CN101822857B - Medicinal instrument combined electric pulse generation and lead-in device - Google Patents
Medicinal instrument combined electric pulse generation and lead-in device Download PDFInfo
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- CN101822857B CN101822857B CN201010139305.2A CN201010139305A CN101822857B CN 101822857 B CN101822857 B CN 101822857B CN 201010139305 A CN201010139305 A CN 201010139305A CN 101822857 B CN101822857 B CN 101822857B
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Abstract
The invention discloses a medicinal instrument combined electric pulse generation and lead-in device. On the one hand, an injection medicament and an electric pulse excitation are combined together to finish injection, so a patient is only subjected to one-time needle injection; and on the other hand, a needle and an electric pulse generation device are integrated and miniaturized to facilitate carrying and convenient operation. The invention adopts the technical scheme that an electric pulse generation assembly and an electric pulse lead-in assembly are arranged in the same device, and the electric pulse generation assembly is miniaturized by using a direct-current power supply so that the device is convenient to carry and the use convenience of the device is improved. On another hand, an injection needle and an electric pulse lead-in needle are arranged together so that a medicament injection process and a lead-in process of electric pulse signals are integrated.
Description
Technical field
The present invention relates to a kind of medical instruments coupling apparatus, relate in particular to a kind of realization medicine importing and electric pulse are imported to the device combining.
Background technology
DNA vaccination is that the exogenous gene of certain antigen protein of coding is directly imported in human or animal's somatic cell, and by the expression system synthetic antigen albumen of host cell, the create antagonism immunne response of former albumen of induction host, to reach the object of prevention and treatment disease.Compare with subunit protein vaccine with traditional attenuated vaccine, the advantage such as DNA vaccination possesses skills wider, and Study On Cellular Immune is more obvious, thereby the exploitation of therapeutic DNA vaccine is an important channel of following clinical treatment.
But because the importing of DNA vaccination is low, objectively affected the performance of vaccine effect.Therefore to give full play to the function of DNA vaccination, also must improve the importing efficiency of vaccine to reach the effect that improves its immune performance.Based on electric field, can on cell membrane, form instantaneous reversible micropore, this makes, by the method for electroporation, gene and other molecules injection living cells are become to possibility: gene or other molecules are injected to cell or tissue, and apply electric field, the many apertures of instantaneous formation on cell membrane, so gene or molecule just enter cell.Utilizing electric pulse to carry gene is the potential technology of current very tool, and current electrical pulse device exists following shortcoming: (1) cannot generate electric pulse and the pulse combined thereof of arbitrary form; (2) cannot whether load electrode be come off and be detected; (3) user cannot be learnt the pulse parameter loading in present load.
In order to overcome the shortcoming of traditional electrical pulser, applicant in July, 2007 10Xiang Patent Office of the People's Republic of China submitted the patent application that application number is 200710043612.9, denomination of invention is " a kind of electroporation leading-in apparatus of medicine " to, and on January 14th, 2009 open (publication number is CN 101342390A).
This application discloses a kind of electroporation leading-in apparatus of medicine, has improved the importing effect of vaccine medicine, has reduced the use amount of medicine, reduces the untoward reaction of medicine.Its technical scheme is: electroporation leading-in apparatus, medicine is imported to target tissue by low-frequency electric pulse, and comprising: pulse arranges module, receive the electric pulse parameter of user's input; Power module, produces a DC signal; Microcontroller, received pulse arranges the electric pulse parameter of module, according to electric pulse parameter, exports a control signal; Pulse generate module, receives the control signal that microcontroller is exported, and the DC signal that this power module is supplied with is processed into electric impulse signal output; Load, the electric impulse signal of received pulse generation module output.
The method of applying this electroporation leading-in apparatus is that injectable drug and electrode importing are two steps of separating, that is: first with injection needle, carry out drug injection, use again the syringe needle (namely load) of this electroporation leading-in apparatus, the electric pulse that device is produced imports in the tissue that receives drug injection, is beneficial to medicine and enters more smoothly histiocyte.
The weak point of above-mentioned gatherer and introduction method is: (1) need to carry out double injection for patient, that is: for the first time by injection needle to its injectable drug, be that the electric pulse output syringe needle by electroporation leading-in apparatus carries out the stimulation of electric pulse to it for the second time.Patient must bear the misery of twice needle injection.(2) electric pulse generator is bulky, and importing syringe needle with electrode is the design of separate type, and inconvenience is carried.
Summary of the invention
The object of the invention is to address the above problem, provide a kind of electric pulse of medical instruments combination to generate and gatherer, on the one hand injectable drug and electric pulse stimulation have been combined, concerning patient, only need stand one time needle injection, the equipment that makes on the other hand syringe needle and electric pulse generate is integrated, miniaturization, be convenient to carry handled easily.
Technical scheme of the present invention is: the electric pulse that the present invention has disclosed a kind of medical instruments combination generates and gatherer, comprising:
Electric pulse formation component, generates electric impulse signal;
Electric pulse imports assembly, and this electric pulse formation component is connected to the end that this electric pulse imports assembly, and the electric impulse signal generating is imported to objective for implementation, and it further comprises:
Shell;
Slot electrode, is positioned on the pedestal of this shell front end, by electric conductance post, is connected with electric pulse formation component, receives the electric impulse signal of this electric pulse formation component output;
Syringe needle group, be positioned at this shell foremost, the several electrodes that comprise an injection needle and periphery import syringe needle, this injection needle and this several electrodes import syringe needle and are all connected with this slot electrode, the electric impulse signal that wherein this several electrodes importing syringe needles reception is conducted by this slot electrode enters to implement electric conductance, and this injection needle is for injectable drug;
Medicine pen core, be positioned at this shell, the inner several drug injections unit forming a line of installing of this medicine pen core, between this several drug injections unit, with reverse wedge piece installing, connect, the front end of this several drug injections unit all has injection orifice, the injection orifice that is wherein positioned at this medicine pen core drug injection unit foremost communicates with this injection needle, rear end outside medicine pen core is provided with syringe pushing ram, be connected with the drug injection unit that is positioned at medicine pen core least significant end, promotion by this syringe pushing ram to this drug injection unit of least significant end in this medicine pen core, push continuously those reverse wedge piece installings so that the drug injection unit that completes injection is released, next one drug injection unit to be injected is shifted onto simultaneously this medicine pen core foremost and its injection orifice communicate with this injection needle.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, this electric pulse formation component further comprises:
Power module, generates running voltage and driving voltage the output respectively of direct current form;
Operation-interface, receives the electric pulse parameter that user inputs;
Microcontroller, connects this operation-interface, according to this electric pulse parameter, exports a control signal;
Pulse generate module, connects this power module and this microcontroller, after the driving voltage of the direct current form of this power module being supplied with according to this control signal of this microcontroller is processed into electric impulse signal, exports.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, this power module further comprises:
DC source, provides initial DC voltage;
The first booster circuit, connects this DC power supplier, and initial DC voltage is boosted to the first driving voltage;
The first mu balanced circuit, connects this first booster circuit, receives this first driving voltage and it is carried out to voltage stabilizing operation;
The second booster circuit, connects this DC power supplier, and initial DC voltage is boosted to the second driving voltage;
The second mu balanced circuit, connects this second booster circuit, receives this second driving voltage and it is carried out to voltage stabilizing operation;
Reduction voltage circuit, connects this DC power supplier, and initial DC voltage is depressurized to running voltage;
The 3rd mu balanced circuit, connects this reduction voltage circuit, receives this running voltage and it is carried out to voltage stabilizing operation.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, this electric pulse formation component also comprises:
The detection module that comes off, connects this pulse generate module and this microcontroller, and the electric impulse signal that electrode is imported on syringe needle is sampled, and sampled signal is sent into this microcontroller and judge;
Pulse display module, connects this microcontroller, receives the electric pulse parameter of this microcontroller output, on a display screen, is shown to user.
Memory module, connects this microcontroller, stores the electric pulse parameter of this microcontroller output.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, the scope of the crest voltage of the electric pulse of this electrode importing syringe needle output is 20～200V.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, this electric pulse imports assembly and also comprises:
Tip protection part, imports syringe needle for the protection of this injection needle in this syringe needle group and this several electrodes, and this Tip protection part further comprises:
Protection pin cap, by the identical monomer pin cap of several shapes that import syringe needle with this injection needle and this several electrodes is integrated, form, the arrangement mode of those monomer pin caps is identical with the arrangement mode of each syringe needle in this syringe needle group, this protection pin cap and this syringe needle group phase buckle closure;
Protection needle guard, covers the periphery that buckle closure has this syringe needle group of protection pin cap.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer; this Tip protection part, this slot electrode and this syringe needle group connect into cap dress integral piece jointly, and this cap dress integral piece is detachable being connected with the shell of this electric pulse gatherer.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, this cap dress integral piece is that spiral is connected with this shell.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, drug injection unit all in this medicine pen core complete after injection, and this cap dress integral piece is removed that medicine pen core is installed again in this shell.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, the inner shell of this several drug injections unit all has the soft draw-in groove with drug injection unit self identical length.
According to the electric pulse generation of medical instruments combination of the present invention and an embodiment of gatherer, this reverse wedge piece installing is the parts that rubber is made.
The present invention contrasts prior art following beneficial effect: technical scheme of the present invention is by electric pulse formation component and electric pulse importing assembly are arranged in same equipment, and miniaturization electric pulse formation component, make it easy to carry, improved the convenience that equipment is used.On the other hand, the present invention is installed together injection needle and electric pulse importing syringe needle, and the importing process of medicament injection process and electric impulse signal is combined together.
Accompanying drawing explanation
Fig. 1 be electric pulse of the present invention generate and the embodiment of gatherer in the module map of part of relevant electric pulse formation component.
Fig. 2 is the refinement module map of the power module in part shown in Fig. 1.
Fig. 3 is the internal structure schematic diagram of the embodiment of electric pulse generation of the present invention and gatherer.
Fig. 4 is the schematic diagram of Tip protection part and syringe needle group buckle closure.
Fig. 5 is the schematic diagram of drug injection unit.
Fig. 6 is the schematic diagram of syringe pushing ram.
Fig. 7 is the schematic diagram of medicine pen core.
Fig. 8 is the schematic appearance of Fig. 3 embodiment.
The specific embodiment
Below in conjunction with drawings and Examples, the invention will be further described.
Please, first referring to Fig. 8, Fig. 8 shows the outward appearance of the electric pulse generation of medical instruments combination of the present invention and the embodiment of gatherer.Front end at device is provided with protection pin cap; end mounting of syringe pushing ram at device; display screen and some buttons are set on the surface of second half section of device, on button, have " beginning " key, " stopping " key and for selecting " 60V " of voltage swing and the button of " 36V ".
Device can be divided into two parts assembly function: for generating the electric pulse formation component of electric impulse signal and importing assembly for electric impulse signal being imported to the electric pulse of objective for implementation.It is the very important inventive point of the present invention that these two assemblies are combined in same device.
The explanation to electric pulse formation component below.Fig. 1 shows the principle of electric pulse formation component.Electric pulse formation component comprises following module: operation-interface 60, power module 61, microcontroller 62, pulse display module 63, pulse generate module 64, the detection module 65 that comes off, memory module 66.Annexation between these modules is: the output of operation-interface 60 connects the input of microcontroller 62, the two-way output of power module 61 is connected respectively to the input of microcontroller 62 and the input of pulse generate module 64, the two-way output of microcontroller 62 is connected respectively to the input of pulse display module 63 and the input of pulse generate module 64, the input of detection module 65 of coming off connects the output of pulse generate module 64, the output of detection module 65 of coming off connects the input of microcontroller 62, the connection of setting up transmitted in both directions between memory module 66 and microcontroller 62.
Operation-interface 60 receives the electric pulse parameter of user's input, that is to say, the parameters of the electric impulse signal that device generates is all that user is adjustable.The waveform that finally exports the electric impulse signal of objective for implementation to is the symmetrical unidirectional continuous impulse ripple that triggers, the way of output can be to trigger output, that is presses and once trigger key, output pulsatile once ripple, the pulse number discharging is 1～20, and the pulse spacing is 1～100ms.The pulse frequency of output can be arranged on 1～50Hz ± 15%, and the pulse width of output can be arranged on 9.5ms～50ms ± 30%, and the output crest voltage that electrode imports syringe needle maximum can be arranged on 20V～200V, and error is ± 10%.
If the outward appearance of operation-interface is as shown in Figure 8 to select electrode to import the output crest voltage of syringe needle by the voltage button of 36V and 60V, if so, illustrate that so other parameters of electric impulse signal are fixed up, user cannot change.Certainly, can open more parameter and be gone to control by user, can on the surface of device, button or the knob that regulates these parameters be set accordingly.
Microcontroller 62 receives after the electric pulse parameter of user's input, according to electric pulse parameter, generates control signal, exports pulse generate module 64 to.
In pulse generate module 64, the driving voltage of the direct current form providing based on power module 61, exports after being processed into electric impulse signal.In this example, because driving voltage only has the unidirectional current of 36V and 60V, when operation-interface 60 receive be the push button signalling of 36V time, the reference signal of pulse generate module 64 is exactly the unidirectional current of 36V, when operation-interface 60 receive be the push button signalling of 60V time, the reference signal of pulse generate module 64 is exactly the unidirectional current of 60V.The electric impulse signal of output need to import assembly through electric pulse could enter objective for implementation smoothly.
The electric impulse signal that the 65 pairs of electrodes of detection module that come off import on syringe needle is sampled, and sampled signal is sent into microcontroller 62.Whether extremely microcontroller 62 judges that according to feedback signal electrode imports syringe needle and whether from objective for implementation, comes off.
In addition, memory module 66 is responsible for storage data, and these data comprise the parameter of electric impulse signal or from the physiological parameter of objective for implementation etc.Memorizer 66, except receiving data storage wherein, can also arrive microcontroller 62 by the data importing being stored in wherein.
The description that electric pulse imports assembly below.
Fig. 3 shows the structure of embodiment of the electric pulse gatherer of medical instruments combination of the present invention.Refer to Fig. 3, the electric pulse of the present embodiment imports assembly and comprises following parts: Tip protection part 1, injection needle 2, electrode import syringe needle 3, slot electrode 4, medicine pen core 5, introducing apparatus shell 6.Wherein, Tip protection part 1 belongs to selectable unit (SU).In addition, in electric pulse formation component 10, operation-interface 7 and power module 11 are also shown in Fig. 3.
Annexation between these parts is: slot electrode 4 is positioned on the pedestal of shell 6 front ends, and delivery outlet 9 electric connections by the electric pulse generator outside electric conductance post 7 and device, receive electric impulse signal.Injection needle 2 forms syringe needle group together with importing syringe needle 3 with a plurality of electrodes, and injection needle 2 is in centre conventionally, and these electrodes import syringe needle 3 in surrounding's distribution of injection needle 2.Injection needle 2 imports syringe needle 3 with electrode and is all connected with slot electrode 4.Medicine pen core 5 is as shown in Figure 5 positioned at shell 6, a plurality of drug injections unit 50 as shown in Figure 3 (being shown in the drawings 4) forming a line is equipped with in inside, between these drug injection unit 50, for example, by reverse wedge piece installing 52 (being the parts that rubber is made), interconnects.The front end of each drug injection unit 50 all has injection orifice, and the injection orifice that is positioned at medicine pen core drug injection unit 50 foremost communicates with injection needle 2.All there is the soft draw-in groove with drug injection unit self identical length at the inner shell place of drug injection unit 50.End at medicine pen core 5 is provided with syringe pushing ram 51 as shown in Figure 4, is connected with the drug injection unit 50 that is positioned at medicine pen core least significant end.It is relations of phase buckle closure that Tip protection part 1 imports syringe needle 3 with injection needle 2 and electrode.
Please be simultaneously referring to Fig. 4, Tip protection part 1 comprises two independently parts: protection pin cap 100 and protection needle guard 102.Protection pin cap 100 is consistent with the shape that these injection needles 2 and electrode import syringe needle 3; that is: the integral structure that protection pin cap 100 is comprised of several monomer pin caps; wherein the arrangement mode of monomer pin cap is identical with the arrangement mode of each syringe needle in syringe needle group, protection pin cap 100 and syringe needle group phase buckle closure.Protection needle guard 102 the has covered buckle closure periphery of syringe needle group of protection pin cap 102.In the present embodiment; Tip protection part 1, slot electrode 4 and syringe needle group (comprising that injection needle 2 and electrode import syringe needle 3) connect into cap dress integral piece jointly; cap dress integral piece is detachable being connected with the shell 6 of electric pulse gatherer, for example spiral connection.
During per injection, rely on the promotion of syringe pushing ram 51 to complete a shot, drug injection unit 50 moves forward through the promotion of syringe pushing ram 51, and the medicine in drug injection unit 50 foremost enters human body by injection orifice and injection needle 2.By 2 pairs of human bodies of injection needle, undertaken in the process of drug injection, electrode imports syringe needle 3 and also by the electric pulse of collecting electrode groove 4 conduction, human body enforcement electric pulse is imported together.Thereby realized drug injection and the target tissue such as the electric pulse stimulation receptor muscle that accompanies with it promotes that medicine imports synchronously carries out, strengthened therapeutic effect.In addition,, by the electric pulse generator of gatherer outside, can realize adjustability and the controllability of the leading-in technique parameters such as electric pulse waveform.After completing a shot, first used cap dress integral piece is taken off, continue pushing syringe pushing ram 51, until being originally pushed out in drug injection unit foremost and drug injection unit 50 is below pulled to after the front end of medicine pen core 5, again reinstall cap dress integral piece, realize the injection and the importing that continue, repeat said process, until the drug injection unit 50 in medicine pen core 5 is all released, again change medicine pen core 5.
One aspect of the present invention imports syringe needle by injection needle and electrode and is set together, and has realized drug injection and the target tissues such as electric pulse stimulation receptor muscle that accompany with it promote synchronously carrying out in medicine transfered cell, has alleviated patient's misery.Medicine pen core is disposable use, sealing and interchangeable on the other hand, and drug injection unit has wherein guaranteed the degree of accuracy of drug dose.
Above-described embodiment is to provide to those of ordinary skills and realizes or use of the present invention; those of ordinary skills can be without departing from the present invention in the case of the inventive idea; above-described embodiment is made to various modifications or variation; thereby protection scope of the present invention do not limit by above-described embodiment, and it should be the maximum magnitude that meets the inventive features that claims mention.
Claims (11)
1. the electric pulse of medical instruments combination generates and a gatherer, comprising:
Electric pulse formation component, generates electric impulse signal;
Electric pulse imports assembly, and this electric pulse formation component is connected to the end that this electric pulse imports assembly, and the electric impulse signal generating is imported to objective for implementation, and it further comprises:
Shell;
Slot electrode, is positioned on the pedestal of this shell front end, by electric conductance post, is connected with electric pulse formation component, receives the electric impulse signal of this electric pulse formation component output;
Syringe needle group, be positioned at this shell foremost, the several electrodes that comprise an injection needle and periphery import syringe needle, this injection needle and this several electrodes import syringe needle and are all connected with this slot electrode, the electric impulse signal that wherein this several electrodes importing syringe needles reception is conducted by this slot electrode enters to implement electric conductance, and this injection needle is for injectable drug;
Medicine pen core, be positioned at this shell, the inner several drug injections unit forming a line of installing of this medicine pen core, between this several drug injections unit, with reverse wedge piece installing, connect, the front end of this several drug injections unit all has injection orifice, the injection orifice that is wherein positioned at this medicine pen core drug injection unit foremost communicates with this injection needle, rear end outside medicine pen core is provided with syringe pushing ram, be connected with the drug injection unit that is positioned at medicine pen core least significant end, promotion by this syringe pushing ram to this drug injection unit of least significant end in this medicine pen core, push continuously those reverse wedge piece installings so that the drug injection unit that completes injection is released, next one drug injection unit to be injected is shifted onto simultaneously this medicine pen core foremost and its injection orifice communicate with this injection needle.
2. the electric pulse of medical instruments combination according to claim 1 generates and gatherer, it is characterized in that, this electric pulse formation component further comprises:
Power module, generates running voltage and driving voltage the output respectively of direct current form;
Operation-interface, receives the electric pulse parameter that user inputs;
Microcontroller, connects this operation-interface, according to this electric pulse parameter, exports a control signal;
Pulse generate module, connects this power module and this microcontroller, after the driving voltage of the direct current form of this power module being supplied with according to this control signal of this microcontroller is processed into electric impulse signal, exports.
3. the electric pulse of medical instruments combination according to claim 2 generates and gatherer, it is characterized in that, this power module further comprises:
DC source, provides initial DC voltage;
The first booster circuit, connects this DC power supplier, and initial DC voltage is boosted to the first driving voltage;
The first mu balanced circuit, connects this first booster circuit, receives this first driving voltage and it is carried out to voltage stabilizing operation;
The second booster circuit, connects this DC power supplier, and initial DC voltage is boosted to the second driving voltage;
The second mu balanced circuit, connects this second booster circuit, receives this second driving voltage and it is carried out to voltage stabilizing operation;
Reduction voltage circuit, connects this DC power supplier, and initial DC voltage is depressurized to running voltage;
The 3rd mu balanced circuit, connects this reduction voltage circuit, receives this running voltage and it is carried out to voltage stabilizing operation.
4. the electric pulse of medical instruments combination according to claim 2 generates and gatherer, it is characterized in that, this electric pulse formation component also comprises:
The detection module that comes off, connects this pulse generate module and this microcontroller, and the electric impulse signal that electrode is imported on syringe needle is sampled, and sampled signal is sent into this microcontroller and judge;
Pulse display module, connects this microcontroller, receives the electric pulse parameter of this microcontroller output, on a display screen, is shown to user.
Memory module, connects this microcontroller, stores the electric pulse parameter of this microcontroller output.
5. according to the electric pulse of the medical instruments combination described in any one in claim 1-4, generate and gatherer, it is characterized in that, the scope of the crest voltage of the electric pulse of this electrode importing syringe needle output is 20～200V.
6. the electric pulse of medical instruments combination according to claim 1 generates and gatherer, it is characterized in that, this electric pulse imports assembly and also comprises:
Tip protection part, imports syringe needle for the protection of this injection needle in this syringe needle group and this several electrodes, and this Tip protection part further comprises:
Protection pin cap, by the identical monomer pin cap of several shapes that import syringe needle with this injection needle and this several electrodes is integrated, form, the arrangement mode of those monomer pin caps is identical with the arrangement mode of each syringe needle in this syringe needle group, this protection pin cap and this syringe needle group phase buckle closure;
Protection needle guard, covers the periphery that buckle closure has this syringe needle group of protection pin cap.
7. the electric pulse of medical instruments combination according to claim 6 generates and gatherer; it is characterized in that; this Tip protection part, this slot electrode and this syringe needle group connect into cap dress integral piece jointly, and this cap dress integral piece is detachable being connected with the shell of this electric pulse gatherer.
8. the electric pulse of medical instruments combination according to claim 7 generates and gatherer, it is characterized in that, this cap dress integral piece is that spiral is connected with this shell.
9. the electric pulse of medical instruments combination according to claim 7 generates and gatherer, it is characterized in that, drug injection unit all in this medicine pen core complete after injection, and this cap dress integral piece is removed that medicine pen core is installed again in this shell.
10. the electric pulse of medical instruments combination according to claim 1 generates and gatherer, it is characterized in that, the inner shell of this several drug injections unit all has the soft draw-in groove with drug injection unit self identical length.
The electric pulse of 11. medical instruments combinations according to claim 1 generates and gatherer, it is characterized in that, this reverse wedge piece installing is the parts that rubber is made.
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| CN201010139305.2A CN101822857B (en) | 2010-04-06 | 2010-04-06 | Medicinal instrument combined electric pulse generation and lead-in device |
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| CN201010139305.2A CN101822857B (en) | 2010-04-06 | 2010-04-06 | Medicinal instrument combined electric pulse generation and lead-in device |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102091370B (en) * | 2011-02-21 | 2013-03-06 | 上海大学 | Medicament automatic lead-in system with electronic stimulating function |
| CN103494607B (en) * | 2013-09-29 | 2016-03-02 | 中国人民解放军第三军医大学 | A kind of brain administration pipe laying sleeve pipe recording extracellular potential |
| WO2018210345A1 (en) * | 2017-05-18 | 2018-11-22 | Chen Wen Shiang | Apparatus for delivery of agent |
| CN113274116A (en) * | 2021-05-12 | 2021-08-20 | 香港普创生物科技有限公司 | Full-automatic electric pulse perforation syringe |
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| CN1345607A (en) * | 2000-09-30 | 2002-04-24 | 杭州泰士生物科技有限公司 | Muscle gene injection needle with electrode |
| CN1357394A (en) * | 2000-12-14 | 2002-07-10 | 上海大学 | Chinese medicine acupoint introducing method and device |
| CN100336569C (en) * | 2002-10-20 | 2007-09-12 | 浙江大学 | Electric perforating system for transdermal medication |
| CN101342390A (en) * | 2007-07-10 | 2009-01-14 | 上海塔瑞莎健康科技有限公司 | Electroporation leading-in apparatus for medicament |
| CN1678369B (en) * | 2002-07-04 | 2010-04-28 | 伊诺维奥公司 | Electro-perforation device and injection apparatus |
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| CN1345607A (en) * | 2000-09-30 | 2002-04-24 | 杭州泰士生物科技有限公司 | Muscle gene injection needle with electrode |
| CN1357394A (en) * | 2000-12-14 | 2002-07-10 | 上海大学 | Chinese medicine acupoint introducing method and device |
| CN1678369B (en) * | 2002-07-04 | 2010-04-28 | 伊诺维奥公司 | Electro-perforation device and injection apparatus |
| CN100336569C (en) * | 2002-10-20 | 2007-09-12 | 浙江大学 | Electric perforating system for transdermal medication |
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