CN101829274A - Medicament for treating liver disease - Google Patents
Medicament for treating liver disease Download PDFInfo
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- CN101829274A CN101829274A CN201010171271A CN201010171271A CN101829274A CN 101829274 A CN101829274 A CN 101829274A CN 201010171271 A CN201010171271 A CN 201010171271A CN 201010171271 A CN201010171271 A CN 201010171271A CN 101829274 A CN101829274 A CN 101829274A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a medicament for treating liver disease, which is prepared from the following medicines in parts by weight: 1 part of radix bupleuri, 4 parts of Arundina graminifolia, 1.25 parts of mahoniae, 2.25 parts of medlar, 1.75 parts of fruit of Chinese magnoliavine, 1.25 parts of radix Salviae Miltiorrhizae, 3.5 parts of hawkthorn, 2.5 parts of areca and 0.5 part of liquorice; the medicament for treating liver disease has the functions of strengthening spleen, soothing liver, promoting blood circulation, stopping pain, protecting liver and benefiting gallbladder, and is used for treating liver and gallbladder dysfunction and liver-gallbladder diseases, such as hepatitis A/B, fatty liver, alcoholic liver, liver cancer, cholecystitis, cholelithiasis and the like, caused by abnormality of bile and toxicant excretion.
Description
Technical field
The present invention relates to a kind of preparation technology who treats medicine and this medicine thereof of hepatopathy.
Background technology
China is hepatopathy big country, viral hepatitis, Patients with Fatty Liver, ethanol hepatopathy go up long year by year, the onset of liver cancer rate is in rising trend, the hepatitis B virus carrying rate whole world first, according to statistics, in the infectious disease of China's statutory report, the morbidity number and the sickness rate of hepatopathy come out at the top so far, and hepatopathys such as viral hepatitis, fatty liver, alcoholic liver, hepatocarcinoma have become one of principal disease of current society threat human health in recent years.Hepatopathy harm is big, refractory more, the most DeGrain of Chinese medicine composition of existing treatment hepatopathy, what have also has certain therapeutic effect, but there is safe and reliable relatively poor problem in most of herbal prescription, what have also has big toxic and side effects.In Chinese Minority Nationalities medical science, hepatopathy there are own unique diagnosis and treatment method and medicine, Dai Nationality's medicine treatment hepatopathy that the doctor of the Dai Nationality adopts detoxifcation to protect the liver usually.
Summary of the invention
The objective of the invention is to propose that a kind of drug effect height, cost are low, the course of treatment medicine of short, easy to use treatment hepatopathy, to solve the deficiencies in the prior art.
The medicine of this treatment hepatopathy that the present invention proposes is made up of following medicaments in part by weight: Radix Bupleuri 1, Herba Murdanniae Divergentis 4, Mahonia fortunei (Lindl.) Fedde 1.25, Fructus Lycii 2.25, Fructus Schisandrae Chinensis 1.75, Radix Salviae Miltiorrhizae 1.25, Fructus Crataegi 3.5, Semen Arecae 2.5, Radix Glycyrrhizae 0.5.
Radix Bupleuri, Herba Murdanniae Divergentis, Mahonia fortunei (Lindl.) Fedde are cool in nature in this prescription, and bitter in the mouth has the function of heat-clearing and toxic substances removing, conditioning liver and gall, and the hepar damnification that causes to remove the invasion of various toxin is principal agent; Fructus Schisandrae Chinensis, Fructus Lycii, property is flat, sweet and sour, inlet air, water tower mid-game liver and gall have the merit of moisturizing nourishing the liver, help principal agent to strengthen the power that detoxifcation protects the liver, and are adjuvant; Radix Salviae Miltiorrhizae, inlet air, soil, water tower, have the ventilation promoting blood circulation and stopping pain merit, both can promote blood, biliary metabolism and quicken the drainage of toxin, strengthen the effect that the principal agent detoxifcation protects the liver, with Fructus Crataegi, Semen Arecae matches and also can mend soil and be good for the stomach, relieving distension by promoting circulation of QI and remove distending pain over the hypochondrium, the disease that diet is not good; Radix Glycyrrhizae, cool in nature, sweet in the mouth can be in harmonious proportion all medicines of full side and is harmonizing drug.Full side share, and brings into play the spleen invigorating soothing liver-QI jointly, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, the effect of hepatic cholagogic and reach the purpose that detoxifcation protects the liver.
Difference according to disease on the basis of above-mentioned prescription also can add Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati, this 3 flavor medical instrument has heat-clearing and toxic substances removing, and the function of promoting the function of the gallbladder to alleviate jaundice and cure mainly various hepatopathys has the effect of significant hepatitis virus resisting, therefore, add this 3 herbal medicine and strengthened the curative effect that detoxifcation protects the liver.
On the basis of above-mentioned two prescriptions, The spleen and stomach provide the material basis of the acquired according to motherland's medical science, the principle of treatment must aim at the pathogenesis of disease, also can add HUANGJIANG, Rhizoma Curcumae Longae, TONGXUEXIANG, 3 medicines are gone into the liver and gall taste, have the soil of benefit and are good for the stomach, ventilation is invigorated blood circulation, the function of human body immunity improving power and strengthen spleen invigorating, protect the liver, the curative effect of toxin expelling.
Prescription provided by the invention is behind the screening plus-minus, under the doctor of Dai Nationality detoxifcation theoretical direction, according to Dai Nationality's medicine combination principle, and to have kept the doctor's of the Dai Nationality administration features from up to a hundred the doctor of Dai Nationality proved recipes, uses Modern New Technology and develops.The medicine of preparation has the spleen invigorating soothing liver-QI, promoting blood circulation and stopping pain, the function of hepatic cholagogic.Be used for the treatment of hepato-biliary function imbalance, bile, poisonous substance abevacuation and the liver and gall diseases that takes place are as first, hepatitis B disease, fatty liver, alcoholic liver, hepatocarcinoma, cholecystitis, cholelithiasis etc.
Medicine of the present invention is applied to clinical according to the requirement of national drug administrative law hospital preparation registration.Studies have shown that through clinical observation on the therapeutic effect and anxious poison do not find toxicity, curative effect is safe and reliable, be the good medicine of treatment hepatopathy, it is evident in efficacy, has the good development prospect and the market competitiveness.The present invention is under the guidance of the doctor of the Dai Nationality " four towers, five accumulate theory ", " detoxifcation is theoretical ", strictly observe the doctor's of the Dai Nationality compound compatibility principle, both kept the administration features that the Dai Nationality cures traditional proved recipe, embodied the characteristics of modern pharmaceutical formulation again, make the medicine for preparing on dosage form, everyway such as the effectiveness of quality standard, medicine and safety is improved.
Through clinical practice, viral hepatitis, liver lesion induced by drugs is bad, the steeping in wine liver damages etc. is had significant curative effect, as treating hepatitis B: 155 examples, produce effects 57 examples, effective 81 examples, invalid 17 examples, total effective rate are 89%; Hepatitis A: 135 examples, produce effects 55 examples, effective 69 examples, invalid 11 examples, total effective rate is 91.8%; Liver lesion induced by drugs is bad: 138 examples, and produce effects 63 examples, effective 56 examples, invalid 19 examples, total effective rate is 86.2%; Alcoholic liver damage: 158 examples, produce effects 59 examples, effective 81 examples, invalid 18 examples, total effective rate is 88.6%.
The specific embodiment
Embodiment 1, a kind of medicine for the treatment of hepatopathy, form by the medicine of following weight parts:
Radix Bupleuri 1, Herba Murdanniae Divergentis 4, Mahonia fortunei (Lindl.) Fedde 1.25, Fructus Lycii 2.25, Fructus Schisandrae Chinensis 1.75, Radix Salviae Miltiorrhizae 1.25, Fructus Crataegi 3.5, Semen Arecae 2.5, Radix Glycyrrhizae 0.5.
The preparation technology of medicine is as follows:
1), get Radix Bupleuri, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Arecae and Radix Glycyrrhizae and add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;
2), get Herba Murdanniae Divergentis and Fructus Schisandrae Chinensis was pulverized 100 mesh sieves, fine powder is standby;
3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule by modern preparation process and corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.
Embodiment 2, a kind of medicine for the treatment of hepatopathy, make by the medicine of following weight parts:
Radix Bupleuri 1, Herba Murdanniae Divergentis 3.5, Mahonia fortunei (Lindl.) Fedde 2.75, Fructus Lycii 2.25, Fructus Schisandrae Chinensis 1.5, Radix Salviae Miltiorrhizae 1.25, Fructus Crataegi 2.5, Semen Arecae 2.5, Herba Scopariae 2.5, Folium Isatidis 0.75, Rhizoma Polygoni Cuspidati 0.75, Radix Glycyrrhizae 0.5.
Preparation technology is as follows:
Get Radix Bupleuri, Herba Murdanniae Divergentis, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae, heat boiled water to flooding medicine 10-15 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boiled 30 minutes, and merged three decocting liquids and obtain decoction.
Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.
Also can make other dosage form in conjunction with the modern pharmaceutical technology, step of preparation process is as follows:
1), gets Radix Bupleuri, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae, adding decocting in water carries three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;
2), get Herba Murdanniae Divergentis, Fructus Schisandrae Chinensis was pulverized 100 mesh sieves, fine powder standby;
3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.
Embodiment 3, a kind of medicine for the treatment of hepatopathy are made by the medicine of following weight parts: Radix Bupleuri 1, Herba Murdanniae Divergentis 3.5, Mahonia fortunei (Lindl.) Fedde 3, Fructus Schisandrae Chinensis 3, Fructus Lycii 2.5, Radix Salviae Miltiorrhizae 1.5, HUANGJIANG 2, Rhizoma Curcumae Longae 2, TONGXUEXIANG 3, Fructus Crataegi 2, Semen Arecae 1, Herba Scopariae 2.5, Folium Isatidis 0.75, Rhizoma Polygoni Cuspidati 0.75, Radix Glycyrrhizae 0.5.
Preparation technology is as follows: get Radix Bupleuri, Herba Murdanniae Divergentis, Mahonia fortunei (Lindl.) Fedde, Fructus Schisandrae Chinensis, Fructus Lycii, Radix Salviae Miltiorrhizae, HUANGJIANG, Rhizoma Curcumae Longae, TONGXUEXIANG, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae and heat boiled water to flooding medicine 10-15 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boils 30 minutes, merges three decocting liquids and obtains decoction.
Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.
Also can make other dosage form in conjunction with the modern pharmaceutical technology, step of preparation process is as follows:
1), getting Radix Bupleuri, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Radix Salviae Miltiorrhizae, TONGXUEXIANG, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae adds decocting in water and carries three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, get extractum, standby;
2), get surplus medicine Herba Murdanniae Divergentis, Fructus Schisandrae Chinensis, HUANGJIANG, Rhizoma Curcumae Longae and pulverized 100 mesh sieves, fine powder is standby;
3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.
Claims (8)
1. medicine for the treatment of hepatopathy is characterized in that being made by the medical material of following weight parts:
Radix Bupleuri 1, Herba Murdanniae Divergentis 4, Mahonia fortunei (Lindl.) Fedde 1.25, Fructus Lycii 2.25, Fructus Schisandrae Chinensis 1.75, Radix Salviae Miltiorrhizae 1.25, Fructus Crataegi 3.5, Semen Arecae 2.5, Radix Glycyrrhizae 0.5.
2. according to the preparation technology of the medicine of the described treatment hepatopathy of claim 1, it is characterized in that step is as follows:
1), get Radix Bupleuri, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Arecae and Radix Glycyrrhizae, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;
2), get Herba Murdanniae Divergentis became 100 mesh sieves with the Fructus Schisandrae Chinensis pulverize separately fine powder, mixing is standby;
3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule by modern preparation process and corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.
3. medicine for the treatment of hepatopathy is characterized in that being made by the medical material of following weight parts:
Radix Bupleuri 1, Herba Murdanniae Divergentis 3.5, Mahonia fortunei (Lindl.) Fedde 2.75, Fructus Lycii 2.25, Fructus Schisandrae Chinensis 1.5, Radix Salviae Miltiorrhizae 1.25, Fructus Crataegi 2.5, Semen Arecae 2.5, Herba Scopariae 2.5, Folium Isatidis 0.75, Rhizoma Polygoni Cuspidati 0.75, Radix Glycyrrhizae 0.5.
4. according to the preparation technology of the medicine of the described treatment hepatopathy of claim 3, it is characterized in that: get Radix Bupleuri, Herba Murdanniae Divergentis, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae, heat boiled water to flooding medicine 10-15 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boils 30 minutes, merges three times decocting liquid.
5. according to the preparation technology of the medicine of the described treatment hepatopathy of claim 3, it is characterized in that step is as follows:
1), gets Radix Bupleuri, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Radix Salviae Miltiorrhizae, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae, adding decocting in water carries three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;
2), get Herba Murdanniae Divergentis became 100 mesh sieves with the Fructus Schisandrae Chinensis pulverize separately fine powder, mixing is standby;
3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.
6. a medicine for the treatment of hepatopathy is characterized in that being made by the medical material of following weight parts: Radix Bupleuri 1, Herba Murdanniae Divergentis 3.5, Mahonia fortunei (Lindl.) Fedde 3, Fructus Schisandrae Chinensis 3, Fructus Lycii 2.5, Radix Salviae Miltiorrhizae 1.5, HUANGJIANG 2, Rhizoma Curcumae Longae 2, TONGXUEXIANG 3, Fructus Crataegi 2, Semen Arecae 1, Herba Scopariae 2.5, Folium Isatidis 0.75, Rhizoma Polygoni Cuspidati 0.75, Radix Glycyrrhizae 0.5.
7. according to the preparation technology of the medicine of the described treatment hepatopathy of claim 6, it is characterized in that: get Radix Bupleuri, Herba Murdanniae Divergentis, Mahonia fortunei (Lindl.) Fedde, Fructus Schisandrae Chinensis, Fructus Lycii, Radix Salviae Miltiorrhizae, HUANGJIANG, Rhizoma Curcumae Longae, TONGXUEXIANG, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae, heat boiled water to flooding medicine 10-15 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boils 30 minutes, merges three times decocting liquid.
8. according to the preparation technology of the medicine of the described treatment hepatopathy of claim 6, it is characterized in that step is as follows:
1), gets Radix Bupleuri, Mahonia fortunei (Lindl.) Fedde, Fructus Lycii, Radix Salviae Miltiorrhizae, TONGXUEXIANG, Fructus Crataegi, Semen Arecae, Herba Scopariae, Folium Isatidis, Rhizoma Polygoni Cuspidati and Radix Glycyrrhizae, adding decocting in water carries three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;
2), get the fine powder that surplus medicine Herba Murdanniae Divergentis, Fructus Schisandrae Chinensis, HUANGJIANG and Rhizoma Curcumae Longae pulverize separately became 100 mesh sieves, mixing is standby;
3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101712715A CN101829274B (en) | 2010-05-13 | 2010-05-13 | Medicament for treating liver disease |
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| CN2010101712715A CN101829274B (en) | 2010-05-13 | 2010-05-13 | Medicament for treating liver disease |
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| CN101829274B CN101829274B (en) | 2011-12-07 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225120A (en) * | 2011-06-16 | 2011-10-26 | 安徽安科生物工程（集团）股份有限公司 | Medicine for treating fatty liver and preparation method thereof |
| CN102389496A (en) * | 2011-11-16 | 2012-03-28 | 蚌埠丰原涂山制药有限公司 | Chinese medical composition for treating hepatitis and preparation method thereof |
| CN103524524A (en) * | 2013-09-10 | 2014-01-22 | 赣南医学院 | New compound in fructus schizandrae as well as preparation and application method of new compound |
| CN103816306A (en) * | 2014-03-07 | 2014-05-28 | 大连圣弘医药有限公司 | Traditional Chinese medicine for protecting liver and gallbladder and preparing method thereof |
| CN103877193A (en) * | 2012-12-20 | 2014-06-25 | 赵翠 | Medicine for treating hepatopathy |
| CN104435977A (en) * | 2014-11-18 | 2015-03-25 | 西双版纳傣族自治州民族医药研究所 | Medicine for treating liver injuries and preparation method of medicine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241613C (en) * | 2002-12-26 | 2006-02-15 | 叶春山 | Chinese medicine for treating hepatopathy |
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2010
- 2010-05-13 CN CN2010101712715A patent/CN101829274B/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225120A (en) * | 2011-06-16 | 2011-10-26 | 安徽安科生物工程（集团）股份有限公司 | Medicine for treating fatty liver and preparation method thereof |
| CN102389496A (en) * | 2011-11-16 | 2012-03-28 | 蚌埠丰原涂山制药有限公司 | Chinese medical composition for treating hepatitis and preparation method thereof |
| CN102389496B (en) * | 2011-11-16 | 2013-07-03 | 安徽丰原药业股份有限公司 | Chinese medical composition for treating hepatitis and preparation method thereof |
| CN103877193A (en) * | 2012-12-20 | 2014-06-25 | 赵翠 | Medicine for treating hepatopathy |
| CN103524524A (en) * | 2013-09-10 | 2014-01-22 | 赣南医学院 | New compound in fructus schizandrae as well as preparation and application method of new compound |
| CN103524524B (en) * | 2013-09-10 | 2016-04-20 | 赣南医学院 | Compound in a kind of shizandra berry and preparation and application thereof |
| CN103816306A (en) * | 2014-03-07 | 2014-05-28 | 大连圣弘医药有限公司 | Traditional Chinese medicine for protecting liver and gallbladder and preparing method thereof |
| CN104435977A (en) * | 2014-11-18 | 2015-03-25 | 西双版纳傣族自治州民族医药研究所 | Medicine for treating liver injuries and preparation method of medicine |
| CN104435977B (en) * | 2014-11-18 | 2017-08-01 | 西双版纳傣族自治州民族医药研究所 | It is a kind of to be used to treat medicine of hepatic injury and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101829274B (en) | 2011-12-07 |
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