Summary of the invention
For prevention and treatment skin pruritus, constantly seeking antibiotic and hormones other method and medicine in addition always.Understanding for Asbestus treatment pruritus is sheerly.Because Asbestus has sight as fossil wood, playing in the process of stone, stumbling on can be by the Oleum Pini sucking-off in Radix Pini massonianae base together with Asbestus is placed with the base that Masson Pine root does.According to this discovery, in conjunction with the cold and cool property of Asbestus, think that this characterization of adsorption of Asbestus probably has absorption body surface wet. heat. the clinical value of poison.And wet, heat, malicious clinical manifestation symptom is mainly pruritus, based on this imagination, some are had to the Chinese medicine of itching-relieving efficacies and method that Asbestus is processed by stewing forms a kind of YAOSHI, in medicine performance Quick itch stopping effect, can, by the property of the cold and cool and absorption of Asbestus, wet, hot, the toxicant that cause pruritus be got rid of external.
Technical assignment of the present invention is the deficiency that solves existing clinical treatment technology, and a kind of YAOSHI formula for the treatment of the obstinate pruritus disease of body surface by stone treatment mode and preparation method thereof is provided.
A kind of YAOSHI formula for the treatment of intractable pruritus of the present invention and preparation method thereof is according to following pharmacology:
Asbestus:
1. come from " Kaibao Bencao ": Asbestus, go out Shangdang, as rotten wood, that burns does not fire, and stone class is also.
2. " Bencao Tujing ": Asbestus, or the root of cloud Talcum is also, and going out Talcum place all has.Asbestus is first appeared in supplement to the Herbal.
3. " Bencao Tujing " said: modern pool, the Lushui River (be with modern Jincheng, Shanxi, Changzhi one) all have it in mountain, and coping stone class also.Its color is bluish white, and as rotten wood, not so (combustion) of burning, gains the name with this.Or the root of cloud Talcum also, going out Talcum place all has.
4. " Chinese medicine voluminous dictionary " [base is former] is silicates mineral amphibole asbestos.
5. " detailed outline " draws " pungent beautiful volume in heptan " cloud: " Asbestus, cloudy stone also.Shape is as pin, if the full wood of stricture of vagina burns smokeless.Shi Zhen says: " Asbestus has two kinds, wood, stone.Asbestus custom mostly is quickly son, and the one-tenth carbon of burning is not and grey, and its leaf is as the stem or leaf of cattail." " the modern Chuzhou of [annex] tophus [song is said] goes out a kind of tophus, as dry in pine, and real stone also for it.Or cloud pine fossil for a long time." two species of different nature of existence under one's name of Asbestus as can be seen here, cause homonym.
This has caused confusion to clinical application undoubtedly, this is had to the apparent point of Crinis Carbonisatus, think: " a lot of documents thought that the Asbestus of ancient book on Chinese herbal medicine was silicates mineral amphibole asbestos in the past; short hard according to investigating amphibole asbestos fiber; after folding, to become needle prick shape, touch and very itch unbearably after one's death, even cause cancer; can not make medicine for external use, with the difficult symbol of name of " not grey "." cause that the reason of mixed meat and fish dishes is the seemingly wood grain of texture classes due to this amphibole asbestos, there is resistance to aptitude to burn.This confusion is because historical reason causes, and before 17th century, people also do not have too many understanding to fossil wood, so often these two kinds of stone class materials are lumped together, are all called Asbestus.
The existence of this homonym is bad while causing clinical efficacy fashion, and this is also this medicinal application of Asbestus main cause less and less.Due to the harm of amphibole asbestos to human body, present many countries have forbidden the use of hornblend cotton, and China also announces to forbid import and the use of hornblend cotton in July, 2007.As medicine, for ensureing the safe and effective of clinical application, also should never allow the existence of this homonym phenomenon.This knows Asbestus true and false and has brought up to an essential angle debating undoubtedly, for avoiding medication confusion, also amphibole asbestos should be distinguished from the angle of clinical application.
Recognize that the Asbestus of being really used as medicine be the material of this fossil wood class of " detailed outline " annex " or cloud pine fossil for a long time ", otherwise we will lose a valuable types of drugs.Certainly, although " detailed outline " proposed the saying of " Asbestus has two kinds, lifeless thing " and " or cloud pine fossil for a long time ".But modern document is only called Asbestus by amphibole asbestos mostly, due to this Asbestus can not be antipruritic can only be to itching, cause the modern clinic dare not external.
The present invention Asbestus used belongs to the fossil wood of " or cloud pine fossil for a long time " class.
Compendium of Material Medica [Plumbum preparatium the 9th volume metal and stone three] Asbestus:
[abnormal smells from the patient] is sweet, Great Cold, nontoxic.Du Gu's flood is said: boil hydrargyrum, tie careless sand, SANHUANG, deficient five metals.
[curing mainly] miliaria alba skin ulcer, and Folium Jujubae, Calx is powder, applies it.
Radix Sophorae Flavescentis
Abnormal smells from the patient: hardship, cold, nontoxic.
Function cures mainly: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Folium Artemisiae Argyi
[source] is the dried leaves of feverfew Chinese mugwort.
[nature and flavor] are warm in nature, bitter in the mouth, pungent; Slightly poisonous.
1. not " not Lu ": bitter in the mouth, tepor, nontoxic.
2. Tang Materia Medica: raw cold, ripe heat.
3. " detailed outline ": bitter and pungent, raw temperature, ripe heat.
Cortex Moutan
[nature and flavor] are cold in nature, bitter in the mouth, pungent.
[function cures mainly] clearing away heat and cooling blood, blood circulation promoting competent silt.
Fructus Cnidii
[nature and flavor] are warm in nature, acrid in the mouth, hardship.
[function cures mainly] external treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
The Fructus Kochiae
[nature and flavor] are cold in nature, acrid in the mouth, hardship.
[function cures mainly] clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Borneolum Syntheticum
[nature and flavor] are pungent, bitter, are slightly cold.
[effect] refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.
Mentholum
For a kind of saturated cyclic alcohol obtaining in peppermint.Have another name called menthol, Mentholum.
Obtain through refining and obtain by Herba Menthae, at present also can synthetic.For colourless needle-like or prism-shaped crystallization or white crystalline powder; Have the special aroma of Herba Menthae, taste is just scorching hot rear refrigerant.
[function cures mainly]: aromatic drug, remedium corrigens and carminative.The main chafe mucosa of function, in antipruritic, antiinflammatory, pain relieving, part has cool feeling.Clinical in pain, inflammation and swelling.
Oleum Caryophylli
[nature and flavor] acrid in the mouth; Sweet; Hot in nature.
Technical scheme of the present invention realizes in the following manner according to above medicinal property, a kind of YAOSHI formula for the treatment of intractable pruritus, and the composition of this formula mainly comprises the Asbestus of stone class medicine.
This formula also comprises through simmering more than one the blending constituent in the Radix Sophorae Flavescentis that enters after processing in Asbestus, Folium Artemisiae Argyi, Cortex Moutan, Fructus Cnidii, the Fructus Kochiae, Borneolum Syntheticum, Mentholum, Oleum Caryophylli.
This formula is made up of the composition of following weight portion proportioning:
10~500 parts of Asbestuss; 0~50 part of Radix Sophorae Flavescentis; 0~50 part of Folium Artemisiae Argyi;
0~50 part of Cortex Moutan; 0~50 part of Fructus Cnidii; 0~50 part of the Fructus Kochiae;
0~50 part of Borneolum Syntheticum; 0~50 part of Mentholum; 0~50 part of Oleum Caryophylli.
The another kind of proportioning of this formula is made up of the composition of following weight portion proportioning:
50~300 parts of Asbestuss; 2~10 parts of Radix Sophorae Flavescentiss; 2~10 parts of Folium Artemisiae Argyis;
1~20 part of Cortex Moutan; 2~30 parts of Fructus Cnidiis; 2~30 parts of the Fructus Kochiae;
1~30 part of Borneolum Syntheticum; 1~40 part of Mentholum; 1~20 part of Oleum Caryophylli.
The optimization proportioning of this formula is to be made up of the composition of following weight portion proportioning:
50~200 parts of Asbestuss; 3~5 parts of Radix Sophorae Flavescentiss; 3~5 parts of Folium Artemisiae Argyis;
2~6 parts of Cortex Moutans; 3~20 parts of Fructus Cnidiis; 3~20 parts of the Fructus Kochiae;
3~6 parts of Borneolum Syntheticums; 3~6 parts of Mentholums; 2~5 parts of Oleum Caryophyllis.
The preparation method of the YAOSHI formula of this treatment intractable pruritus is first by for subsequent use Asbestus pretreatment, then by Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Cortex Moutan, Fructus Cnidii, the Fructus Kochiae, Borneolum Syntheticum, Mentholum, Oleum Caryophylli pretreatment, again Asbestus is mixed with above-mentioned pretreated composition and be placed on 45 ± 5 DEG C of condition lower seals and simmer and process, finally be placed in not higher than preserving under the condition of 15 DEG C, obtain finished product.
The pretreatment of described Asbestus is first by the Asbestus shaping by stock removal of obtaining and grinding process surface; repeatedly rinse with clear water; then be placed in clear water and often change water soaking 5~10 days; after taking-up, again clean; after drying, use again 75% alcohol-pickled 2~5 days, be finally placed in clear water and boil to take out for 30~60 minutes and dry.
The pretreatment of described Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Cortex Moutan, Fructus Cnidii, the Fructus Kochiae, Borneolum Syntheticum, Mentholum, Oleum Caryophylli is first Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Cortex Moutan, Fructus Cnidii, the Fructus Kochiae to be pulverized separately to 80 mesh sieves, according to formulation ratio, the Radix Sophorae Flavescentis powder that sifts out, Folium Artemisiae Argyi powder, Cortex Moutan powder, Fructus Cnidii powder, the first equal portions of Fructus Kochiae powder are progressively increased to mix and mixed with Oleum Caryophylli, then with Borneolum Syntheticum, the Mentholum equal portions mixing and stirring of progressively increasing.
The beneficial effect that the present invention compared with prior art produced is:
YAOSHI formula for the treatment of intractable pruritus of the present invention and preparation method thereof, mainly antipruritic by YAOSHI. the characteristic of cold and cool and absorption, safety, effectively, impel fast body surface sufferer skin to recover normal, pass through observation on Clinical Application, this YAOSHI can not produce untoward reaction to skin histology, the effect of the skin pruritus that many factors is caused and the quick removing of swelling and ache, having the YANG toxin syndrome of suction element goes out. damp eliminating heat extraction, detoxifying and relieving itching, effect of reducing swelling and alleviating pain, the clinical eczema dermatosis that the reasons such as damp and hot poison are caused, fungoid dermatosis, bacterial furuncle and phyma, the pruritus that the herpes zoster that virus causes and steroid-dependent dermatitis and mosquito bite cause has itching-relieving efficacies fast.
The present invention's reason evident in efficacy is: Asbestus of the prior art still external for oral administration or other prescriptions are all that levigation uses.As external, levigation has destroyed the fine pore space structure of Asbestus, and the absorption of Asbestus and cold and cool property are weakened, can not be wet. heat. and poison etc. is gone out from skin internal adsorption.The present invention has kept the solid state of Asbestus, utilizes the power of absorption of Asbestus and cold and cool property to adsorb to invade wet, the heat of skin histology, poison to go out.Wet, heat, poison are gone out to need a time course from body internal adsorption, but removing pruritus is the task of top priority, so first other drug is placed in stone, its objective is anxious its mark of first controlling, utilize the itching-relieving efficacies of other medicines, first remove the hardship of pruritus, in releasing pruritus, utilize absorption and the cold and cool time that property absorption is wet, hot, poison is gone out a radical treatment in chronic case to Asbestus.After wet, heat, poison are adsorbed and go out, the microecological balance of skin surface part is restored, so pruritus no longer.
The YAOSHI that the present invention configures has no side effect to body surface organization, easily suffer from pruritus and be difficult for the people who recovers for some, pruritus from the beginning of, use immediately, can play the effect checking erroneous ideas at the outset, go out for the adsorbable toxin of obstinate pruritus patient, Quick itch stopping, has advantages of and does not recur.There is great clinical value at substitute antibiotics and hormone medicine in the application aspect of body surface disease.Compared with Asbestus levigation being used with other prescriptions, have absorption affinity strong, not pollution clothes, can repeated multiple timesly use, safety, and economy, being easy to penetration and promotion is its feature, is the product of a kind of family indispensability.
Use medicine and the Therapeutic Method of the traditional Chinese medical science, in especially using, YAOSHI therapy reduces the effective means of antibiotic and hormone medicine application just, is a kind of new therapy for the treatment of body surface pruritus disease that uses theory of Chinese medical science to form in practice.The medicine of this formula and unique preparation method thereof, giving the strong support of middle YAOSHI therapy aspect treatment body surface disease especially, ensured that the safety of clinical application treatment is with effective.
Detailed description of the invention
Below in conjunction with embodiment, a kind of YAOSHI formula for the treatment of intractable pruritus of the present invention and preparation method thereof is described in detail below.
Embodiment 1:
The YAOSHI formula for the treatment of intractable pruritus of the present invention is:
350 grams of Asbestuss; 20 grams of Radix Sophorae Flavescentiss; 20 grams of Folium Artemisiae Argyis;
20 grams of Cortex Moutans; 20 grams of Fructus Cnidiis; 20 grams of the Fructus Kochiae;
10 grams of Borneolum Syntheticums; 10 grams of Mentholums; 7 grams of Oleum Caryophyllis.
The preparation method of this YAOSHI is first Asbestus to be carried out to pretreatment: the definite shape that the Asbestus cutting grinding process obtaining is become to meet to the states such as human body application, external application, clamping, after repeatedly rinsing with clear water, be placed in clear water and constantly change water soaking 5~10 days, after soaking, take out again and clean, dry rear use 75% two days later alcohol-pickled, be placed in clear water and boil taking-up oven dry in 30~60 minutes.To first Radix Sophorae Flavescentis, Folium Artemisiae Argyi, Cortex Moutan, Fructus Cnidii, the Fructus Kochiae be pulverized separately again to 80 mesh sieves, according to formulation ratio, the Radix Sophorae Flavescentis powder that sifts out, Folium Artemisiae Argyi powder, Cortex Moutan powder, Fructus Cnidii powder, the first equal portions of Fructus Kochiae powder are progressively increased to mix and mixed with Oleum Caryophylli, then with Borneolum Syntheticum, the Mentholum equal portions mixing and stirring of progressively increasing.The sealing of mixing homogeneously with Asbestus is placed in 45 ± 5 DEG C of stewings and processs.Asbestus sealing after finally stewing being processed, sealing adopts sealed plastic bag, is placed in 15 DEG C and saves backup below, obtains finished product.
Embodiment 2:
The optimization of C/C composites of the YAOSHI formula for the treatment of intractable pruritus of the present invention is:
250 grams of Asbestuss; 8 grams of Radix Sophorae Flavescentiss; 8 grams of Folium Artemisiae Argyis;
8 grams of Cortex Moutans; 15 grams of Fructus Cnidiis; 15 grams of the Fructus Kochiae;
5 grams of Borneolum Syntheticums; 5 grams of Mentholums; 5 grams of Oleum Caryophyllis.
The preparation method of this YAOSHI optimization of C/C composites is identical with the preparation method of embodiment mono-.
Embodiment 3:
The optimum formula of the YAOSHI formula for the treatment of intractable pruritus of the present invention is:
180 grams of Asbestuss; 4 grams of Radix Sophorae Flavescentiss; 4 grams of Folium Artemisiae Argyis;
4 grams of Cortex Moutans; 10 grams of 10 grams of Fructus Kochiae of Fructus Cnidii;
3 grams of Borneolum Syntheticums; 3 grams of Mentholums; 2 grams of Oleum Caryophyllis.
The preparation method of this YAOSHI optimum formula is identical with the preparation method of embodiment mono-.
This YAOSHI using method: this YAOSHI preparing is directly positioned over to the body surface position of pruritus, rubs gently friction.
Clinical therapeutic efficacy:
For verifying the curative effect of this YAOSHI, to being caused that by mosquito bite 50 routine patients of pruritus have carried out and scratched antipruritic self application contrast experiment with hands.And carried out the treatment of some other pruritus diseases, wherein treat the obstinate pruritus Disease of body surface 90 examples.Clinical efficacy makes considerable, and the stone class medicine of recording in this ancient doctor's nationality of Asbestus has been had to understanding again.
By clinical 50 examples, by mosquito bite patient's own control application verification, the therapeutic effect of the distant method of middle YAOSHI has reached 98%.Only have 18% and scratch antipruritic effect with hands, because having reached 22% with the antipruritic ulceration infection rate causing of hands scratching.The expansion application experiment carrying out on this basis, through the treatment of 90 routine obstinate pruritus Diseases is summed up, according to curative effect determinate standard, the total effective rate that middle YAOSHI is treated has reached 85.6%.
Criterion of therapeutical effect: because the object of observation is obstinate pruritus patient, so formulate voluntarily criterion of therapeutical effect, observe so that unified.Treat and be limited for 5 days, all disappearance person is for fully recovering for disease, and obviously alleviator, for taking a turn for the better, is invalid without obvious changer.
In patient's 90 examples, the elder of medical history is for 10 years, and the shortest person 2 years, is and uses existing multiple medical treatment nonresponder, and wherein male's 56 examples, account for 62%, and women's 34 examples account for 38%, the age between 35~67 years old, 51 years old mean age.
Wherein:
1, Wang Min, female, 47 years old, peasant.On July 17th, 2005 goes to a doctor, and private prosecution is suffered from fungoid skin pruritus 2 years, causes left side to tuck in nest position redness owing to often scratching. ulceration, and patient is reflected acute pruritus, and with obvious scorching hot and pain.Due to household economy difficulty, before 2 years, after examination in hospital is made a definite diagnosis, never had regular treatment.Sometimes cannot stand and have to use folk prescription Folium Artemisiae Argyi. Pericarpium Zanthoxyli. salt, decocting in water is scalded, bad when fashion, and outbreak is frequent recently.According to patient's situation, advise patient to use medicine of the present invention, YAOSHI is folded in and tucks in nest position in bed.With stone treatment time must not be lower than two hours.Use two days later, patient's redness disappears, ulceration incrustation, and pruritus obviously alleviates.Advise and continue to use, after 5 days, further consultation informs that pruritus and pain sense disappear.As sense pruritus, not antipruritic with hands scratching after advising patient to go home, as long as sensation pruritus treats according to this method.Within 2008, pay a return visit, patient is without recurrence.
2, Zhang Yunhua, female, 35 years old, civil servant.In May, 2007 is medical, and cervical region is by mosquito bite in the time that reservoir is swum summer in 2006 for patient's private prosecution, and pruritus unbearably, occurring red and swollen ulceration through scratching skin, there is bunch shape vesicle in periphery, and the place of scratching has yellow limpid liquid to ooze out, and stretch to shirtfront back fast, with obvious scorching hot and pain.Be diagnosed as and infect the eczematoid dermatitis causing.After treatment by Chinese herbs, turn for the better by and large, but do not healed by mosquito bite place always, use afterwards PIYANPING to smear affected part, due to prolonged application, cause dependency, medication number of times showed increased.Advise patient's PIYANPING of stopping using, use medicine of the present invention, the same day, affected part rubbed friction three times, and pruritus symptom obviously disappears, and through with after 4 days, affected part incrustation is healed.
3, Liu Chuanzhen, man, 48 years old.First visit in May, 2006, patient's private prosecution was suffered from vulval eczema with nearly ten years, outbreak repeatedly recently, night-time attack is frequent, and walking produces frictional property pain.There is obvious symmetry ulceration patient's pudendum and both legs inner side on inspection, the red class of redness and pimple sample.According to the medication history of patient's life-time service antibiotic and hormone medicine, tentative diagnosis is that eczema pudendal pruritus merges the steroid-dependent dermatitis that life-time service hormone medicine causes.After advising it to go home, in bed YAOSHI is placed between pudendum two lower limbs, standing time must not be less and two hours, then smears affected part with the medicine of simmering stone residue, and maintenance medication every day is more than 3 times.Treatment pruritus through 1 day obviously alleviates, and continuous use is its pruritus disappearance after 5 days, affected part incrustation.More of a specified duration according to patient's sick time, for consolidating curative effect, require patient to continue every night to use YAOSHI after treatment January, the treatment number of times that then progressively successively decreases, observed drug withdrawal to 3rd month.Treatment finishes later six months follows up a case by regular visits to, and status of patient is good, follows up a case by regular visits to altogether 5 times in November, 2009, and patient is without recurrence.
Table 1: middle YAOSHI therapy contrasts with self applying of hands scratching antipruritic effect
Contrast method |
Excellent |
Superior rate (%) |
Good |
Acceptance rate (%) |
Infect |
Infection rate (%) |
The antipruritic time (min) |
Middle YAOSHI is treated |
32 |
64 |
17 |
98 |
1 |
2 |
13 |
In scratching |
- |
- |
9 |
18 |
11 |
22 |
20 |
Contrast difference |
-- |
- |
8 |
90 |
10 |
20 |
7 |
Table 2: the clinical effectiveness statistical table of the obstinate pruritus dermatosis of middle YAOSHI therapy external treatment
Disease |
Number of cases |
Recovery from illness number |
Good revolution |
Invalid number |
Effective percentage (%) |
Wet treasure's property pruritus genitalium |
41 |
12 |
21 |
8 |
80.5 |
Fungoid skin pruritus |
38 |
9 |
25 |
4 |
89 |
Steroid-dependent dermatitis |
11 |
3 |
7 |
1 |
91. |
Total routine rate (%) |
90 |
26.6 |
59 |
14.4 |
85.6 |
Discuss: scratch self applying of antipruritic 50 examples by middle YAOSHI therapy and hands and contrast, and observation on Clinical Application to 90 routine intractable pruritus, can recognize, antipruritic with hands scratching, owing to cannot causing the wet of pruritus. heat. the materials such as poison are got rid of external, thus grab and more itch, and easily cause ulceration and the infection of skin, result has to use antibiotic and hormone medicine treatment, so that form more serious dermatosis.And the method for passing through YAOSHI is antipruritic, utilize the characteristic of the cold and cool of YAOSHI and absorption, can be by wetting in body. heat. poison etc. is adsorbed onto external to the material of itching, played the effect of removing burning wood away under the boiler.Its result shows: treat the prescription drug of external treatment as middle YAOSHI, the curative effect of this YAOSHI is better than the therapeutic effect of other method.There is unique effect, and safety is good, has no side effect.Aspect the treatment of the obstinate pruritus disease of body surface, alternative or reduce the use of antibiotic and hormone medicine, can not produce dependency.
The pruritus symptom at people's body surface position, due to body void mostly, skin space between skin and muscles does not cause exopathogen wet admittedly. heat. and poison (comprises multiple pathogenic microorganism, as antibacterial. fungus etc.) invasion and attack are detained outbreak between skin space between skin and muscles and cause, outbreak severe patient is very itched incomparably, causes very big harm to people's psychosoma.Malpractice, life-time service antibiotic and hormone medicine can cause again Drug resistance and hormone to rely on the generation of the toxic and side effects such as dermatitis, so that medication is invalid, outbreak repeatedly.Use YAOSHI of the present invention, its reason is: symptomatic treatment in acute condition, it is damp and hot in order to dispel using Chinese medicine.By Asbestus and the medicine method of processing by stewing that is sealed, make drug osmotic in Asbestus after, when Asbestus is contacted with affected part, due to the effect of body temperature, medicine from stone release action to affected part, thereby play the effect of Quick itch stopping.And use the reason of Asbestus to be: radical treatment in chronic case, stopping after pruritus, because this stone is cold, there is the power of dry absorption, in the time of contact affected part, utilize cold and cool dry property on the one hand, dispel damp and hot, the property that the most important thing is the absorption that utilizes Asbestus is adsorbed onto the heresy of the delay between skin space between skin and muscles external, to reach the final purpose of getting rid of evils and curing the disease.