterol concentration of mite biological activity test missible oil is killed in the laboratory.
The invention provides a kind of and environment compatibility good, to the novel harmonious miticide of mammalian safe, the comprehensive regulation of ecological long term growth, human beings'health and evil mite is all had profound significance.Compare with traditional agricultural chemicals, the present invention has following characteristics and advantage: 1, stigmasterol is general at occurring in nature, content is big, can become well to exploit natural resources; 2, fat-soluble characteristics do not cause pesticide injury, toxic residue to mammalian safe, to people and animals, ecological environment security; 3, carry out synthetic easily, very help carrying out suitability for industrialized production; 4, in conjunction with other effectively kill acaricidal composition in the preparation type plant, pharmaceutical mixture can further increase effective acaricidal action.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example
With the stigmasterol petroleum ether dissolution, add emulsifier tween-80, according to stigmasterol 50%, solubilizer 20%, emulsifier 10%, synergist 10%, bleeding agent 10%.Experimental result sees the following form:
Table 1 stigmasterol is to the biologically active (24h, FAO method) of the female one-tenth mite of Tetranychus cinnabarinus
Table 2 stigmasterol is to the bioactive gradient (24h, FAO method) of the female one-tenth mite of Tetranychus cinnabarinus
Annotate: lowercase alphabet shows that the F value less than 0.05, has significant difference among the figure.
The result proves that stigmasterol of the present invention has significant contact toxicity to the female adult worm of Tetranychus cinnabarinus.
Following embodiment all can realize the beneficial effect of experimental example of the present invention.
Embodiment
Embodiment 1
Stigmasterol 50%, solubilizer 20%, emulsifier 10%, synergist 10%, bleeding agent 10% are got above-mentioned raw materials and are made missible oil according to common process, adopt spray pattern control herbivore mite.
Embodiment 2
Stigmasterol 40%, solubilizer 30%, emulsifier 10%, synergist 10%, bleeding agent 10% are got above-mentioned raw materials and are made suspending agent according to common process, adopt spray pattern control herbivore mite.
Embodiment 3
Stigmasterol 30%, solubilizer 40%, emulsifier 10%, synergist 10%, bleeding agent 10% are got above-mentioned raw materials and are made pulvis according to common process, adopt the spraying mode to prevent and treat the herbivore mite.
Embodiment 4
Stigmasterol 20%, solubilizer 50%, emulsifier 10%, synergist 10%, bleeding agent 10% are got above-mentioned raw materials and are made spray according to common process, adopt spray pattern control herbivore mite.
Claims (13)
1. stigmasterol is in the new purposes of preparation in the plant acaricide.
2. application as claimed in claim 1 is characterized in that described mite extremely is to kill the female one-tenth mite of Tetranychus cinnabarinus.
3. application as claimed in claim 1 is characterized in that described miticide is that stigmasterol adds solubilizer, synergist, emulsifier and/or suspending agent, bleeding agent auxiliary material therein.Among the acaricidal preparation method, solvent is selected from a kind of in water, ethanol, methyl alcohol, acetone, cyclohexanone, toluene, dimethylbenzene, benzinum, petroleum aromatic, the purified petroleum benzin; Solubilizer be neopelex, Potassium dodecylbenzenesulfonate, polysorbate, polyethylene glycol, sorbierite polyoxy ether, lignosulfonates, tea withered, take any in the Chinese honey locust; Synergist is any in Tea Saponin, 2-C1C6H4-N=OCH3SCH3, methylenedioxy benzene derivative, 6-vinyl capraldehyde, the Octachlorodipropyl Ether; Emulsifier is any in C15～17H31～37COONa, odium stearate, lauryl sodium sulfate, N-domiphen, APEO, polyethenoxy ether, paraoctyl phenol APEO, aliphatic alcohol polyethenoxy base ether, aliphatic acid polyethenoxy base ester, the alkylaryl sulfonates; Bleeding agent is any in emulsifier BP, azone, the triphen phosphorus.
4. an acaricidal cream is characterized in that the component of this missible oil is: stigmasterol 20%～50%, solubilizer 50%～20%, emulsifier 10%, synergist 10%, bleeding agent 10%.
5. the described acaricidal cream of claim 4 is characterized in that the component of this missible oil is: stigmasterol 50%, solubilizer 20%, emulsifier 10%, synergist 10%, bleeding agent 10%.
6. acaricidal cream as claimed in claim 4 is characterized in that the component of this missible oil is: stigmasterol 40%, solubilizer 30%, emulsifier 10%, synergist 10%, bleeding agent 10%.
7. acaricidal cream as claimed in claim 4 is characterized in that the component of this missible oil is: stigmasterol 30%, solubilizer 40%, emulsifier 10%, synergist 10%, bleeding agent 10%.
8. acaricidal cream as claimed in claim 4 is characterized in that the component of this missible oil is: stigmasterol 20%, solubilizer 50%, emulsifier 10%, synergist 10%, bleeding agent 10%.
9. the application of stigmasterol as claimed in claim 1 or 2 in the preparation miticide.
10. solubilizer as claimed in claim 3, synergist, emulsifier and/or suspending agent, the application of bleeding agent in the preparation miticide.
11. the application of stigmasterol as claimed in claim 4 in the preparation miticide.
12. as the application of the described stigmasterol of claim 5-8 in the preparation miticide.
13. the application of stigmasterol in the preparation miticide farm chemical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910180614A CN101692821A (en) | 2009-10-27 | 2009-10-27 | New application of stigmasterol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910180614A CN101692821A (en) | 2009-10-27 | 2009-10-27 | New application of stigmasterol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101692821A true CN101692821A (en) | 2010-04-14 |
Family
ID=42091850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910180614A Pending CN101692821A (en) | 2009-10-27 | 2009-10-27 | New application of stigmasterol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101692821A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109293815A (en) * | 2018-09-18 | 2019-02-01 | 佛山市顺德区巴德富实业有限公司 | A kind of acrylic emulsion and preparation method thereof of anti-dust mite |
| CN114271270A (en) * | 2021-12-31 | 2022-04-05 | 广西壮族自治区农业科学院 | Composition for preventing and controlling sugarcane smut and preparation method thereof |
-
2009
- 2009-10-27 CN CN200910180614A patent/CN101692821A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109293815A (en) * | 2018-09-18 | 2019-02-01 | 佛山市顺德区巴德富实业有限公司 | A kind of acrylic emulsion and preparation method thereof of anti-dust mite |
| CN114271270A (en) * | 2021-12-31 | 2022-04-05 | 广西壮族自治区农业科学院 | Composition for preventing and controlling sugarcane smut and preparation method thereof |
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Application publication date: 20100414 |