CN101849962A - Lipid-lowering and weight-losing complex nutrient preparation and preparation method thereof - Google Patents
Lipid-lowering and weight-losing complex nutrient preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a lipid-lowering and weight-losing complex nutrient preparation and a preparation method thereof. The preparation is prepared with the following raw materials by molar ratio: conjugated linoleic acid, soluble zinc salt, soluble ferrous salt, soluble magnesium salt and soluble calcium salt, with the molar ratio being 200: (0.35-0.65): (0.65-1.5): (20-50): (50-100). The preparation method comprises the following steps: carrying out saponifiacation reaction of the conjugated linoleic acid with a biological functional activity and aqueous solution or alcoholic solution of alkali metal hydroxides or alkali metal alcoholate at the room temperature or a temperature close to the room temperature under the inert gas protection, and synthesis reaction of the reaction products with metal salt solution of soluble nutrient elements, thereby obtaining the lipid-lowering and weight-losing complex nutrient preparation. The invention has the advantages of simple process and easy operation, and the preparation product has the advantages of high purity and stable quality, and can be used as the functional additive, pharmaceutical component and feed additive of the nutrient.
Description
Technical field
The present invention relates to a kind of lipid-lowering and weight-losing complex nutrient preparation and preparation method thereof, concrete, relate to a kind of conjugated linoleic acid complex nutrient preparation and preparation method thereof.
Background technology
Human body is by various elementary composition unified organisms.Can be divided into macroelement and trace element in various elements shared ratio in human body.Traditionally proportion in the human body is higher than 0.01% element, is called macroelement, be lower than the element of this value, be called trace element.As ferrum, zinc, copper, iodine, lead etc.Macroelement has 11 kinds, accounts for 95% of body mass, and all the other account for 4%, and in addition, trace element accounts for 1%.In teleorganic element, metallic element has 14 kinds, and wherein the content of potassium, sodium, calcium, magnesium accounts for more than 99% of metallic element total amount in the human body, and the content of all the other 10 kinds of elements seldom.
Human body can cause the function of human body imbalance if lack certain macroelement, when people replenish the calcium, only notes vitamin D Can, does not but often know to want Mg supplementation.Calcium and magnesium always will occur in pairs like a pair of twin brother, and the ratio of calcium and magnesium is 2: 1 o'clock, are to be beneficial to absorbing of calcium most, just take in 200 milligrams calcium every day, should take in 100 milligrams magnesium, ability onset like this.Magnesium is the necessary macroelement of human body, and people are more and more abundant to the understanding of health for magnesium at present.Magnesium is one of composition that constitutes skeleton and tooth, also is to constitute one of cytoplasmic key element, and it regulates the activity of N﹠M, promotes the metabolism of carbohydrate.Magnesium participates in all energy metabolisms in the human body, activates or 325 kinds of important enzyme systems of catalysis, is referred to as by the sports medicine expert by " health catalyst ".Calcium is one of magnanimity nutrient of wanting of body weight for humans, from the skeleton to muscle, blood, from the cell membrane to the Cytoplasm, nucleus, the existence of calcium is arranged all, and the calcium normal presence just can be kept normal life.Calcium is the metal macroelement that content is maximum in the human body, and 99% is present in skeleton and the tooth, forms the support of human body, and as the storage vault of calcium in the body.1% is present in soft tissue, extracellular fluid and the blood, is referred to as the calcium mixture pond, keeps dynamic equilibrium with skeletal calcium, essential by the normal condition of keeping all cells, brings into play very important physical effect in vivo, suppresses the absorption of poisonous substance (as lead).Health absorbs calcium certain condition: need sunlight, good digestive function, modest movement or work, the participation of magnesium also will be arranged, this is most of single The misunderstanding of calcium supplementation.
Trace element generally is meant the mineral of people's in-vivo content less than body weight 0.01%, as ferrum, zinc, selenium, iodine etc.,, the human body growth promoter is played indispensable effect though these mineral seldom, the material composition of their structure human bodies is regulated body physiological and biochemical reaction.Trace elements iron content in human body is about the 4-5 gram.The function of ferrum in human body mainly is to participate in the formation of hemoglobin and promote hemopoietic, and its content in hemoglobin is about 72%, and its synthetic flesh red eggs hundred simultaneously constitute the enzyme of needed by human, regulate Tissue respiration, keep body immunity and anti-tumor capacity.Ferrum is the abundantest trace element of content in the human body, and nearly all organizing all has ferrum, and important effect is being brought into play in the activity of earning a bare living.Trace element zinc plays an important role to the human body different physiological roles.Participate in the synthetic of plurality of enzymes, acceleration of growth is grown, and strengthens wound tissue's regeneration capacity, builds up resistance, and promotes sexual function; Zinc is a kind of biological element, zinc has participated in the metabolic process of 80 plurality of enzymes in the human body, especially DNA and RNA polymerase, it participates in the synthetic of nucleic acid protein directly, the differentiation of cell and propagation and many metabolism, therefore, zinc is requisite material in the important physiological process such as human body growth promoter, reproduction heredity, immune endocrine, nerve, body fluid, zinc deficiency can have a negative impact to each system of human body, so zinc is described as " flower of life " by people.
Nutrient ferrum, zinc, magnesium, calcium are mended significant together, in fact, various trace element are in an equilibrated state in human body, if blindly replenish certain trace element, the problem that resists then can appear refusing mutually between trace element, too much can influence the absorption of ferrum as zinc in the body, and ferrum too much also can reduce the absorption of zinc etc.; The absorption of calcium has certain condition, not only needs sunlight, good digestive function, modest movement or work, and the participation of magnesium also will be arranged, and this is most of single The misunderstanding of calcium supplementation.
Ferrum, zinc, calcium, four kinds of element scientific combination of magnesium can be improved the shortage of ferrum in the human body, zinc, calcium, magnesium elements effectively, promote the needs of growth promoter, promote the healthy growth and development of intelligence and health.In iron supplement, replenish the necessary zinc element of human body, when replenishing the calcium, replenish the aggregate balancing that the necessary magnesium elements of human body can reach nutrition, supplement and complement each other, improve the action effect of nourishing.
Conjugated linoleic acid (CLA) is found to be the natural acid with many important physiologically actives in late 1980s.Zoopery shows, conjugated linoleic acid has the fat of reduction, increases muscle, anticancer, atherosclerosis, enhancing human body immunocompetence, the function such as metabolism of bone tissue of improving.Because it is the secondary metabolite of animal, there is not so-called homology problem as a kind of newfound nutrient in conjugated linoleic acid, does not have the upper limit problem of use in principle, and is often edible useful and harmless to health.In food, add the conjugated linoleic acid of doses, can remedy the deficiency that human body is taken in, have lowering blood-fat and reducing weight usefulness, strengthen the ability of human body opposing numerous disease, improve body immunity.Chinese patent CN1357406A discloses a kind of microcapsule of conjugated linoleic acid.This method conjugated linoleic acid is difficult to transform fully, and product is impure, and the oxidation factor in addition operating simultaneously influences constant product quality.
The oxidation stability of conjugated linoleic acid is relatively poor, be converted into the lipid-lowering and weight-losing complex nutrient preparation form after, can strengthen stability of formulation and ease for use.
Visitor in the invention
The objective of the invention is provides a kind of lipid-lowering and weight-losing complex nutrient preparation in order to overcome the deficiency that prior art exists, and a kind of preparation method of lipid-lowering and weight-losing complex nutrient preparation is provided simultaneously.
For achieving the above object, the technical scheme taked of the present invention is that this lipid-lowering and weight-losing complex nutrient preparation is to be made by the raw material of following mole (mol) ratio: conjugated linoleic acid: soluble zinc salt: soluble ferrite: solubility magnesium salt: soluble calcium salt=200: 0.35～0.65: 0.65～1.5: 20～50: 50～100;
Described lipid-lowering and weight-losing complex nutrient preparation is in room temperature or nearly room temperature; under the inert gas shielding; the conjugated linoleic acid of biologically active is carried out saponification with alkali metal hydroxide or alkali alcoholate earlier, carry out metathesis reaction with solubility nutrient metal salt solution again and make.
Described conjugated linoleic acid is the pure product of conjugated linoleic acid or the fatty acid mixed of conjugated linoleic acid.
A kind of preparation method of lipid-lowering and weight-losing complex nutrient preparation, said preparation are to be made by the raw material of following mole (mol) ratio: conjugated linoleic acid: soluble zinc salt: soluble ferrite: solubility magnesium salt: soluble calcium salt=200: 0.35～0.65: 0.65～1.5: 20～50: 50～100;
Its preparation method is in room temperature or nearly room temperature; under the inert gas shielding; the conjugated linoleic acid of biologically active is carried out saponification with alkali metal hydroxide or alkali alcoholate earlier, carries out metathesis reaction with solubility nutrient metal salt solution again, specifically comprise following operating procedure:
(1), in room temperature or nearly room temperature, under the inert gas shielding,, join in the conjugated linoleic acid liquid of equivalent the aqueous solution of alkali metal hydroxide or alkali alcoholate or alcoholic solution, stirring reaction 2-6 hour, the alkali metal soap solution of conjugated linoleic acid;
(2), the solubility nutrient metal salt solution that in the solution that step (1) generates, adds equivalent, being stirred to granule separates out, liquid is partly clarified, and centrifugalize discards clear liquid, get thick lipid-lowering and weight-losing complex nutrient preparation slaine, use distilled water successively, deionized water, low mass molecule alcohol or ether washing, at 30-90 ℃ of vacuum drying, get lipid-lowering and weight-losing complex nutrient preparation after the pulverizing.
Described conjugated linoleic acid is the pure product of conjugated linoleic acid or the fatty acid mixed of conjugated linoleic acid.
Described alkali metal is potassium or sodium; Described alcohol is any one in methanol or ethanol or propanol or the isopropyl alcohol; Described ether is any one in ether or the petroleum ether.
Described solubility nutrient slaine is a certain proportion of zinc salt, iron salt, magnesium salt and calcium salt, the mol ratio of selected zinc salt, iron salt, magnesium salt and calcium salt is 1: 1.2～3.0: 50～100: 100～200, soluble zinc salt is selected from any one in zinc acetate, zinc chloride, zinc sulfate, zinc bromide, zinc tartrate, zinc iodide, zinc phosphate or the zinc nitrate, and soluble ferrite is selected from any one in ferrous chloride or ferrous bromide or the ferrous sulfate; The solubility magnesium salt is selected from any one in magnesium acetate, magnesium chloride, magnesium sulfate, magnesium tartrate or the magnesium nitrate, and soluble calcium salt is selected from any one in calcium acetate, calcium propionate, calcium lactate, calcium chloride, lime nitrate, D-natural gum Calciofon or the calcium bromide.
The mol ratio of described conjugated linoleic acid and alkali metal hydroxide or alkali alcoholate is 1: 1～1.5.
The mol ratio of described conjugated linoleic acid and solubility nutrient slaine is 1: 0.5～1.0.
Lipid-lowering and weight-losing complex nutrient preparation of the present invention is a kind of rising new formulation, can be widely used in nutriment, food additive and medicine etc.
The specific embodiment
The content of zinc, ferrum, magnesium and calcium is measured with plasma emission spectrometer Perkin-Elmer Optima 3300DV spectrometer in the lipid-lowering and weight-losing complex nutrient preparation of the present invention.Cla levels in the lipid-lowering and weight-losing complex nutrient preparation of the present invention is measured with gas chromatograph ShimadzuGC-7AG.Conjugated linoleic acid of the present invention is a fatty acid mixed, and it forms by weight that content is: conjugated linoleic acid (CLA) is 83.16%, and other fatty acid (comprising linoleic acid, oleic acid, stearic acid etc.) is 16.84%.
Embodiment one
(1), 5 ℃ of nearly room temperatures, under the nitrogen protection, take by weighing the 20g conjugated linoleic acid in the 300ml distilled water, stir the sodium hydroxide solution 31ml that adds 10%wt down, stirred 4.5 hours, make it become clear solution;
(2), the acetic acid zinc solution 0.3ml that adds 10%wt, the solution of ferrous chloride 0.77ml of 10%wt, the magnesium chloride solution 28ml of 10%wt, the calcium acetate solution 70ml of 10%wt, the limit edged stirs, form the light green particulate material, through centrifugalize, use distilled water successively, deionized water, methanol wash, at 40 ℃ of vacuum dryings, pulverize, product 22.68g.
Embodiment two
(1), 10 ℃ of nearly room temperatures, under the nitrogen protection, take by weighing the 20g conjugated linoleic acid in the 350ml distilled water, stir the potassium hydroxide solution 32ml that adds 10%wt down, stirred 4 hours, make it become clear solution;
(2), the zinc tartrate solution 0.5ml that adds 10%wt, the copperas solution 1.1ml of 10%wt, the magnesium acetate solution 34ml of 10%wt, the calcium propionate solution 81ml of 10%wt, the limit edged stirs, form the light green particulate material, through centrifugalize, use distilled water successively, deionized water, methanol wash, at 50 ℃ of vacuum dryings, pulverize, product 21.92g.
Embodiment three
(1), 25 ℃ of room temperatures, under the nitrogen protection, take by weighing the 20g conjugated linoleic acid in 280ml methanol, stir the potassium hydroxide solution 30ml that adds 10%wt down, stirred 3.5 hours, make it become clear solution;
(2), the zinc nitrate solution 0.4ml that adds 10%wt, the ferrous bromide solution 1.2ml of 10%wt, the magnesium chloride solution 40ml of 10%wt, the calcium acetate solution 92ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, methanol wash, at 70 ℃ of vacuum dryings, pulverize, product 22.41g.
Embodiment four
(1), 0 ℃ of nearly room temperature, under the argon shield, take by weighing the 20g conjugated linoleic acid in 400ml methanol, stir the Feldalat KM solution 29ml that adds 10%wt down, stirred 5.5 hours, make it become clear solution;
(2), the zinc phosphate solution 0.25ml that adds 10%wt, the copperas solution 1.2ml of 10%wt, the Adlerika 30ml of 10%wt, the calcium acetate solution 90ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, ether washing, at 85 ℃ of vacuum dryings, pulverize, product 22.07g.
Embodiment five
(1), 15 ℃ of nearly room temperatures, under the argon shield, take by weighing the 20g conjugated linoleic acid in 340ml ethanol, stir the sodium hydroxide solution 33ml that adds 10%wt down, stirred 4.5 hours, make it become clear solution;
(2), the zinc nitrate solution 0.7ml that adds 10%wt, the solution of ferrous chloride 1.8ml of 10%wt, the magnesium tartrate solution 42ml of 10%wt, the calcium lactate solution 85ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, ether washing, at 65 ℃ of vacuum dryings, pulverize, product 22.17g.
Embodiment six
(1), 25 ℃ of room temperatures, under the argon shield, take by weighing the 10g conjugated linoleic acid in the 150ml propanol, stir the sodium methoxide solution 16ml that adds 10%wt down, stirred 3.8 hours, make it become clear solution;
(2), the liquor zinci chloridi 0.41ml that adds 10%wt, the copperas solution 1.50ml of 10%wt, the magnesium nitrate solution 39ml of 10%wt, the calcium acetate solution 83ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, petroleum ether, at 55 ℃ of vacuum dryings, pulverize, product 12.14g.
Embodiment seven
(1), 40 ℃ of nearly room temperatures, under the argon shield, take by weighing the 10g conjugated linoleic acid in 300ml ethanol, stir the Feldalat KM solution 15ml that adds 10%wt down, stirred 5.5 hours, make it become clear solution;
(2), the zinc bromide solution 0.26ml that adds 10%wt, the ferrous bromide solution 0.65ml of 10%wt, the magnesium tartrate solution 32ml of 10%wt, the calcium acetate solution 95ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, petroleum ether, at 39 ℃ of vacuum dryings, pulverize, product 11.10g.
Embodiment eight
(1), 30 ℃ of nearly room temperatures, under the argon shield, take by weighing the 10g conjugated linoleic acid in 310ml ethanol, stir the potassium hydroxide solution 17ml that adds 10%wt down, stirred 4.6 hours, make it become clear solution;
(2), the solution of zinc sulfate 0.23ml that adds 10%wt, the solution of ferrous chloride 0.77ml of 10%wt, the magnesium nitrate solution 29ml of 10%wt, the D-natural gum saccharic acid calcium solution 85ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, methanol wash, at 90 ℃ of vacuum dryings, pulverize, product 12.19g.
Embodiment nine
(1), 45 ℃ of nearly room temperatures, under the nitrogen protection, take by weighing the 10g conjugated linoleic acid in 270ml methanol, stir the Feldalat KM solution 15ml that adds 10%wt down, stirred 3.5 hours, make it become clear solution;
(2), the zinc bromide solution 0.29ml that adds 10%wt, the copperas solution 0.87ml of 10%wt, the magnesium nitrate solution 36ml of 10%wt, the calcium bromide solution 79ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, washing with alcohol, at 80 ℃ of vacuum dryings, pulverize, product 11.68g.
Embodiment ten
(1), 45 ℃ of nearly room temperatures, under the nitrogen protection, take by weighing the 10g conjugated linoleic acid in the 310ml propanol, stir the sodium hydroxide solution 17ml that adds 10%wt down, stirred 4.8 hours, make it become clear solution;
(2), the zinc iodide solution 0.36ml that adds 10%wt, the solution of ferrous chloride 0.90ml of 10%wt, the magnesium chloride solution 38ml of 10%wt, the calcium nitrate solution 97ml of 10%wt, the limit edged stirs, form green particles shape material, through centrifugalize, use distilled water successively, deionized water, washing with alcohol, at 87 ℃ of vacuum dryings, pulverize, product 12.20g.
The constituent content of the compound formulation of table 1 embodiment of the invention preparation
| Embodiment | ?CLA(％) | ??Zn(％) | ??Fe(％) | ??Mg(％) | ??Ca(％) | Other fatty acid | ?H 2O(％) |
| ??1 | ??78.88 | ??0.18 | ??0.39 | ??1.10 | ??2.56 | ??12.14 | ??4.75 |
| ??2 | ??78.70 | ??0.31 | ??0.51 | ??1.21 | ??2.85 | ??11.33 | ??5.09 |
| ??3 | ??79.27 | ??0.27 | ??0.47 | ??1.14 | ??2.68 | ??11.19 | ??4.98 |
| ??4 | ??79.26 | ??0.29 | ??0.60 | ??1.35 | ??2.79 | ??10.05 | ??5.03 |
| ??5 | ??78.76 | ??0.31 | ??0.72 | ??1.46 | ??3.01 | ??10.53 | ??5.21 |
| ??6 | ??78.93 | ??0.19 | ??0.42 | ??1.52 | ??2.96 | ??10.89 | ??5.09 |
| ??7 | ??79.47 | ??0.24 | ??0.41 | ??1.34 | ??2.47 | ??10.95 | ??5.12 |
| ??8 | ??78.51 | ??0.19 | ??0.38 | ??1.27 | ??2.97 | ??11.81 | ??4.87 |
| ??9 | ??79.06 | ??0.30 | ??0.64 | ??1.29 | ??3.02 | ??10.68 | ??5.01 |
| ??10 | ??78.96 | ??0.22 | ??0.57 | ??1.35 | ??2.86 | ??11.39 | ??4.65 |
Claims (8)
1. lipid-lowering and weight-losing complex nutrient preparation is characterized in that it being that raw material by following mole (mol) ratio is made: conjugated linoleic acid: soluble zinc salt: soluble ferrite: solubility magnesium salt: soluble calcium salt=200: 0.35～0.65: 0.65～1.5: 20～50: 50～100;
Described lipid-lowering and weight-losing complex nutrient preparation is in room temperature or nearly room temperature; under the inert gas shielding; the conjugated linoleic acid of biologically active is carried out saponification with alkali metal hydroxide or alkali alcoholate earlier, carry out metathesis reaction with solubility nutrient metal salt solution again and make.
2. according to the described lipid-lowering and weight-losing complex nutrient preparation of claim 1, it is characterized in that: described conjugated linoleic acid is the pure product of conjugated linoleic acid or the fatty acid mixed of conjugated linoleic acid.
3. the preparation method of a lipid-lowering and weight-losing complex nutrient preparation is characterized in that: said preparation is to be made by the raw material of following mole (mol) ratio: conjugated linoleic acid: soluble zinc salt: soluble ferrite: solubility magnesium salt: soluble calcium salt=200: 0.35～0.65: 0.65～1.5: 20～50: 50～100;
Its preparation method is in room temperature or nearly room temperature; under the inert gas shielding; the conjugated linoleic acid of biologically active is carried out saponification with alkali metal hydroxide or alkali alcoholate earlier, carries out metathesis reaction with solubility nutrient metal salt solution again, specifically comprise following operating procedure:
(1), in room temperature or nearly room temperature, under the inert gas shielding,, join in the conjugated linoleic acid liquid of equivalent the aqueous solution of alkali metal hydroxide or alkali alcoholate or alcoholic solution, stirring reaction 2-6 hour, the alkali metal soap solution of conjugated linoleic acid;
(2), the solubility nutrient metal salt solution that in the solution that step (1) generates, adds equivalent, being stirred to granule separates out, liquid is partly clarified, and centrifugalize discards clear liquid, get thick lipid-lowering and weight-losing complex nutrient preparation slaine, use distilled water successively, deionized water, low mass molecule alcohol or ether washing, at 30-90 ℃ of vacuum drying, get lipid-lowering and weight-losing complex nutrient preparation after the pulverizing.
4. according to the preparation method of the described lipid-lowering and weight-losing complex nutrient preparation of claim 3, it is characterized in that: described conjugated linoleic acid is the pure product of conjugated linoleic acid or the fatty acid mixed of conjugated linoleic acid.
5. according to the preparation method of the described lipid-lowering and weight-losing complex nutrient preparation of claim 3, it is characterized in that: described alkali metal is potassium or sodium; Described alcohol is any one in methanol or ethanol or propanol or the isopropyl alcohol; Described ether is any one in ether or the petroleum ether.
6. according to the preparation method of the described lipid-lowering and weight-losing complex nutrient preparation of claim 3, it is characterized in that described solubility nutrient slaine is a certain proportion of zinc salt, iron salt, magnesium salt and calcium salt, the mol ratio of selected zinc salt, iron salt, magnesium salt and calcium salt is 1: 1.2～3.0: 50～100: 100～200, soluble zinc salt is selected from any one in zinc acetate, zinc chloride, zinc sulfate, zinc bromide, zinc tartrate, zinc iodide, zinc phosphate or the zinc nitrate, and soluble ferrite is selected from any one in ferrous chloride or ferrous bromide or the ferrous sulfate; The solubility magnesium salt is selected from any one in magnesium acetate, magnesium chloride, magnesium sulfate, magnesium tartrate or the magnesium nitrate, and soluble calcium salt is selected from any one in calcium acetate, calcium propionate, calcium lactate, calcium chloride, lime nitrate, D-natural gum Calciofon or the calcium bromide.
7. according to the preparation method of claim 3 or 4 described lipid-lowering and weight-losing complex nutrient preparations, it is characterized in that: the mol ratio of described conjugated linoleic acid and alkali metal hydroxide or alkali alcoholate is 1: 1～1.5.
8. according to the preparation method of claim 3 or 4 described lipid-lowering and weight-losing complex nutrient preparations, it is characterized in that: the mol ratio of described conjugated linoleic acid and solubility nutrient slaine is 1: 0.5～1.0.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108450938A (en) * | 2017-02-20 | 2018-08-28 | 广州小杉健康科技有限公司 | A kind of fat reducing meal replacement powder and preparation method thereof |
| CN110897165A (en) * | 2019-12-31 | 2020-03-24 | 山西凯瑞森生物科技有限公司 | Conjugated zinc linoleate preparation and preparation method thereof |
| CN111840321A (en) * | 2020-09-08 | 2020-10-30 | 山西凯瑞森生物科技有限公司 | Polyunsaturated fatty acid calcium zinc ferrous magnesium composite preparation and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562944A (en) * | 2004-04-14 | 2005-01-12 | 中国科学院新疆理化技术研究所 | Method for synthesizing edible conjugated calcium linoleic acid |
| CN1795848A (en) * | 2004-12-27 | 2006-07-05 | 中国科学院地理科学与资源研究所 | Magnesium preparation of conjugate linoleic acid and preparation method |
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- 2010-04-15 CN CN201010152773A patent/CN101849962A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562944A (en) * | 2004-04-14 | 2005-01-12 | 中国科学院新疆理化技术研究所 | Method for synthesizing edible conjugated calcium linoleic acid |
| CN1795848A (en) * | 2004-12-27 | 2006-07-05 | 中国科学院地理科学与资源研究所 | Magnesium preparation of conjugate linoleic acid and preparation method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108450938A (en) * | 2017-02-20 | 2018-08-28 | 广州小杉健康科技有限公司 | A kind of fat reducing meal replacement powder and preparation method thereof |
| CN110897165A (en) * | 2019-12-31 | 2020-03-24 | 山西凯瑞森生物科技有限公司 | Conjugated zinc linoleate preparation and preparation method thereof |
| CN111840321A (en) * | 2020-09-08 | 2020-10-30 | 山西凯瑞森生物科技有限公司 | Polyunsaturated fatty acid calcium zinc ferrous magnesium composite preparation and preparation method and application thereof |
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