The bonded electric pulse of medical instruments generates and gatherer
Technical field
This utility model relates to a kind of medical instruments coupling apparatus, relates in particular to a kind of the realization medicine importing and electric pulse are imported the device that combines.
Background technology
Dna vaccination is that the exogenous gene with certain antigen protein of coding directly imports in human or animal's somatic cell, by the expression system synthetic antigen albumen of host cell, induces host's former proteic immunne response that creates antagonism, to reach the purpose of prevention and treatment disease.Compare with the subunit protein vaccine with traditional attenuated vaccine, advantage such as dna vaccination possesses skills wider, and the cellular immunization effect is more obvious, thereby the exploitation of therapeutic DNA vaccine is an important channel of following clinical treatment.
But, objectively influenced the performance of vaccine effect because the importing of dna vaccination is low.Therefore will give full play to the function of dna vaccination, the importing efficient that also must improve vaccine is to reach the effect that improves its immune performance.Can on cell membrane, form instantaneous reversible micropore based on electric field, this makes that by the method for electroporation gene and other molecules being injected living cells becomes possibility: gene or other molecules are injected cell or tissue, and apply electric field, the many apertures of instantaneous formation on the cell membrane are so gene or molecule just enter cell.Utilizing electric pulse to carry gene is the technology of current very potentialization, and there is following shortcoming in present electrical pulse device: (1) can't generate the electric pulse and the pulse combined thereof of arbitrary form; (2) can't whether come off to load electrode and detect; (3) user can't be learnt loading pulse parameter in the present load.
In order to overcome the shortcoming of traditional electrical pulser, the applicant on July 10th, 2007 to Patent Office of the People's Republic of China submitted that application number is 200710043612.9 to, the utility model name is called the patent application of " a kind of electroporation leading-in apparatus of medicine ", and on January 14th, 2009 open (publication number is CN 101342390A).
This application discloses a kind of electroporation leading-in apparatus of medicine, has improved the importing effect of vaccine medicine, has reduced the use amount of medicine, reduces the untoward reaction of medicine.Its technical scheme is: electroporation leading-in apparatus, medicine is imported target tissue by low-frequency electric pulse, and comprising: pulse is provided with module, receives the electric pulse parameter of user's input; Power module produces a direct current signal of telecommunication; Microcontroller, received pulse are provided with the electric pulse parameter of module, export a control signal according to electric pulse parameter; The pulse generation module receives the control signal that microcontroller is exported, and the dc signal that this power module is supplied with is processed into electric impulse signal and output; Load, the electric impulse signal of received pulse generation module output.
The method of using this electroporation leading-in apparatus is that injectable drug and electrode importing are two steps of separating, that is: carry out the medicine injection with injection needle earlier, the syringe needle of this electroporation leading-in apparatus of reuse (load just), the electric pulse that device is produced imports in the tissue that receives the medicine injection, is beneficial to medicine and enters histiocyte more smoothly.
The weak point of above-mentioned gatherer and introduction method is: (1) need carry out double injection for patient, that is: to its injectable drug, be for the second time to export syringe needle by the electric pulse of electroporation leading-in apparatus it is carried out the stimulation of electric pulse by injection needle the first time.Patient must bear the misery of twice needle injection.(2) electric pulse generator is bulky, and importing syringe needle with electrode is the design of separate type, and inconvenience is carried.
The utility model content
The purpose of this utility model is to address the above problem, provide the bonded electric pulse of a kind of medical instruments to generate and gatherer, making injectable drug and electric pulse stimulation combine on the one hand finishes, concerning patient, only need stand one time needle injection, integrated, the miniaturization of equipment that syringe needle and electric pulse are generated, be convenient to carry handled easily.
The technical solution of the utility model is: this utility model has disclosed the bonded electric pulse of a kind of medical instruments and has generated and gatherer, comprising:
The electric pulse formation component generates electric impulse signal;
Electric pulse imports assembly, and this electric pulse formation component is connected the end that this electric pulse imports assembly, and the electric impulse signal that generates is imported objective for implementation, and it further comprises:
Shell;
Slot electrode is positioned on the pedestal of this shell front end, is connected with the electric pulse formation component by the electric conductance post, receives the electric impulse signal of this electric pulse formation component output;
The syringe needle group, be positioned at this shell foremost, several electrodes that comprise an injection needle and periphery import syringe needle, this injection needle and this several electrodes import syringe needle and all are connected with this slot electrode, wherein these several electrodes importing syringe needles receive by the electric impulse signal of this slot electrode conduction to go into to implement electric conductance, and this injection needle is used for injectable drug;
The medicine pen core, be positioned at this shell, inner several medicine injecting units that form a line of installing of this medicine pen core, connect with reverse wedge piece installing between these several medicine injecting units, the front end of these several medicine injecting units all has injection orifice, the injection orifice that wherein is positioned at this medicine pen core medicine injecting unit foremost communicates with this injection needle, rear end outside the medicine pen core is provided with the syringe pushing ram, be connected with the medicine injecting unit that is positioned at medicine pen core least significant end, by of the promotion of this syringe pushing ram to this medicine injecting unit of least significant end in this medicine pen core, push those reverse wedge piece installings continuously and release with the medicine injecting unit that will finish injection, medicine injecting unit simultaneously that the next one is to be injected shift onto this medicine pen core foremost and its injection orifice communicate with this injection needle.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, this electric pulse formation component further comprises:
Power module generates running voltage and the driving voltage and the output respectively of direct current form;
Operation-interface receives the electric pulse parameter that the user imports;
Microcontroller connects this operation-interface, exports a control signal according to this electric pulse parameter;
The pulse generation module connects this power module and this microcontroller, exports after the driving voltage of the direct current form of this power module being supplied with according to this control signal of this microcontroller is processed into electric impulse signal.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, this power module further comprises:
Dc source provides initial DC voltage;
First booster circuit connects this DC power supplier, and initial DC voltage is boosted to first driving voltage;
First mu balanced circuit connects this first booster circuit, receives this first driving voltage and it is carried out the voltage stabilizing operation;
Second booster circuit connects this DC power supplier, and initial DC voltage is boosted to second driving voltage;
Second mu balanced circuit connects this second booster circuit, receives this second driving voltage and it is carried out the voltage stabilizing operation;
Reduction voltage circuit connects this DC power supplier, and initial DC voltage is depressurized to running voltage;
The 3rd mu balanced circuit connects this reduction voltage circuit, receives this running voltage and it is carried out the voltage stabilizing operation.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, this electric pulse formation component also comprises:
The detection module that comes off connects this pulse generation module and this microcontroller, and the electric impulse signal that counter electrode imports on the syringe needle is sampled, and sampled signal is sent into this microcontroller judge;
The pulse display module connects this microcontroller, receives the electric pulse parameter of this microcontroller output, is shown to the user on a display screen.
Memory module connects this microcontroller, stores the electric pulse parameter of this microcontroller output.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, the scope of the crest voltage of the electric pulse of this electrode importing syringe needle output is 20~200V.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, this electric pulse imports assembly and also comprises:
Tip protection spare is used for protecting this injection needle of this syringe needle group and this several electrodes to import syringe needle, and this Tip protection spare further comprises:
Protection pin medicated cap, the monomer pin medicated cap that the shape that imports syringe needle by several and this injection needle and this several electrodes is identical is integrated to be constituted, the arrangement mode of those monomer pin medicated caps is identical with the arrangement mode of each syringe needle in this syringe needle group, and this protection pin medicated cap and this syringe needle group be buckle closure mutually;
The protection needle guard covers the periphery that buckle closure has this syringe needle group of protection pin medicated cap.
Embodiment according to bonded electric pulse generation of medical instruments of the present utility model and gatherer; this Tip protection spare, this slot electrode and this syringe needle group connect into medicated cap dress integral piece jointly, and this medicated cap dress integral piece is detachable being connected with the shell of this electric pulse gatherer.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, this medicated cap dress integral piece is that spiral is connected with this shell.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, after all medicine injecting units were finished injection in this medicine pen core, this medicated cap dress integral piece was removed so that the medicine pen core to be installed in this shell again.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, the inner shell of these several medicine injecting units all has the soft draw-in groove with medicine injecting unit self identical length.
According to an embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer, this reverse wedge piece installing is the parts that rubber is made.
This utility model contrast prior art has following beneficial effect: the technical solution of the utility model is by electric pulse formation component and electric pulse importing assembly are installed in the same equipment, and miniaturized electric pulse formation component, make it easy to carry, improved the convenience that equipment uses.On the other hand, this utility model is installed together injection needle and electric pulse importing syringe needle, and the importing process of medical injection procedure and electric impulse signal is combined together.
Description of drawings
Fig. 1 be electric pulse of the present utility model generate and the embodiment of gatherer in the module map of part of relevant electric pulse formation component.
Fig. 2 is the refinement module map of the power module in the part shown in Figure 1.
Fig. 3 is the internal structure sketch map of the embodiment of electric pulse generation of the present utility model and gatherer.
Fig. 4 is the sketch map of Tip protection spare and syringe needle group buckle closure.
Fig. 5 is the sketch map of medicine injecting unit.
Fig. 6 is the sketch map of syringe pushing ram.
Fig. 7 is the sketch map of medicine pen core.
Fig. 8 is the schematic appearance of Fig. 3 embodiment.
The specific embodiment
The utility model will be further described below in conjunction with drawings and Examples.
Please earlier referring to Fig. 8, Fig. 8 shows the outward appearance of the embodiment of bonded electric pulse generation of medical instruments of the present utility model and gatherer.Front end at device is equipped with protection pin medicated cap; terminal mounting of syringe pushing ram at device; display screen and some buttons are set on the surface of the second half section of installing, " beginning " key, " stopping " key are arranged on the button and be used to select " 60V " of voltage swing and the button of " 36V ".
Device can be divided into two parts assembly on function: the electric pulse importing assembly that is used for generating the electric pulse formation component of electric impulse signal and is used for electric impulse signal is imported to objective for implementation.It is the very important utility model point of this utility model that these two assemblies are combined in the same device.
Be explanation below to the electric pulse formation component.Fig. 1 shows the principle of electric pulse formation component.The electric pulse formation component comprises following module: operation-interface 60, power module 61, microcontroller 62, pulse display module 63, pulse generation module 64, the detection module 65 that comes off, memory module 66.Annexation between these modules is: the output of operation-interface 60 connects the input of microcontroller 62, the two-way output of power module 61 is connected respectively to the input of microcontroller 62 and the input of pulse generation module 64, the two-way output of microcontroller 62 is connected respectively to the input of pulse display module 63 and the input of pulse generation module 64, the input of detection module 65 of coming off connects the output of pulse generation module 64, the output of detection module 65 of coming off connects the input of microcontroller 62, the connection of setting up transmitted in both directions between memory module 66 and the microcontroller 62.
Power module 61 generates the running voltage and the driving voltage of direct current form, and exports running voltage to microcontroller 62, exports driving voltage to pulse generation module 64.The operation principle of power module 61 inside is asked for an interview Fig. 2, comprising: dc source 610, first booster circuit 611, second booster circuit 613, reduction voltage circuit 615, first mu balanced circuit 612, second mu balanced circuit 614, the 3rd mu balanced circuit 616.Dc source 610 for example is the dc source of 9V, and the 9V voltage here is promptly as initial DC voltage, and its output is divided into three the tunnel: the first via boosts to 36V via first booster circuit 611, carries out exporting after voltage stabilizing is handled through first mu balanced circuit 612 again; The second the tunnel boosts to 60V via second booster circuit 613, carries out voltage stabilizing through second mu balanced circuit 614 again and handles the back and export; Third Road is depressurized to 5V via reduction voltage circuit 615, carries out exporting after voltage stabilizing is handled through the 3rd mu balanced circuit 616 again.Wherein the output after the first via and the second tunnel boost is as driving voltage, and the output after the blood pressure lowering of Third Road is as running voltage.The unidirectional current of power module 61 and unidirectional current boosted and the processing of blood pressure lowering is the key that equipment can miniaturization, legacy equipment is difficult to one of reason of miniaturization and just is to use alternating current as power supply.
Operation-interface 60 receives the electric pulse parameter of user's input, that is to say, each parameter of the electric impulse signal that device generates all is that the user is adjustable.The waveform that exports the electric impulse signal of objective for implementation at last to is that symmetry triggers unidirectional continuous impulse ripple, the way of output can be to trigger output, that is by once triggering key, output pulsatile once ripple, the pulse number that discharges is 1~20, and the pulse spacing is 1~100ms.The pulse frequency of output can be arranged on 1~50Hz ± 15%, and the pulse width of output can be arranged on 9.5ms~50ms ± 30%, and the output crest voltage that electrode imports the syringe needle maximum can be arranged on 20V~200V, and error is ± 10%.
If the outward appearance of operation-interface as shown in Figure 8 is to select electrode to import the output crest voltage of syringe needle by the voltage button of 36V and 60V, if like this, illustrate that so other parameters of electric impulse signal are fixed up, the user can't change.Certainly, can open more parameter and go control, can on the surface of device button or the knob of regulating these parameters be set accordingly by the user.
After microcontroller 62 receives the electric pulse parameter of user's input, generate control signal, export pulse generation module 64 to according to electric pulse parameter.
In pulse generation module 64, the driving voltage of the direct current form that provides based on power module 61 is exported after it is processed into electric impulse signal.In this example, because driving voltage has only the unidirectional current of 36V and 60V, when operation-interface 60 receive be the push button signalling of 36V the time, the reference signal of pulse generation module 64 is exactly the unidirectional current of 36V, when operation-interface 60 receive be the push button signalling of 60V the time, the reference signal of pulse generation module 64 is exactly the unidirectional current of 60V.The electric impulse signal of output need import assembly through electric pulse could enter objective for implementation smoothly.
After pulse display module 63 receives the electric pulse parameter of microcontrollers 62 outputs, the display screen of parameter by Fig. 8 is shown to the user.Certainly, display screen can also show other information except showing electric pulse parameter, for example user's current operation etc.
The electric impulse signal that detection module 65 counter electrode that come off import on the syringe needle is sampled, and sampled signal is sent into microcontroller 62.Whether unusually microcontroller 62 judges that according to feedback signal electrode imports syringe needle and whether comes off from objective for implementation.
In addition, memory module 66 is responsible for the storage data, and these data comprise the parameter of electric impulse signal or from the physiological parameter of objective for implementation etc.Memorizer 66 can also arrive microcontroller 62 with the data importing that is stored in wherein except receiving data storage wherein.
Be the description that electric pulse imports assembly below.
Fig. 3 shows the structure of the embodiment of the bonded electric pulse gatherer of medical instruments of the present utility model.See also Fig. 3, the electric pulse of present embodiment imports assembly and comprises following parts: Tip protection spare 1, injection needle 2, electrode import syringe needle 3, slot electrode 4, medicine pen core 5, introducing apparatus shell 6.Wherein, Tip protection spare 1 belongs to selectable unit (SU).In addition, operation-interface 7 and power module 11 are also shown among Fig. 3 in the electric pulse formation component 10.
Annexation between these parts is: slot electrode 4 is positioned on the pedestal of shell 6 front ends, and delivery outlet 9 electric connections by the outer electric pulse generator of electric conductance post 7 and device receive electric impulse signal.Injection needle 2 and a plurality of electrode import syringe needle 3 and form the syringe needle group together, and injection needle 2 is in the centre usually, and these electrodes import syringe needle 3 and distribute around injection needle 2.Injection needle 2 imports syringe needle 3 with electrode and all is connected with slot electrode 4.Medicine pen core 5 as shown in Figure 5 is positioned at shell 6, the a plurality of medicine injecting units 50 as shown in Figure 3 (being shown 4 in the drawings) that form a line are equipped with in inside, interconnect by reverse wedge piece installing 52 (for example being the parts that rubber is made) between these medicine injecting units 50.The front end of each medicine injecting unit 50 all has injection orifice, and the injection orifice that is positioned at medicine pen core medicine injecting unit 50 foremost communicates with injection needle 2.All there is the soft draw-in groove with medicine injecting unit self identical length at the inner shell place of medicine injecting unit 50.Be provided with as shown in Figure 4 syringe pushing ram 51 at the end of medicine pen core 5, be connected with the medicine injecting unit 50 that is positioned at medicine pen core least significant end.It is relations of buckle closure mutually that Tip protection spare 1 and injection needle 2 and electrode import syringe needle 3.
Please be simultaneously referring to Fig. 4, Tip protection spare 1 comprises two independently parts: protection pin medicated cap 100 and protection needle guard 102.Protection pin medicated cap 100 is consistent with the shape that these injection needles 2 and electrode import syringe needle 3; that is: the integral structure formed by several monomer pin medicated caps of protection pin medicated cap 100; wherein the arrangement mode of monomer pin medicated cap is identical with the arrangement mode of each syringe needle in the syringe needle group, and protection pin medicated cap 100 and syringe needle group be buckle closure mutually.Protection needle guard 102 the has covered buckle closure periphery of syringe needle group of protection pin medicated cap 102.In the present embodiment, Tip protection spare 1, slot electrode 4 and syringe needle group (comprising that injection needle 2 and electrode import syringe needle 3) connect into medicated cap dress integral piece jointly, and medicated cap dress integral piece is detachable being connected with the shell 6 of electric pulse gatherer, for example spiral connection.
During per injection, rely on the promotion of syringe pushing ram 51 to finish a shot, medicine injecting unit 50 moves forward through the promotion of syringe pushing ram 51, and the medicine in the medicine injecting unit 50 foremost enters human body by injection orifice and injection needle 2.In the process of carrying out the medicine injection by 2 pairs of human bodies of injection needle, electrode imports syringe needle 3 and also by the electric pulse of collecting electrode groove 4 conduction human body enforcement electric pulse is imported together.Thereby realized that target tissues such as the medicine injection and the electric pulse stimulation receptor muscle that accompanies with it promote to have strengthened therapeutic effect by carrying out synchronously of medicine importing.In addition, by the electric pulse generator of gatherer outside, can realize the adjustability and the controllability of leading-in technique parameters such as electric pulse waveform.After finishing a shot, earlier used medicated cap dress integral piece is taken off, continue pushing syringe pushing ram 51, treat originally to be in after foremost medicine injecting unit is pushed out and the medicine injecting unit 50 of back is pulled to the front end of medicine pen core 5, reinstall medicated cap dress integral piece once more, realize the injection and the importing of continuation, repeat said process, medicine injecting unit 50 in medicine pen core 5 is all released, and changes medicine pen core 5 again.
This utility model imports syringe needle by injection needle and electrode on the one hand and is set together, and has realized that medicine injection and the target tissues such as electric pulse stimulation receptor muscle that accompany with it promote carrying out synchronously in the medicine transfered cell, have alleviated patient's misery.The medicine pen core is disposable use, sealing and interchangeable on the other hand, and medicine injecting unit has wherein guaranteed the degree of accuracy of drug dose.
The foregoing description provides to those of ordinary skills and realizes or use of the present utility model; those of ordinary skills can be under the situation that does not break away from invention thought of the present utility model; the foregoing description is made various modifications or variation; thereby protection domain of the present utility model do not limit by the foregoing description, and should be the maximum magnitude that meets the inventive features that claims mention.