CN101822767A

CN101822767A - External plaster for treating sclerotin and osseous nerve diseases

Info

Publication number: CN101822767A
Application number: CN200910021385A
Authority: CN
Inventors: 张文建; 钱兴英
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-05
Filing date: 2009-03-05
Publication date: 2010-09-08
Anticipated expiration: 2029-03-05
Also published as: CN101822767B

Abstract

The invention relates to an external plaster for treating sclerotin and osseous nerve diseases, such as lumbar cervical herniated disk, osteoproliferation, waist and keen ache, arthritis, traumatic injury and the like. A special external plaster is prepared according to the therapeutic principles of internal diseases treated by external application and searching for the primary cause of disease in treatment by processing the following pure traditional Chinese medicine raw materials: herba ephedrae, Caulis Spatholobi, ground beeltle, Alangium platanifolium root, leech, centipede, ciliate desert-grass, asarum, borneol, dragon's blood, Pariphyllin, cassia twig and the like as base recipes. The external plaster has the functions of softening sclerotin, relaxing muscles, invigorating the circulation of blood, promoting blood circulation and removing blood stasis, dispersing swelling, diminishing inflammation and relieving pain, has good effect in the aspect of treating the sclerotin and osseous nerve diseases and can obviously reduce the threat and the harm to human health.

Description

The external plaster that is used for the treatment of the neural class disease of sclerotin and bone

Technical field

Content of the present invention belongs to the preparing technical field of pharmaceuticals, relates to a kind of external plaster that can be used for treating sclerotin and the neural class disease of bone.

Background technology

Sclerotin and bone neural class disease such as waist, prolapse of cervical intervertebral disc, hyperosteogeny, slippage, deviate from, diseases such as waist, knee joint pain, rheumatic arthritis, traumatic injury all bring great misery to the patient.It is more at present to be used for the method for above-mentioned disease at medical domain, mainly comprises operative treatment and non-operative treatment.Operative treatment is owing to big, the suitable narrow range of misery, postoperative may be left over reasons such as sequela and surgery cost height, and a lot of people are unwilling to accept.Non-operative treatment mainly refers to interior or topical Drug therapy.External used medicine comprises plaster agent, paste etc., but effect is also not fully up to expectations.And traditional innerlich anwenden therapeutic modality is because the route of administration limitation, curative effect is relatively poor, ingredient in the administration process through intestinal juice stomach acids destroy and liver metabolism, often do not reach effective blood drug concentration, influenced curative effect of medication, in addition in the high amount of drug with the toxic and side effects that also may cause other, impairing the liver, the impairment of the spleen, injure one's stomach.

Summary of the invention

The objective of the invention is to the problem that exists at state of the art, by excavating the abundant Chinese medicine resource of motherland, and then provide a kind of prescription science, easy to prepare, the external plaster that is used for the treatment of sclerotin and the neural class disease of bone that curative effect is high.

The preparation scheme of external plaster of the present invention comes from motherland's medical science about traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs thoughts such as " inner disease outer treat ", " treatment must aim at the pathogenesis of disease ", and it is the designer by concentrating on studies for a long time and develop acquisition by the empirical concentrated summary of designer's clinical practice for many years many medicine and pharmacology books and folk remedy at all times.According to medical science at all times to sclerotin and the neural class disease of bone pathogenesis pathological knowledge, designer of the present invention is high with pure Chinese medicine raw material Herba Ephedrae, Caulis Spatholobi, Eupolyphaga Seu Steleophaga, Radix Alangii, Hirudo, Scolopendra, one, Herba Asari, Borneolum Syntheticum, Sanguis Draxonis, Rhizoma Paridis, Ramulus Cinnamomi etc. are basic recipe, be processed into special-purpose external plaster, this plaster has softening sclerotin clinically, dredge that muscle is invigorated blood circulation, the effect of invigorating blood circulation paralysis, detumescence, anti-inflammatory analgetic, aspect sclerotin and the neural class treatment of diseases of bone, good effect being arranged, can significantly reduce its threat and harm to health of people.

Each the active drug raw material and the weight proportion that constitute this external plaster are:

Herba Ephedrae 7～10, Caulis Spatholobi 10～15, Eupolyphaga Seu Steleophaga 10～15,

Radix Alangii 6～8, Hirudo 7～10, Scolopendra 4～6,

Make one high 6～10, Herba Asari 6～8, Borneolum Syntheticum 6～8,

Sanguis Draxonis 10～13, Rhizoma Paridis 15～20, Ramulus Cinnamomi 12～16.

The medicinal ingredient and the pharmacological action of each herbal medicine are as described below in the present invention's prescription.

Herba Ephedrae

[composition] Ephedra sinica stem contains alkaloid 1%～2%, and wherein 40%～90% is ephedrine, secondly is the LN monomethyl ephedrine of pseudo-numb ephedrine and trace.

[pharmacology] function relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, diuretic.The vasoconstriction effect of ephedrine is relatively gentleer and lasting, can make coronary vasodilation, increases coronary blood flow.

Caulis Spatholobi

[composition] contains milletol.

The agent of [pharmacology] Caulis Spatholobi raised path between farm fields has significant curative effect for rat oral gavage PARA FORMALDEHYDE PRILLS(91,95) " arthritis ", and decoct or tincture intravenous injection do not make significant difference to breathing, blood pressure and the Bufo siccus lower limb vascular perfusion of anesthetized dog

Eupolyphaga Seu Steleophaga

[composition] main volatile oil, aminoacid, protein, saccharide, fat, steroid, phenols, organic acid and alkaloid etc. of containing, 8 kinds of micro elements needed by human such as iron content, manganese, zinc, copper in addition.Oneself identifies 20 components base volatile oil, and wherein naphthalene content is the highest, accounts for 22.19%, and various fatty aldehydes and aromatic aldehyde account for 24.95%, and aldehyde may be the stink composition of this product.

[pharmacology] blood coagulation resisting function, eupolyphoge sinensis water extract are given rat oral gavage 7 days continuously, all obvious prolong rats bleeding time of heavy dose of group and usual amounts group and recalcification time.

Radix Alangii

Fibrous root and the root bark of [composition] Radix Alangii contain alkaloid, phenols, aminoacid, organic acid, resin, and fibrous root mainly contains alkaloid and glucoside, contains cardiotonic glycoside again.

[pharmacology] of flaccid muscles and analgesic activity, the total alkaloids that proposes from the Radix Alangii fibrous root all can cause of flaccid muscles to rabbit, rat, mice and Canis familiaris L..

Hirudo

[composition] Hirudo mainly contains protein.Contain a kind of anticoagulative substance name hirudin in the fresh Hirudo saliva.

[pharmacology] hirudin is not heated or the destruction of ethanol, can stop the effect of thrombin to fibronectin, hinders blood coagulation.Hirudo can also secrete a kind of H-subst, thereby expansible blood capillary and increase hemorrhagely, and its alcohol extract has the effect that suppresses blood coagulation, is better than Tabanus, Moschus moschiferous worm, Semen Persicae etc., and the alcohol formulations effect is better than water formulation.20 milligrams of hirudins can stop solidifying of 100 gram human bloods.

Scolopendra

[composition] contains the toxic component of two kinds of similar Venenum apis; be histamine sample material and hemolytic protein; still fatty oil, cholesterol, formic acid etc.; once isolated oxylysine again, aminoacid has histidine, arginine, ornithine, lysine, glycine, alanine, leucine, phenylalanine, serine, taurine, glutamic acid etc.

[pharmacology] antitumor action, the injection of Scolopendra Hirudo can be made the spermatogonium of white mice necrose, disappear, and illustrating has inhibitory action to tumor cell.Experiment in vitro proves: Scolopendra Hirudo injection is positive to the red rate of dying of cancerous cell, and Scolopendra Hirudo to the suppression ratio to white mice hepatocarcinoma tumor body is 26%, and the reticuloendothelial cell function is had potentiation.

-branch is high

[composition] contains Millefolium element, blue Oleum sesami, Camphora and takes off the acetyl matricin, contains equisetic acid, inulin and cineole again.

[pharmacology] achillea millefolium in vitro has the bacteriostasis of height to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, sonne bacillus, bacterium flexneri.

Herba Asari

[composition] Herba Asari contains that volatile oil is about 3%, and main component of essential oil is methyleugenol (accounting for 50%), also has saishinone, pinene, Eucarvone, safrole, 1,8-cineole, stamen asarinin etc.

[pharmacology] local anesthesia effect, magnificent Herba Asari water logging agent or pure preserved material can be blocked the sciatic conduction of impulse of the frog, and Herba Asari volatile oil still has surface anesthetic effect.

Borneolum Syntheticum

[composition] Borneolum Syntheticum is the crystallization that obtains in the resin of Borneolum Syntheticum and the volatile oil.Contain multiple ter penoids in the resin of Borneolum Syntheticum and the volatile oil, except that Borneolum Syntheticum, still contain triterpenoids such as sesquiterpenes such as oxalene, beta-elemene, caryophyllene and oleanolic acid, dipterocarpol, dryobalanone, erythrodiol.

[pharmacology] its effect is similar to Camphora, is mainly used in promoting the circulation of QI to relieve pain, at external higher concentration bacteriostasis is arranged, and can be used for osteoneuralgia or antiinflammatory.

Sanguis Draxonis

[composition] is the mixture of a kind of resin ester and dracoresinotannol.

[pharmacology] antifungic action, Sanguis Draxonis water logging agent (1: 2) are in vitro to the multiple pathogenic inhibitory action that has in various degree such as trichophyton, trichophyton gypseum, oidium schoenleinii.

Rhizoma Paridis

[composition] rhizome contains the multiple Saponins such as 3-glycoside, 3-rhamnose Fructus Vitis viniferae glycoside, 3-rhamnose arabinose glycoside and 3-tetrose glycoside of pariphylin, dioscin, the pre-ruscogenin of potato, also contains tannin and 18 gynaminic acid, kreatinin, alkaloid, yellow intoxicated, sterone, ecdyson, daucosterol etc.

[pharmacology] anti-microbial effect, the tumor of can subsiding a swelling.100% Rhizoma Paridis preparation all has inhibitory action to dysentery bacterium, Bacillus typhi, Salmonella paratyphi, bacillus enteritidis, escherichia coli, paracolon, bacillus pyocyaneus, staphylococcus aureus, Hemolytic streptococcus, meningococcus, and the inhibitory action of pyococcus is better than Rhizoma Coptidis.

Ramulus Cinnamomi

[composition] contains Ramulus Cinnamomi alcohol etc.

[pharmacology] antibacterial action, the Ramulus Cinnamomi ethanol extract can suppress escherichia coli, bacillus subtilis and staphylococcus aureus external, and Staphylococcus albus, dysentery bacterium, typhoid fever and paratyphoid fever bacillus, streptococcus pneumoniae, aerobacteria, Bacillus proteus, anthrax bacillus, Salmonella enteritidis, vibrio cholera etc. are also had inhibitory action.

In the practical application, the external plaster that is used for the treatment of the neural class disease of sclerotin and bone of the present invention technology is routinely made the external plaster of pharmaceutics record, applies ointment or plaster as medical ointment plaster, medicated powder etc.During use,, then the medicated powder face is affixed on patient's sore place or the grain corresponding and the place at acupuncture point, reaches the effect of the neural class disease of effective treatment sclerotin and bone with disease earlier with the heating of this plaster.Generally, stick once can go again in sustainable 5～7 days and exchange cards containing all personal details and become sworn brothers.Be noted that: as patient's skin has the reaction of itching after sticking plaster, then this place's skin is smeared with the Rhizoma Zingiberis Recens wiping or with the clear ointment of skin to get final product; The anemia of pregnant woman prohibits subsides in addition, does not also use if any indivedual anaphylaxis persons.

In development process of the present invention, be therapeutic effect and the safety that proves this external plaster, the designer had once carried out the experimental study of clinicing aspect with regard to this plaster, and the patient that 102 examples are accepted diagnosis and treatment has been carried out visiting statistics, and the result is as described below.

One, tcm diagnosis: lumbar vertebra point dish is outstanding, hyperosteogeny, slippage, lumbocrural pain, rheumatic arthritis, traumatic injury etc.

Two, Therapeutic Method: be affixed on patient's diseased region after the thermoplastic, changed once in per 5～7 days, per 30～35 days is a course of treatment.

Three, efficacy assessment standard: be divided into recovery from illness, produce effects, effective, invalid four kinds with reference to " partially new tcm clinical practice choosing " and " Surgery of Chinese Medicine ".

1. recovery from illness: diseased region transference cure General Symptoms disappears;

2. produce effects: the diseased region symptom is obviously improved and is reached 70% above part and General Symptoms disappears substantially;

3. effective: diseased region passs on 30%～70% well;

4. invalid: diseased region improves less than 30%, and part and whole body do not have improvement.

Four, therapeutic outcome: for many years clinical, hundreds of surplus routine patients obtain curative effect.

Show that by clinical research Chinese medicine external of the present invention is pasted, and is 100% to institute's test of cure case total effective rate, 98 examples of wherein fully recovering, effective 2 examples, produce effects 1 example, invalid 1 example to 102 routine patients.Clinical observation demonstrates fully this plaster and has effects such as thin muscle is invigorated blood circulation, anti-inflammatory analgetic, putrefaction removing and tissue regeneration promoting, the cold expelling that stimulates the menstrual flow, and easy to use, safe.

The specific embodiment

Embodiment one:

Get Herba Ephedrae 80g, Caulis Spatholobi 150g, Eupolyphaga Seu Steleophaga 120g, Radix Alangii 70g, Hirudo 80g, Scolopendra 50g, system high 80g, a Herba Asari 60g, Borneolum Syntheticum 70g, Sanguis Draxonis 120g, Rhizoma Paridis 180g, Ramulus Cinnamomi 150g respectively, with above-mentioned active drug raw material routinely preparation technology make the coating unguentum, with the above-mentioned coating unguentum polylith diameter that is laid in respectively is on the medical paster material of 8～10cm, every drug of topical application amount is 8～12g, and makes the external plaster that is used for the treatment of sclerotin and the neural class disease of bone of the present invention with this.

Embodiment two:

Get Herba Ephedrae 100g, Caulis Spatholobi 130g, Eupolyphaga Seu Steleophaga 130g, Radix Alangii 75g, Hirudo 80g, Scolopendra 55g, system high 90g, a Herba Asari 70g, Borneolum Syntheticum 75g, Sanguis Draxonis 120g, Rhizoma Paridis 175g, Ramulus Cinnamomi 150g respectively, with above-mentioned active drug raw material routinely preparation technology make powder, above-mentioned powder is set in respectively in the medical paster material of penetrating cotton system that the polylith diameter is 8～10cm, establishing dose in every is 8～12g, and makes the external plaster that is used for the treatment of sclerotin and the neural class disease of bone of the present invention with this.

Claims

1. external plaster that is used for the treatment of the neural class disease of sclerotin and bone is characterized in that it is by the active drug raw material of the following weight proportion external plaster made of technology routinely:

Radix Alangii 6～8, Hirudo 7～10, Scolopendra 4～6,

Make one high 6～10, Herba Asari 6～8, Borneolum Syntheticum 6～8,

Sanguis Draxonis 10～13, Rhizoma Paridis 15～20, Ramulus Cinnamomi 12～16.