CN102210810A - Medicament for treating alopecia - Google Patents

Abstract

The invention discloses a medicament for treating alopecia, which is prepared from the following components: 10-20 parts of radix rehmanniae, 15-30 parts of fleece-flower root, 5-10 parts of angelica, 5-10 parts of chuanxiong rhizome, 7.5-15 parts of dodder, 5-10 parts of sealwort, 2.5-5 parts of licorice, 7.5-15 parts of prepared rehmannia root and 7.5-15 parts of raw milk vetch. The medicament is cleaned and aired to be prepared into 150-mesh fine powder, and then, the fine powder is encapsulated and sterilized to be prepared into a capsule. The medicament disclosed by the invention has the functions of promoting blood circulation, promoting the circulation of qi, nourishing the liver and kidney, reinforcing the spleen, replenishing qi, enriching the blood and nourishing yin and does not have toxic side effects, and the total effective rate of the medicament for treating alopecia reaches 89.1%.

Description

A kind of medicine for the treatment of alopecia

Technical field

The present invention relates to a kind of medicine, particularly a kind of preparation method for the treatment of the medicine and the medicine of alopecia.

Background technology

Alopecia is meant the phenomenon of alopecia.The hair that normal physiological comes off all is the hair that is in catagen and resting stage, constantly is in dynamic equilibrium owing to enter catagen with the hair that newly enters trophophase, so can keep the hair of normal quantity.The pathologic alopecia is meant unusual or over-drastic the coming off of hair, and male pattern baldness mainly is front and head, and the hairline and the temples of forehead up move, and the hair at front and top is sparse, flavescence, deliquescing, makes volume top a slice baldness or some fine hair eventually; Female alopecia is portion overhead, and hair becomes sparse, but can in blocks fully not coming off.

Chinese medicine thinks that alopecia has two kinds of reasons: the one, and the heat in blood wind-dryness, heat in blood wins partially, consumption impairment of YIN blood, the blood tiger gives birth to wind, impairment of YIN blood more, cloudy blood can not be gone up to the top, mountain peak and moisten foster Rhizoma Imperatae, and Rhizoma Imperatae is dry, or apprehensive coming off; The 2nd, damp-heat in the spleen and stomach, insufficiency of the spleen fortuneization is unable, addiction to greasy and sweet foods savoury in addition, the damage that injures one's stomach spleen causes damp and hot going up to steam the top, mountain peak, carves the erosion root of hair, and root of hair gradually is corroded, and hair then shows sticky and comes off.

Alopecia is a kind of common hair diseases, relevant medicine, great majority are conceived to Rhizoma Imperatae is partly carried out the supply of nutritional labeling, the expansion peripheral vessel, suppress androgen and activate Rhizoma Imperatae metabolism etc. to the effect of Rhizoma Imperatae and on cellular level, can not fundamentally treat alopecia, drug withdrawal rear section patient alopecia once again.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of alopecia, have no side effect, evident in efficacy for the treatment alopecia.

Medicine of the present invention is to be the medicament that crude drug prepares by following parts by weight of traditional Chinese medicines:

The Radix Rehmanniae 10-20 Radix Polygoni Multiflori 15-30 Radix Angelicae Sinensis 5-10

Rhizoma Chuanxiong 5-10 Semen Cuscutae 7.5-15 Rhizoma Polygonatis 5-10

Radix Glycyrrhizae 2.5-5 Radix Rehmanniaes Preparata 7.5-15 Radix Astragali 7.5-15.

Further, medicine of the present invention is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:

The Radix Rehmanniae 15-20 Radix Polygoni Multiflori 20-25 Radix Angelicae Sinensis 7-10

Rhizoma Chuanxiong 5-8 Semen Cuscutae 10-15 Rhizoma Polygonatis 6-8

Radix Glycyrrhizae 3-5 Radix Rehmanniaes Preparata 10-15 Radix Astragali 9-12.

The preparation method of medicine of the present invention is made 150 purpose fine powders for described medicine is cleaned to dry, and incapsulates sterilization and makes capsule.

Described medicine can also be made any peroral dosage form on the pharmaceutics, as tablet, pill etc. except that being prepared into capsule.

The traditional Chinese medical science thinks that alopecia mostly is the blood deficiency wind-engaging, and it is dry that wind is contained blood, and a mistake is moistened and supported and cause.Radix Rehmanniae clearing away heat and cooling blood in this prescription, yin nourishing is promoted the production of body fluid; The Radix Polygoni Multiflori nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria dispels the wind, detoxifcation; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; The Semen Cuscutae nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal; The Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; The Radix Rehmanniae Preparata yin nourishing of enriching blood, life essence-filling, marrow-benefitting; Radix Astragali has invigorating QI to consolidate the body surface resistance, the effect of holder skin ulcer granulation promoting, diuretic, and all medicines share can blood-activating and qi-promoting, nourishing the liver and kidney, invigorating the spleen and replenishing QI, the yin nourishing of enriching blood.

For safety and the curative effect that guarantees medicine of the present invention, use medicine capsule of the present invention that observation of curative effect has been carried out in the treatment alopecia clinically.

1. patient's situation

112 routine patients are divided into treatment group and matched group, and 64 examples are organized in treatment, wherein male's 36 examples, women's 28 examples, the oldest 55 years old, minimum 15 years old, the course of disease is the shortest 1 month, and is the longest 5 years, matched group 48 examples, male's 29 examples wherein, women's 19 examples, the oldest 55 years old, minimum 15 years old, the course of disease is the shortest 1 month, and is the longest 4 years.

2, diagnostic criteria

Observed patient is diagnostic criteria with reference to " the new Chinese medicine clinical research guideline " of Ministry of Public Health promulgation: the scalp Pruritus, hair is withered, tens of to hundred of alopecias every day, part patient's alopecia nearly half, it is thin, soft, rare, short that hair becomes, even the scalp light, hair is very few, only leaves a little fine hair on birds or animals hair.Most of patients companion complexion is withered, two dryness and uneasy feeling of the eye, soreness of the waist and knees, diseases such as xerostomia.

3, get rid of the case standard

(1) age is at under-18s or over-65s, gestation or age of sucking the woman, allergic constitution or to this medicine allergy sufferers;

(2) be associated with serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic;

(3) congenital alopecia, cicatrix alopecia.

4, Therapeutic Method

The treatment group is taken capsule of the present invention, and three times on the one, each three, it is logical for relaxing that matched group is taken peace, a twice-daily, and each 20mg, be three months the course of treatment.

5, curative effect determinate standard:

" new Chinese medicine clinical research guideline " with the Ministry of Public Health promulgation is that efficacy assessment standard carries out efficacy evaluation:

Recovery from illness: hair stops to come off, and alopecia all grows, and its distribution density, thickness, color and luster are with strong to send out the district identical, and sebum secretion recovers normally;

Produce effects: hair stops to come off, and hair replacement reaches more than 70%, and all near the strong district of sending out, sebum secretion obviously reduces for its density, thickness and color and luster;

Effectively: hair stops to come off, and hair replacement reaches more than 30%, comprises that fine hair on birds or animals hair and poliosis grow;

Invalid: hair replacement less than 30% or still continue alopecia.

6, therapeutic outcome

Recovery from illness 22 examples among the 64 routine patients, cure rate 34.4% are organized in treatment; Produce effects 26 examples, obvious effective rate 40.6%; Effective 9 examples, effective percentage 14.1%; Total effective rate reaches 89.1%; Invalid 7 examples, inefficiency are 10.9%.Recovery from illness 7 examples among the matched group 48 routine patients, cure rate 14.6%; Produce effects 12 examples, obvious effective rate 25%; Effective 14 examples, effective percentage 29.2%; Total effective rate reaches 68.8%; Invalid 15 examples, inefficiency are 31.2%.The alopecia once again about drug withdrawal January of matched group individual patient continues dosing and still can take effect.

The specific embodiment

Embodiment 1

Get Radix Rehmanniae 20g, Radix Polygoni Multiflori 50g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 20g, Semen Cuscutae 15g, Rhizoma Polygonati 15g, Radix Glycyrrhizae 10g, Radix Rehmanniae Preparata 30g, Radix Astragali 20g;

Clean the drying of described medicine made 150 purpose fine powders, incapsulating sterilization and making capsule, each capsule 0.5g.

Embodiment 2

Get Radix Rehmanniae 15g, Radix Polygoni Multiflori 25g, Radix Angelicae Sinensis 8g, Rhizoma Chuanxiong 5g, Semen Cuscutae 15g, Rhizoma Polygonati 6g, Radix Glycyrrhizae 5g, Radix Rehmanniae Preparata 12g, Radix Astragali 10g;

Clean the drying of described medicine made 150 purpose fine powders, incapsulating sterilization and making capsule, each capsule 0.5g.

Claims (3)

1. medicine for the treatment of alopecia is characterized in that being is the medicament that crude drug prepares by following parts by weight of traditional Chinese medicines:

The Radix Rehmanniae 10-20 Radix Polygoni Multiflori 15-30 Radix Angelicae Sinensis 5-10

Rhizoma Chuanxiong 5-10 Semen Cuscutae 7.5-15 Rhizoma Polygonatis 5-10

Radix Glycyrrhizae 2.5-5 Radix Rehmanniaes Preparata 7.5-15 Radix Astragali 7.5-15.

2. the medicine of treatment alopecia according to claim 1 is characterized in that being is the medicament that crude drug prepares by following parts by weight of traditional Chinese medicines:

The Radix Rehmanniae 15-20 Radix Polygoni Multiflori 20-25 Radix Angelicae Sinensis 7-10

Rhizoma Chuanxiong 5-8 Semen Cuscutae 10-15 Rhizoma Polygonatis 6-8

Radix Glycyrrhizae 3-5 Radix Rehmanniaes Preparata 10-15 Radix Astragali 9-12.

3. the preparation method of claim 1 or 2 described medicines is described crude drug to be cleaned to dry make 150 purpose fine powders, incapsulates sterilization and makes capsule.