CN101848908B - 激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途 - Google Patents

激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途 Download PDF

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CN101848908B
CN101848908B CN200880114705.9A CN200880114705A CN101848908B CN 101848908 B CN101848908 B CN 101848908B CN 200880114705 A CN200880114705 A CN 200880114705A CN 101848908 B CN101848908 B CN 101848908B
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heterocycle
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cycloalkyl
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CN101848908A (zh
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李嘉强
刘继峰
李有志
李伟
H·罗格夫
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1Globe Biomedical Co Ltd
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CN200880114705.9A 2007-09-06 2008-09-05 激酶抑制剂的组合物及其在治疗癌症和其它与激酶相关的疾病中的用途 Active CN101848908B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US97041007P 2007-09-06 2007-09-06
US60/970,410 2007-09-06
US1338907P 2007-12-13 2007-12-13
US61/013,389 2007-12-13
US7429508P 2008-06-20 2008-06-20
US61/074,295 2008-06-20
PCT/US2008/075418 WO2009033033A2 (en) 2007-09-06 2008-09-05 Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases

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CN101848908A CN101848908A (zh) 2010-09-29
CN101848908B true CN101848908B (zh) 2014-07-02

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CA2736177A1 (en) * 2007-09-06 2009-03-12 Boston Biomedical, Inc. Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
KR101300916B1 (ko) * 2007-12-10 2013-08-27 인터디지탈 패튼 홀딩스, 인크 무선 링크 제어 패킷 폐기 및 무선 링크 제어 재확립을 트리거하는 방법 및 장치
AU2012222812A1 (en) 2011-02-28 2013-05-02 Mcmaster University Treatment of cancer with dopamine receptor antagonists
WO2014030001A1 (en) * 2012-08-23 2014-02-27 The Institute Of Cancer Research: Royal Cancer Hospital Fused heterocyclic compounds and their use
JP6378308B2 (ja) * 2013-03-13 2018-08-22 ボストン バイオメディカル， インコーポレイテッド がんの処置のための、がん幹細胞経路キナーゼの阻害剤としての３−（アリールまたはヘテロアリール）メチレンインドリン−２−オン誘導体
US9227962B2 (en) 2013-03-13 2016-01-05 Boston Biomedical, Inc. Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative
US9187454B2 (en) 2013-03-13 2015-11-17 Boston Biomedical, Inc. Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof
EP3010903A1 (en) * 2013-06-20 2016-04-27 Boehringer Ingelheim International GmbH Olefin substituted oxindoles having ampk activity
MX2016009655A (es) * 2014-01-27 2016-11-09 Boston Biomedical Inc Metodos novedosos para el tratamiento del cancer.
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
KR20170141716A (ko) * 2015-04-27 2017-12-26 보스톤 바이오메디칼, 인크. Stat3 경로 저해제 및 카이나제 저해제를 사용하여 암을 치료하는 방법
JPWO2017026119A1 (ja) * 2015-08-10 2018-05-24 大日本住友製薬株式会社 ５−（チアゾール−４−イル）インドリン−２−オン誘導体の精製方法
WO2017160978A1 (en) 2016-03-15 2017-09-21 Boston Biomedical, Inc. Cell cultures and use thereof
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
KR102964218B1 (ko) * 2018-09-18 2026-05-13 1글로브 바이오메디칼 씨오., 엘티디. 비만의 치료
BR112021005086A2 (pt) * 2018-09-18 2021-06-08 1Globe Biomedical Co., Ltd. tratamento para doença hepática gordurosa não alcoólica
US20250129067A1 (en) 2021-11-08 2025-04-24 Progentos Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof

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WO2009033033A2 (en) 2009-03-12
US20100285006A1 (en) 2010-11-11
ES2759347T3 (es) 2020-05-08
CY1118012T1 (el) 2017-05-17
EP2197878B1 (en) 2016-08-17
JP5452490B2 (ja) 2014-03-26
ES2591028T3 (es) 2016-11-24
EP3037419A1 (en) 2016-06-29
JP2010538091A (ja) 2010-12-09
US20180022743A1 (en) 2018-01-25
JP5701372B2 (ja) 2015-04-15
HRP20161114T1 (hr) 2016-11-04
LT2197878T (lt) 2016-09-26
SI2197878T1 (sl) 2016-10-28
WO2009033033A3 (en) 2009-04-30
US20190248781A1 (en) 2019-08-15
JP2019070051A (ja) 2019-05-09
EP2197878A2 (en) 2010-06-23
EP2197878A4 (en) 2012-02-08
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JP6495868B2 (ja) 2019-04-03
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CA2736177A1 (en) 2009-03-12
JP2016180013A (ja) 2016-10-13
PT2197878T (pt) 2016-11-04
JP2015129152A (ja) 2015-07-16
CN101848908A (zh) 2010-09-29
DK2197878T3 (en) 2016-11-14
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