CN101843821B - Chinese medicinal composition for treating chromatosis and preparation thereof - Google Patents
Chinese medicinal composition for treating chromatosis and preparation thereof Download PDFInfo
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- CN101843821B CN101843821B CN2010101892224A CN201010189222A CN101843821B CN 101843821 B CN101843821 B CN 101843821B CN 2010101892224 A CN2010101892224 A CN 2010101892224A CN 201010189222 A CN201010189222 A CN 201010189222A CN 101843821 B CN101843821 B CN 101843821B
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Abstract
The invention relates to a Chinese medicinal composition for treating chromatosis and a preparation thereof. The Chromatosis occurs in various kinds of dermatosis, and is caused by forming pigmentation of black skin pigments after skin is often irritated by sunshine, ultraviolet radiation or cosmetics, medicaments and other substance. One part of the black skin pigments sheds with corneum, while one part is precipitated at the bottom layer and discharged from the body through blood circulation. If the functions are disordered, chromatosis forms. According to the formula, the Chinese medicinal composition comprises Chinese patent medicmaments such as campanumaea pilosula, astragalus, largehead atractylodes rhizome, glabrous greenbrier rhizome and the like which have the effects of supplementing the center and boosting qi, and strengthening spleen and benefiting lung as primary materials, and is supplemented with Chinese angelica for enriching blood and activating blood, dioscorea batatas decene for strengthening spleen, reinforcing kidney and moisturizing lung, benefiting brain, replenishing essence and beautifying, white paeony root for nourishing blood and softening liver, red paeony root for clearing heat and cooling blood, and activating blood and dissolving stasis, motherwort herb for eliminating stasis and engendering the new, and activating blood and regulating menstruation, and fresh liquoric root for tonifying spleen and benefiting qi, clearing heat and detoxicating. The medicaments are processed into an oral preparation which has the effects of supplementing center and boosting qi, strengthening spleen and benefiting lung, and activating blood and dissolving stasis. Decades of clinical application proves that the Chinese medicinal composition has good effects of treating the chromatosis.
Description
Technical field:
The present invention relates to medical technical field, be specifically related to Pigmented Chinese medicine composition of a kind of treatment and preparation thereof.
Background technology:
Pigmentation is found in many dermatosiss, and dermatological is referred to as the excessive property of cutaneous pigmentation disease to the disease that with the cutaneous pigmentation is main performance.The Pigmented origin cause of formation, be subjected to sunlight, ultraviolet radiation or cosmetics, medicine and other material incentive usually after, the skin pigment deposition that forms black forms, a part is along with horny layer comes off; A part is deposited in bottom, excretes by blood circulation, and above function is in case imbalance has just formed pigmentation.Chloasma more commonly clinically.
Theory of Chinese medical science is thought the formation of primary disease, and how relevant with the liver,spleen,kidney functional disorder, feelings will is lost freely, and depression of liver-QI makes stagnation of QI-blood in face; Deficiency of the spleen causing weakness of QI, fortuneization is unable, and QI-blood failing to nourish upward is in face; Insufficiency of kidney-YANG, kidney yin is filled the air, and makes face qi-blood disharmony; Deficiency of kidney yin, kidney water can not on hold.With the passing of time the course of disease all can cause blood stasis, so black speck, brown patch color are also deepened thereupon." General Treatise on the Cause and Symptoms of Diseases " cloud: " vital organs of the human body 12 menses are all gone up in face, all flourish the exterior and the interior of husband's blood trip; people or phlegm retention stain is dirty, or the space between skin and muscles wind-engaging, causes disharmony between QI and blood; puckery or turbid, can not be flourish in skin, so Shao-takes place to deceive " have accurately discussed the etiology and pathogenesis of facial pigmentation.Black belongs to kidney from the five elements, and the visible colour of skin of nephropathy is dark.Dark due to the nephropathy is not that the damp and hot institute of exopathogen haunts, no matter insufficiency of kidney-YANG or deficiency of kidney-essence all are deficiency in origin, or for drying up in deficiency of vital energy cold coagulation or damage of essence Tianjin, but not the dirt heresy is turbid.
Summary of the invention:
The object of the present invention is to provide Pigmented Chinese medicine composition of a kind of treatment and preparation thereof.
The invention provides the Pigmented Chinese medicine composition of a kind of treatment, said composition is made by following weight parts proportion raw material medicine:
Radix Codonopsis 8-12 part Radix Astragali 8-12 part Rhizoma Atractylodis Macrocephalae 8-12 part Rhizoma Smilacis Glabrae 16-24 part
Radix Angelicae Sinensis 7-11 part RHIIZOMA DIOSCOREAE frOm Henan of China 12-18 part Radix Paeoniae Rubra 4-8 part Radix Paeoniae Alba 4-8 part
Herba Leonuri 7-11 part Radix Glycyrrhizae 9-15 part.
Preferably, the weight portion of each component is:
20 parts of 10 parts of Rhizoma Smilacis Glabraes of 10 parts of Rhizoma Atractylodis Macrocephalaes of 10 parts of Radixs Astragali of Radix Codonopsis
6 parts of 6 portions of Radix Paeoniae Albas of 15 parts of Radix Paeoniae Rubra of 9 parts of RHIIZOMA DIOSCOREAE frOm Henan of China of Radix Angelicae Sinensis
12 parts of 9 parts of Radix Glycyrrhizae of Herba Leonuri.
The present invention also provides the oral formulations of the Pigmented Chinese medicine composition of above-mentioned treatment, is medically acceptable various peroral dosage forms, as granule, tablet, capsule, oral liquid or syrup.
The present invention also provides the preparation method of the oral formulations of the Pigmented Chinese medicine composition of above-mentioned treatment, and this method comprises:
(I) preparation of active component extract
Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Radix Angelicae Sinensis, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Herba Leonuri, Radix Glycyrrhizae medical material with above-mentioned weight proportion, soaked 2-8 hour with 3 times of water yields earlier, decoct 2 times with 10 times of water yields, each 1 hour, decocting liquid filtered again, filtrate merges, being concentrated into relative density is the clear paste of 1.3～1.35 (50 ℃), adds 2 times of amount ethanol, stirs evenly, left standstill 24 hours, supernatant reclaims ethanol;
(II) preparation of oral formulations
With (I) active component extract, make liquid oral medicine or solid orally ingestible with pharmaceutic adjuvant according to a conventional method.
The present invention also provides the syrup of the Pigmented Chinese medicine composition of above-mentioned treatment.Step (II) is specifically: with (I) active component extract, add white sugar water 200ml, add water to 1000ml, stir evenly, cold preservation 24h filters, fill, and sterilization promptly gets syrup.
The present invention also provides the dissolved granule of the Pigmented Chinese medicine composition of above-mentioned treatment.Step (II) is specifically: with (I) active component extract, add water to 1000ml, stir evenly, cold preservation 24h filters, fill, and sterilization promptly gets extractum.The dextrin and a certain amount of sucrose that add 10～40g in gained extractum are crossed 16 mesh standard sieves, make dissolved granule, 80 ℃ of freeze-day with constant temperature.Wherein add the 40g dextrin during extractum 10g, rate of drying is the fastest.
Chinese medicine composition of the present invention, prescription is with invigorating the spleen and replenishing QI such as Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabraes, spleen invigorating lung benefiting Chinese patent medicine is main, the Radix Angelicae Sinensis that being aided with enriches blood invigorates blood circulation, the RHIIZOMA DIOSCOREAE frOm Henan of China of spleen benefiting and strengthen kidney lung moistening, beneficial brain replenishing essence skin care, the Radix Paeoniae Alba of nourishing blood to suppress the hyperactive liver, the Radix Paeoniae Rubra of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, the Herba Leonuri of eliminating blood stasis to promote regeneration of blood, promoting blood flow to regulate menstruation, the Radix Glycyrrhizae of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, become the oral formulations of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, blood circulation promoting and blood stasis dispelling with superior processes, confirm that through the clinical practice of many decades the treatment pigmentation is had favorable effects.
The specific embodiment:
Below in conjunction with embodiment the present invention is further described, but enforcement of the present invention is not limited only to this:
Embodiment 1:
Prescription: Radix Codonopsis 10.0g Radix Astragali 10.0g Rhizoma Atractylodis Macrocephalae 10.0g Rhizoma Smilacis Glabrae 20.0g
Radix Angelicae Sinensis 9.0g RHIIZOMA DIOSCOREAE frOm Henan of China 15.0g Radix Paeoniae Rubra 6.0g Radix Paeoniae Alba 6.0g
Herba Leonuri 9.0g Radix Glycyrrhizae 12.0g.
Preparation method:
Get 10 flavor medical materials in the prescription, soak 6h with 3 times of water yields earlier,, decoct 2 times with 10 times of water yields again, each 1 hour, decocting liquid filtered, and filtrate merges, and being concentrated into relative density is the clear paste of 1.3～1.35 (50 ℃), add 2 times of amount ethanol, stir evenly, leave standstill 24h, supernatant reclaims ethanol, adds white sugar water 200ml, adds water to 1000ml, stir evenly, cold preservation 24h filters, fill, sterilization, promptly.
Embodiment 2: the pharmaceutically active test
One, data and method
1, case: 200 female patients are all from outpatient service, the course of disease 6 months～5 years, and 20 years old～50 years old age, wherein, chloasma 72 examples, freckle 48 examples, cutaneous pigmentation 80 examples.
1, experimental group: 102 examples, 21～47 years old age, average 36.5 years old
2, matched group: 98 examples, 20～50 years old age, average 38.6 years old
3, Therapeutic Method:
Experimental group: the oral syrup of making by embodiment 1 (A-speckle syrup) every day 2 times, matched group: oral vitamin E, viewing duration other for oral administration and external used medicine of stopping using.In total 8 weeks of the course of treatment, observed once record curative effect and side effect in per 7 days.
Three, efficacy assessment standard
Produce effects: after treating a course of treatment, pigmentation is partly desalinated obviously, and skin recovers gloss.
Effectively: after treating a course of treatment, pigmentation is partly desalinated, and still has some pigmentations, and the skin glossiness still can.
Invalid: after treating a course of treatment, pigment is supportting does not partly have desalination.
Four, observed result: treatment group and matched group ordinary circumstance, no significant difference meets comparability.Two groups of therapeutic outcomes see Table 1, and it is effective percentage effectively that produce effects adds, and two groups total effective rate is respectively 89.12% and 62.24%, and there were significant differences (P＜0.05) to learn processing by statistics, illustrates that treatment group curative effect is apparently higher than matched group.
Table 1 experimental group and matched group curative effect are relatively
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 102 | 53(51.96) | 38(37.22) | 11(10.78) | 89.21％ |
| Matched group | 98 | 45(45.91) | 16(16.32) | 23(23.47) | 62.24％ |
The toxic and side effects observed result: 102 routine experimental grouies are observed patients and any skin allergy, untoward reaction such as uncomfortable are not all occurred, illustrate that Chinese medicine composition of the present invention is clinical safe in utilization.
Through 102 routine skin of face patient observed results are shown, medicine of the present invention all has significant curative effect for skin of face pigmentation diseases such as cutaneous pigmentation such as chloasma, freckles, any untoward reaction is not seen in clinical observation, illustrates that Chinese medicine composition of the present invention is a kind of safe and effective medicine for the treatment of face dermatosis.
Claims (5)
1. Pigmented Chinese medicine composition of treatment is characterized in that said composition made by following weight parts proportion raw material medicine:
Radix Codonopsis 8-12 part Radix Astragali 8-12 part Rhizoma Atractylodis Macrocephalae 8-12 part Rhizoma Smilacis Glabrae 16-24 part
Radix Angelicae Sinensis 7-11 part RHIIZOMA DIOSCOREAE frOm Henan of China 12-18 part Radix Paeoniae Rubra 4-8 part Radix Paeoniae Alba 4-8 part
Herba Leonuri 7-11 part Radix Glycyrrhizae 9-15 part.
2. the Pigmented Chinese medicine composition of a kind of treatment according to claim 1 is characterized in that said composition made by following weight parts proportion raw material medicine:
20 parts of 10 parts of Rhizoma Smilacis Glabraes of 10 parts of Rhizoma Atractylodis Macrocephalaes of 10 parts of Radixs Astragali of Radix Codonopsis
6 parts of 6 portions of Radix Paeoniae Albas of 15 parts of Radix Paeoniae Rubra of 9 parts of RHIIZOMA DIOSCOREAE frOm Henan of China of Radix Angelicae Sinensis
12 parts of 9 parts of Radix Glycyrrhizae of Herba Leonuri.
3. the Pigmented Chinese medicine composition of a kind of treatment according to claim 1 and 2, this Chinese medicine composition of its feature and conventional pharmaceutic adjuvant are made oral formulations.
4. the Pigmented Chinese medicine composition of a kind of treatment according to claim 3, the oral formulations that this Chinese medicine composition of its feature and conventional pharmaceutic adjuvant are made is syrup or dissolved granule.
5. method for preparing the oral formulations for the treatment of Pigmented Chinese medicine composition, this method comprises:
(I) preparation of active component extract
Medical material with the following weight parts proportioning:
Radix Codonopsis 8-12 part Radix Astragali 8-12 part Rhizoma Atractylodis Macrocephalae 8-12 part Rhizoma Smilacis Glabrae 16-24 part
Radix Angelicae Sinensis 7-11 part RHIIZOMA DIOSCOREAE frOm Henan of China 12-18 part Radix Paeoniae Rubra 4-8 part Radix Paeoniae Alba 4-8 part
Herba Leonuri 7-11 part Radix Glycyrrhizae 9-15 part,
Soaked 2-8 hour with 3 times of water yields earlier, decoct 2 times with 10 times of water yields, each 1 hour, decocting liquid filtered, and filtrate merges, and was concentrated into 50 ℃ of relative densities and is 1.3～1.35 clear paste, added 2 times of amount ethanol, stirred evenly, and left standstill 24 hours, and supernatant reclaims ethanol;
(II) preparation of oral formulations
With (I) active component extract, make liquid oral medicine or solid orally ingestible with pharmaceutic adjuvant according to a conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010101892224A CN101843821B (en) | 2010-06-01 | 2010-06-01 | Chinese medicinal composition for treating chromatosis and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101892224A CN101843821B (en) | 2010-06-01 | 2010-06-01 | Chinese medicinal composition for treating chromatosis and preparation thereof |
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| CN101843821A CN101843821A (en) | 2010-09-29 |
| CN101843821B true CN101843821B (en) | 2011-12-07 |
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| CN102204878B (en) * | 2011-05-04 | 2012-05-30 | 北京华夏美枫化妆品技术中心 | Skin-care composition and preparation with whitening effect and preparation method thereof |
| CN102895461A (en) * | 2012-09-14 | 2013-01-30 | 陆宏成 | Decoction medicine for treating liver-spleen disharmony type chloasma |
| CN109620947A (en) * | 2019-02-27 | 2019-04-16 | 刘文英 | U.S. face nti-freckle Chinese materia medica preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422644A (en) * | 2001-12-06 | 2003-06-11 | 高大海 | Skin-beauty capsule |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422644A (en) * | 2001-12-06 | 2003-06-11 | 高大海 | Skin-beauty capsule |
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Owner name: ARMY MEDICAL UNIV. NO.2, CHINESE PLA Free format text: FORMER OWNER: LIAO WANQING Effective date: 20120411 Free format text: FORMER OWNER: KANG SHANZHU Effective date: 20120411 |
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Effective date of registration: 20120411 Address after: 200433 No. 800 Xiang Yin Road, Shanghai Patentee after: Army Medical Univ. No.2, Chinese PLA Address before: 200433, room 9, building 873, Lane 401, Xiang Yin Road, Shanghai Co-patentee before: Kang Shanzhu Patentee before: Liao Wanqing |