CN101606525A - The new purposes of cupreol - Google Patents
The new purposes of cupreol Download PDFInfo
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- CN101606525A CN101606525A CNA2009100878316A CN200910087831A CN101606525A CN 101606525 A CN101606525 A CN 101606525A CN A2009100878316 A CNA2009100878316 A CN A2009100878316A CN 200910087831 A CN200910087831 A CN 200910087831A CN 101606525 A CN101606525 A CN 101606525A
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- Prior art keywords
- cupreol
- emulsifier
- dimethylbenzene
- missible oil
- common process
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Abstract
The invention discloses application and a kind of acaricidal cream of cupreol in the preparation plant acaricide, the component of this missible oil is: cupreol 20%～50%, emulsifier 10%, all the other are dimethylbenzene.Described miticide can be that cupreol adds conventional auxiliary material, according to common process, and the missible oil of making, suspending agent, pulvis, spray, aerosol spraying agent.
Description
Technical field
The present invention relates to the new purposes of cupreol, particularly the new purposes of cupreol in the preparation plant acaricide.
Background technology
Cupreol, English name: β-Sitosterol another name: (3 β)-beans steroid-5-alkene-3-alcohol.Source: vegetable oil, molecular formula: C
29H
50O, molecular weight: 414.71.Proterties: outward appearance is white crystals or crystalline powder.Be soluble in chloroform, ether, benzene, heat acetone, ethanol, be slightly soluble in dry and cold ethanol, water insoluble.Can generate white precipitate with digitonin reaction, can be hydrogenated to hydrocarbon.Sitosterol is a kind of Combination phytosterol, extensively is present in the plants such as paddy, wheat, corn, and cupreol is a kind of valuable medical material and intermediate that is worth that have.
Function:
1, cupreol can suppress the absorption of human body to cholesterol, promotes the katabolism of cholesterol, suppresses the synthetic effect that waits cholesterol reducing of biochemistry of cholesterol.Be used to prevent and treat the cardiopathy of coronary disease atherosclerotic class, treatment ulcer, skin squama cancer, cervical carcinoma etc. are had obvious curative effects.
2, cupreol has stronger antiinflammatory action.Can promote wound healing, make the muscle hyperplasia, strengthen the capillary circulation, various wounds are had good healing and elimination effect.
3, cupreol is the important steroid drugs and the raw materials for production of cholecalciferol.
4, cupreol has good permeability to skin, can keep skin surface moisture, promotes skin metabolism, suppresses scytitis, can prevent sunburn and skin aging, also has effects such as generating and nourishing hair.
But still there be not the application report of cupreol in the preparation plant acaricide in the existing document; Still do not have at present a kind of good with environment compatibility, to the harmonious agricultural chemicals of mammalian safe.
Summary of the invention
The objective of the invention is to the new purposes of open cupreol in the preparation plant acaricide; Another object of the present invention is to plant acaricide of open cupreol preparation and preparation method thereof.
The present invention seeks to be achieved through the following technical solutions:
The application of cupreol in the preparation plant acaricide.Mite extremely of the present invention can be to kill the female one-tenth mite of Tetranychus cinnabarinus.Cupreol of the present invention adds conventional auxiliary material, according to common process, makes various forms of miticides, for example missible oil, suspending agent, pulvis, spray etc.
Prepare plant with the organic solvent lixiviate---chemical composition in the peppermint, according to extraction and chromatographic theory knowledge, chemical composition is divided into different material segments, the material segment is by separation chromatography post purifying active substance, and the pure active substance that obtains is accredited as cupreol through a series of wave spectrum spectrophotometers; In the process of separation and purification material, follow the tracks of biological activity determination, active substance---sitosterol has acaricidal activity to the laboratory test proof; The pure product of the standard of buying from market---sitosterol has acaricidal activity.
Cupreol plant acaricide of the present invention is with the cupreol dissolution with solvents, can selectively add the dissolving of solubilizer, emulsifier promotion cupreol therein, promptly can be used for mite extremely.
Above-mentioned solvent can be a kind of in the acetone of chloroform, ether, benzene, heat and the ethanol, preferred dimethylbenzene; Solubilizer and/or emulsifier are selected from: one or both in spans, Tweens, glycol ester class, propylene glycol ester class, the polyethylene glycol type non-ionic surface active agent.Utilize the HLB value to select emulsifier, the HLB of emulsifier tween-80 is 15, can obtain the good missible oil of emulsifiability; The component of missible oil is: cupreol 20%～50%, emulsifier 10%, and all the other are dimethylbenzene; Preferred cupreol 50%, dimethylbenzene 40%, emulsifier 10%; Cupreol 30%, dimethylbenzene 60%, emulsifier 10% or cupreol 40%, dimethylbenzene 50%, emulsifier 10%.Adopt spray pattern control herbivore mite.
The invention provides a kind of and environment compatibility good, to the novel harmonious agricultural chemicals of mammalian safe, the comprehensive regulation of ecological long term growth, human beings'health and evil mite is all had profound significance.Compare with traditional agricultural chemicals, the present invention has following characteristics and advantage: 1, cupreol is general at occurring in nature, content is big, can become well to exploit natural resources; 2, fat-soluble characteristics do not cause pesticide injury, toxic residue to mammalian safe, to people and animals, ecological environment security; 3, carry out synthetic easily, very help carrying out suitability for industrialized production; 4, in conjunction with other effectively kill acaricidal composition in the preparation type plant, pharmaceutical mixture can further increase effective acaricidal action.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1
(β-Sitosterol) adds emulsifier tween-80 with the chloroform dissolving, the missible oil that is made into according to 50% cupreol, 40% dimethylbenzene and 10% Tween 80 with cupreol.Experimental result sees Table 1:
Table 1 cupreol is to the biologically active (24h, FAO method) of the female one-tenth mite of Tetranychus cinnabarinus
Table 2 cupreol is to the bioactive gradient (FAO method) of the female one-tenth mite of Tetranychus cinnabarinus
Annotate: lowercase alphabet shows that the F value less than 0.05, has significant difference among the figure.
The result proves that cupreol of the present invention has significant contact toxicity to the female adult worm of Tetranychus cinnabarinus.
Following embodiment all can realize the beneficial effect of experimental example of the present invention.
Embodiment
Embodiment 1:
Cupreol 50%, dimethylbenzene 40%, emulsifier 10%
Get above-mentioned raw materials and make missible oil, adopt spray pattern control herbivore mite according to common process.
Embodiment 2:
Cupreol 50%, dimethylbenzene 40%, emulsifier 10%
Get above-mentioned raw materials and make suspending agent, adopt spray pattern control herbivore mite according to common process.
Embodiment 3:
Cupreol 50%, dimethylbenzene 40%, emulsifier 10%
Get above-mentioned raw materials and make pulvis, adopt the spraying mode to prevent and treat the herbivore mite according to common process.
Embodiment 4:
Cupreol 50%, dimethylbenzene 40%, emulsifier 10%
Get above-mentioned raw materials and make spray, adopt spray pattern control herbivore mite according to common process.
Embodiment 5:
Cupreol 30%, dimethylbenzene 60%, emulsifier 10%
Get above-mentioned raw materials and make missible oil, adopt spray pattern control herbivore mite according to common process.
Embodiment 6:
Cupreol 30%, dimethylbenzene 60%, emulsifier 10%
Get above-mentioned raw materials and make suspending agent, adopt spray pattern control herbivore mite according to common process.
Embodiment 7:
Cupreol 30%, dimethylbenzene 60%, emulsifier 10%
Get above-mentioned raw materials and make pulvis, adopt the spraying mode to prevent and treat the herbivore mite according to common process.
Embodiment 8:
Cupreol 30%, dimethylbenzene 60%, emulsifier 10%
Get above-mentioned raw materials and make spray, adopt spray pattern control herbivore mite according to common process.
Embodiment 9:
Cupreol 40%, dimethylbenzene 50%, emulsifier 10%
Get above-mentioned raw materials and make missible oil, adopt spray pattern control herbivore mite according to common process.
Embodiment 10:
Cupreol 40%, dimethylbenzene 50%, emulsifier 10%
Get above-mentioned raw materials and make suspending agent, adopt spray pattern control herbivore mite according to common process.
Embodiment 11:
Cupreol 40%, dimethylbenzene 50%, emulsifier 10%
Get above-mentioned raw materials and make pulvis, adopt the spraying mode to prevent and treat the herbivore mite according to common process.
Embodiment 12:
Cupreol 40%, dimethylbenzene 50%, emulsifier 10%
Get above-mentioned raw materials and make spray, adopt spray pattern control herbivore mite according to common process.
Claims (7)
1, the application of cupreol in the preparation plant acaricide.
2, application as claimed in claim 1 is characterized in that described mite extremely is to kill the female one-tenth mite of Tetranychus cinnabarinus.
3, application as claimed in claim 1 is characterized in that described miticide is that cupreol adds conventional auxiliary material, according to common process, and the missible oil of making, suspending agent, pulvis, spray or aerosol spraying agent.
4, a kind of acaricidal cream is characterized in that the component of this missible oil is: cupreol 20%～50%, emulsifier 10%, all the other are dimethylbenzene.
5, acaricidal cream as claimed in claim 4 is characterized in that the component of this missible oil is: cupreol 50%, dimethylbenzene 40%, emulsifier 10%.
6, acaricidal cream as claimed in claim 4 is characterized in that the component of this missible oil is: cupreol 30%, dimethylbenzene 60%, emulsifier 10%.
7, acaricidal cream as claimed in claim 4 is characterized in that the component of this missible oil is: cupreol 40%, dimethylbenzene 50%, emulsifier 10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100878316A CN101606525A (en) | 2009-06-26 | 2009-06-26 | The new purposes of cupreol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100878316A CN101606525A (en) | 2009-06-26 | 2009-06-26 | The new purposes of cupreol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101606525A true CN101606525A (en) | 2009-12-23 |
Family
ID=41480567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009100878316A Pending CN101606525A (en) | 2009-06-26 | 2009-06-26 | The new purposes of cupreol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101606525A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104855398A (en) * | 2015-04-03 | 2015-08-26 | 上海交通大学 | Application of beta-sitosterol linoleate and acaricide |
| CN107114386A (en) * | 2017-05-04 | 2017-09-01 | 四川农业大学 | The application of Sitosterolum and preparation |
| CN115968876A (en) * | 2023-01-12 | 2023-04-18 | 中山榄菊日化实业有限公司 | Long-acting insecticidal ultra-low volume liquid and preparation method thereof |
-
2009
- 2009-06-26 CN CNA2009100878316A patent/CN101606525A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104855398A (en) * | 2015-04-03 | 2015-08-26 | 上海交通大学 | Application of beta-sitosterol linoleate and acaricide |
| CN107114386A (en) * | 2017-05-04 | 2017-09-01 | 四川农业大学 | The application of Sitosterolum and preparation |
| CN107114386B (en) * | 2017-05-04 | 2019-11-29 | 四川农业大学 | The application of cupreol and preparation |
| CN115968876A (en) * | 2023-01-12 | 2023-04-18 | 中山榄菊日化实业有限公司 | Long-acting insecticidal ultra-low volume liquid and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20091223 |