CN101862472A - Method for preparing oily yarn for treating fistula - Google Patents
Method for preparing oily yarn for treating fistula Download PDFInfo
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- CN101862472A CN101862472A CN 201010182551 CN201010182551A CN101862472A CN 101862472 A CN101862472 A CN 101862472A CN 201010182551 CN201010182551 CN 201010182551 CN 201010182551 A CN201010182551 A CN 201010182551A CN 101862472 A CN101862472 A CN 101862472A
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Abstract
The invention discloses a method for treating oily yarns for treating fistula, which comprises the following steps: A preparing Periplaneta americana extract for later use; B, adding pure water and glycerol in the Periplaneta americana extract, fully stirring the mixture uniformly, filtering the mixture by using a plate-frame type filter, boiling filtrate for 25 to 35 minutes, and cooling the fitrate to room temperature for later use; C adding gelatin to prepare paste; and D, placing oily yarns in the paste obtained by the step C, standing the oily yarns for 10 to 14 hours, taking the oily yarns out and drying the oily yarns at 70 to 90 DEG C. The preparation method of the invention is simple, allows the action of the Periplaneta americana extract to be used fully by treating the oily yarns properly and improves the treatment effect of the oily yarns on fistula effectively. The oily yarns are convenient to use, have light side effect and are novel oily yarns worthy to promote.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of preparation method that is used for the treatment of the oily yarn of hole fistula.
Technical background
As everyone knows, ointment ribbon gauze is used very extensive clinically, is used for debridement hemostatic materials such as filling, drain more.At present, common ointment ribbon gauze is through the vaseline dipping or it is clinical to smear, be used for behind the sterilizing, and present this ointment ribbon gauze is easy to make, and use cost is low.
Because adopt is coated in vaseline on the ointment ribbon gauze by hand, vaseline coating layer thickness inequality usually can occur, and the little meeting of vaseline consumption of smearing do not have due lubricated and drainage, and the phenomenon of overflow everywhere takes place in the vaseline amount conference of smearing.Especially for hole fistula patient, because the complex structure of ill portion is neural densely distributed, easily accompanying infection causes patient's the course of disease to prolong, problems such as wound healing is slow, complication rate height.
Therefore, for hole fistula patient, develop and a kind ofly have granulation promoting removing the necrotic tissue, anti-inflammatory analgetic, can promote the ointment ribbon gauze of wound healing just to seem particularly important.
In order to remedy above-mentioned deficiency of the prior art, the present invention proposes a kind of new solution.
Summary of the invention
The objective of the invention is to: overcome above-mentioned deficiency of the prior art, a kind of pharmaceutical composition and preparation method thereof of treatment hole fistula of effective raising cure rate is provided.
Purpose of the present invention is achieved through the following technical solutions: a kind of preparation method that is used for the treatment of the oily yarn of hole fistula is provided, it is characterized in that: this preparation method comprises the steps:
A, preparation American-cockroach-extract, standby;
B, according to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 25～35 minutes, and is standby;
C, add the ratio of 5-250g according to every 800ml again, add gelatin, make paste;
D, oily yarn is put into the prepared paste of step C, leave standstill after 10-14 hour and take out, after drying under 70 ℃～90 ℃ the temperature conditions, promptly.
Big Lian preparation method of extract comprises the steps: in above-mentioned steps A Central America
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: will add the water of 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrate;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the one-level filtrate in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that makes in step e gradually, and fully stir, making it contain the alcohol amount reaches till 45%～55%, under 70 ℃～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate;
H, the second time concentrate: after the secondary filtrate in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the secondary concentrated solution among the step h is concentrated into the unguentum of moisture≤25%～35% under condition of normal pressure, promptly gets American-cockroach-extract.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
In sum, have granulation promoting removing the necrotic tissue, anti-inflammatory analgetic, can promote advantages such as wound healing according to the prepared oily yarn of preparation method that is used for the treatment of the oily yarn of hole fistula provided by the present invention, also have simultaneously and make advantage easy to use, with low cost, not only be suitable for large batch of production, also be suitable for clinical being extensive use of.
The specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is described in further detail:
The preparation method that is used for the treatment of the oily yarn of hole fistula provided by the present invention comprises the steps:
A, preparation American-cockroach-extract, standby;
B, according to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 25～35 minutes, and is standby;
C, add the ratio of 5-250g according to every 800ml again, add gelatin, make paste;
D, oily yarn is put into the prepared paste of step C, leave standstill after 10-14 hour and take out, after drying under 70 ℃～90 ℃ the temperature conditions, promptly.
Big Lian preparation method of extract comprises the steps: in above-mentioned steps A Central America
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: will add the water of 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrate;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the one-level filtrate in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that makes in step e gradually, and fully stir, making it contain the alcohol amount reaches till 45%～55%, under 70 ℃～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate;
H, the second time concentrate: after the secondary filtrate in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the secondary concentrated solution among the step h is concentrated into the unguentum of moisture≤25%～35% under condition of normal pressure, promptly gets American-cockroach-extract.
Amount of water is 4 times of amounts in above-mentioned steps b, and soak time is 1 hour, and soaking temperature is 74 ℃.
Embodiment 1:
With exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 300Kg water, soaks after 0.5 hour, and temperature is extracted three times about 70 ℃, 7 hours for the first time; For the second time add water 200Kg, extracted 5 hours; Add water 200Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.05 (70 ℃), adding concentration was the ethanol of 93%w/w, make that to become to contain alcohol amount be 45%, 70 ℃ of insulated and stirred 20 minutes left standstill 10 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (70 ℃), normal pressure is concentrated into the cream of moisture≤25%; According to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 1200ml: 6ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 35 minutes, and is standby; Add the ratio of 250g again according to every 800ml, add gelatin, make paste; Oily yarn is put into the prepared paste of step C, leave standstill after 14 hours and take out, after drying under 90 ℃ the temperature conditions, promptly.
Embodiment 2:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 200 parts of Pericarpium Granatis.
Preparation method is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 500Kg water, soaks after 2 hours, and temperature is extracted three times about 78 ℃, 9 hours for the first time; For the second time add water 400Kg, extracted 7 hours; Add water 400Kg for the third time, extracted 5 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.25 (90 ℃), adding concentration was the ethanol of 97%w/w, make that to become to contain alcohol amount be 55%, 90 ℃ of insulated and stirred 40 minutes left standstill 14 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.25 (90 ℃), normal pressure is concentrated into the cream of moisture≤35%; According to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 1000ml: 5ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 30 minutes, and is standby; Add the ratio of 150g again according to every 800ml, add gelatin, make paste; Oily yarn is put into the prepared paste of step C, leave standstill after 12 hours and take out, after drying under 80 ℃ the temperature conditions, promptly.
Embodiment 3:
The prescription that is adopted is: 100 parts of American-cockroach-extracts; 300 parts of Pericarpium Granatis.
Preparation method is: with exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 400Kg water, soaks after 1 hour, and temperature is extracted three times about 74 ℃, 8 hours for the first time; For the second time add water 300Kg, extracted 6 hours; Add water 300Kg for the third time, extracted 4 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.15 (80 ℃), adding concentration was the ethanol of 95%w/w, make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes left standstill 12 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.25 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; According to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 800ml: 4ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 25 minutes, and is standby; Add the ratio of 5g again according to every 800ml, add gelatin, make paste; Oily yarn is put into the prepared paste of step C, leave standstill after 10 hours and take out, after drying under 70 ℃ the temperature conditions, promptly.
Embodiment 4:
With exsiccant periplaneta americana coarse crushing, every 100Kg coarse powder adds 380Kg water, soaks after 0.8 hour, and temperature is extracted three times about 74 ℃, 7.5 hours for the first time; For the second time add water 280Kg, extracted 5 hours; Add water 280Kg for the third time, extracted 3 hours.Merge three times extracting solution, filter, when filtrate was concentrated into relative density and is 1.2 (80 ℃), adding concentration was the ethanol of 95%w/w, make that to become to contain alcohol amount be 50%, 80 ℃ of insulated and stirred 30 minutes left standstill 11 hours, discarded the upper strata oils and fats, lower floor's medical filtration, filtrate recycling ethanol, being evaporated to relative density is 1.20 (80 ℃), normal pressure is concentrated into the cream of moisture≤30%; According to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 900ml: 6ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 28 minutes, and is standby; Add the ratio of 50g again according to every 800ml, add gelatin, make paste; Oily yarn is put into the prepared paste of step C, leave standstill after 11 hours and take out, after drying under 80 ℃ the temperature conditions, promptly.
Clinical testing data about hole fistula cure rate:
One, patient's classified data:
Hole fistula patient 99 examples meet diagnostic criteria.Be divided into treatment group and matched group at random, 52 examples are organized in treatment, 18～56 years old age; Matched group 47 examples, 18～56 years old age.The two groups of patient ages and the course of disease are learned processing by statistics, and difference does not have the significance meaning, has comparability.
Two, Therapeutic Method:
Treatment group: adopt according to the prepared oily yarn of the present invention, change once 7 days～10 days course of treatment every day.
Matched group: adopt existing oily yarn, change every day once, 7 days～10 days course of treatment.
Three, curative effect comparative result:
Table 1 is depicted as two groups of curative effects relatively, and wherein 50 examples are organized in treatment, cure 48 examples, and cure rate is 96.00%, and total effective rate is 100%; Matched group 50 examples are cured 42 examples, and cure rate is 84.00%, and total effective rate is 100.00%.Table 2 is depicted as two groups of 7 days curative effects relatively, treats in 7 days, and treatment group cure rate is 82.00%, and the matched group cure rate is 68.00%.This shows that treatment group curative effect obviously is better than matched group.(n number of delegates in table 1 and the table 2)
Table 1
Table 2
| Group | ??n | 7 days healing patient numbers | 7 days cure rates (%) |
| The treatment group | ??50 | ??41 | ?82.00 |
| Group | ??n | 7 days healing patient numbers | 7 days cure rates (%) |
| Matched group | ??50 | ??34 | ?68.00 |
Four, conclusion (of pressure testing):
Periplaneta americana is a kind of insecticide, be commonly called as Blatta seu periplaneta, body contains the various active composition, and its extract main component is polyalcohols and peptide class active substance, confirm to have promotion epithelial cell, granulation tissue growth through pharmacological research, promote wound repair, the effect of enhance immunity, but do not have antibacterial action, the medicine that American-cockroach-extract and gelatin are made not only can infection, simultaneously can promote hole fistula tissue repair, improve hole fistula ulcer healing rate, shorten hole fistula healing time.Comparing data shows that this curative effect that is used for the treatment of the oily yarn of hole fistula obviously is better than existing oily yarn.
Though in conjunction with specific embodiments the specific embodiment of the present invention has been done to describe in detail, should not be construed as is limitation of the invention.In the protection domain that claims limited, various modifications that those skilled in the art can make without creative work or distortion still belong to the protection domain of this patent.
Claims (3)
1. preparation method that is used for the treatment of the oily yarn of hole fistula, it is characterized in that: this preparation method comprises the steps:
A, preparation American-cockroach-extract, standby;
B, according to American-cockroach-extract: the ratio of purified water: glycerol=1000g: 800ml～1200ml: 4ml～6ml, in American-cockroach-extract, add purified water and glycerol, stir, through plate-and-frame filtration, filtrate is chilled to room temperature after boiling 25～35 minutes, and is standby;
C, the ratio that adds 5-250g according to every 800ml add gelatin, make paste;
D, oily yarn is put into the prepared paste of step C, leave standstill after 10-14 hour and take out, after drying under 70 ℃～90 ℃ the temperature conditions, promptly.
2. the preparation method that is used for the treatment of the oily yarn of hole fistula according to claim 1 is characterized in that: the big Lian preparation method of extract in described steps A Central America comprises the steps:
A, coarse crushing: exsiccant periplaneta americana is pulverized, make the periplaneta americana coarse powder;
B, immersion: will add the water of 3～5 times of amounts in the coarse powder among the step a, soak and made the coarse powder mixed liquor in 0.5～2 hour, soaking temperature is 70 ℃～78 ℃, and the coarse powder mixed liquor adopts the method that decocts to carry out three times and extracts, and makes extracting solution;
C, three extractions: the coarse powder mixed liquor is carried out the first time extract, extraction time is 7～9 hours; Carry out the second time then behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the first time and extract, extraction time is 5～7 hours; Extract for the third time behind the water that adds 2～4 times of amounts of surplus liquid in the surplus liquid after extracting for the second time at last, extraction time is 3～5 hours;
D, filtration for the first time: the extracting solution that three times are extracted among the step c is merged mixing, filter then and make one-level filtrate;
E, concentrated for the first time: relative density was 1.05～1.25 one-level concentrated solution when the one-level filtrate in the steps d was concentrated into 70 ℃～90 ℃;
F, alcoholization are handled: add the ethanol that concentration is 93%w/w～97%w/w in the one-level concentrated solution that makes in step e gradually, and fully stir, making it contain the alcohol amount reaches till 45%～55%, under 70 ℃～90 ℃ temperature conditions, be incubated 20～40 minutes, left standstill then 10～14 hours, and made solution of alcoholized;
G, filtration for the second time: the solution of alcoholized among the step f is discarded the upper strata oils and fats, and lower floor's medicinal liquid filters and makes secondary filtrate;
H, the second time concentrate: after the secondary filtrate in the step g was carried out the ethanol recycling, relative density was 1.20～1.25 secondary concentrated solution when being concentrated into 70 ℃～90 ℃;
I, unguentum preparation: the secondary concentrated solution among the step h is concentrated into the unguentum of moisture≤25%～35% under condition of normal pressure, promptly gets American-cockroach-extract.
3. the preparation method that is used for the treatment of the oily yarn of hole fistula according to claim 2 is characterized in that amount of water is 4 times of amounts among the described step b, and soak time is 1 hour, and soaking temperature is 74 ℃.
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| CN 201010182551 CN101862472A (en) | 2010-05-25 | 2010-05-25 | Method for preparing oily yarn for treating fistula |
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| CN 201010182551 CN101862472A (en) | 2010-05-25 | 2010-05-25 | Method for preparing oily yarn for treating fistula |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943600A (en) * | 2006-10-17 | 2007-04-11 | 耿福能 | Medicinal composition containing American cockroach and its ethanol extract and new use |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943600A (en) * | 2006-10-17 | 2007-04-11 | 耿福能 | Medicinal composition containing American cockroach and its ethanol extract and new use |
Non-Patent Citations (2)
| Title |
|---|
| 《中国消毒学杂志》 20071231 王玉芳等 凡士林油纱条灭菌盒的研制及灭菌效果监测 第187-188页 1-3 第24卷, 第2期 2 * |
| 《河南外科学杂志》 20091231 王素辉 压疮的护理体会 第107-108页 1-3 第15卷, 第5期 2 * |
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Application publication date: 20101020 |