CN102526888A - Cell excitation treatment instrument for cardiovascular diseases - Google Patents
Cell excitation treatment instrument for cardiovascular diseases Download PDFInfo
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Abstract
The invention discloses a cell excitation treatment instrument for cardiovascular diseases. The cell excitation treatment instrument for cardiovascular diseases comprises an electromagnetic wave generator capable of applying electromagnetic wave to a human body, and is characterized in that the current waveform of electromagnetic wave-generating current which changes along with time is as follows: I(t)=0, t<0, Imax*(1-(1/e<t/ tau >)), 0, t>t1, wherein t is more than or equal to 0, but less than or equal to t1; tau is equal to a time constant of the waveform generator; t is a time (point); t1-t is the lasting time or the working time of a pulse; Imax is the maximum current flowing through a circuit; the ranges of tau and t1 are as follows: a), tau is more than or equal to 300usec, but less than or equal to 0.1sec, and b), t1 is more than or equal to 5msec, but less than or equal to 0.1sec; and c), Imax is more than or equal to 50mA, but less than or equal to 200 Ma. The cell excitation treatment instrument for cardiovascular diseases uses customized electromagnetic wave, so that the electromagnetic wave has relatively good therapeutic effect on specific diseases, namely the cardiovascular diseases, in particular on hypertension and heart disease; and the therapeutic effect has been verified by a considerable number of comparative tests.
Description
Technical Field
The present invention relates to a disease treatment apparatus, and more particularly to an apparatus for treating cardiovascular disease by stimulating cells with electromagnetic radiation.
Technical Field
The circulatory system, which is composed of abundant vascular tissue, is one of the largest organs in the human body. People have used systems for bathing the entire body with electromagnetic radiation in an attempt to achieve beneficial effects on the body, reminiscent of beneficial effects similar to traditional needle-based therapies.
For example, chinese patent application No. 200810010145.4 discloses a high-energy biological field effect therapeutic apparatus, which comprises a power circuit, wherein the output of the power circuit is connected to a sampling amplifying circuit, the output of the sampling amplifying circuit is connected to a pulse generating circuit, the output of the pulse circuit is connected to a power amplifying circuit, one path of the output of the power amplifying circuit is connected to the sampling amplifying circuit through a voltage regulating circuit, the other path is connected to an indicating circuit, and the output end of the indicating circuit is provided with an electrode A, B. The electromagnetic wave with the output voltage adjusted between 35V and 220V can quickly get through the human body channels and collaterals, promote blood circulation to remove blood stasis, expel wind and cold, adjust the yin-yang balance of the human body viscera, adjust the potential difference between the human body cells, change the molecular structure sequencing of the cells, and change the disorder into the order; regulating endocrine of human body to balance acid and base; reducing blood viscosity, softening blood vessel, improving cerebral blood supply, and improving immunity and self-healing ability of human body to reach optimal state.
The Chinese utility model with application number 200620031025.9 provides a broadband electromagnetic spectrum health care therapeutic device. The main characteristic is that the middle part of the machine cover body is provided with a main machine, the machine cover body is provided with a spectrum treatment body, and the spectrum treatment body is divided into red light spectrum and infrared light spectrum. The host is internally provided with a low and medium frequency generator, a spectrum generator and a control panel which are respectively connected with the low and medium frequency therapeutic body and the spectrum therapeutic body. Because the infrared spectrum, the red spectrum and the low-medium frequency spectrum are perfectly combined together, the three spectra realize the purposes of mutual complement, complementary advantages and resource sharing in a common treatment range. Thereby achieving the functions of promoting the blood circulation of the human body, activating cells, improving the immunity, regulating the nervous system and the like.
These conventional treatment methods and apparatuses only ensure that a certain amount of electromagnetic waves are applied to the human body, and have no special definition on the waveform and light intensity of the electromagnetic waves, and the intensity of the electromagnetic waves only considers the safety, and the waveforms adopted for specific diseases have no obvious difference, and the treatment effect has no related medical verification, and has certain blindness and poor safety and reliability.
At present, cardiovascular diseases such as heart disease and hypertension are a great trouble for human beings, and the implementation has proved that the effect of treating cardiovascular diseases by only using medicaments is not ideal, and the diseases are not specially treated except the medicaments.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a cardiovascular disease cell stimulation therapeutic apparatus, which uses a specific waveform to treat and improve a specific disease, namely cardiovascular disease.
In order to achieve the above object, the present invention provides a cardiovascular disease cell stimulation therapeutic apparatus comprising an electromagnetic wave generator for applying electromagnetic waves to a human body, wherein a current waveform of a current for generating the electromagnetic waves with time variation is as follows:
wherein:
- τ is equal to the time constant generated by the waveform generator
-t is time (point)
-(t1-t) is the duration or on-time of the pulse
-ImaxIs the maximum current flowing through the circuit
And, τ and t1The range of (A):
a)300μsec≤τ≤0.1sec
b)1msec≤t1≤0.1sec
c)50mA≤Imax≤200mA。
wherein: msec represents msec; μ sec represents microseconds; mA stands for milliamp.Further, the range of Imax is between 75mA and 110 mA. Still further, the τ and t1The ranges of (A) are as follows:
a)8.33msec≤τ≤33.33msec
b)1.25msec≤t1≤2.0msec
further, the frequency is between 20Hz and 120Hz, even more typically between 20Hz and 40Hz, and in one particular case, about or substantially 30Hz (e.g., 30Hz + or-3 Hz).
Further, the electromagnetic wave generator includes a central processing unit, a digital-to-analog converter and a multiplexer, and a current sensor, the central processing unit outputs a pulse width modulation waveform (PWM) which is input to the digital-to-analog converter, the digital-to-analog converter generates a voltage waveform with time variation of voltage, and the voltage waveform is converted into the current waveform by the multiplexer, and the current waveform is input to the current sensor so as to generate an electromagnetic wave (field) (PEMF) with corresponding characteristics.
The cardiovascular disease cell excitation therapeutic apparatus provided by the invention adopts the customized electromagnetic wave, the electromagnetic wave can have a better therapeutic effect on a specific disease, namely cardiovascular disease, particularly has a good therapeutic effect on hypertension and heart disease, and the therapeutic effect is verified by a considerable number of comparative tests.
Drawings
FIG. 1 is a schematic diagram of the construction of one embodiment of the cardiovascular disease cell stimulation treatment apparatus of the present invention;
FIG. 2 is a current waveform diagram of the current of the cardiovascular disease cell stimulation treatment apparatus of the present invention with time varying for generating the treatment electromagnetic wave;
FIG. 3 is a circuit diagram for generating such a pulse width modulated waveform (PWM);
FIG. 4 shows the results of in vitro cell assays performed on genetically hypertensive rats;
FIGS. 5-9 show the results of a significant drop in blood pressure after treatment in rats with essential hypertension;
FIG. 10 is a treatment electrocardiogram for myocardial ischemia case 1 before treatment;
FIG. 11 is a treatment electrocardiogram after treatment for myocardial ischemia case 1;
FIG. 12 is a treatment electrocardiogram for myocardial ischemia case 2 before treatment;
FIG. 13 is a treatment electrocardiogram after treatment for case 2 of myocardial ischemia;
FIG. 14 is a treatment electrocardiogram for myocardial ischemia case 3 before treatment;
FIG. 15 is a treatment electrocardiogram after treatment for myocardial ischemia case 3;
FIG. 16 is a treatment electrocardiogram for myocardial ischemia case 4 before treatment;
FIG. 17 is a treatment electrocardiogram after treatment for myocardial ischemia case 4;
FIG. 18 is a treatment electrocardiogram for myocardial ischemia case 5 prior to treatment;
FIG. 19 is a treatment electrocardiogram after treatment for myocardial ischemia case 5;
FIG. 20 is a treatment electrocardiogram for myocardial ischemia case 6 before treatment;
FIG. 21 is a treatment electrocardiogram after treatment for myocardial ischemia case 6;
FIG. 22 is a treatment electrocardiogram for myocardial ischemia case 7 before treatment;
FIG. 23 is a treatment electrocardiogram after treatment for myocardial ischemia case 7;
fig. 24 is a treatment electrocardiogram before treatment for sinus bradycardia case 1;
FIG. 25 is a treatment electrocardiogram following treatment for sinus bradycardia case 1;
fig. 26 is a treatment electrocardiogram for sinus bradycardia case 2 prior to treatment;
figure 27 is a treatment electrocardiogram following treatment for sinus bradycardia case 2;
fig. 28 is a treatment electrocardiogram for sinus bradycardia case 3 prior to treatment;
FIG. 29 is a treatment electrocardiogram following treatment for sinus bradycardia case 3;
FIG. 30 is a treatment electrocardiogram for sinus bradycardia case 4 prior to treatment;
FIG. 31 is a treatment electrocardiogram following treatment for sinus bradycardia case 4;
FIG. 32 is a treatment electrocardiogram for sinus bradycardia case 5 prior to treatment;
FIG. 33 is a treatment electrocardiogram following treatment for sinus bradycardia case 5;
FIG. 34 is a treatment electrocardiogram for sinus bradycardia case 6 prior to treatment;
FIG. 35 is a treatment electrocardiogram following treatment for sinus bradycardia case 6;
FIG. 36 is a treatment electrocardiogram for sinus bradycardia case 7 prior to treatment;
figure 37 is a treatment electrocardiogram following treatment for sinus bradycardia case 7;
FIG. 38 is a treatment electrocardiogram for sinus bradycardia case 8 prior to treatment;
FIG. 39 is a treatment electrocardiogram following treatment for sinus bradycardia case 8;
FIG. 40 is a treatment electrocardiogram for sinus bradycardia case 9 prior to treatment;
FIG. 41 is a treatment electrocardiogram after treatment for sinus bradycardia case 9;
fig. 42 is a treatment electrocardiogram for old inferior myocardial infarction case 1 before treatment;
figure 43 is a treatment electrocardiogram following treatment for old inferior myocardial infarction case 1;
fig. 44 is a treatment electrocardiogram for old inferior myocardial infarction case 2 before treatment;
figure 45 is a treatment electrocardiogram following treatment for old inferior myocardial infarction case 2;
FIG. 46 is a treatment electrocardiogram for ventricular premature beat case 1 prior to treatment;
FIG. 47 is a treatment electrocardiogram after treatment for ventricular premature beat case 1;
fig. 48 is a treatment electrocardiogram before treatment for conduction block case 1;
fig. 49 is a treatment electrocardiogram after treatment for conduction block case 1.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
Referring to fig. 1, the cardiovascular disease cell-stimulating therapeutic apparatus of the present invention comprises a Central Processing Unit (CPU)50, a human condition detecting device connected to the CPU 50 for monitoring the condition of the human body, a device for communicating with the outside, one or more bio-electromagnetic wave generators, and a power supply device for supplying power to the device. Each of the bio-electromagnetic wave generators is connected to the central processing unit, and the central processing unit 50 can output a pulse width modulation waveform (PWM) as required.
Of course, the pulse width modulation waveform (PWM) may also be generated by hardware. Fig. 3 is a circuit diagram for generating such a pulse width modulation waveform (PWM). In the figure, R1, R2, R6, C1, D1, D2, and CP1 form a sawtooth wave generator. CP2 and R7 form an analog comparator. The CP2 will compare the modulation level of the sawtooth wave at the positive input, thus producing a pulse width modulated oval wave at the output of CP 2.
For those skilled in the art, how to select an appropriate PWM to generate the required electromagnetic wave is common knowledge, and may be provided by corresponding electronic devices on the market.
In addition, in this embodiment, the cardiovascular disease cell stimulation therapeutic apparatus of the present invention can communicate with the outside, receive related control signals, or download related programs through a common communication device, such as an antenna and a related communication module of a mobile phone connected through a wireless communication network, or a wired or wireless network connection device connected to the internet.
The power supply device uses a battery, such as a common lithium battery, and includes a battery charger 51, a battery 52, and power supply modules 521, 522, and 523. The battery charger 51 is externally connected or configured to charge the battery 52 to ensure a continuous supply of power to the battery 52. The battery 52 supplies power to each component of the cardiovascular disease cell stimulation therapeutic apparatus through the power supply modules 521, 522 and 523. The battery charger 51 is connected to an external power source through the power connection port 531 for charging.
The electromagnetic wave generator is composed of a waveform MULTIPLEXER (MULTIPLEXER)56, drivers 561 and 562, and waveform generators 581 and 582 connected to the drivers 561 and 562. The digital-to-analog conversion module 55 receives a Pulse Width Modulation (PWM) waveform required by the cpu 50 and outputs an analog voltage waveform with a voltage varying with time. The multiplexer 56 is also a commercially available device, and receives the voltage waveform from the digital-to-analog conversion module 55 to divide it into several identical signals. The present embodiment includes two electromagnetic wave output devices, the waveform multiplexer 56 can output two waveform analog voltage signals to be respectively input into the drivers 561 and 562, and the drivers 561 and 562 respectively drive the generated waveforms, such as the current waves shown in fig. 2, to flow through the waveform generators 581 and 582 for generation. The waveform generators 581 and 582 may employ a current inductor or a coil inductor (inductor), which is substantially a coil through which a current flows to generate an electromagnetic wave of a certain intensity. The present embodiment generates two sets of current waves, and the two electromagnetic waves may have the same waveform or different waveforms. The waveform multiplexer 56 may also generate one or more control pulses as needed, and generate one or more current waves via one or more drivers. Waveform generators 581 and 582 are configured to stimulate blood circulation in a patient with a pulsed magnetic field of relatively low frequency, which may typically be between about 10Hz and 200Hz, more typically between 20Hz and 120Hz, even more typically between 20Hz and 40Hz, and in one particular case, about or substantially 30Hz (e.g., 30Hz + or-3 Hz).
The central control unit 50 is capable of controlling the operations of the above components, and the central control unit 50 may also be a control unit such as a microprocessor or a single chip microcomputer.
In the present embodiment, the human condition detecting means employs one heartbeat sensor 58 and motion sensor 54. The heart rate sensor 58 can measure the heart rate of the human body and input it to the central control unit 50. The motion sensor 54 can measure the motion characteristics of the body such as vibration, acceleration, etc. in time, for example, how to move and the motion characteristics thereof over a period of time, and the motion data of the period of time is analyzed and processed to obtain data of other physical conditions of a part of the human body.
The motion sensor 54 may be implemented as a motion accelerometer (accelerometer), which is a very sensitive motion sensor that can see most of the minute vibrations (e.g., heartbeat or blood flow pulse) from the human body when the patient or user holds the device in his or her hand and is stationary, and the heartbeat spectrum of the patient will be embedded in the vibration signal, and the detected signal is input to the central control unit 50 and the user's heartbeat spectrum or pulse is detected and extracted from the total signal by Digital Signal Processing (DSP) techniques.
In addition, the central control unit 50 can customize or adjust the electromagnetic wave shape to the patient based on the above-mentioned body condition information such as the treatment history of the patient, the electrical properties of the patient and/or the treatment on the patient, the location (meridian point) of these factors and other specific factors such as the skin thickness, the amount of adipose tissue at the treatment location, the normal heart rate, and/or other body factors to ensure better treatment.
A Liquid Crystal Display (LCD)551 is used to display the operation state of the entire cell stimulation terminal or the operation parameters of each relevant component.
The function connection port 532 is used for connection with the outside to input data from the outside or to download a program for the cell-stimulating terminal function such as game, clock, communication, etc.
The power connection port 531 is used for connecting a power supply.
The battery level detector 53 is used to monitor the system level usage.
FIG. 2 is a current waveform diagram of the current of the cardiovascular disease cell stimulation therapeutic apparatus of the present invention, which is used for generating therapeutic electromagnetic waves, according to the time variation. As described above, the current waveform, once flowing through the coil inductors 581, 582, generates corresponding electromagnetic waves that may be used to treat cardiovascular disease in humans.
The mathematical formula for the current waveform in fig. 2 is:
wherein:
- τ is equal to the time constant generated by the waveform generator
-t is time (point)
-(t1-t) is the duration or on-time of the pulse
-ImaxIs the maximum current flowing through the circuit
And: tau and t1The range of (A):
a)300μsec≤τ≤0.1sec
b)1msec≤t1≤0.1sec
in the above formula and fig. 2, the magnitude of Imax determines the magnitude of the current flowing through the waveform generators 581 and 582 in fig. 1, and also directly determines the intensity of the therapeutic electromagnetic wave. The significant contribution of the invention is that through a large number of experiments, on the basis of the waveform, the range of Imax is found to be between 50mA and 200mA to achieve a certain treatment effect, and when the range of Imax is between 75mA and 110mA, a better treatment effect can be achieved, and the specific treatment effect can be verified from the following experiments.
It will be apparent to those skilled in the art that the current waveform provided by the present invention can be easily used by the central control unit 50 to generate a suitable required Pulse Width Modulation (PWM) waveform, and that the current waveform disclosed by the present invention can generate corresponding electromagnetic waves.
Of course, it will be apparent to those skilled in the art that software or hardware may be used to generate the current wave shown in FIG. 2.
Moreover, the invention can generate one kind of electromagnetic wave to treat the human body, and can also adopt two or more kinds of electromagnetic waves to treat the human body at the same time, and the treatment mode can be selected according to the situation.
The electromagnetic wave of the cardiovascular disease cell excitation therapeutic apparatus can be stored in the therapeutic apparatus, can be downloaded from the outside through a wireless network, and can be continuously adjusted and changed.
The following are experimental results for verifying the therapeutic effect of the cardiovascular disease cell-stimulated therapeutic apparatus provided by the present invention:
Patient name: gender of king XX: age of the male: 60 years old
The main symptoms are as follows: coronary heart disease, old myocardial infarction. Chest distress phenomenon appears after fatigue, and the patient is hospitalized in 2007 for acute myocardial infarction. The disease condition is controlled by taking 3 quick-acting heart-saving pills every day.
The treatment mode comprises the following steps: the left hand Laogong acupoint is irradiated on the cardiovascular disease cell stimulation therapeutic apparatus for 2 times/day, and the total time is 8 days. Wherein Imax is 79.3mA, τ is 300 μ sec, and t1 is 1 msec.
The treatment results are as follows: after fatigue, the patient does not have palpitation and chest distress, and the quick-acting heart-saving pill is stopped taking.
Referring to fig. 10, 2011/6/9 before the cardiovascular disease cell stimulation treatment apparatus of the present invention is treated, the ECG shows: sinus rhythm, the QS type of V1, V2 leads, suggests old, anterior septal myocardial infarction.
Referring to fig. 11, 2011/6/17 after 8 days of the cardiovascular disease cell stimulation therapy device irradiating laogong acupoint, the ECG showed: sinus rhythm, QS type V1 and rS type V2, are normal electrocardiograms.
As a result: cure of disease
Patient name: urx gender: age of the woman: age 75 years old
The main symptoms are as follows: coronary heart disease, hypertension, palpitation, chest distress, and short breath after fatigue.
The treatment mode comprises the following steps: the left hand Laogong acupoint is irradiated by the cardiovascular disease cell stimulation therapeutic apparatus for 2 times per day. Wherein Imax is 79.3mA, τ is 500 μ sec, and t1 is 5 msec.
The treatment results are as follows: after fatigue, there are no palpitation, chest distress and shortness of breath, and after fatigue, there is slight chest distress.
Referring to fig. 12, 2011/6/30 shows an electrocardiogram: the V1, V2 lead exhibits QS waveform, and the T wave of V4, V5, V6 lead is low.
And (4) prompting: 1. sinus rhythm, 2, anterior septal myocardial infarction (old), 3, ischemic change of anterior inferior wall myocardium, 4, increased left ventricular voltage (moderate), 5, slight left deviation of electrical axis.
Referring to fig. 13, an electrocardiogram of 2011/8/11 after treatment shows: the V2 lead has qrS type, V4, V5 and V6 lead T-wave amplitude is raised.
And (4) prompting: 1. sinus rhythm, 2, left ventricular voltage increase, 3, electrical axis left deviation.
As a result: cure of disease
Patient name: and sex of model XX: age of the woman: age 48 years old
The main symptoms are as follows: myocardial ischemia without obvious clinical symptoms
The treatment mode comprises the following steps: the left hand Laogong acupoint is irradiated on the cardiovascular disease cell stimulation therapeutic apparatus for 2 times per day for 24 days. Wherein Imax is 78.9mA, tau is 550 mu sec, and t11.25 msec. The treatment results are as follows: the myocardial ischemia disappears.
Referring to fig. 14, 2011/5/19 before the cardiovascular disease cell stimulation treatment apparatus of the present invention is treated, the ECG shows: sinus rhythm, the ST segment of the II, III and aVF leads is obliquely moved down by 0.05mV, and the possibility of lower wall myocardial ischemia is considered.
Referring to fig. 15, 2011/6/25 shows that after the cardiovascular disease cell stimulation therapeutic apparatus provided by the present invention irradiates laogong acupoint for treatment, ECG shows: sinus rhythm, sinus bradycardia, elevation of ST segment of II, III, aVF leads to normal.
As a result: obvious curative effect
Patient name: what XX sex: age of the woman: age 74 years old
The main symptoms are as follows: old myocardial infarction.
Poor cardiac function, marked soreness and tiredness of the thighs when walking at night.
The treatment mode comprises the following steps: the left hand Laogong acupoint is irradiated on the cardiovascular disease cell stimulation therapeutic apparatus for 2 times/day for 7 days. Wherein Imax is 78.9mA, tau is 23msec, t 180 msec. The treatment results are as follows: the cardiac function is obviously improved, and the feeling of aching and tired legs basically disappears when walking at night.
Referring to fig. 16, 2011/7/12, the electrocardiogram shows: sinus rhythm, mild left electrical axis deviation, QS type V1, V2, and marked ST elevation of V1, V2 leads.
Referring to fig. 17, 2011/7/24, the electrocardiogram shows: sinus rhythm, mild left electrical axis deviation, QS type V1, V2, and marked ST drop-back of V1, V2 leads.
As a result: obvious curative effect
Patient name: gender of king XX: age of the woman: age 77
The main symptoms are as follows: myocardial ischemia.
The treatment mode comprises the following steps: the left hand Laogong acupoint is irradiated on the cardiovascular disease cell stimulation therapeutic apparatus for 2 times/day, and the total time is 16 days. Wherein Imax is 77mA, tau is 13.8msec, and t is1＝0.1sec。。
The treatment results are as follows: the myocardial ischemia phenomenon is improved.
Referring to fig. 18, 2011/8/11 shows an electrocardiogram: 1. sinus rhythm
2. Generalized myocardial ischemia, I, II, aVF, V1, V2, V3, V4, V5, V6 lead T-wave abnormalities.
Referring to fig. 19, 2011/8/16 shows an electrocardiogram: 1. sinus rhythm
2. Myocardial ischemia, abnormalities of the T waves of V3, V4 and V5 leads.
As a result: is effective
Patient name: sex of roxx: age of the male: age 81
The main symptoms are as follows: myocardial ischemia and obvious sense of premature beat.
The treatment mode comprises the following steps: the cardiovascular disease cell exciting therapeutic instrument irradiates the left hand Laogong acupoint for 2 times/day for 22 days, wherein Imax is 78.9mA, tau is 25msec, and t is1＝0.05sec。
The treatment results are as follows: the sense of premature beat is reduced.
Referring to fig. 20, 2011/8/8 shows an electrocardiogram: 1. sinus rhythm;
2. left deflection of the electric axis;
3. ST segment ischemic change of V5 and V6 leads, T wave of V6 lead is low, and aVL lead is QR type.
Referring to fig. 21, 2011/8/30 shows an electrocardiogram: 1. sinus rhythm;
2. left deflection of the electric axis;
3. the ST segment of the V6 lead is subjected to ischemic change, the ST segment of the aVL lead is pressed down and lifted, and the amplitude of the T wave is lifted back.
As a result: is effective
Case 7
Patient name: gender of Yang XX: age of the male: age 62 years old
The main symptoms are as follows: myocardial infarction of the inferior wall combined with extensive anterior wall ischemia.
The treatment mode comprises the following steps: the cardiovascular disease cell exciting therapeutic apparatus irradiates the left hand Laogong acupoint for 2 times/day for 27 days, wherein Imax is 79.3mA, tau is 20.5msec, and t is1＝1.5msec。
The treatment results are as follows: the myocardial ischemia phenomenon is improved.
Referring to fig. 22, 2011/8/3 shows an electrocardiogram: 1. sinus rhythm
2. Inferior myocardial infarction, extensive T-wave inversion of the V1-V6 lead.
Referring to fig. 23, 2011/8/30 shows an electrocardiogram: 1. sinus rhythm;
2. the old inferior myocardial infarction has low T wave of V1, V4-V6 leads and reduced inversion of T wave of V2 and V5 leads.
As a result: is effective
The results show that the cardiovascular disease cell stimulation therapeutic apparatus has better therapeutic effect on common myocardial ischemia of middle-aged and elderly people.
Experiment two aiming at sinus bradycardia
Patient name: gold XX sex: age of the woman: age 48 years old
The main symptoms are as follows: sinus bradycardia.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left hand Laogong acupoint for 2 times/day for 3 days. Wherein Imax is 79.3mA, tau is 20.5msec, and t is1＝1.5msec。
The treatment results are as follows: the heart rate was normal.
Referring to fig. 24, 2011/8/8 shows an electrocardiogram: sinus bradycardia with heart rate of 57 beats/minute
Referring to fig. 25, 2011/8/30 shows an electrocardiogram: sinus rhythm, normal electrocardiogram, heart rate 62 beats/minute
As a result: cure of disease
Patient name: jin XX sex: age of the woman: age 67 years old
The main symptoms are as follows: sinus bradycardia.
The treatment mode comprises the following steps: the cardiovascular disease cell exciting therapeutic instrument irradiates the left hand Laogong acupoint for 2 times/day for 12 days, wherein Imax is 79.3mA, tau is 33.33msec, and t is1＝2.0msec。
The treatment results are as follows: the heart rate was normal.
Referring to fig. 26, 2011/8/12 shows an electrocardiogram: sinus bradycardia, heart rate 52 beats/minute, long QT interval (0.49s)
Referring to fig. 27, 2011/8/30 shows an electrocardiogram: sinus rhythm, low chest conductance voltage, heart rate of 65 times/min, normal QT interval (0.40s)
As a result: cure of disease
Patient name: guo XX sex: age of the male: age 74 years old
The main symptoms are as follows: no history and symptom of heart disease, and electrocardiogram shows myocardial ischemia and bradycardia
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left hand Laogong acupoint for 2 times/day for 6 days. Wherein Imax is 78.0mA, tau is 8.33msec, t1＝1.25msec。
The treatment results are as follows: myocardial ischemia disappeared and heart rate was normal.
Referring to fig. 28, 2011/8/11 shows an electrocardiogram: v4, V5, V6 lead T-wave inversions. And (4) prompting: 1. sinus bradycardia, 55 times/min; 2. the V4, V5 and V6 leads show myocardial ischemia type changes
Referring to fig. 29, 2011/8/16 shows an electrocardiogram: v4, V5, V6 lead T wave elevation. And (4) prompting: 1. sinus rhythm, 82 beats/minute; 2. and (4) normal electrocardiogram.
As a result: cure of disease
Patient name: gender of Yang XX: age of the woman: age 72
The main symptoms are as follows: no history and symptom of heart disease, and electrocardiogram shows myocardial ischemia and bradycardia
The treatment mode comprises the following steps: the cardiovascular disease cell exciting therapeutic instrument irradiates the left hand Laogong acupoint for 2 times/day for 5 days, wherein Imax is 78.0mA, tau is 33.33msec, and t is1＝2.0msec。
The treatment results are as follows: myocardial ischemia disappeared and heart rate was normal.
Referring to fig. 30, 2011/8/11 shows an electrocardiogram: the V1 lead T wave is inverted. And (4) prompting: 1. sinus bradycardia, 56 times/min; 2. the V1 lead T wave exhibits ischemic changes.
Referring to fig. 31, 2011/8/16 shows an electrocardiogram: the T wave of the V1 lead rises back, and the T wave of the V2 lead is low and flat. And (4) prompting: 1. sinus rhythm, 64 beats/minute; 2. the V2 lead T wave is low.
As a result: cure of disease
Patient name: sex of sheet XX: age of the male: age 74 years old
The main symptoms are as follows: sinus bradycardia, heart rate 58 beats/minute.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left laogong acupoint, the left Yongquan acupoint for 2 times/day for 7 days. Wherein Imax is 78.9mA, tau is 9.55msec, t1＝1.8msec。
The treatment results are as follows: the heart rate rises to 70 times/min, and no obvious discomfort is caused.
Referring to fig. 32, 2011/6/17 shows an electrocardiogram: sinus bradycardia, heart rate 58 beats/minute.
Referring to fig. 33, 2011/7/1 shows an electrocardiogram: heart rate 69 beats/minute, normal electrocardiogram.
As a result: cure of disease
Patient name: gender protection XX: age of the woman: age 53
Treatment of the disorders: sinus bradycardia.
Chest distress, short breath and obvious night, and the symptoms are relieved after the salvia miltiorrhiza dropping pill is taken by oneself when the salvia miltiorrhiza dropping pill is in attack, and the sleep quality is poor.
The treatment mode comprises the following steps: irradiate Laogong acupoint for 2 times per day for 8 days. Wherein Imax is 75mA, tau is 20.5msec, t1＝1.6msec。
The treatment results are as follows: no chest distress phenomenon occurs at night, and the administration of Saviae Miltiorrhizae radix dripping pill is stopped.
Referring to fig. 34, 2011/6/18 before the cardiovascular disease cell stimulation treatment apparatus of the present invention, the ECG showed: sinus bradycardia with a heart rate of 49 beats/minute.
Referring to fig. 35, 2011/6/30 after the cardiovascular disease cell stimulation treatment device of the present invention, the ECG showed: sinus rhythm, heart rate 67 beats/minute, normal electrocardiogram.
As a result: cure of disease
Case 7
Patient name: sex of sheet XX: age of the woman: age 77
Treatment of the disorders: sinus bradycardia.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the Laogong acupoint for 3 days and the Yongquan acupoint for 3 days, which are 6 days. Wherein Imax is 80.4mA, tau is 20.5msec, and t is1＝1.9msec。
The treatment results are as follows: the heart rate was normal.
Referring to fig. 36, 2011/8/22 before the cardiovascular disease cell stimulation treatment apparatus of the present invention is used for treatment, the ECG shows: sinus bradycardia, heart rate 54 beats/minute.
Referring to fig. 37, 2011/8/28 after the treatment of the cardiovascular disease cell stimulation therapy apparatus of the present invention, the ECG showed: sinus rhythm, normal electrocardiogram, heart rate 67 beats/minute.
As a result: cure of disease
Case 8
Patient name: liu XX gender: age of the male: age 56
Treatment of the disorders: sinus bradycardia.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the Laogong acupoint for 9 days. Wherein Imax is 50mA, tau is 25.5msec, t1＝1.85msec。
The treatment results are as follows: the heart rate was normal.
Referring to fig. 38, 2011/8/22 before the treatment of the cardiovascular disease cell stimulation treatment apparatus of the present invention, the ECG showed: 1. sinus bradycardia, heart rate 56 beats/minute. 2. Old inferior myocardial infarction. 3. Anterior myocardial ischemia.
Referring to fig. 39, 2011/9/1 before the treatment of the cardiovascular disease cell stimulation treatment apparatus of the present invention, the ECG shows: 1. sinus rhythm, heart rate 68 beats/minute.
2. Old inferior myocardial infarction, inversion of the T wave of the III and aVF leads is relieved, ST segment ischemia type change of the V4-V6 lead is realized, and the amplitude of the T wave of the V3 lead is reduced.
As a result: cure of disease
The above results indicate that the cardiovascular disease cell stimulation therapeutic apparatus of the present invention has a superior therapeutic effect on sinus bradycardia common to middle aged and elderly people (ranging from age 48 to age 77).
Case 9:
name: gender of king XX: age of the male: age 51 years old
Treatment of the disorders: sinus arrhythmia
The treatment mode comprises the following steps: left palm was irradiated 2 times/day for 8 min/time for 30 days. Wherein Imax is 200mA, tau is 30msec, t1＝1.89msec。
The treatment results are as follows: sinus rhythm, normal electrocardiogram.
Referring to fig. 40, the electrocardiogram before treatment shows: sinus arrhythmia.
Referring to fig. 41, the electrocardiogram after treatment: sinus rhythm, normal electrocardiogram.
Case 10
Name: sex of roxx: age of the male: age 49 years old
Treatment of the disorders: sinus bradycardia, hypertension.
The treatment mode comprises the following steps: irradiating palm and sole for 4 times/day and 8 min/time for 45 days. Wherein Imax is 200mA, tau is 65.5msec, t1＝10msec。
The treatment results are as follows: sinus rhythm, heart rate increased from 56/min to 65/min; the blood pressure is reduced from 153/95mmHg to 126/87 mmHg.
Experiment three: for-old inferior myocardial infarction
Patient name: sex of grandchild XX: age of the male: age 59
The main symptoms are as follows: coronary heart disease, tightness in the precordial region, chest distress, shortness of breath and stabbing pain in the precordial region after fatigue.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left hand Laogong acupoint for 2 times/day, and the total time is 15 days. Wherein Imax is 79.3mA, tau is 20.5msec, and t is1＝1.5msec。
The treatment results are as follows: chest distress, short breath and precordial stabbing pain after fatigue are obviously relieved.
Referring to fig. 42, 2011/6/30 shows an electrocardiogram: old posterior inferior myocardial infarction, low level of T wave of V4 lead.
Referring to fig. 43, 2011/7/19 shows an electrocardiogram: sinus rhythm, old posterior inferior myocardial infarction, V4 lead T-wave amplitude rise back.
As a result: is effective
Patient name: sex of congratulatory XX: age of the male: age 78
The main symptoms are as follows: coronary heart disease, old myocardial infarction of inferior wall, sinus bradycardia.
In 2003, the patient is treated with various antihypertensive drugs before hospitalization due to sudden coronary heart disease, and the patient has no obvious symptoms and is accompanied with a history of hypertension for many years, wherein the patient is treated with the antihypertensive drugs, and the patient takes the beta-lactam which has the effect of reducing the heart rate.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left hand Laogong acupoint for 2 times/day, and the total time is 20 days. Wherein Imax is 79.3mA, tau is 28.5msec, and t is12.5 msec. The treatment results are as follows: the electrocardiogram indicates that the myocardial ischemia is obviously improved, the heart rate is increased to a normal value, and the treatment is still continued.
Referring to fig. 44, 2011/6/21 shows an electrocardiogram: sinus bradycardia: heart rate 54 times/minute, left electric axis, old inferior myocardial infarction, low and flat T-wave in V4 lead, and low ST-segment pressure in V5 and V6 lead.
Referring to fig. 45, 2011/7/18 shows an electrocardiogram: sinus rhythm, 74 heart rate/partial axis left deviation, old inferior myocardial infarction, increased T wave amplitude of V4 lead, ST segment rising of V5 and V6 lead.
As a result: is effective
The results show that the cardiovascular disease cell stimulation therapeutic apparatus has better therapeutic effect on old inferior ventricular infarction which is common in the elderly.
Experiment four aiming at ventricular premature beat
Patient name: threx sex: age of the woman: age 76 years old
The main symptoms are as follows: the heart is premature beat.
Spontaneous paroxysmal chest distress and shortness of breath, ventricular premature beat can be seen in the electrocardiographic monitoring.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left hand Laogong acupoint and the left foot Yongquan acupoint for 2 times/day for 10 days. Wherein Imax is 110mA, tau is 20.5msec, t1＝1.5msec。
The treatment results are as follows: the chest distress and short breath are obviously improved, and premature beat is not found within 30 minutes of the electrocardiographic monitoring.
Referring to fig. 46, 2011/6/29 ecg display: sinus rhythm, occasional ventricular premature beat, long intermittent time after premature beat, and 15 ventricular premature beats in the half-hour monitoring process.
Referring to fig. 47, 2011/7/9 shows an electrocardiogram: sinus rhythm, normal electrocardiogram. The selection time of the two electrocardio-monitoring is approximately the same, and premature beat is not found.
As a result: obvious curative effect
Experiment five aims at-conduction block
Patient name: gender of Zhao XX: age of the woman: age 54
The main symptoms are as follows: incomplete right bundle branch block, occasional feeling of chest distress.
The treatment mode comprises the following steps: the cardiovascular disease cell stimulation therapeutic apparatus irradiates the left hand Laogong acupoint for 2 times/day, and the total time is 41 days. Wherein Imax is 78.9mA, tau is 20.5msec, t1＝2.0msec。
The treatment results are as follows:
referring to fig. 48, 2011/6/19 shows an electrocardiogram: heart rate 58 beats/minute, V1 lead rSR' with T wave inversion, suggesting incomplete right bundle branch block.
Referring to fig. 49, 2011/7/30 shows an electrocardiogram: heart rate 67 beats/minute, sinus rhythm, V1 lead S wave slightly wider, normal electrocardiogram.
As a result: is effective
Six cases of hypertension treatment
Patient name: plum xx gender: age of the woman: age 74 years old
Treatment of the disorders: hypertension, blood pressure fluctuation around 150/90mmHg, no obvious clinical symptoms.
The treatment mode comprises the following steps: wherein: imax is 78.9 mA; the arch of the foot was irradiated 2 times a day for 15 days.
The treatment results are as follows: the blood pressure is reduced and maintained at 120-130/70-80 mmHg.
The effect is as follows: is effective
Patient name: beam xx gender: age of the woman: age 90
Treatment of the disorders: hypertension is generally maintained at 150-160/90-95mmHg, and no clinical symptoms are caused when the medicine is not taken.
The treatment mode comprises the following steps: wherein: imax is 78.9 mA; 1 time/day for 4 days.
The treatment results are as follows: the blood pressure is recovered to be normal and is maintained at about 110/70mmHg, and the heart rate and the respiration are not obviously changed.
The effect is as follows: is effective
Patient name: liu xx gender: age of the woman: age 54
Treatment of the disorders: hypertension, oral hypotensor maintained at 130/80mmHg, and wake-up with heart fibrillation.
The treatment mode comprises the following steps: wherein: imax is 78.9 mA; the sole was irradiated for 1 time/day for 23 days.
The treatment results are as follows: the sleep-wake heart fibrillation feeling disappears, the half amount of the antihypertensive drug is reduced to the first, and the blood pressure is maintained at 120/70 mmHg.
The effect is as follows: is effective
Patient name: gender of king XX: age of the woman: age 77
The main symptoms are as follows: hypertension, 152/82mmHg before morning drug administration.
The treatment mode comprises the following steps: wherein: the left hand core was irradiated at Imax of 77.0mA 2 times/day, and the right hand core was added at 9.21 times/day for 40 days.
The treatment results are as follows: the blood pressure lowering medicine is reduced to 1/4, and the blood pressure before taking medicine in the morning is 140/75 mmHg.
The effect is as follows: is effective
Patient name: jin XX sex: age of the woman: age 67 years old
The main symptoms are as follows: hypertension is maintained at 130/80mmHg by taking hypotensor for a long time.
The treatment mode comprises the following steps: wherein: imax is 79.3 mA; irradiating the left palm for 2 times per day, adding the right palm for 1 time at 9.21 times, and adding the right palm for 1 time at 9.26 times, wherein the scheme is that the left palm and the right palm are respectively used for 2 times per day and 2 times per day for 40 days.
The treatment results are as follows: the blood pressure of the hypotensor is reduced to 1/4 of the original dosage, and the blood pressure is maintained at 120/65mmHg in the morning.
The effect is as follows: is effective
Patient name: cypress XX sex: age of the male: 65 years old
The main symptoms are as follows: hypertension is caused by taking hypotensor for a long time, and the blood pressure is maintained at about 140/90 mmHg.
The treatment mode comprises the following steps: wherein: imax is 78.9 mA; left palm was irradiated 2 times per day for 30 days.
The treatment results are as follows: the patient had stopped taking the medicine and the blood pressure was maintained at about 130/80mmHg in the morning (the patient was still on treatment and the blood pressure was still on the decline).
The effect is as follows: is effective
Case 7
Patient name: gender of Zhao XX: age of the male: 65 years old
The main symptoms are as follows: hypertension, 130-160/90-100 mmHg of blood pressure without taking hypotensor.
The treatment mode comprises the following steps: wherein: imax 80.4 mA; the left and right palms and the left and right soles were irradiated for 4 times a day for 10 days.
The treatment results are as follows: blood pressure was maintained at around 110-120/70-80mmHg (patient is still on treatment).
The effect is as follows: is effective
Case 8
Name: sex of roxx: age of the male: age 49 years old
Treatment of the disorders: hypertension was maintained at 153/95 mmHg.
The treatment mode comprises the following steps: wherein: imax is 200 mA; irradiating palm and sole for 4 times/day and 8 min/time for 45 days.
The treatment results are as follows: the blood pressure is reduced from 153/95mmHg to 126/87 mmHg.
The effect is as follows: is effective
Case 9
Name: high XX sex: age of the male: 71 years old
Treatment of the disorders: hypertension is treated by taking hypotensor, and the blood pressure is maintained at 130-140/80-90 mmHg. The treatment mode comprises the following steps: wherein: imax 80.4 mA; the palm and the sole are irradiated for 4 times/day and 8 minutes/time, and the treatment time is 25 days.
The treatment results are as follows: the blood pressure is reduced to 1/2 of the original dosage, and the blood pressure is maintained at 110-120/70-80 mmHg.
The effect is as follows: is effective
The above results further indicate that if the current wave generating electromagnetic waves of the cardiovascular disease cell-stimulation therapeutic apparatus of the present invention is the waveform of fig. 2, the mathematical formula of the waveform is as follows, which has better therapeutic effects on common ventricular premature beat, conduction block and hypertension:
wherein:
- τ is equal to the time constant generated by the waveform generator
-t is time (point)
-(t1-t) is the duration or on-time of the pulse
-ImaxIs the maximum current flowing through the circuit
And, τ and t1The range of (A):
a)300μsec≤τ≤0.1sec
b)5msec≤t1≤0.01sec
c)50mA≤Imax≤200mA。
still further, the range of Imax is between 75mA and 110mA, which leads to better treatment effect.
Still further, also if said τ and t are1The following ranges, the therapeutic effect can be achieved to a relatively good degree:
a)8.33msec≤τ≤33.33msec
b)1.25msec≤t1≤2.0msec
as can be seen from the above results of the treatment of patients of different ages and various cardiovascular diseases, the cardiovascular disease cell stimulation therapeutic apparatus of the present invention has a significant therapeutic effect on cardiovascular diseases of patients of different ages.
In the case trials described above, the frequency range used is between 20Hz and 120Hz, more typically between 20Hz and 40Hz, and in one particular case, about or substantially 30Hz (e.g., 30Hz + or-3 Hz).
Principle analysis:
the cardiovascular disease cell excitation therapeutic apparatus provided by the invention adopts the principle of magnetic to electric in clinic, and releases a specific pulse magnetic field which can induce and generate a cardiovascular regeneration signal waveform in a human body outside the human body. The PEMF pulse magnetic field generates a cardiovascular simulation regeneration current signal in a human body, the signal is transmitted to the brain through a nervous system, the brain starts an inherent cardiovascular regeneration and repair mechanism in the body, so that vascular endothelial cells are promoted to divide quickly, the proembryo cells gather at the damaged part of a blood vessel, the endothelial cells are promoted to grow, the capillary vessels are regenerated, NO is released, the blood vessel is softened, the blood pressure is reduced, the thrombus is dissolved, the damaged cardiac muscle is regenerated and repaired, and the prevention and treatment effects on cardiovascular system diseases are achieved.
In vitro cell assay:
referring to fig. 4, the college of medicine of shanghai compound denier university measures the change of blood pressure after stimulation by the cardiovascular disease cell stimulation therapy apparatus by performing a hereditary hypertension rat test using a carotid artery cannula (n ═ 1). The results of the in vitro cell tests show that the growth rate of the endothelial cells of the blood vessels of the human body cultured in vitro is greatly increased by 25 percent through one-time activation of the cardiovascular disease cell stimulation therapeutic apparatus for 8 minutes.
Animal experiments:
referring to fig. 5-9, the results of the animal test at the college of pharmacy of shanghai compound denier university show that the blood pressure of the rats with essential hypertension is obviously reduced after three days of treatment by the cardiovascular disease cell-stimulated therapeutic apparatus with different parameters of the present invention.
In the present invention, the electromagnetic wave generator is configured to stimulate blood circulation in a patient with a relatively low pulsed electromagnetic field (PEMF), where such low frequencies may generally be between about 10Hz and 200Hz, more typically between 20Hz and 120Hz, even more typically between 20Hz and 40Hz, and most preferably between 15Hz and 60 Hz. And in one particular case, about or actually 30Hz (e.g., 30Hz and + -3 Hz).
Furthermore, the present invention can provide a medical staff, such as a medical staff (or a staff managing the treatment by himself/herself), with a situation in which the waveform frequency, waveform shape, and waveform amplitude of the magnetic field can be modified to suit the diagnosis of the patient. A variety of different waveforms may also or alternatively be used, and a waveform applied to a portion of a patient's body or meridians may be different from a waveform applied to a different portion of the patient's body or meridians. Furthermore, when multiple portable devices are provided, they may be simultaneously applied to different parts of the body or different meridians with the same or, more typically, different waveforms and dynamically modifiable waveforms. Further still, multiple devices may be used with different devices phased in a manner such that only a selected subset of the devices (emitting electromagnetic or EM radiation) of one or all of the devices are operational (emitting electromagnetic or EM radiation) at the same time. In this way, multiple devices can be applied to different meridians of a single patient's body and controlled (e.g., by a timer, or local wireless or wired connection) to operate according to a programmed treatment protocol.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the present invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims.
Claims (7)
1. A cardiovascular disease cell excitation therapeutic apparatus, it includes an electromagnetic wave generator that can exert the electromagnetic wave to the human body, characterized by, the current waveform of the current variation with time of producing the electromagnetic wave is:
wherein,
- τ is equal to the time constant generated by the waveform generator
-t is time (point)
-(t1-t) is the duration or on-time of the pulse
-ImaxIs the maximum current flowing through the circuit
And, τ and t1The range of (A):
a)300μsec≤τ≤0.1sec
b)5msec≤t1≤0.1sec
c)50mA≤Imax≤200mA。
2. the cardiovascular disease cell stimulation apparatus of claim 1, wherein Imax ranges between 75mA and 110 mA.
3. The cardiovascular disease cell stimulation apparatus of claim 1, wherein τ and t are1The ranges of (A) are as follows:
a)8.33msec≤τ≤33.33msec
b)1.25msec≤t1≤2.0msec
4. the cardiovascular disease cell stimulation therapy apparatus of claim 1, wherein the frequency is between 20Hz and 120 Hz.
5. The cardiovascular disease cell stimulation therapy apparatus of claim 4, wherein the frequency is between 20Hz and 40 Hz.
6. The cardiovascular disease cell stimulation therapy apparatus of claim 5, wherein the frequency is between 30 Hz.
7. The cardiovascular disease cell excitation therapeutic apparatus of any one of claims 1-6, wherein the electromagnetic wave generator comprises a central processing unit, a digital-to-analog converter and a multiplexer, and a current sensor, the central processing unit outputting a pulse width modulation waveform (PWM) which is inputted to the digital-to-analog converter, the digital-to-analog converter generating a voltage waveform with time variation of voltage, the multiplexer converting the voltage waveform into the current waveform, and the current waveform being inputted to the current sensor to generate an electromagnetic wave with corresponding characteristics.
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| CN107485791A (en) * | 2016-06-13 | 2017-12-19 | 百慕迪（上海）再生医学科技有限公司 | It is a kind of to utilize the therapeutic equipment for sick headache for integrating the micro- magnetic field of ripple |
| CN107485792A (en) * | 2016-06-13 | 2017-12-19 | 百慕迪（上海）再生医学科技有限公司 | It is a kind of to utilize the apoplexy curing instrument for integrating the micro- magnetic field of ripple |
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| CN110038222A (en) * | 2019-02-22 | 2019-07-23 | 百慕迪（上海）再生医学科技有限公司 | A kind of apparatus for curing insomnia using pulse electromagnetic field |
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